| hong kong health chief falls ill with suspected sars virus. | | 2003 | 12672321 |
| faster... but fast enough? responding to the epidemic of severe acute respiratory syndrome. | | 2003 | 12672880 |
| acute respiratory syndrome. china, hong kong special administrative region of china, and viet nam. | | 2003 | 12674023 |
| there are two sides to biodefence. | | 2003 | 12686959 |
| identification of a novel coronavirus in patients with severe acute respiratory syndrome. | the severe acute respiratory syndrome (sars) has recently been identified as a new clinical entity. sars is thought to be caused by an unknown infectious agent. | 2003 | 12690091 |
| a novel coronavirus associated with severe acute respiratory syndrome. | a worldwide outbreak of severe acute respiratory syndrome (sars) has been associated with exposures originating from a single ill health care worker from guangdong province, china. we conducted studies to identify the etiologic agent of this outbreak. | 2003 | 12690092 |
| infectious diseases. deferring competition, global net closes in on sars. | | 2003 | 12690153 |
| a mystery bug wreaks havoc. | | 2003 | 12698752 |
| taiwan left isolated in fight against sars. | | 2003 | 12700727 |
| infectious diseases. calling all coronavirologists. | | 2003 | 12702853 |
| epidemiology, clinical presentation and laboratory investigation of severe acute respiratory syndrome (sars) in canada, march 2003. | as of 23 march, 2003, 11 cases of sars have been reported in canada. three patients had travelled to china, including hong kong sar. the remaining eight had a history of close contact with cases. there have been three deaths. to date, evidence for human metapneumovirus has been found in six cases; further studies are ongoing to determine whether this virus is the causative agent of the sars or whether other, so far undetected, pathogens are responsible. public health measures are being implement ... | 2003 | 12710251 |
| apartment complex holds clues to pandemic potential of sars. | | 2003 | 12721585 |
| biologists seek to head off future sources of infection. | | 2003 | 12721586 |
| solid response to sars--almost. | | 2003 | 12724737 |
| editors sound the sars alarm bells. | | 2003 | 12725741 |
| an appropriate response to sars. | | 2003 | 12726954 |
| closing in on the cause of sars. | | 2003 | 12726969 |
| joseph malik peiris--on the trail of pneumonia in hong kong interviewed by pam das. | | 2003 | 12726983 |
| masks can't stop this virus. | | 2003 | 12728648 |
| update: outbreak of severe acute respiratory syndrome--worldwide, 2003. | cdc and the world health qrganization (who) are continuing to investigate the multicountry outbreak of unexplained atypical pneumonia referred to as severe acute respiratory syndrome (sars). pending development of confirmatory laboratory testing capacity, cdc's interim suspected sars case definition is based on clinical criteria and epidemiologic linkage to other sars cases or areas with community transmission of sars. this case definition will be updated periodically as new information becomes ... | 2003 | 12729074 |
| characterization of a novel coronavirus associated with severe acute respiratory syndrome. | in march 2003, a novel coronavirus (sars-cov) was discovered in association with cases of severe acute respiratory syndrome (sars). the sequence of the complete genome of sars-cov was determined, and the initial characterization of the viral genome is presented in this report. the genome of sars-cov is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. phylogenetic analyses and sequence comparisons showed that sars- ... | 2003 | 12730500 |
| the genome sequence of the sars-associated coronavirus. | we sequenced the 29,751-base genome of the severe acute respiratory syndrome (sars)-associated coronavirus known as the tor2 isolate. the genome sequence reveals that this coronavirus is only moderately related to other known coronaviruses, including two human coronaviruses, hcov-oc43 and hcov-229e. phylogenetic analysis of the predicted viral proteins indicates that the virus does not closely resemble any of the three previously known groups of coronaviruses. the genome sequence will aid in the ... | 2003 | 12730501 |
| infectious diseases. battling sars on the frontlines. | | 2003 | 12730562 |
| infectious diseases. hungry for details, scientists zoom in on sars genomes. | | 2003 | 12730563 |
| [severe acute respiratory syndrome. a new emergent infectious disease]. | | 2003 | 12732127 |
| [severe acute respiratory syndrome]. | | 2003 | 12732129 |
| update: severe acute respiratory syndrome--united states, 2003. | cdc and the world health organization (who) are continuing to investigate the multicountry outbreak of severe acute respiratory syndrome (sars). this report updates information on reported sars cases among u.s. residents and summarizes information on patients with no recent travel outside the united states. | 2003 | 12733864 |
| from the centers for disease control and prevention. severe acute respiratory syndrome (sars) and coronavirus testing--united states, 2003. | | 2003 | 12734120 |
