| heterothallic mating in mucor irregularis and first isolate of the species outside of asia. | this study reports on the discovery of heterothallic mating in mucor irregularis (formerly rhizomucor variabilis var. variabilis) and it extends the range of this species from asia to the united states. we report on a case of primary cutaneous mucormycosis, involving the forearms of a cotton farmer from north carolina, in which the infection was cured using amphotericin b therapy. intraspecific crosses between the north carolina strain dumc 150.04 and m. irregularis cbs 103.93, the ex-type strai ... | 2011 | 21453223 |
| chronic rhinofacial mucormycosis caused by mucor irregularis (rhizomucor variabilis) in india. | in this article, we describe a chronic case of rhinofacial mucormycosis caused by mucor irregularis, formerly known as rhizomucor variabilis var. variabilis, a rare mycotic agent in humans. the infection caused progressive destruction of the nasal septum and soft and hard palate, leading to collapse of the nose bridge and an ulcerative gaping hole. the mucoralean mold cultured from a nasal biopsy specimen was determined by multilocus dna sequence data to be conspecific with m. irregularis. | 2011 | 21508154 |
| the emerging epidemiology of mould infections in developing countries. | purpose of review: the present review describes the emerging trends of mould infections in developing countries, and highlights the major epidemiological differences from the developed countries. recent findings: the limited data available from developing countries suggest an alarming increase in invasive mould infections, especially aspergillosis and mucormycosis, and also a difference in risk factors and causative agents between the developed and developing world. sino-orbital, cerebral and op ... | 2011 | 21799406 |
| image gallery: cutaneous infections caused by alternaria alternata and mucor irregularis 1 year apart in a patient with iatrogenic cushing syndrome. | | 2016 | 27317292 |
| mucormycosis in india: unique features. | mucormycosis remains a devastating invasive fungal infection, with high mortality rates even after active management. the disease is being reported at an alarming frequency over the past decades from india. indian mucormycosis has certain unique features. rhino-orbito-cerebral presentation associated with uncontrolled diabetes is the predominant characteristic. isolated renal mucormycosis has emerged as a new clinical entity. apophysomyces elegans and rhizopus homothallicus are emerging species ... | 2014 | 25187095 |
| rapid screening for human-pathogenic mucorales using rolling circle amplification. | mucormycosis has emerged as a relatively common severe mycosis in patients with haematological and allogeneic stem cell transplantation. source of transmission is from unidentified sources in the environment. early diagnosis of infection and its source of contamination are paramount for rapid and appropriate therapy. in this study, rolling circle amplification (rca) is introduced as a sensitive, specific and reproducible isothermal dna amplification technique for rapid molecular identification o ... | 2014 | 25187214 |
| characterization of two new records of mucoralean species isolated from gut of soldier fly larva in korea. | while surveying the diversity of fungi of the order mucorales, two isolates, eml-puki12-1 and eml-puki06-1, were obtained from the gut of soldier fly larvae inhabiting the bulrush at a pond located in the chonnam national university arboretum, gwangju, korea. the isolates were confirmed as mucor irregularis and mucor fragilis species, respectively, based on the morphological characteristics and phylogenetic analysis of rdna internal transcribed spacer region. such mucoralean species belonging to ... | 2016 | 28154489 |
| taxonomy and epidemiology of mucor irregularis, agent of chronic cutaneous mucormycosis. | mucormycosis usually presents as a progressive infection with significant angio-invasion. mucormycosis due to mucor irregularis (formerly rhizomucor variabilis var. variabilis), however, is exceptional in causing chronic cutaneous infection in immunocompetent humans, ultimately leading to severe morbidity if left untreated. more than 90 % of the cases known to date were reported from asia, mainly from china. the nearest neighbour of m. irregularis is the saprobic species m. hiemalis. the aim of ... | 2013 | 24027346 |
