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[a clinical study on the treatment of acute upper digestive tract hemorrhage with wen-she decoction].this paper deals with the prospective clinical study on treatment of acute upper digestive tract hemorrhage with wen-she decoction (wsd). an opened sequential controlled trial method of simple orientation quality reaction was adopted in this study. 7 cases were treated and all of them were cured. it was concluded that wsd was an excellent therapy to treat the middle or small amount hemorrhage of acute upper digestive tract. the effective rate of wsd of the stool ob (+) becoming (-) within 5 days ...19892766422
[f3, a fractionated extract of astragalus membranaceus, potentiates lymphokine-activated killer cell cytotoxicity generated by low-dose recombinant interleukin-2].success with ril-2 immunotherapy of human cancer appears to depend on the administration of high doses which are frequently associated with excessive toxicity. future use of ril-2 will require certain modifications based on the use of lower doses of ril-2 without significant loss of antitumor efficacy. the authors tested in vitro the possibility of potentiating the activity of ril-2 in terms of lak cell generation. the authors hypothesized that co-incubation of lak cell precursors with a chinese ...19902350835
[immune restoration of local xenogeneic graft-versus-host reaction in cancer patients in vitro and reversal of cyclophosphamide-induced immune suppression in the rat in vivo by fractionated astragalus membranaceus].through the process of fractionation, purification by gel filtration chromatography and thereafter the screening with an in vitro local xenogeneic graft-versus-host reaction (xgvhr) model, a fraction was identified as a potent immunorestorative agent and was designated "fraction 3" (f3). using the xgvhr in vitro as a model assay for t cell function again, f3 was studied on mononuclear cells (mnc) from 13 cancer patients and exhibited significant immunorestorative activity, with an increase in lo ...19892789109
[an experimental study on the anti-senility effects of shou xing bu zhi].this paper presents the anti-senility effects of shou xing bu zhi (sxbz. made of thirteen herbs: polygonum multiflorum, codonopsis silvestris, astragalus membranaceus, poria cocos, etc.) in mice. the mice were administered with the sxbz orally at dosage of 10 g/kg daily for three months. the results showed that the lipofuscin of liver and brain tissues was significantly reduced in both young (1 month old) and adult (11 months) mice. examination of lipid peroxidation of liver tissue revealed a ma ...19892758519
chinese medicinal herbs reverse macrophage suppression induced by urological tumors.tumors are known to produce factors suppressing macrophage function. in this study we demonstrated in vitro suppression of macrophage chemiluminescent oxidative burst associated with viable cells and cell-free extracts of two urological neoplasms--murine renal cell carcinoma (renca) and murine bladder tumor (mbt). suppression was reversed by extracts of two chinese medicinal herbs, astragalus membranaceus (am) and ligustrum lucidum (ll). murine macrophage cell line j774 was incubated with either ...19911856958
[inotropic action of astragalus membranaceus bge. saponins and its possible mechanism].astragalus membranaceus saponins (ams) 50-200 micrograms/ml had a positive inotropic action on the isolated working heart of rats, but in the case of 30 micrograms/ml the inotropic action turned negative. the contractility recovered after washing out the ams. strophanthin k performed in a similar manner as ams. ams 500 micrograms/ml decreased the resting potential of cultured rat heart cells by 10 mv. the results suggest that ams plays its inotropic role through influencing the na-k-atpase.19921292500
[the effect of astragalus polysaccharide on endotoxin-induced toxicity in mice].astragalus polysaccharide (aps), an active component, was isolated from the radix of astragalus membranaceus bge var. mongholicus (bge) hsiao, and the effects of aps on e. coli endotoxin-induced liver damage were investigated in mice. the results showed that when mice were pretreated with aps (30, 60, 100 mg.kg-1.d-1 x 7d, ip), the survival rate of endotoxin intoxicated mice was increased the lowering of atp levels and adenylate energy charge in mouse liver could be prevented. aps 100 mg.kg-1 co ...19921529714
immunotherapy with chinese medicinal herbs. ii. reversal of cyclophosphamide-induced immune suppression by administration of fractionated astragalus membranaceus in vivo.a partially purified fraction (f3) with an estimated molecular weight of 20,000 to 25,000 derived from the traditional chinese medicinal herb astragalus membranaceus, was found to possess a potent immunorestorative activity in vitro. its capacity to aborogate the local xenogeneic graft versus host reaction (xgvhr) following injection in vivo was further studied in a newly developed animal model designed for preclinical evaluation of various biological response modifiers. f3 was injected intraven ...19883260961
[effect of astragalus membranaceus on electrical activities of coxsackie b-2 virus-infected rat myocardial cells in culture].beating myocardial cell cultures of neonatal rats were prepared in vitro and infected with coxsackie b-2 virus. the cells were evaluated in the post-infected period for changes in beating percentage and cytopathic effect (cpe), alterations in the electrical activities by standard microelectrode techniques, and the protective effect of astragalus membranaceus (am) on coxsackie b-2 virus-infected neonatal rat myocardial cell cultures was observed. the beating percentage began to decrease in the in ...19892550160
immunotherapy with chinese medicinal herbs. i. immune restoration of local xenogeneic graft-versus-host reaction in cancer patients by fractionated astragalus membranaceus in vitro.the in vitro immunomodulatory activity of fractions derived from astragalus membranaceus, an herb commonly used in the practice of traditional chinese medicine, was first screened by studying their individual effects on mononuclear cells (mnc) derived from healthy normal donors using the local xenogeneic graft-versus-host reaction (xgvhr). sephacryl s-200 column-separated fraction 3 (mw 20,000-25,000) along with its crude extract precursor, fraction 7, and another crude extract derivative, fract ...19883260960