| severe acute respiratory syndrome: providing care in the face of uncertainty. | | 2003 | 12734146 |
| clinical features and short-term outcomes of 144 patients with sars in the greater toronto area. | severe acute respiratory syndrome (sars) is an emerging infectious disease that first manifested in humans in china in november 2002 and has subsequently spread worldwide. | 2003 | 12734147 |
| sars testing: first past the post. | | 2003 | 12736651 |
| infectious diseases. up close and personal with sars. | | 2003 | 12738826 |
| from the centers for disease control and prevention. update: severe acute respiratory syndrome--united states, 2003. | | 2003 | 12746346 |
| the truth about sars. | | 2003 | 12747032 |
| tale of two countries. a time investigation into what went wrong. | | 2003 | 12747033 |
| gene patents and the public good. | | 2003 | 12748599 |
| aetiology: koch's postulates fulfilled for sars virus. | | 2003 | 12748632 |
| sars outbreak. flood of sequence data yields clues but few answers. | | 2003 | 12750482 |
| severe acute respiratory syndrome (sars) in china and status of scientific and clinical knowledge, 14 april 2003. | | 2003 | 12751412 |
| [gene sequence analysis of sars-associated coronavirus by nested rt-pcr]. | to explore an effective means for the detection of severe acute respiratory syndrome (sars)- associated coronavirus. | 2003 | 12754117 |
| [clinical detection of polymerase gene of sars-associated coronavirus]. | to analyze the heterogeneity of polymerase gene fragment of sars-associated coronavirus from sars patients, and establish a rt-pcr method for detecting sars-associated coronavirus. | 2003 | 12754118 |
| sars challenges therapeutics. | | 2003 | 12756421 |
| [ 'severe acute respiratory syndrome' (sars) in perspective]. | in the netherlands, the risk of an outbreak of the severe acute respiratory syndrome (sars) appears to be limited, if people in contact with a possibly imported case observe strict measures to prevent contamination. sars may well be a zoonosis. bovine spongiform encephalopathy and outbreaks of virus infections in the bioindustry, such as swine fever, foot-and-mouth disease and classical avian influenza, have led to massive killing of cattle, swine and fowl in the netherlands. the possibility tha ... | 2003 | 12756874 |
| from the centers for disease control and prevention. update: severe acute respiratory syndrome--united states, 2003. | | 2003 | 12759315 |
| animal studies hint at staying power of sars. | | 2003 | 12761509 |
| albert osterhaus profile. the virus collector. | | 2003 | 12764171 |
| preventing local transmission of sars: lessons from singapore. | | 2003 | 12765503 |
| rapid diagnosis of a coronavirus associated with severe acute respiratory syndrome (sars). | | 2003 | 12765993 |
| sars may have a silver lining, who says. | | 2003 | 12771091 |
| from the centers for disease control and prevention. updated interim surveillance case definition for severe acute respiratory syndrome (sars)--united states, april 29, 2003. | | 2003 | 12771098 |
| from the centers for disease control and prevention. update: severe acute respiratory syndrome--united states, 2003. | | 2003 | 12771099 |
| virus detectives seek source of sars in china's wild animals. | | 2003 | 12774078 |
| mass spectrometric characterization of proteins from the sars virus: a preliminary report. | a new coronavirus has been implicated as the causative agent of severe acute respiratory syndrome (sars). we have used convalescent sera from several sars patients to detect proteins in the culture supernatants from cells exposed to lavage another sars patient. the most prominent protein in the supernatant was identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (maldi-tof ms) as a approximately 46-kda species. this was found to be a novel nucleocapsid prote ... | 2003 | 12775768 |
| infectious diseases. clues to the animal origins of sars. | | 2003 | 12775803 |
| virology. the sars coronavirus: a postgenomic era. | | 2003 | 12775826 |
| sars. nurses among first quarantined. | | 2003 | 12778607 |
| severe acute respiratory syndrome. the mount sinai experience. | | 2003 | 12778609 |
| krüppel cripples prostate cancer: klf6 progress and prospects. | | 2003 | 12651597 |
| the mystery bug. public-health detectives are racing to identify the germ that is sickening people around the globe. | | 2003 | 12688078 |
| from the centers for disease control and prevention. update: outbreak of severe acute respiratory syndrome--worldwide, 2003. | | 2003 | 12697782 |
| from the centers for disease control and prevention. update: outbreak of severe acute respiratory syndrome--worldwide, 2003. | | 2003 | 12709450 |
| sars virus identified, but the disease is still spreading. | | 2003 | 12714455 |
| sars outbreak. modelers struggle to grasp epidemic's potential scope. | | 2003 | 12714711 |
| [sars: a new paramyxovirus or coronavirus?]. | | 2003 | 12723569 |
