| molecular characterization of a new species in the genus alphacoronavirus associated with mink epizootic catarrhal gastroenteritis. | a coronavirus (cov) previously shown to be associated with catarrhal gastroenteritis in mink (mustela vison) was identified by electron microscopy in mink faeces from two fur farms in wisconsin and minnesota in 1998. a pan-coronavirus and a genus-specific rt-pcr assay were used initially to demonstrate that the newly discovered mink covs (mcovs) were members of the genus alphacoronavirus. subsequently, using a random rt-pcr approach, full-genomic sequences were generated that further confirmed t ... | 2011 | 21346029 |
| coronaviruses associated with the superfamily musteloidea. | among the animal superfamily musteloidea, which includes those commonly known as mustelids, naturally occurring and species-specific alphacoronavirus infections have been observed in both mink (mustela vison/neovison vison) and domestic ferrets (mustela putorius furo). ferret systemic coronavirus (frscv), in particular, has been associated with a rare but fatal systemic disease. in recent months, it has become apparent that both minks and ferrets are susceptible to severe acute respiratory syndr ... | 2021 | 33468694 |
| coronavirus infections in companion animals: virology, epidemiology, clinical and pathologic features. | coronaviruses are enveloped rna viruses capable of causing respiratory, enteric, or systemic diseases in a variety of mammalian hosts that vary in clinical severity from subclinical to fatal. the host range and tissue tropism are largely determined by the coronaviral spike protein, which initiates cellular infection by promoting fusion of the viral and host cell membranes. companion animal coronaviruses responsible for causing enteric infection include feline enteric coronavirus, ferret enteric ... | 2020 | 32933150 |
| pancreatitis and systemic coronavirus infection in a ferret (mustela putorius furo). | a 1-y-old spayed female ferret (mustela putorius furo) was referred for additional diagnostic evaluation after physical examination by the referring veterinarian revealed a cranial abdominal mass. the ferret had a 2-wk history of inappetence, weight loss, and lethargy. on presentation, the ferret was thin, and an approximately 3-cm mass was palpable in the cranial abdomen. no other abnormalities were noted. abdominal ultrasonography confirmed the presence of a soft-tissue structure, with a moder ... | 2018 | 29776456 |
| cerebral pyogranuloma associated with systemic coronavirus infection in a ferret. | a 2-year-old male ferret was presented with central nervous system signs. computed tomography (ct) of the brain revealed a well-defined contrast-enhancing lesion on the rostral forebrain that appeared extraparenchymal. surgical excision of the mass was performed and the ferret was euthanised during the procedure. histopathology of the excised mass showed multiple meningeal nodular lesions with infiltrates of epithelioid macrophages, occasionally centred on degenerated neutrophils and surrounded ... | 2016 | 26046449 |
| coronavirus infection in ferrets: antigen distribution and inflammatory response. | multisystemic granulomatous lesions are the most common finding in ferrets infected by ferret systemic coronavirus (frscv). to characterize the inflammatory response developed against this virus, lesions from 4 naturally infected ferrets were examined. lesions were classified into the 4 known types of granulomas (granulomas without necrosis [g], granulomas with necrosis [g-n], granulomas with neutrophils [g-nl], and diffuse granulomatous inflammation [dg]). the cellular composition of the lesion ... | 2016 | 27106741 |
| naturally occurring recombination in ferret coronaviruses revealed by complete genome characterization. | ferret coronaviruses (frcovs) exist as an enteric and a systemic pathotype, of which the latter is highly lethal to ferrets. to our knowledge, this study provides the first full genome sequence of a frcov, tentatively called frcov-nl-2010, which was detected in 2010 in ferrets in the netherlands. phylogenetic analysis showed that frcov-nl-2010 is most closely related to mink cov, forming a separate clade of mustelid alphacoronavirus that split off early from other alphacoronaviruses. based on se ... | 2016 | 27283016 |
| determination of ferret enteric coronavirus genome in laboratory ferrets. | ferret enteric coronavirus (frecv) rna was detected in laboratory ferrets. analysis of the complete genome sequence of 2 strains, frcov4370 and frcov063, revealed that frecv shared 49.9%-68.9% nucleotide sequence identity with known coronaviruses. these results suggest that frecv might be classified as a new species in the genus alphacoronavirus. | 2017 | 28820366 |
| pyogranulomatous panophthalmitis with systemic coronavirus disease in a domestic ferret (mustela putorius furo). | a 15-month-old spayed female ferret (mustela putorius furo) presented for lethargy and weight loss of 2 weeks duration. upon physical examination, a 2-mm-diameter focal area of opacity was noted in the left cornea. in addition, the ferret was quiet, in poor body condition, and dehydrated. a complete blood count and plasma biochemistry revealed a severe nonregenerative anemia, azotemia, hyperproteinemia, hypoalbuminemia, and mild hyperphosphatemia and hyperchloremia. urinalysis revealed hyposthen ... | 2016 | 25918975 |
| first case of systemic coronavirus infection in a domestic ferret (mustela putorius furo) in peru. | a domestic ferret from lima, peru, died after ten days of non-specific clinical signs. based on pathology, immunohistochemistry and molecular analysis, ferret systemic coronavirus (frscv)-associated disease was diagnosed for the first time in south america. this report highlights the potential spread of pathogens by the international pet trade. | 2015 | 26301572 |
| abdominal radiographic and ultrasonographic findings in ferrets (mustela putorius furo) with systemic coronavirus infection. | ferret systemic coronavirus infection (fscv) is a systemic disease in ferrets that clinically and pathologically resembles the dry form of fip. the present study describes abdominal imaging features of 11 ferrets with fscv. abdominal survey radiographs were available for eight ferrets and ultrasound examination for all cases. loss of lumbar musculature, decreased peritoneal detail, presence of mid-abdominal soft-tissue masses and splenomegaly were the most significant radiographic signs in these ... | 2011 | 21862468 |
| ferret coronavirus-associated diseases. | a novel coronavirus of ferrets was first described in 1993. this coronavirus caused an enteric disease called epizootic catarrhal enteritis (ece). recently, a ferret systemic coronavirus (frscv)-associated disease was discovered. this new systemic disease resembles the dry form of feline infectious peritonitis (fip) and has been reported in the united states and europe. this article addresses the clinical signs, pathology, pathogenesis, diagnosis, treatment, and prevention of this ferret fip-lik ... | 2010 | 20682435 |
| comparative sequence analysis of the distal one-third of the genomes of a systemic and an enteric ferret coronavirus. | ferret systemic coronavirus (frscv) infection is associated with an emerging, highly fatal disease of ferrets. enhanced macrophage tropism and the resulting induction of pyogranulomatous lesions are shared with feline infectious peritonitis virus (fipv) infection in cats, but are not features of ferret enteric coronavirus (frecv) infection. comparative sequence analysis of the distal one-third of the genomes of one frscv and one frecv strain showed that these two ferret coronaviruses share >96% ... | 2010 | 20079778 |
| two cases of systemic coronavirus-associated disease resembling feline infectious peritonitis in domestic ferrets in japan. | a systemic disease of domestic ferrets characterized by pyogranulomatous inflammation was first recognized in europe and the united states in 2002. the disease closely resembled feline infectious peritonitis and subsequently has been shown to be associated with ferret systemic coronavirus (frscv). a definitive laboratory diagnosis of this disease is typically based on a combination of immunohistochemistry (ihc) and reverse-transcriptase polymerase chain reaction tests to detect frscv in granulom ... | 2014 | 32288680 |