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the virus-host interface: molecular interactions of alphacoronavirus-1 variants from wild and domestic hosts with mammalian aminopeptidase n.the alphacoronavirus-1 species include viruses that infect numerous mammalian species. to better understand the wide host range of these viruses, better knowledge on the molecular determinants of virus-host cell entry mechanisms in wildlife hosts is essential. we investigated alphacoronavirus-1 infection in carnivores using long-term data on serengeti spotted hyenas (crocuta crocuta) and molecular analyses guided by the tertiary structure of the viral spike (s) attachment protein's interface wit ...202133786949
molecular characterization of a new species in the genus alphacoronavirus associated with mink epizootic catarrhal gastroenteritis.a coronavirus (cov) previously shown to be associated with catarrhal gastroenteritis in mink (mustela vison) was identified by electron microscopy in mink faeces from two fur farms in wisconsin and minnesota in 1998. a pan-coronavirus and a genus-specific rt-pcr assay were used initially to demonstrate that the newly discovered mink covs (mcovs) were members of the genus alphacoronavirus. subsequently, using a random rt-pcr approach, full-genomic sequences were generated that further confirmed t ...201121346029
molecular detection of viral agents in free-ranging and captive neotropical felids in brazil.we describe molecular testing for felid alphaherpesvirus 1 (fhv-1), carnivore protoparvovirus 1 (cppv-1), feline calicivirus (fcv), alphacoronavirus 1 (feline coronavirus [fcov]), feline leukemia virus (felv), feline immunodeficiency virus (fiv), and canine distemper virus (cdv) in whole blood samples of 109 free-ranging and 68 captive neotropical felids from brazil. samples from 2 jaguars ( panthera onca) and 1 oncilla ( leopardus tigrinus) were positive for fhv-1; 2 jaguars, 1 puma ( puma conc ...201728677421
emergence of porcine epidemic diarrhea virus in the united states: clinical signs, lesions, and viral genomic sequences.during the 10 days commencing april 29, 2013, the iowa state university veterinary diagnostic laboratory received the first 4 of many submissions from swine farms experiencing explosive epidemics of diarrhea and vomiting affecting all ages, with 90-95% mortality in suckling pigs. histology revealed severe atrophy of villi in all segments of the small intestines with occasional villus-epithelial syncytial cells, but testing for rotaviruses and transmissible gastroenteritis virus (alphacoronavirus ...201323963154
full-length genome analysis of canine coronavirus type i.canine coronavirus types i (ccov-i) and ii (ccov-ii) are usually responsible for mild enteritis in dogs. while the ccov-ii genome has been completely sequenced, to date there are no complete genomic sequence data available publicly for ccov-i. thus, the aim of the present study was to analyze the full-length genome of a ccov-i prototype strain that had been recovered from a dog with diarrhea in italy. ccov-i strain 23/03 has a genome of 30,000 nucleotides, excluding the 3' poly(a) tail, displayi ...201526221765
glomerulonephritis in a ferret with feline coronavirus infection.a male domestic ferret (mustela putorius furo), which was purchased from outside of japan at 13 weeks of age, was euthanized at 18 months of age because of poor health. at autopsy, the liver, spleen, and mesenteric lymph node were enlarged, and white foci were observed on the outer surface of the liver. the outer surface of the mesenteric lymph node was dark red. histologically, granulomas were observed in the liver, spleen, bone marrow, and lymph nodes, composed mainly of aggregated epithelioid ...201526319601
diagnostic investigation of porcine periweaning failure-to-thrive syndrome: lack of compelling evidence linking to common porcine pathogens.porcine periweaning failure-to-thrive syndrome (pfts), an increasingly recognized syndrome in the swine industry of north america, is characterized by the anorexia of nursery pigs noticeable within 1 week of weaning, and progressive loss of body condition and lethargy during the next 1-2 weeks. morbidity caused by pfts is moderate, but case fatality is high. the etiology of pfts is presently unknown and may include infectious agent(s), noninfectious factors, or both. pfts was identified in a hig ...201122362939
coronavirus persistence on a plastic carrier under refrigeration conditions and its reduction using wet wiping technique, with respect to food safety.the global sars-cov-2 pandemic dictates that anti-contagion strategies should become matters of essential routine in everyday life. fomite transference is one of the routes of transmission that has been considered for this virus. however, the risks associated with contaminated surfaces of food packaging kept in refrigerators have not yet been adequately assessed. in this study, a surrogate virus, alphacoronavirus 1, was used to investigate the persistence of coronavirus dried on a plastic carrie ...202033057921
first complete genome sequence of a feline alphacoronavirus 1 strain from brazil.we identified a strain of alphacoronavirus 1, fcov-sb22, from a pool of fecal samples from domestic cats from a rural settlement in the municipality of santa bárbara, pará, brazil. the nucleotide identity with feline coronavirus was 91.5%. the present study reports the first complete genome sequence of a feline coronavirus from brazil.201930863824
molecular diversity of alphacoronavirus 1 in dogs and cats in colombia.alphacoronavirus 1 (subgenus tegacovirus, genus alphacoronavirus, family coronaviridae), which encompasses transmissible gastroenteritis virus (tgev), feline coronavirus (fcov) and canine coronavirus (ccov), is an important pathogen that can cause severe gastroenteritis and is distributed worldwide. ccov has two different genotypes: ccov type i, which has a high identity with fcov-i, and ccov type ii, which is divided into two subtypes, ccov iia (pantropic) and ccov iib, which is related to fcov ...202032665984
in silico perspectives on the prediction of the plp's epitopes involved in multiple sclerosis.multiple sclerosis (ms) is the most common autoimmune disease of the central nervous system (cns). the main cause of the ms is yet to be revealed, but the most probable theory is based on the molecular mimicry that concludes some infections in the activation of t cells against brain auto-antigens that initiate the disease cascade.201728959348
improving virus taxonomy by recontextualizing sequence-based classification with biologically relevant data: the case of thealphacoronavirus 1species.the difficulties related to virus taxonomy have been amplified by recent advances in next-generation sequencing and metagenomics, prompting the field to revisit the question of what constitutes a useful viral classification. here, taking a challenging classification found in coronaviruses, we argue that consideration of biological properties in addition to sequence-based demarcations is critical for generating useful taxonomy that recapitulates complex evolutionary histories. within thealphacoro ...201829299531
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