| severe acute respiratory syndrome (sars) and coronavirus testing--united states, 2003. | cdc and the world health organization (who) are continuing to investigate the multicountry outbreak of severe acute respiratory syndrome (sars). infection with a novel coronavirus has been implicated as a possible cause of sars. this report updates information on u.s. residents with sars and summarizes the clinical histories of the five u.s. residents identified as of april 9, 2003, who have both suspected sars and laboratory evidence of infection with a novel coronavirus. | 2003 | 12731699 |
| severe acute respiratory syndrome: a storm in a teacup? | | 2003 | 12740617 |
| coronavirus main proteinase (3clpro) structure: basis for design of anti-sars drugs. | a novel coronavirus has been identified as the causative agent of severe acute respiratory syndrome (sars). the viral main proteinase (mpro, also called 3clpro), which controls the activities of the coronavirus replication complex, is an attractive target for therapy. we determined crystal structures for human coronavirus (strain 229e) mpro and for an inhibitor complex of porcine coronavirus [transmissible gastroenteritis virus (tgev)] mpro, and we constructed a homology model for sars coronavir ... | 2003 | 12746549 |
| managing sars amidst uncertainty. | | 2003 | 12748313 |
| sars-associated coronavirus. | | 2003 | 12748314 |
| update: severe acute respiratory syndrome--united states, 2003. | cdc continues to work with the world health organization (who) and other partners to investigate cases of severe acute respiratory syndrome (sars). this report updates information on reported sars cases worldwide and among u.s. residents and summarizes information on one additional case with laboratory evidence of infection with the sars-associated coronavirus (sars-cov). | 2003 | 12749474 |
| update: severe acute respiratory syndrome--united states, 2003. | cdc continues to work with state and local health departments, the world health organization (who), and other partners to investigate cases of severe acute respiratory syndrome (sars). during november 1, 2002-april 30, 2003, a total of 5,663 sars cases were reported to who from 26 countries, including the united states; 372 deaths (case-fatality proportion: 6.6%) have been reported. this report updates information on reported sars cases among u.s. residents and provides an overview regarding cdc ... | 2003 | 12765203 |
| updated interim surveillance case definition for severe acute respiratory syndrome (sars)--united states, april 29, 2003. | cdc's interim surveillance case definition for severe acute respiratory syndrome (sars) has been updated to include laboratory criteria for evidence of infection with the sars-associated coronavirus (sars-cov) (figure, box). in addition, clinical criteria have been revised to reflect the possible spectrum of respiratory illness associated with sars-cov. epidemiologic criteria have been retained. the majority of u.s. cases of sars continue to be associated with travel, with only limited secondary ... | 2003 | 12765204 |
| the sars coronavirus: rapid diagnostics in the limelight. | | 2003 | 12765977 |
| transmission dynamics of the etiological agent of sars in hong kong: impact of public health interventions. | we present an analysis of the first 10 weeks of the severe acute respiratory syndrome (sars) epidemic in hong kong. the epidemic to date has been characterized by two large clusters-initiated by two separate "super-spread" events (sses)-and by ongoing community transmission. by fitting a stochastic model to data on 1512 cases, including these clusters, we show that the etiological agent of sars is moderately transmissible. excluding sses, we estimate that 2.7 secondary infections were generated ... | 2003 | 12766206 |
| epidemiology. modeling the sars epidemic. | | 2003 | 12766208 |
| a multicentre collaboration to investigate the cause of severe acute respiratory syndrome. | severe acute respiratory syndrome is a new disease in human beings, first recognised in late february, 2003, in hanoi, vietnam. the severity of the disease, combined with its rapid spread along international air-travel routes, prompted who to set up a network of scientists from 11 laboratories around the world to try to identify the causal agent and develop a diagnostic test. the network unites laboratories with different methods and capacities to rapidly fulfil all postulates for establishing a ... | 2003 | 12767752 |
| sars: new sequence could lead to better diagnostic tests. | | 2003 | 12779001 |
| severe acute respiratory syndrome (sars): update on a moving target. | | 2003 | 12779131 |
| severe acute respiratory syndrome (sars) in singapore: clinical features of index patient and initial contacts. | severe acute respiratory syndrome (sars) is an emerging viral infectious disease. one of the largest outbreaks of sars to date began in singapore in march 2003. we describe the clinical, laboratory, and radiologic features of the index patient and the patient's initial contacts affected with probable sars. | 2003 | 12781012 |