[influence of astragalus membranaceus (am) polysaccharide fb on immunologic function of human periphery blood lymphocyte].chemotherapy and/or radiotherapy are believed to further lower the already low cellular immunologic response of cancer patients giving poorer prognosis. a number of chinese medicinal herbs known as fuzheng therapy (fzt), in which am is an active one, are being used to enhance the natural host defence function in cancer patients. among some fractions of am polysaccharide extracts, fb was the strongest. in vitro restorative effects of fb in 18 normal healthy individuals and in 9 previously untreat ...19892612327
[effects of astragalus membranaceus and tripterygium hypoglancum on natural killer cell activity of peripheral blood mononuclear in systemic lupus erythematosus].natural killer (nk) activity of peripheral blood mononuclear cells (pbmc) from 28 patients with systemic lupus erythematosus (sle) was measured using enzyme-release assay. the sle patients had significantly decreased nk activity in comparing with normal controls. the levels of nk activity correlated with disease activity. pre-incubation of pbmc separately with astragalus membranaceus and tripterygium hypoglaucum or with their mixture considerably stimulated nk cytotoxicity both in sle patients a ...19921301849
[influence of yang-restoring herb medicines upon metabolism of thyroid hormone in normal rats and a drug administration schedule].large dose of yang-restoring herb medicines. (radix codonopsis pilosulae, astragalus membranaceus, radix aconiti praeparata, epimedium brevicornum, cortex cinnamomi and herba cistanchis) may exert an unfavorable effect on normal rats, i. e. natural weight gain reduced (p less than 0.01), serum t3 decreased (p less than 0.05), rt3, trh levels raised (p less than 0.01) and tsh showed a raising tendency. lower t3 and higher rt3 levels may be the effects of yang-restoring herb medicines on the perip ...19892500264
[clinical study of 96 cases with chronic hepatitis b treated with jiedu yanggan gao by a double-blind method].this paper reported 96 cases with chronic hepatitis b treated by a double-blind method. there were 51 cases of observation group(og) and 45 cases of control group (cg). og was treated with jiedu yanggan gao consisting of artemisia capillaris, taraxacum mongolicum, plantago seed, cephalanoplos segetum, hedyotis diffusa, flos chrysanthemi indici, smilax glabra, astragalus membranaceus, salviae miltiorrhizae, fructus polygonii orientalis, radix paeoniae alba, polygonatum sibiricum, etc.). cg was pr ...19902364464
[immunomodulatory action of the total saponin of gynostemma pentaphylla].the specimen of the total saponin for this experimental study was extracted from gynostemma pentaphylla growing in suining county in hunan province. weight of immune organs, content of anti-srbc hemolysin, rate of special ea-rfc formation and percentage of nk cell activity had been employed for the study as experimental indices, both the normal healthy mice and the mice with immunity impairment due to cyclophosphamide (cy) management as experimental models. the results of the study exhibited: (1 ...19902364471
effect of astragalus membranaceus on electric activities of cultured rat beating heart cells infected with coxsackie b-2 virus.astragalus membranaceus (am) which has a protective effect on rat beating heart cells infected experimentally with coxsackie b-2 virus was evaluated on the basis of changes in morphologic and electric activity of the cells. rhythm, beating frequency, beating percentage, cardiac cellular damage and cytopathic effects (cpe) were monitored every 24 h after challenge; electric activities parameters were measured by conventional intracellular microelectrode technique. significant protective effects w ...19902164463
viral etiology of chronic cervicitis and its therapeutic response to a recombinant interferon.chronic cervicitis was shown to be related to papillomavirus type 16(hpv-16), herpes simplex virus type 2 and cytomegalovirus (cmv) infections as demonstrated by dna hybridization technique and virus isolation method from samples taken from erosive and normal cervices. after one course of treatment with recombinant interferon alpha 1 (rifn-alpha 1), 93.8% of cases showed clinical improvement and 60% marked improvement. the hpv-16 and hsv detection rates dropped down significantly after rifn-alph ...19902173655
[preliminary study of traditional chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases].this paper reports the clinical treatment of 100 patients with minimal brain dysfunction (mbd), their age ranged from 7-14.2 years, and the average age was 10.5. patients were divided into tcm and wm group randomly. the tcm group (80 cases) were treated with the therapy of subdueing hyperactivity of the liver and invigorating the function of the spleen by using: bupleurum chinense, scutellaria baicalensis, astragalus membranaceus, codonopsis pilosula, ligustrum lucidum, lophatherum gracile and t ...19902397543
treatment of experimental coxsackie b-3 viral myocarditis with astragalus membranaceus in mice.a murine model system for observing the effect of astragalus membranaceus (am) on experimental myocarditis caused by coxsackie b-3 virus (cb3v) was developed in 4-week-old male balb/c mice. gross, histopathologic and ultrastructural examinations of the infected-am treated group showed that the severity and involved area of the myocardial lesions became milder and smaller than those in the infected-ns treated mice. the total lesion area, and the total lesion area/total myocardial area examined (% ...19902161724
[clinical and experimental study of the effect of kang er xin-i on viral myocarditis].kang er xin-i (kex-i) is a proved recipe used to treat viral myocarditis. it consists of lonicera japonica, ophiopogon japonicus, astragalus membranaceus mainly and possesses the effect of clearing away heat and toxic materials and supplementing the vital energy and nourishing. the clinical study was carried out with kex-i according to a random, paired and cross-over design. coenzyme q10 was used as a control and left ventricular function was observed. the result showed: after being treated with ...19911659497
[experimental study on yiqi-huoxue therapy of liver fibrosis].the experimental hepatic fibrosis was treated with yiqi (reinforcing qi, yq) huoxue (activating blood circulation, hx) principle which was consisted of astragalus membranaceus, ligusticum wallichii, paeonia lactiflora, etc. after stimulation with ccl4 over four months, the wistar rat developed liver fibrosis. rats were divided into the normal control, the toxifying control, yqhx group and hx group. the experimental period lasted over four months. results: (1) mortality of animal: both toxifying ...19921498545
