Publications

infection and pathogenesis of huaiyangshan virus (a novel tick-borne bunyavirus) in laboratory rodents.	a novel tick-borne bunyavirus (huaiyangshan virus, hysv), which causes haemorrhagic fever-like disease, has recently been reported in china. so far no animal experiments have been performed to study its pathogenesis. towards developing an animal model for hysv fever, newborn and adult mice and rats and golden hamsters were inoculated intracerebrally or intraperitoneally with hysv. newborn rats and newborn mice, especially kunming (km) mice, appeared highly susceptible. remarkably, the km mice th ...	2012	22357748
infection with a novel virus causes hemorrhagic fever in china.	patients have been identified with hemorrhagic fever (hf) caused by huaiyangshan virus (hysv) infection since 2009. this study aimed to investigate the characteristics of clinical symptoms, laboratory examinations, epidemiological factors, and therapeutic responses in patients with huaiyangshan hemorrhagic fever (hyshf).	2013	23611634
pediatric huaiyangshan virus infection: a case report with literature review.	to define the clinical manifestations and laboratory characteristics of pediatric severe fever with thrombocytopenia syndrome (sfts) case caused by a novel bunyavirus. we retrospectively analyzed a pediatric case of viral sfts in a 13 year old successfully managed and confirmed to be due to the novel bunyavirus now referred to as huaiyangshan virus. a literature review of related cases was performed.our pediatric case was a 13.3-year-old middle school student no underlying disease. major clinica ...	2017	28560174
genome-wide analysis of synonymous codon usage in huaiyangshan virus and other bunyaviruses.	huaiyangshan virus (hysv) is a newly discovered bunyavirus, which is transmitted by ticks and causes hemorrhagic fever-like illness in human. the interplay of codon usage among viruses and their hosts is expected to affect viral survival, evasion from host's immune system and evolution. however, little is known about the codon usage in hysv genome. in the present study, we analyzed synonymous codon usage in 120 available full-length hysv sequences and performed a comparative analysis of synonymo ...	2015	26173646
hemorrhagic fever caused by a novel bunyavirus in china: pathogenesis and correlates of fatal outcome.	background. hemorrhagic fever-like illness caused by a novel bunyavirus, huaiyangshan virus (hysv, also known as severe fever with thrombocytopenia virus [sftsv] and fever, thrombocytopenia and leukopenia syndrome [ftls]), has recently been described in china.methods. patients with laboratory-confirmed hysv infection who were admitted to union hospital or zhongnan hospital between april 2010 and october 2010 were included in this study. clinical and routine laboratory data were collected and blo ...	2011	22144540
the ecology, genetic diversity and phylogeny of huaiyangshan virus in china.	surveys were carried out to better understand the tick vector ecology and genetic diversity of huaiyangshan virus (hysv) in both endemic and non-endemic regions. haemaphysalis longicornis ticks were dominant in endemic regions, while rhipicephalus microplus is more abundant in non-endemic regions. hysv rna was found in human and both tick species with more prevalence in h. longicornis and lesser in r. microplus. phylogenetic analyses indicate that hysv is a novel species of the genus phlebovirus ...	2011	22190717
the emergence and cross species transmission of newly discovered tick-borne bunyavirus in china.	a novel tick-borne bunyavirus, discovered in china and later in south korea and japan, is now known as huaiyangshan virus or severe fever with thrombocytopenia syndrome virus and has been identified as the causative agent of a hemorrhagic fever-like disease. of five species of ticks carrying huaiyangshan viruses, haemaphysalis longicornis was the most abundant in regions where the virus was endemic. its usual hosts (cattle, goats, dogs, rats and chickens) tested positive for huaiyangshan virus r ...	2016	26949898