| fast technique for the identification of gilbertella persicaria via optical microscopy. | gilbertella persicaria is an important phytopathogen that is confused with mucor spp. and rhizopus spp. the main distinguishing characteristic of g. persicaria is the presence of appendages in sporangiospores, and their observation by conventional staining techniques generally fails. a technique is described using light microscopy for fast and reliable diagnosis. | 2017 | 28899635 |
| the influence of the mating type on virulence of mucor irregularis. | mucor irregularis is an emerging fungal pathogen that cause cutaneous infection and could cause death. however, little is known about its mechanism of pathogenesis. there is evidence suggesting virulence vary with mating types in fungi, including the mucorales. here, we characterized the mating type locus of m. irregularis and the mating type ratio of 17 clinical isolates in china. genomic data indicated m. irregularis is heterothallic having two mating types - bearing either sexp or sexm allele ... | 2017 | 28878325 |
| rhizovarins a-f, indole-diterpenes from the mangrove-derived endophytic fungus mucor irregularis qen-189. | genome mining of the fungus mucor irregularis (formerly known as rhizomucor variabilis) revealed the presence of various gene clusters for secondary metabolite biosynthesis, including several terpene-based clusters. investigation into the chemical diversity of m. irregularis qen-189, an endophytic fungus isolated from the fresh inner tissue of the marine mangrove plant rhizophora stylosa, resulted in the discovery of 20 structurally diverse indole-diterpenes including six new compounds, namely, ... | 2016 | 27462726 |
| cutaneous infection due to mucor irregularis (rhizomucor variabilis) in a immunocompetent traveller. | | 2017 | 27435037 |
| unguisin f, a new cyclic peptide from the endophytic fungus mucor irregularis. | the new cyclic heptapeptide unguisin f (1) and the known congener unguisin e (2), were obtained from the endophytic fungus mucor irregularis, isolated from the medicinal plant moringa stenopetala, collected in cameroon. the structure of the new compound was unambiguously determined on the basis of one- and two-dimensional nmr spectroscopy as well as by high-resolution mass spectrometry. the absolute configuration of the amino acid residues of 1 and 2 was determined using marfey's analysis. compo ... | 2016 | 26812868 |
| changing epidemiology of mucoralean fungi: chronic cutaneous infection caused by mucor irregularis. | the fungi pertaining to order mucorales usually cause an acute form of clinical disease called mucormycosis. a primary chronic presentation in an immunocompetent patient is a rare form of mucormycosis. mucor irregularis is known for causing chronic cutaneous infections geographically confined to asia, mainly in china. we describe a case of primary chronic cutaneous mucormycosis caused by m. irregularis from a new geographical niche in india, highlighting changing aspects of its epidemiology. | 2015 | 26170185 |
| primary cutaneous mucormycosis caused by mucor irregularis. | we describe a case of primary cutaneous mucormycosis in a 44-year-old man with an 18-month history of infiltrative erythematous plaques and haemorrhagic crusting on the dorsum of his left hand. the isolate was identified as mucor irregularis (formerly rhizomucor variabilis) based on the fungus morphology and dna sequencing results. improvement was observed after a 6-month treatment course of itraconazole. no recrudescence was seen during a follow-up of 23 months after treatment. | 2015 | 25810249 |
| primary cutaneous mucormycosis caused by mucor irregularis in an immunocompetent patient. | | 2015 | 25736319 |
| primary cutaneous mucormycosis caused by mucor irregularis in an elderly person. | primary cutaneous mucormycosis is a rare but often lethal severe fungal infection, which usually occurs in immunocompromised patients. we report a case of primary cutaneous mucormycosis caused by mucor irregularis in an elderly patient. seven months after the surgical dissection of the involved skin, cutaneous mucormycosis recurred at the peripheral edge of the skin graft. shortly subsequent to the administration of liposomal amphotericin b, the remaining skin lesion was excised again. m. irregu ... | 2015 | 25510200 |