astragalus membranaceus stimulates human sperm motility in vitro.poor sperm motility is an important cause of male infertility. in an attempt to identify chinese medicinal herbs that might improve human sperm motility in vitro, we screened water extracts of 18 herbs with a trans-membrane migration method which measured the percentage of sperm that moved across the 5 micron pores of a nucleopore membrane from a semen-drug mixture into phosphate buffered saline during 2 hours incubation. astragalus membranaceus was the only herb that showed a significant stimul ...19921471613
chinese medicinal herbs modulate mutagenesis, dna binding and metabolism of aflatoxin b1.oldenlandia diffusa (od) and scutellaria barbata (sb) have been used in traditional chinese medicine for treating liver, lung and rectal tumors while astragalus membranaceus (am) and ligustrum lucidum (ll) are often used as an adjunct in cancer therapy. in this study, we determined the effects of aqueous extracts of these four herbs on aflatoxin b1 (afb1)-induced mutagenesis using salmonella typhimurium ta100 as the bacterial tester strain and rat liver 9000 x g supernatant as the activation sys ...19921377337
[effect of fu-zheng qu-xie on gastric disease infected with campylobacter pyloridis].chinese herbal medicine and gentamycin were used separately in the treatment of 75 cases of gastric disease by campylobacter pyloridis (cp). surveying the changes of the gastrofiberscope, pathological test, bacteriology and immunology. this study, found that in the chinese herbal medicine group clinical symptoms were obviously improving the effective rate for cp being 80% (24/30), the death rate for cp 30% (9/30), and the effective rate for patho-histological changes 50% (15/30). differences of ...19912065393
effect of astragalus membranaceus injecta on coxsackie b-2 virus infected rat beating heart cell culture. 19872827966
mechanism of inhibition of hiv-1 infection in vitro by purified extract of prunella vulgaris.crude extracts of four chinese herbs, arctium lappa, astragalus membranaceus, andrographis paniculata, and prunella vulgaris, were assessed in several tissue culture lines for anti-hiv activity and for cytotoxicity. one extract, obtained from p. vulgaris, was able to significantly inhibit hiv-1 replication with relatively low cytotoxicity. the active factor was purified using sequential precipitations with ethanol and n-butanol, followed by reverse-phase and gel permeation high-performance liqui ...19921371029
shi-quan-da-bu-tang (ten significant tonic decoction), sqt. a potent chinese biological response modifier in cancer immunotherapy, potentiation and detoxification of anticancer drugs.shi-quan-da-bu-tang (ten significant tonic decoction), or sqt (juzentaihoto, tj-48) was formulated by taiping hui-min ju (public welfare pharmacy bureau) in chinese song dynasty in ad 1200. it is prepared by extracting a mixture of ten medical herbs (rehmannia glutinosa, paeonia lactiflora, liqusticum wallichii, angelica sinesis, glycyrrhiza uralensis, poria cocos, atractylodes macrocephala, panax ginseng. astragalus membranaceus and cinnamomum cassia) that tone the blood and vital energy, and s ...19921294861
[fungi isolated from diseased medicinal plants].one hundred and forty-four fungal isolates were obtained from diseased paeonia albiflora pall. var. trichocarpa bung., astragalus membranaceus bung., lithospermum erythrorhizon sieb. et zucc., ledebouriella seseloides wolff and bupleurum falcatum l. which were collected in the test field of tsukuba medicinal plant research station, national institute of hygienic sciences. most of them were identified into 15 genera containing 8 species. fungal species presumed to be pathogens of the host plants ...19921364438
[effect of astragalus membranaceus on myoelectric activity of small intestine].astragalus membranaceus (am) is one of the important chinese medicinal herbs which are widely used and well known for its invigoration of vital energy. in the present experiment, the cycle duration of interdigestive myoelectric complex (idmec) and the durations of every phase were observed electrophysiologically before and after the 25% concentrated solution (1 ml/kg) was instilled into the empty stomach of the healthy, awakened dog. signals of idmec were recorded by microcomputer. no significan ...19938312701
effects of compound injection of pyrola rotundifolia l and astragalus membranaceus bge on experimental guinea pigs' gentamicin ototoxicity.in attempting to find drugs effective in preventing and remedying ototoxic injury caused by aminoglycoside antibiotics, we relied on the theory that the induction of ototoxic injury by aminoglycoside antibiotics is related to a decrease of cyclic adenosine monophosphate and rna content in the cochlea or a dysfunction of the kidney. we selected pyrola rotundifolia l and astragalus membranaceus bge from traditional chinese herbal medicine, made a compound injection of them, and observed the effect ...19957747908
[study on the biologically active constituents of astragalus membranaceus]. 19846237798
[comparison of effect of astragalus membranaceus and huoxuefang on thromboxane, prostacyclin and adenosine cyclic monophosphate in cerebral reperfusion injury in rabbits].the cerebral ischemia rabbit model was made by using the occlusion of four vessels. the results showed that txb2 and camp contents in brain tissues and the latter in plasma markedly increased (p < 0.05, p < 0.01), the 6-keto-pgf1 alpha in brain tissues significantly lowered (p < 0.05) in ischemia formed 30 minutes and 45 minutes after reperfusion. after intravenous injection of astragalus membranaceus (am) extracts (3.3 g/kg), huoxuefang (hxfo and yiqi houxue fang (yqhxf) consisted of am and hxf ...19957647534
[effect of ph on hemolytic activity and stability of astragalus membranaceus injection]. 19846237759
[clinical and experimental study on yi-gan-ning granule in treating chronic hepatitis b].this paper reports that 320 patients with chronic hepatitis b (chb) were treated with yi-ganning granule (ygng) and the pharmacodynamics of ygng in the animal study. as control, another 70 patients with chb receiving oleanolic acid granule (oag) were compared to 68 patients in ygng group. ygng is consisted of astragalus membranaceus , artemisia capillaris, codonopsis pilosula, et al. each patient has taken ygng or oag for 3 months. the result showed ygng was effective on recovering the liver fun ...19938312695
immune restoration and/or augmentation of local graft versus host reaction by traditional chinese medicinal herbs.the in vitro restorative effect of aqueous extracts from two traditional chinese medicinal herbs were studied in 19 cancer patients and in 15 normal healthy donors. using the local graft versus host (gvh) reaction as a test assay for t-cell function, the extract from astragalus membranaceus (10 microgram/ml) induced a restored reaction in nine of ten patients with an increase in local gvh reaction from 18.2 plus/minus 15.8 mm3 to 112.9 plus/minus 94.2 mm3 (p less than 0.01). the extract from lig ...19836336578
