| emerging ferret diseases. | there are a number of newly described and emerging disease syndromes affecting the domestic ferret, and the purpose of this article is to make veterinarians aware of these diseases. a recently described systemic coronavirus infection appears to be a variant of the ferret enteric coronavirus and is currently termed "ferret infectious peritonitis." disseminated immunopathologic myositis, aplastic anemia/bone marrow aplasia, acute hemorrhagic syndrome, and oral ulcerations are also described, altho ... | 2010 | 32288674 |
| coronavirus infections in companion animals: virology, epidemiology, clinical and pathologic features. | coronaviruses are enveloped rna viruses capable of causing respiratory, enteric, or systemic diseases in a variety of mammalian hosts that vary in clinical severity from subclinical to fatal. the host range and tissue tropism are largely determined by the coronaviral spike protein, which initiates cellular infection by promoting fusion of the viral and host cell membranes. companion animal coronaviruses responsible for causing enteric infection include feline enteric coronavirus, ferret enteric ... | 2020 | 32933150 |
| persistent infection and pancytopenia associated with ferret systemic coronaviral disease in a domestic ferret. | ferret systemic coronaviral disease (fscd) is a well-established cause of mortality in domestic ferrets. we describe herein novel findings in a case of fscd that was diagnosed and medically managed following virus detection by immunohistochemical (ihc) staining of surgical biopsy samples. hematologic changes in this ferret suggested spread of the virus to the bone marrow, which was confirmed by ihc staining of a postmortem sample. genotyping of the virus indicated that the virus grouped with alp ... | 2020 | 32589111 |
| comparative sequence analysis of the distal one-third of the genomes of a systemic and an enteric ferret coronavirus. | ferret systemic coronavirus (frscv) infection is associated with an emerging, highly fatal disease of ferrets. enhanced macrophage tropism and the resulting induction of pyogranulomatous lesions are shared with feline infectious peritonitis virus (fipv) infection in cats, but are not features of ferret enteric coronavirus (frecv) infection. comparative sequence analysis of the distal one-third of the genomes of one frscv and one frecv strain showed that these two ferret coronaviruses share >96% ... | 2010 | 20079778 |
| molecular characterization of a novel coronavirus associated with epizootic catarrhal enteritis (ece) in ferrets. | a novel coronavirus, designated as ferret enteric coronavirus (fecv), was identified in feces of domestic ferrets clinically diagnosed with epizootic catarrhal enteritis (ece). initially, partial sequences of the polymerase, spike, membrane protein, and nucleocapsid genes were generated using coronavirus consensus pcr assays. subsequently, the complete sequences of the nucleocapsid gene and the last two open reading frames at the 3' terminus of the fecv genome were obtained. phylogenetic analyse ... | 2006 | 16499943 |
| naturally occurring recombination in ferret coronaviruses revealed by complete genome characterization. | ferret coronaviruses (frcovs) exist as an enteric and a systemic pathotype, of which the latter is highly lethal to ferrets. to our knowledge, this study provides the first full genome sequence of a frcov, tentatively called frcov-nl-2010, which was detected in 2010 in ferrets in the netherlands. phylogenetic analysis showed that frcov-nl-2010 is most closely related to mink cov, forming a separate clade of mustelid alphacoronavirus that split off early from other alphacoronaviruses. based on se ... | 2016 | 27283016 |
| determination of ferret enteric coronavirus genome in laboratory ferrets. | ferret enteric coronavirus (frecv) rna was detected in laboratory ferrets. analysis of the complete genome sequence of 2 strains, frcov4370 and frcov063, revealed that frecv shared 49.9%-68.9% nucleotide sequence identity with known coronaviruses. these results suggest that frecv might be classified as a new species in the genus alphacoronavirus. | 2017 | 28820366 |
| pyogranulomatous panophthalmitis with systemic coronavirus disease in a domestic ferret (mustela putorius furo). | a 15-month-old spayed female ferret (mustela putorius furo) presented for lethargy and weight loss of 2 weeks duration. upon physical examination, a 2-mm-diameter focal area of opacity was noted in the left cornea. in addition, the ferret was quiet, in poor body condition, and dehydrated. a complete blood count and plasma biochemistry revealed a severe nonregenerative anemia, azotemia, hyperproteinemia, hypoalbuminemia, and mild hyperphosphatemia and hyperchloremia. urinalysis revealed hyposthen ... | 2016 | 25918975 |
| clinicopathologic features of a systemic coronavirus-associated disease resembling feline infectious peritonitis in the domestic ferret (mustela putorius). | from 2002 to 2007, 23 ferrets from europe and the united states were diagnosed with systemic pyogranulomatous inflammation resembling feline infectious peritonitis (fip). the average age at the time of diagnosis was 11 months. the disease was progressive in all cases, and average duration of clinical illness was 67 days. common clinical findings were anorexia, weight loss, diarrhea, and large, palpable intra-abdominal masses; less frequent findings included hind limb paresis, central nervous sys ... | 2008 | 18424841 |
| molecular characterization of a new species in the genus alphacoronavirus associated with mink epizootic catarrhal gastroenteritis. | a coronavirus (cov) previously shown to be associated with catarrhal gastroenteritis in mink (mustela vison) was identified by electron microscopy in mink faeces from two fur farms in wisconsin and minnesota in 1998. a pan-coronavirus and a genus-specific rt-pcr assay were used initially to demonstrate that the newly discovered mink covs (mcovs) were members of the genus alphacoronavirus. subsequently, using a random rt-pcr approach, full-genomic sequences were generated that further confirmed t ... | 2011 | 21346029 |