| mucor irregularis-associated cutaneous mucormycosis: case report and review. | solid organ transplant recipients are at risk for invasive fungal diseases, and are also exposed to healthcare-associated mucormycosis. mainly causing localized cutaneous mucormycosis, mucor irregularis infection is reported for the first time in a kidney-transplant recipient. a healthcare-associated origin was highly suspected in this case. we performed a literature review and highlight the characteristics of this very rare fungus. | 2014 | 25379401 |
| mucor irregularis infection around the inner canthus cured by amphotericin b: a case report and review of published literatures. | we report a case of primary cutaneous mucormycosis caused by mucor irregularis. a 47-year-old farmer was presented to our clinic with the history of progressive red plaque around the inner canthus following dacryocystectomy about a year earlier. linear, aseptate hyphae were seen by direct koh examination and in biopsy. fungal culture revealed light yellow filamentous colonies that were identified as mucor irregularis by nucleotide sequencing of rrna gene. amphotericin b and dexamethasone were us ... | 2014 | 24947172 |
| drug combinations against mucor irregularis in vitro. | combinations of terbinafine or caspofungin with amphotericin b, posaconazole, or itraconazole were studied as potential treatments against 18 isolates of mucor irregularis in vitro. synergism of the combinations of terbinafine with amphotericin b, posaconazole, and itraconazole against 38.9, 33.3, and 44.4% of the strains studied was observed. in contrast, synergism of the combinations of caspofungin with amphotericin b, posaconazole, and itraconazole against 99.4, 66.7, and 99.4% of the strains ... | 2013 | 23587956 |
| slowly progressive cutaneous, rhinofacial, and pulmonary mucormycosis caused by mucor irregularis in an immunocompetent woman. | we herein report a case of slowly progressive cutaneous, rhinofacial, and pulmonary mucormycosis caused by mucor irregularis in an immunocompetent woman who was successfully managed by combined surgical debridement and antifungal therapy. slow progression, pulmonary involvement, occurrence in an immunocompetent patient, and good prognosis are unusual features of our case. | 2013 | 23243187 |
| mucor irregularis infection and lethal midline granuloma: a case report and review of published literature. | mucor irregularis (rhizomucor variabilis) infection and lethal midline granuloma (lmg) are characterized by progressive swelling, ulceration, and destruction of the central face that is usually fatal. pathological features are inflammation, necrosis, and granulation. lmg has been called by various names, and in recent years, it has been known as nk/t cell lymphoma. however, diagnosis still relies on the progressive necrosis course rather than malignancy in histology. the disease has long challen ... | 2012 | 22744721 |
| transcriptional profile of the human skin pathogenic fungus mucor irregularis in response to low oxygen. | | 2017 | 29182775 |
| chlorflavonin targets acetohydroxyacid synthase catalytic subunit ilvb1 for synergistic killing of mycobacterium tuberculosis. | the flavonoid natural compound chlorflavonin was isolated from the endophytic fungus mucor irregularis, which was obtained from the cameroonian medicinal plant moringa stenopetala. chlorflavonin exhibited strong growth inhibitory activity in vitro against mycobacterium tuberculosis (mic90 1.56 μm) while exhibiting no cytotoxicity toward the human cell lines mrc-5 and thp-1 up to concentrations of 100 μm. mapping of resistance-mediating mutations employing whole-genome sequencing, chemical supple ... | 2017 | 29108416 |
| successful treatment by surgery of a primary cutaneous mucormycosis caused by mucor irregularis. | we report a case of primary cutaneous mucormycosis caused by mucor irregularis. a 66-year-old man was presented to our hospital with a history of gradually enlarging plaque on the right leg for about a year. the identification of pathogen based on the fungus morphology and dna sequencing revealed m. irregularis as the responsible fungus for skin lesion. the lesion was removed incidentally by a surgery procedure, and no recrudescence was seen during a follow-up of 24-month observation. | 2017 | 29086142 |