fractionated extract of astragalus membranaceus, a chinese medicinal herb, potentiates lak cell cytotoxicity generated by a low dose of recombinant interleukin-2.success with ril-2 immunotherapy of human cancer appears to depend on the administration of high doses which are frequently associated with excessive toxicity. future use of ril-2 will require certain modifications based on the use of lower doses of ril-2 without significant loss of antitumor efficacy. we tested in vitro the possibility of potentiating the activity of ril-2 in terms of lak cell generation. we hypothesized that co-incubation of lak cell precursors with a chinese herbal extract (f ...19883264344
[effects of astragalus membranaceus on enhancement of mouse natural killer cell activity]. 19836197202
chinese medicinal herbs inhibit growth of murine renal cell carcinoma.tumors are known to produce factors suppressing immune functions. we previously showed that a murine renal cell carcinoma (renca) suppressed macrophage function in vitro and that this suppression was abolished by co-incubation with extracts of two chinese medicinal herbs. we now report that these phytochemicals are capable of inhibiting growth of renca in vivo. balb/c mice were transplanted intraperitoneally (ip) with 1-2 x 10(5) renca cells. one day after tumor transplant, mice were randomized ...19947812364
[effect and mechanism of astragalus membranaceus on coxsackie b3 virus rna in mice].using balb/c mice infected with coxsackie virus b3 (cvb3) as a model, the effect of astragalus membranaceus (am) on cvb3-rna has been observed in myocardial tissues of mice by rna-rna in situ hybridization with negative-strand rna probes leballing with 35s and quantitative imaging analysis of positive hybridization signals. the mechanism of its effect on cvb3-rna has also been investigated by induction with am and detection of beta-interferon (beta-ifn). results showed that the copy numbers of c ...19947703635
[non-surgical treatment of small cell lung cancer with chemo-radio-immunotherapy and traditional chinese medicine].54 consecutive cases of small cell lung cancer (sclc) were treated with longterm short-interval combined treatment modalities of chemotherapy, radiotherapy (55-65 gy), immunotherapy, traditional chinese medicine (leaf of asiatic ginseng, root of astragalus membranaceus bge, etc) and other adjuvants. chemotherapy consisted of vincristine, cyclophosphamide, methotrexate and carmustine. a complete response of 59.2%, partial response of 38.9% and an overall response of 98.1% were achieved. according ...19947867442
[clinical study of baoyuan dahuang decoction in the treatment of chronic renal failure].the quality of life of 56 chronic renal failure (crf) patients using two kinds of treatment has been observed. 36 of them were taken as group a with bun 21.62 +/- 5.96 mmol/l, cr 528.63 +/- 176.3 mumol/l and hb 65 +/- 13 g/l were treated with baoyuan dahuang decoction consisted of panax ginseng, astragalus membranaceus, cassia cinnamomi, glycyrrhiza uralensis and rheum palmatum. result: six symptoms were observed, that were: fatigue, lassitude in loin and legs, aversion of cold, anorexia, sexual ...19947950208
[effect of astragalus membranaceus on electrophysiological activities of acute experimental coxsackie b3 viral myocarditis in mice].a murine model for observing the effect of astragalus membranaceus (am) on electrophysiological activity of the right ventricular myocardium was developed in 4 week-old male balb/c mice infected with coxsackie b3 virus (cb3v). the conventional microelectrode technique and real-time microcomputer data processor system was used. the survival rate in infected-am treated mice was significantly higher and the percentage of abnormal action potential was much lower than those in control mice (p < 0.05 ...19947950216
preliminary observations on the effects of the chinese medicinal herbs astragalus membranaceus and ligustrum lucidum on lymphocyte blastogenic responses.the biological effects of extracts of two chinese medicinal herbs, astragalus membranaceus and ligustrum lucidum, on in vitro lymphocyte blastogenesis were assessed. aqueous extracts augmented the spontaneous [3h]thymidine incorporation in the mononuclear cells (mnc) of 14 normal subjects from 273.0 to 609.3 counts per minute (cpm) and 252.9 to 656.9 cpm for the two herbs, respectively. the stimulation indices were 2.4 and 3.1, respectively (p less than 0.001). they also augmented the proliferat ...19836644339
[effects of the combination of astragalus membranaceus (fisch.) bge. (am), tail of angelica sinensis (oliv.) diels. (tas), cyperus rotundus l. (cr), ligusticum chuanxiong hort. (lc) and paeonia veitchii lynch (pv) on the hemorrheological changes in normal rats].the results showed that am and tas had significant effects of enriching the blood. cr, a qi-regulating drug, lc and pv, two blood-activating drugs, could improve all hemorrheological indexes, such as the whole blood specific viscosity, the plasma specific viscosity, erythrocyte electrophoresis, etc. the combination of qi-regulating drug and blood-activating drug displayed more favorable effect. this experiment has provided some pharmacological evidence for the theory of "qi xue xiang guan" (corr ...19938003220
astragalus membranaceus and polygonum multiflorum protect rat heart mitochondria against lipid peroxidation.we isolated rat heart mitochondria and induced lipid peroxidation with adp and feso4. oxygen consumption and mda formation were measured for quantitating the amount of lipid peroxidation. using these methods, we screened the water extracts of 14 chinese medicinal herbs for their effect on lipid peroxidation. it was found that astragalus membranaceus inhibited 42.1 +/- 3.4% of oxygen consumption and 39.8 +/- 3.2% of mda production at concentration of 2 mg dried herb/ml mitochondrial suspension. a ...19948030620
[effects of the combination of astragalus membranaceus (fisch.) bge. (am), angelica sinensis (oliv.) diels (tas), cyperus rotundus l. (cr), ligusticum chuangxiong hort (lc) and peaonìa veitchii lynch (pv) on the hemorheological changes in "blood stagnating" rats].the "blood stagnating" rat model was built with adrenaline and cold stimulation. its hemorrheological character was an increase in the viscosity, thickness and liability to coagulate. the experimental result showed that am and tas could decrease the whole blood specific viscosity, but at the same time increase the plasma specific viscosity. the qi-regulating drug cr and two blood-activating drugs lc and pv could improve the hemorrheological changes in "blood stagnating" rats. the combination of ...19948011132