| control measures for severe acute respiratory syndrome (sars) in taiwan. | as of april 14, 2003, taiwan had had 23 probable cases of severe acute respiratory syndrome (sars), 19 of which were imported. taiwan isolated all 23 patients in negative-pressure rooms; extensive personal protective equipment was used for healthcare workers and visitors. for the first 6 weeks of the sars outbreak, recognized spread was limited to one healthcare worker and three household contacts. | 2003 | 12781013 |
| comparative analysis of the sars coronavirus genome: a good start to a long journey. | | 2003 | 12781529 |
| clinical progression and viral load in a community outbreak of coronavirus-associated sars pneumonia: a prospective study. | we investigated the temporal progression of the clinical, radiological, and virological changes in a community outbreak of severe acute respiratory syndrome (sars). | 2003 | 12781535 |
| lung pathology of fatal severe acute respiratory syndrome. | severe acute respiratory syndrome (sars) is a novel infectious disease with global impact. a virus from the family coronaviridae has been identified as the cause, but the pathogenesis is still unclear. | 2003 | 12781536 |
| comparative full-length genome sequence analysis of 14 sars coronavirus isolates and common mutations associated with putative origins of infection. | the cause of severe acute respiratory syndrome (sars) has been identified as a new coronavirus. whole genome sequence analysis of various isolates might provide an indication of potential strain differences of this new virus. moreover, mutation analysis will help to develop effective vaccines. | 2003 | 12781537 |
| sars coronavirus: a new challenge for prevention and therapy. | | 2003 | 12782660 |
| from the centers for disease control and prevention. cluster of severe acute respiratory syndrome cases among protected health-care workers--toronto, canada, april 2003. | | 2003 | 12783898 |
| from the centers for disease control and prevention. update: severe acute respiratory syndrome--united states, may 14, 2003. | | 2003 | 12783900 |
| [sars--severe acute respiratory syndrome]. | | 2003 | 12784177 |
| identifying a killer: sars virus. | | 2003 | 12784939 |
| pet theory comes to the fore in fight against sars. | | 2003 | 12789305 |
| putative hapn receptor binding sites in sars_cov spike protein. | to obtain the information of ligand-receptor binding between the s protein of sars-cov and cd13, identify the possible interacting domains or motifs related to binding sites, and provide clues for studying the functions of sars proteins and designing anti-sars drugs and vaccines. | 2003 | 12791172 |
| identification of probable genomic packaging signal sequence from sars-cov genome by bioinformatics analysis. | to predict the probable genomic packaging signal of sars-cov by bioinformatics analysis. the derived packaging signal may be used to design antisense rna and rna interfere (rnai) drugs treating sars. | 2003 | 12791173 |
| a 3d model of sars_cov 3cl proteinase and its inhibitors design by virtual screening. | to constructed a three-dimensional (3d) model for the 3c like (3cl) proteinase of sars coronavirus (sars-cov), and to design inhibitors of the 3cl proteinase based on the 3d model. | 2003 | 12791174 |
| small envelope protein e of sars: cloning, expression, purification, cd determination, and bioinformatics analysis. | to obtain the pure sample of sars small envelope e protein (sars e protein), study its properties and analyze its possible functions. | 2003 | 12791175 |
| infectious diseases. searching for a sars agenda. | | 2003 | 12791953 |
| updated sars case definition using laboratory criteria. | | 2003 | 12796338 |
| [the biological characteristics of sars virus and its related coronaviruses]. | cases of the life-threatening respiratory disease with no identified cause (designated as "severe acute respiratory syndrome", sars, in march 2003) were first reported in late 2002 from guangdong province, china; they were followed by reports from about other 30 countries (or regions) such as vietnam, singapore, thailand, hong kong (china), canada, and usa etc. because of its ongoing epidemic and high death rate, sars has shined an intense spotlight all over the world. the world health organizat ... | 2003 | 12796808 |
| morphology and morphogenesis of severe acute respiratory syndrome (sars)-associated virus. | after infecting the vero e6 cells by nasal/throat swabs collected from sars patients, we studied the sars-associated virus by electron microscopy and molecular biological technique. the results show that the diameter of newly isolated virus is about 50 nm without envelope or 100 nm with envelope. the virus was proved to be a new coronavirus by rt-pcr and it responded positively to convalescent-phase serum specimen from sars patients, which is the evidence that this new virus is etiologically lin ... | 2003 | 12796822 |
| war against the virus--who is winning? | | 2003 | 12797689 |
| from the centers for disease control and prevention. severe acute respiratory syndrome--taiwan, 2003. | | 2003 | 12799395 |