| complement activation and complement-dependent inflammation by neisseria meningitidis are independent of lipopolysaccharide. | fulminant meningococcal sepsis has been termed the prototypical lipopolysaccharide (lps)-mediated gram-negative septic shock. systemic inflammation by activated complement and cytokines is important in the pathogenesis of this disease. we investigated the involvement of meningococcal lps in complement activation, complement-dependent inflammatory effects, and cytokine or chemokine production. whole blood anticoagulated with lepirudin was stimulated with wild-type neisseria meningitidis h44/76 (l ... | 2004 | 15155639 |
| dissecting the effects of lipopolysaccharides from nonlipopolysaccharide molecules in experimental porcine meningococcal sepsis. | to dissect the in vivo responses to lipopolysaccharide compared with nonlipopolysaccharide structures of whole meningococci. | 2010 | 20400898 |
| neisseria meningitidis lipid a mutant lpss function as lps antagonists in humans by inhibiting tlr 4-dependent cytokine production. | lipopolysaccharide is a major constituent of the outer membrane of gram-negative bacteria and important in the induction of pro-inflammatory responses. recently, novel lps species derived from neisseria meningitidis h44/76 by insertional inactivation of the lpxl1 and lpxl2 genes have been created with a lipid a portion consisting of five (penta-acylated lpxl1) or four (tetra-acylated lpxl2) fatty acids connected to the glucosamine backbone instead of six fatty acids in the wild-type lps. we show ... | 2010 | 21088052 |
| a critical contribution of both cd28 and icos in the adjuvant activity of neisseria meningitidis h44/76 lps and lpxl1 lps. | the development of novel vaccines against neisseria meningitidis recently gained momentum by the generation of penta-acylated lpxl1 lps which has similar adjuvant activity, but reduced endotoxic activity as compared to hexa-acylated wild type (h44/76) lps. we investigated the costimulation requirements for the adjuvant activity of both forms of lps by immunizing cd28-, icos- and b7.1/2/icos-deficient mice. both icos and cd28 appeared essential for optimal adjuvant activity of h44/76 lps or lpxl1 ... | 2007 | 17499399 |
| high-level endothelial e-selectin (cd62e) cell adhesion molecule expression by a lipopolysaccharide-deficient strain of neisseria meningitidis despite poor activation of nf-kappab transcription factor. | binding of host inflammatory cells to the endothelium is a critical contributor to the vascular damage characteristic of severe meningococcal disease and is regulated by endothelial cell adhesion molecules such as icam-1, vcam-1 and cd62e. intact meningococci induce far higher levels of cd62e than lipopolysaccharide (lps) alone, whereas lps is at least as potent as meningococci at inducing both vcam-1 and icam-1 expression. this suggests that meningococci possess additional factors other than lp ... | 2004 | 14678268 |