effect of astragalus membranaceus on electrophysiological activities of acute experimental coxsackie b-3 viral myocarditis in mice.a murine model for observing the effect of astragalus membranaceus (am) on electrophysiological action of the right ventricular myocardium was developed in 4-week-old male balb/c mice infected with coxsackie b-3 virus (cb3v). the conventional microelectrode technique and a real-time data processor system were used. the survival rate in am-treated mice was much higher and the percentage of abnormal action potential was much lower than those in infected control mice (p < 0.05, p < 0.01, respective ...19938032064
[effect of improving memory and inhibiting acetylcholinesterase activity by invigorating-qi and warming-yang recipe].invigorating-qi and warming-yang (iqwy) had a good curative effect to some senile diseases such as senile dementia, senile hypomnesia etc. this experiment was designed for probing into the therapeutical mechanism of iqwy recipe. balb/c pure bred mice were divided into five groups. group i was taken per os of invigorating qi (iq), group ii warming yang (wy), group iii iqwy drugs, group iv was dysmnesia model, and group v blank control group injected with normal saline only. all groups except grou ...19938155947
[effect of astragalus membranaceus on ca2+ influx and coxsackie virus b3 rna replication in cultured neonatal rat heart cells].the effect of astragalus membranaceus (am) on ca2+ influx across the myocardial plasma membrane and coxsackie virus b3(cvb3)-rna replication in cultured neonatal rat heart cells infected with cvb3 was investigated. it was found that the ca2+ influx could be inhibited significantly (p < 0.01) by am after infection of heart cells for 48 h. in addition, when the cultured heart cells infected with cvb3 and treated with am for 48 h, the ca2+ influx of infected heart cells also could be inhibited by a ...19958580697
[the effect of the chinese medical herbs astragalus membranaceus and angelica sinensis on 3 kinds of experimental nephritis]. 19863743217
the inhibitory effect of astragalus membranaceus on coxsackie b-3 virus rna replication.using mice infected with coxsackie b-3 virus (cvb3) as a viral myocarditis model, we observed the inhibitory effect of astragalus membranaceus (am) on cvb3-rna replication in myocardial tissue of mice by rna-rna in situ hybridization with negative-strand rna probes labelled with 35s and quantitative imaging analysis of positive signals. the mechanism of its effect on cvb3-rna replication has been investigated by detection of beta-interferon (beta-ifn) as well. results showed that the copy number ...19958580483
extract of astragalus membranaceus and ligustrum lucidum does not prevent cyclophosphamide-induced myelosuppression.there is increasing evidence that many chinese medicinal herbs are promising biological response modifiers in cancer treatment. the extract of some chinese herbs have shown ability in stimulating the bone marrow and improving the peripheral white cell counts in rats. we studied the effect of a dried extract of two commonly used chinese herbs, astragalus membranaceus (am) and ligustrum lucidum (ll) on cytotoxic-induced myelosuppression. wistar rats weighing 250-300g each were divided into two gro ...19958919152
[clinical and experimental study on inhibitory effect of sanhuang mixture on platelet aggregation].sanhuang mixture (xinmai capsule) is composed of astragalus membranaceus, coptis chinensis and scutellaria baicalensis. it could inhibit platelet aggregation (pag) induced by adp in rats or by adp and adr in vivo. patients with high pag took xinmai capsule for 4 weeks, the effective rate was 88.7%, which was same as the efficacy of aspirin 50 mg/day. in syndrome differentiation of tcm, the effective rate was the highest (92.3%) in the syndrome of qi deficiency-blood stasis, and the lowest (72.7% ...19958580692
[preliminary observation on the therapeutic effect of astragalus membranaceus in experimental anti-glomerular basement membrane nephritis in rabbits]. 19836227416
the protective effects of traditional chinese medicine prescription, han-dan-gan-le, on ccl4-induced liver fibrosis in rats.han-dan-gan-le, a chinese medicine preparation composed of salvia miltorrhiza, radix paeoniae, astragalus membranaceus, stephania tetrandra, and dried leaves of ginkgo biloba, has been used successfully to treat human liver fibrosis and cirrhosis for years. this study was designed to examine the mechanisms of the protection. male wistar rats were given ccl4 (1.2 ml/kg, 2 times/week), 20% fat diet, and 30% alcohol in drinking water (every other day) for 6 weeks. han-dan-gan-le (0.5 and 1.0 g/kg, ...19989862020
myocardial protection against ischaemia-reperfusion injury by a polygonum multiflorum extract supplemented 'dang-gui decoction for enriching blood', a compound formulation, ex vivo.'dang-gui decoction for enriching the blood' (be), a traditional chinese formulation comprising angelica sinensis and astragalus membranaceus, is used for stimulating red blood cell production as well as enhancing cardiovascular function. in the present study, we have demonstrated the myocardial protection afforded by be pretreatment against ischaemia-reperfusion (ir) injury in isolated-perfused rat hearts. a more complete and potent myocardial protection against ir injury was also shown by a po ...200010815014
[effect of astragalan on secretion of tumor necrosis factors in human peripheral blood mononuclear cells].the extracts of astragalus membranaceus have been further isolated by liquid chromatography. one of the fractions (astragalan, m.w. 20,000-25,000) could enhance the secretion of tumor necrosis factor (tnf) from human peripheral blood mononuclear cells (pbmc) in vitro. after isolation of adherent and nonadherent mononuclear cells from pbmc, astragalan increased the secretion of tnf-alpha and tnf-beta respectively. these results suggest further study of astragalan would promote the application of ...19938219673
regulation of the fibrinolytic potential of cultured human umbilical vein endothelial cells: astragaloside iv downregulates plasminogen activator inhibitor-1 and upregulates tissue-type plasminogen activator expression.we have investigated whether the saponin astragaloside iv (as-iv), a 3-o-beta-d-xylopyranosyl-6-o-beta-d-glucopyranosylcycloastragenol, purified from the chinese herb drug astragalus membranaceus, which is used in traditional chinese medicine to treat cardiovascular diseases, might affect the fibrinolytic potential of cultured human umbilical vein endothelial cells (huvecs). when huvecs were conditioned with as-iv, a dose (0.01-100 microg as-iv/ml)- and time-dependent decrease in plasminogen act ...19979256087
