new natural products isolated from metarhizium robertsii arsef 23 by chemical screening and identification of the gene cluster through engineered biosynthesis in aspergillus nidulans rapidly identify novel natural products and their associated biosynthetic genes from underutilized and genetically difficult-to-manipulate microbes, we developed a method that uses (1) chemical screening to isolate novel microbial secondary metabolites, (2) bioinformatic analyses to identify a potential biosynthetic gene cluster and (3) heterologous expression of the genes in a convenient host to confirm the identity of the gene cluster and the proposed biosynthetic mechanism. the chemical sc ...201627189118
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