| mycoleptodiscus indicus: a new etiologic agent of phaeohyphomycosis. | mycoleptodiscus indicus, a dematiaceous hyphomycete, was identified as the causal agent of subcutaneous infection in the knee of a 72-year-old male gardener residing in coastal south carolina. the patient had wegener's granulomatosis and immunodeficiency. synovial fluid and biopsy tissue sections from the prepatellar bursa stained with hematoxylin and eosin, periodic acid-schiff, and gomori methenamine silver stains revealed branched, septate hyphae and many moniliform hyphal elements. when tiss ... | 1995 | 8567931 |
| a case of subcutaneous mycoleptodiscus indicus infection in a liver transplant recipient successfully treated with antifungal therapy. | mycoleptodiscus indicus, a dematiaceous mold, occurs on the leaves of a number of different host plants and has been only recently described as a cause of human infection. immunosuppressed individuals are at risk for developing infections with opportunistic fungal pathogens, which are a major cause of morbidity and mortality in this population. in addition, the treatment of infections caused by these fungi is frequently challenging. we report a case of m. indicus subcutaneous infection in a 51-y ... | 2008 | 17944811 |
| subcutaneous mycoleptodiscus indicus infection in an immunosuppressed dog. | an 8-year-old dog presented with several dermal excoriations. lesion cytology revealed pyogranulomatous inflammation with branching, septate hyphae. a mold identified as mycoleptodiscus indicus by morphology and sequencing was cultured from fine-needle aspirates. this is the first report of a mycoleptodiscus species as an etiologic agent in a dog. | 2010 | 20519473 |
| invasive mycoleptodiscus fungal cellulitis and myositis. | we report progressive necrotizing fungal cellulitis and myositis in the leg of a patient with glioblastoma multiforme treated with temozolomide and corticosteroids. while the morphologic appearance of the isolate and its ability to grow at temperatures greater than 32°c were suggestive of mycoleptodiscus indicus, some of the conidia were atypical for this species in that they had single septa and occasional lateral appendages. furthermore, the isolate was different from m. indicus based on the s ... | 2012 | 22332907 |
| endo-xylanase gh11 activation by the fungal metabolite eugenitin. | eugenitin, a chromone derivative and a metabolite of the endophyte mycoleptodiscus indicus, at 5 mm activated a recombinant gh11 endo-xylanase by 40 %. the in silico prediction of ligand-binding sites on the three-dimensional structure of the endo-xylanase revealed that eugenitin interacts mainly by a hydrogen bond with a serine residue and a stacking interaction of the heterocyclic aromatic ring system with a tryptophan residue. eugenitin improved the gh11 endo-xylanase activity on different su ... | 2012 | 22481300 |
| mycoleptones a-c and polyketides from the endophyte mycoleptodiscus indicus. | three new azaphilones with an unusual methylene bridge, named mycoleptones a, b, and c (2, 4, and 5), were isolated from cultures of mycoleptodiscus indicus, a fungus associated with the south american medicinal plant borreria verticillata. additionally, four known polyketides, austdiol (1), eugenitin (3), 6-methoxyeugenin (6), and 9-hydroxyeugenin (7), were also isolated. the structural characterization of compounds was carried out by nuclear magnetic resonance spectroscopy, high-resolution mas ... | 2014 | 24387625 |
| fungal arthritis of the knee caused by mycoleptodiscus indicus. | mycoleptodiscus indicus is a recognized plant pathogen which has very rarely been reported as a cause of human infection. it is a tropical or subtropical fungus which is difficult to culture and identify from clinical specimens. this is the first report of septic arthritis with this fungus in a healthy canadian male. the fungal infection was contracted on a vacation in costa rica, probably through direct inoculation through injured skin. the fungus was isolated from synovial fluid and identifica ... | 2010 | 20383730 |