chinese medicinal herbs for asymptomatic carriers of hepatitis b virus infection.about 350 million people are chronically infected carriers of hepatitis b virus and are at a higher risk of serious illness and death from cirrhosis of the liver and liver cancer. chinese medicinal herbs have been used widely for more than 2000 years to treat chronic liver disease.200111406038
[study on the anti-herpes simplex virus activity of a suppository or ointment form of astragalus membranaceus combined with interferon alpha 2b in human diploid cell culture].a study on the anti-herpes simplex virus activity of the suppository or ointment form of astragalus membranaceus(am) combined with recombinant human interferon alpha 2b(ifn) was carried out in human diploid cell culture. am is a chinese herb medicine and have been used in china as a tonic for thousands of years and the ifn was produced from e. coli with 95% purity. obtained results indicated that the placebo suppository and ointment(without am and ifn) seemed not to decrease markedly the anti-vi ...199812526333
[experimental study on treatment of viral myocarditis in mice by integrated traditional chinese and western medicine].to clarify the effects of astragalus membranaceus (am) combined with taurine and/or coenzyme q10(coq10) on coxsackievirus b3 (cvb3) murine myocarditis.199811477833
[protective effect of astragalus membranaceus (fisch.) bge. and hedysarum polybotrys hand.-mazz. on experimental model of cerebral ischemia in rats].the experimental model of middle cerebral artery embolism in rats was made by inserting nylon thread. it was discovered that astragalus membranaceus decoction(both 4.26 g.kg-1 and 7.1 g.kg-1) could reduce the capillary hyperpermeability and alleviate the dyskinesia caused by cerebral ischemia in rats. purified hedysarum polybotrys decoction (waste substances removed with alcohol after decocting with water) (12.5 g.kg-1) could reduce the water content in brain caused by occlusion of bilateral car ...199811601305
effects of herbal preparation equiguard on hormone-responsive and hormone-refractory prostate carcinoma cells: mechanistic studies.the equiguard is a dietary supplement comprised of standardized extracts from nine herbs, respectively, herba epimedium brevicornum maxim (stem and leaves), radix morindae officinalis (root), fructus rosa laevigatae michx (fruit), rubus chingii hu (fruit), schisandra chinensis (turz.) baill (fruit), ligustrum lucidum ait (fruit), cuscuta chinensis lam (seed), psoralea corylifolia l. (fruit), and astragalus membranaceus (fisch.) bge (root). this proprietary product, formulated according to chines ...200211894110
chemical analysis of radix astragali (huangqi) in china: a comparison with its adulterants and seasonal variations.radix astragali (root of astragalus; huangqi) is a popular traditional chinese medicine, and astragalus membranaceus and a. membranaceus var. mongolicus are two commonly used species; however, there are many astragalus species that could act as adulterants of radix astragali. to find the chemical composition of radix astragali, the main constituents including flavonoids, saponins, polysaccharides, amino acids, and trace elements were determined in two radices astragali, a. membranaceus and a. me ...200212166972
inhibitory effects of astragali radix, crude drug in oriental medicines on lipid peroxidation and protein oxidative modification of mouse brain homogenate by copper.astragali radix, the root of astragalus membranaceus bunge, is a crude drug used widely in oriental medicines. it is a major component of ougi-keishi-gomotsu-to, a traditional herbal medicine, used for neurop patients with abnormal sensations and neuropathic pain of the legs. it was shown to have inhibitory effects on lipid peroxidation and protein oxidative modification by copper. the effects were similar to and stronger than those of mannitol and superoxide dismutase as free radical scavengers ...200010861978
in vitro fermentation characteristics of two mushroom species, an herb, and their polysaccharide fractions, using chicken cecal contents as inoculum.in vitro fermentabilities of two mushrooms (lentinus edodes--lens; tremella fuciformis--tres), an herb (astragalus membranaceus--asts), and their polysaccharide fractions (lene, tree, and aste) were investigated using microflora from chicken ceca. polysaccharides were extracted using the hot water method. the mushrooms had lower polysaccharide yields (8 to 10%) than the herb (31%). fermentation kinetics were determined using the in vitro cumulative gas production technique. end-products, such as ...200314601740
botanical influences on cardiovascular disease.several botanicals, including crataegus oxycantha, terminalia arjuna, inula racemosa, and astragalus membranaceus, have been found to have therapeutic benefit for the treatment of cardiovascular disease. crataegus oxycantha has been used traditionally as a cardiac tonic and current uses include treatment for angina, hypertension, arrhythmias, and congestive heart failure. animal studies have also indicated that crataegus extracts may also have potential use as anti-ischemic and lipid-lowering ag ...19989855567
messenger rna expressions of vasopressin system and aquaporin-2 in adriamycin-induced nephrotic rats and effects of astragalus membranaceus.to investigate the expressions of hypothalamic arginine vasopressin (avp) mrna, renal avp v2 receptor mrna, and avp-dependent aquaporin-2 (aqp2) mrna in rats with adriamycin-induced nephrotic syndrome. effects of chinese herb astragalus membranaceus (am) were also tested.199911721440
[effects of astragaloside in treating myocardial injury and myocardial sarco/endoplasmic ca(2+)-atpase of viral myocarditis mice].to investigate the effects on myocardial injury and sarcoplasmic reticulum (sr) ca(2+)-atpase of viral myocarditis mice treated with astragaloside (as) and astragalus injection (ai).199911783161
[studies on pharmacological junctions of hairy root of astragalus membranaceus].to investigate the effect of hairy root of astragalus membranaceus(hra).199912205961
antidotal effect of glucoside extracted from astragalus membranaceus on dimethoate intoxication in guinea pigs.therapeutic effect of the glucoside extracted from the root of astragalus membranaceus (am) was studied in guinea pigs intoxicated with 600 mg/kg doses of dimethoate (d). four groups of guinea pigs, each consisting of two males and two females, were treated with (a) d, (b) d + atropine, and (c) d + am, (d) d + atropine + am. the survival time of the animals increased from an average of 70 minutes without am to an average of 235 minutes with am. severe changes in ecg were observed prior to respir ...199810217935
