| [effect of carbon sources on the biosynthesis of ergot alkaloids and the activity of carbon metabolism enzymes in penicillium sizovae]. | the study was aimed at finding out how different carbon sources influenced the growth of penicillium sizovae, the biosynthesis of epoxyagroclavine-1 and agroclavine-1 as well as the activity of key enzymes involved in the citric acid cycle, the pentose phosphate pathway and the glyoxylate cycle. the fungal growth was shown to depend on the carbohydrate substrate: it had a two-phase profile when p. sizovae was cultivated on mannitol and glucose, but not on sorbitol. the quantitative content and c ... | 2006 | 3696015 |
| [alkaloid production in the fungus penicillium sizovae]. | the dynamics of production of agroclavine-i and epoxyagroclavine-i, the basic components of the penicillium sizovae alkaloid fraction, was being studied. the biosynthesis of alkaloids occurs in two stages coinciding in time with the growth phases. the culture studied is shown to have a considerably higher content of extracellular alkaloids than that of the mycelium. when the culture is grown on a medium with mannitol and succinic acid, separate consumption of carbon sources is observed. the alka ... | 2012 | 3703836 |
| [effect of the exogenous tryptophan on biosynthesis of ergot alkaloids in penicillium sizovae]. | various concentrations of exogenous l and d-tryptophan as well as of their analogue d,l-6-methyltryptophan were added to the growth medium of penicillium sizovae during its inoculation and after the active growth of the fungus was over. the authors studied the effect of these compounds on the accumulation of exocellular alkaloids and biomass as well as on the synthesis of proteins, the content of free tryptophan in the cells, and the activity of tryptophan synthetase. as was shown in experiments ... | 2013 | 4094575 |