| host range, prevalence, and genetic diversity of adenoviruses in bats. | bats are the second largest group of mammals on earth and act as reservoirs of many emerging viruses. in this study, a novel bat adenovirus (adv) (btadv-tjm) was isolated from bat fecal samples by using a bat primary kidney cell line. infection studies indicated that most animal and human cell lines are susceptible to btadv-tjm, suggesting a possible wide host range. genome analysis revealed 30 putative genes encoding proteins homologous to their counterparts in most known advs. phylogenetic ana ... | 2010 | 20089640 |
| first genetic characterization of equine adenovirus type 1 (eadv-1) in turkey. | equine adenovirus type 1 (eadv-1) is a cause of repiratory tract infection in equids. in present study for the first time in turkey, the prevalence of eadv-1 in nasal swab samples obtained from horses showing respiratory symptoms was investigated by polymerase chain reaction (pcr), and molecular characterization of the hexon gene detected in the turkish (tr) strain was performed. overall, the prevalence of eadv-1 was found low (1.4%) as indicated by a positive pcr reaction from the nasal swab ex ... | 2011 | 21440276 |
| Genome Analysis of Bat Adenovirus 2: Indications of Interspecies Transmission. | The genome of bat adenovirus 2 was sequenced and analyzed. It is similar in size (31,616 bp) to the genomes of bat adenovirus 3 and canine adenoviruses 1 and 2. These four viruses are monophyletic and share an identical genome organization, with one E3 gene and four E4 genes unique to this group among the mastadenoviruses. These findings suggest that canine adenoviruses may have originated by interspecies transfer of a vespertilionid bat adenovirus. | 2011 | 22130531 |
| evolution and cryo-electron microscopy capsid structure of a north american bat adenovirus and its relationship to other mastadenoviruses. | since the first description of adenoviruses in bats in 2006, a number of micro- and megabat species in europe, africa, and asia have been shown to carry a wide diversity of adenoviruses. here, we report on the evolutionary, biological, and structural characterization of a novel bat adenovirus (btadv) recovered from a rafinesque's big-eared bat (corynorhinus rafinesquii) in kentucky, usa, which is the first adenovirus isolated from north american bats. this virus (btadv 250-a) exhibits a close ph ... | 2017 | 27807242 |
| cloning, expression, and antiviral activity of interferon β from the chinese microbat, myotis davidii. | bats are natural reservoir hosts for many viruses that produce no clinical symptoms in bats. therefore, bats may have evolved effective mechanisms to control viral replication. however, little information is available on bat immune responses to viral infection. type i interferon (ifn) plays a key role in controlling viral infections. in this study, we report the cloning, expression, and biological activity of interferon β (ifnβ) from the chinese microbat species, myotis davidii. we demonstrated ... | 2015 | 26645237 |
| molecular detection of adenoviruses, rhabdoviruses, and paramyxoviruses in bats from kenya. | we screened 217 bats of at least 20 species from 17 locations in kenya during july and august of 2006 for the presence of adenovirus, rhabdovirus, and paramyxovirus nucleic acids using generic reverse transcription polymerase chain reaction (rt-pcr) and pcr assays. of 217 bat fecal swabs examined, 4 bats were adenovirus dna-positive, 11 bats were paramyxovirus rna-positive, and 2 bats were rhabdovirus rna-positive. three bats were coinfected by two different viruses. by sequence comparison and p ... | 2014 | 24865685 |
| deep rna sequencing reveals complex transcriptional landscape of a bat adenovirus. | bat adenoviruses are a group of recently identified adenoviruses (advs) which are highly prevalent in bats yet share low similarity to known advs from other species. in this study, deep rna sequencing was used to analyze the transcriptome at five time points following the infection of a bat adv in a kidney cell line derived from a myotis bat species. evidence of adv replication was observed with the proportion of viral rnas ranging from 0.01% at 6 h to 1.3% at 18 h. further analysis of viral tem ... | 2013 | 23097437 |