| new natural products isolated from metarhizium robertsii arsef 23 by chemical screening and identification of the gene cluster through engineered biosynthesis in aspergillus nidulans a1145. | to rapidly identify novel natural products and their associated biosynthetic genes from underutilized and genetically difficult-to-manipulate microbes, we developed a method that uses (1) chemical screening to isolate novel microbial secondary metabolites, (2) bioinformatic analyses to identify a potential biosynthetic gene cluster and (3) heterologous expression of the genes in a convenient host to confirm the identity of the gene cluster and the proposed biosynthetic mechanism. the chemical sc ... | 2016 | 27189118 |