mechanisms of the therapeutic effect of astragalus membranaceus on sodium and water retention in experimental heart failure.to investigate the therapeutic effect of astragali on sodium and water retention in aortocaval fistula-caused experimental congestive heart failure and its involved mechanisms.199810322646
[influence of a triplex superimposed treatment on hbv replication and mutation during treating chronic hepatitis b].to observe and evaluate the influence of a new antiviral treatment scheme on hbv replication and mutation during treating chronic hepatitis b.200111986694
[comparative study on effect of recipe for activating blood circulation and replenishing qi on left ventricular remodeling in rats with left heart failure after myocardial infarction].comparative study to the effect of chinese herbal medicine on left ventricular remodeling in rats with left heart failure after myocardial infarction (mi).200212584842
suppressive effect of astragalus membranaceus bunge on chemical hepatocarcinogenesis in rats.astragalus membranaceus (am) has been widely used for treating liver diseases in traditional chinese medicine. experimental evidence indicates that it has antitumor potential. in this study, the effect of am on hepatocarcinogenesis induced by diethylnitrosamine (den), two-thirds partial hepatectomy, and 2-acetylaminofluorene (2-aaf) (den-ph-aaf) was evaluated using glutathione s-transferase placenta form (gst-p) as marker. first, rats were injected intraperitoneally (i.p.) with den (200 mg/kg in ...200312497209
inhibition of trypanosoma cruzi growth by medical plant extracts.this study describes the screening of extracts obtained from 18 plants and two fungi used in the chinese and mediterranean traditional medicines on epimastigote forms of trypanosoma cruzi. the extracts were tested against epimastigote of t. cruzi bra c15c2 clone in vitro at 27 degrees c and at a concentration of 250 microg/ml in axenic culture. angelica dahurica, a. pubescens, a. sinensis, astragalus membranaceus, coptis chinensis, haplophyllum hispanicum, phellodendron amurense, poria cocos, ra ...200212490214
[extracorporeal experimental study on immuno-modulatory activity of astragalus memhranaceus extract].to study the effect of astragalus membranaceus extract (ame) in regulating the immune function of human peripheral blood immune cells (pbic) in vitro.200212585195
[effects of components isolated from astragalus membranaceus bunge on cardiac function injured by myocardial ischemia reperfusion in rats].to investigate the effects of components isolated from astragalus membranaceus on myocardial ischemia reperfusion injury.200012512456
[the diuretic and hypotensive action of astragalus membranaceus bge]. 196514324678
[determination of organochlorine pesticide multi-residues in astragalus membranaceus (fisch.) bge. var. mongholicus (bge.) hsiao, panax notoginseng (burk.) f. h. chen and p. quin quefolium l].to determine 15 organochlorine pesticide residues in astragalus membranaceus, panax notoginseng and p. quinquefolium.200012515220
influence of traditional chinese anti-inflammatory medicinal plants on leukocyte and platelet functions.the enzymes 5-lipoxygenase and elastase are therapeutic targets in dermatological disorders such as psoriasis. fifteen extracts from traditional chinese medicinal plants used to treat topical inflammations were screened for their inhibitory effect on lipoxygenase, cyclooxygenase and elastase activity in intact leukocytes and platelets. astragalus membranaceus, forsythia suspensa and poria cocos inhibited 5-lipoxygenase, with ic50 values of 141, 80 and 141 microg ml(-1), respectively. the latter ...200314604471
studies on chemical constituents and immunological function activity of hairy root of astragalus membranaceus.using a large-scale culture technique, the hairy roots of astragalus membranaceus were produced with a yield reaching 10 g/l. the results from rp-hplc detection showed that the contents of crude saponin and astragaloside i.v. in the hairy roots were 5.81% and 0.14%, respectively. six isoflavonoid compounds were also determined. polysaccharide analysis showed that the total polysaccharide content in the hairy roots was 22.97%; of this content, acidic 8.29% and soluble 14.88%. in comparison with t ...199810196633
[study on effects of astragalus, angelica and their combination on vascular endothelial cell proliferation in vitro].to study the effects of astragalus membranaceus (am), angelica sinensis (as) and their combination on human umbilical vein endothelial cell (huvec) proliferation and cells cycle.200314626189
[experimental study on treatment of pulmonary fibrosis by chinese drugs and integrative chinese and western medicine].to compare the effects of treatment of pulmonary fibrosis (pf) by the chinese herbal medicines, radix salviae miltiorrhizae (c1), radix astragalus membranaceus (c2) and caulis tripterygium wilfordii (c3); western drugs, hydrocortisone (w1) and azathioprine (w2), and combined w2 with c3.200415015446
induction of growth hormone by the roots of astragalus membranaceus in pituitary cell culture.the traditional asian medicinal herb, roots of astragalus (a.) membranaceus (leguminosae), is used for many purposes, some of which are purported to stimulate the release of growth hormone in vivo. extracts of a. membranaceus were tested to determine whether they stimulate the release of growth hormone in rat pituitary cell culture. a. membranaceus was extracted sequentially with 80% ethanol (fraction a), n-hexane (fraction b); the test compound from the herbal extraction was isolated using sili ...200312568355
the collagenolytic effects of the traditional chinese medicine preparation, han-dan-gan-le, contribute to reversal of chemical-induced liver fibrosis in rats.han-dan-gan-le (hdgl), a chinese herb preparation composed of stephaniat tetrandra, salvia miltorrhiza, radix paeoniae, astragalus membranaceus, and ginkgo biloba, has been used to treat human liver fibrosis. this study was designed to examine the therapeutic effect of hdgl on chemical-induced liver fibrosis in adult wistar rats. liver fibrosis was produced in rats by carbon tetrachloride (1.2 ml ccl(4)/kg, 2 times/week, after an initial dose of 5.0 ml ccl(4)/kg, sc), plus a diet of 20% fat, 0.0 ...200312551745
effects of several chinese herbal aqueous extracts on human sperm motility in vitro.the effects of six kinds of aqueous extracts of chinese herbal medicine (astragalus membranaceus, acanthopanacis senticosi, panax genseng and ophiopogon japonicus, p. genseng and aconitum carmichaeli, salviae miltiorrhiae, polyporus umbellatus polysaccharide) on sperm motility characteristics of 30 infertile male volunteers were studied in vitro with a computer-assisted sperm analysis at 15, 60 and 180 min after incubated with the drugs. the results showed that per cent viability, number of prog ...200415084153
