| strain-specific properties and t cells regulate the susceptibility to papilloma induction by mus musculus papillomavirus 1. | the immunocytes that regulate papillomavirus infection and lesion development in humans and animals remain largely undefined. we found that immunocompetent mice with varying h-2 haplotypes displayed asymptomatic skin infection that produced l1 when challenged with 6×1010 muspv1 virions, the recently identified domestic mouse papillomavirus (also designated "mmupv1"), but were uniformly resistant to muspv1-induced papillomatosis. broad immunosuppression with cyclosporin a resulted in variable ind ... | 2014 | 25121947 |
| characterization of mus musculus papillomavirus 1 infection in situ reveals an unusual pattern of late gene expression and capsid protein localization. | full-length genomic dna of the recently identified laboratory mouse papillomavirus 1 (muspv1) was synthesized in vitro and was used to establish and characterize a mouse model of papillomavirus pathobiology. muspv1 dna, whether naked or encapsidated by muspv1 or human papillomavirus 16 (hpv 16) capsids, efficiently induced the outgrowth of papillomas as early as 3 weeks after application to abraded skin on the muzzles and tails of athymic ncr nude mice. high concentrations of virions were extrac ... | 2013 | 24067981 |
| spontaneous and vaccine-induced clearance of mus musculus papillomavirus 1 infection. | mus musculus papillomavirus 1 (mmupv1/muspv1) induces persistent papillomas in immunodeficient mice but not in common laboratory strains. to facilitate the study of immune control, we sought an outbred and immunocompetent laboratory mouse strain in which persistent papillomas could be established. we found that challenge of skh1 mice (crl:skh1-hrhr) with mmupv1 by scarification on their tail resulted in three clinical outcomes: (i) persistent (>2-month) papillomas (∼20%); (ii) transient papillom ... | 2017 | 28515303 |
| immunologic control of mus musculus papillomavirus type 1. | persistent papillomas developed in ~10% of out-bred immune-competent skh-1 mice following muspv1 challenge of their tail, and in a similar fraction the papillomas were transient, suggesting potential as a model. however, papillomas only occurred in balb/c or c57bl/6 mice depleted of t cells with anti-cd3 antibody, and they completely regressed within 8 weeks after depletion was stopped. neither cd4+ nor cd8+ t cell depletion alone in balb/c or c57bl/6 mice was sufficient to permit visible papill ... | 2015 | 26495972 |
| secondary infections, expanded tissue tropism, and evidence for malignant potential in immunocompromised mice infected with mus musculus papillomavirus 1 dna and virus. | papillomavirus disease poses a special challenge to people with compromised immune systems. appropriate models to study infections in these individuals are lacking. we report here the development of a model that will help to address these deficiencies. the mmupv1 genome was synthesized and used successfully to produce virus from dna infections in immunocompromised mice. in these early studies, we have demonstrated both primary and secondary infections, expanded tissue tropism, and extensive dysp ... | 2013 | 23785210 |