immunomodulatory and antimicrobial effects of some traditional chinese medicinal herbs: a review.the current practice of ingesting phytochemicals to support the immune system or to fight infections is based on centuries-old tradition. we review reports on seven chinese herbs, (aloe vera mill. (aloaceae), angelica species (umbelliferae), astragalus membranaceus bunge. (leguminosae), ganoderma lucidum (fr.) karst. (ganodermataceae), panax ginseng c.a mey. (araliaceae), scutellaria species (lamiaceae) and zingiber officinale rosc. (zingiberaceae) with emphasis to their immunomodulatory and ant ...200415180575
effects of huangqi (hex) on inducing cell differentiation and cell death in k562 and hel cells.huangqi (astragalus membranaceus), a traditional chinese medicine, has been used to ameliorate side effects of cancer chemotherapy in china. however, little is known about its molecular mechanisms. here we show that induction of k562 or hel cells with 1.5 mg/ml of huangqi (hex) (components extracted from huangqi) for 3-5 d results in the expression of beta-globin gene in both cell lines and leads to terminal differentiation. moreover, the apoptosis in hel cells can be induced by increasing conce ...200415202506
herbal extract prevents bone loss in ovariectomized rats.this research aims to test a new drug candidate based on a traditional medicinal herb, f1, an herbal extract obtained from astragalus membranaceus and its main ingredient, 1-monolinolein that may have fewer side effects and less uterine hypertrophy. in vitro experiments, human osteoblast-like cell lines, mg-63 and saos-2, were analyzed by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (mtt) and an alkaline phosphatase (alp) assays. mouse osteoclasts were induced through a calcium-d ...200314661857
[effects of astragalus membranaceus injection on sperm abnormality in cd-induced rats].to study the effects of astragalus membranaceus injection on sperm abnormality in cd-induced rats.200414979208
protective effects of astragalus saponin i on early stage of diabetic nephropathy in rats.diabetic nephropathy (dn) has become the leading cause of end stage failure, but no renoprotective treatment has been very available for use in dn. astragalus saponin i (as i), a component extracted from astragalus membranaceus bunge, was studied in experimental dn induced by administration of streptozotocin in male rats. the early dn rats were treated with 3 doses of as i for 8 weeks to analyze its efficacy with different parameters. by comparison with vehicle-treated dn rats, the renal hypertr ...200415215651
effects of mushroom and herb polysaccharides, as alternatives for an antibiotic, on the cecal microbial ecosystem in broiler chickens.an in vivo experiment was conducted to study the potential prebiotic effects of mushroom and herb polysaccharide extracts, lentinus edodes extract (lene), tremella fuciformis extract, and astragalus membranaceus radix extract, on chicken growth and the cecal microbial ecosystem, as compared with the antibiotic apramycin (apr). this investigation was carried out in terms of a dose-response study. the chickens were naturally infected with avian mycoplasma gallisepticum prior to the experiment. the ...200414979567
[effect of astragalus membranaceus on baroreflex sensitivity in spontaneously hypertensive rats].to observe the chronicity decompression effect of astragalus membranaceus(am) and evaluate the effect on baroreflex sensitivity (brs).200315015293
[comparative study on angiogenesis effect of astragalus membranaceus and angelica sinensis in chick embryo choriollantoic membrane].to explore the angiogenesis effect of astragalus membranaceus and angelica sinensis with different ratio in chick embryo chorioallantoic membrane (cam).200315015388
[experimental study of the effect of astragalus membranaceus against herpes simplex virus type 1].to study the inhibitory effects of astragalus membranaceus on herpes simplex virus type 1(hsv-1).200414724098
a study on the immune receptors for polysaccharides from the roots of astragalus membranaceus, a chinese medicinal herb.the immunopotentiating effect of the roots of astragalus membranaceus, a medicinal herb, has been associated with its polysaccharide fractions (astragalus polysaccharides, aps). we herein demonstrate that aps activates mouse b cells and macrophages, but not t cells, in terms of proliferation or cytokine production. fluorescence-labeled aps (fl-aps) was able to selectively stain murine b cells, macrophages and a also human tumor cell line, thp-1, as determined in flow cytometric analysis and conf ...200415249203
[influence of ganciclovir and astragalus membranaceus on proliferation of hematopoietic progenitor cells of cord blood after cytomegalovirus infection in vitro].cytomegalovirus (cmv) infection was greatly common in the world. cmv infection produces usually mild or asymptomatic infections in individuals with normal immune responses, whereas it may cause serious disease in immunosuppressive patients. clinical manifestations include suppression of myelopoiesis, a mononucleosis like syndrome, hepatosplenomegaly, lymphadenopathy, thrombocytopenia, and hemolytic anemia. in patients undergoing bone marrow transplantation cmv remains the most common infectious ...200415324563
macrophage activation by polysaccharide isolated from astragalus membranaceus.we show that aps, a polysaccharide isolated from the roots of astragalus membranaceus, significantly induces nitric oxide (no) production and inducible no synthase (inos) transcription through the activation of nuclear factor-kappab/rel (nf-kappab/rel). in vivo administration of aps induced no production by peritoneal macrophages of b6c3f1 mice. aps also dose-dependently induced the production of no in isolated mouse peritoneal macrophages and raw 264.7, a mouse macrophage-like cell line. moreov ...200515914327
immune receptors for polysaccharides from ganoderma lucidum.this study was designed to identify and characterize the immune receptors for polysaccharides from ganoderma lucidum, a chinese medicinal fungus that exhibits anti-tumor activities via enhancing host immunity. we herein demonstrate that g. lucidum polysaccharides (glps) activated balb/c mouse b cells and macrophages, but not t cells, in vitro. however, glps was unable to activate splenic b cells from c3h/hej mice that have a mutated tlr4 molecule (incapable of signal transduction) in proliferati ...200415351712
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