| marinactinospora thermotolerans gen. nov., sp. nov., a marine actinomycete isolated from a sediment in the northern south china sea. | a novel marine actinomycete, designated scsio 00652(t), was isolated from a marine sediment collected from the northern south china sea at a depth of 3865 m. the strain formed branched substrate mycelia and no fragmentation was found. abundant aerial mycelia differentiated into long spore chains and the spores had a wrinkled surface. growth occurred on isp medium 2 with 0-5 % (w/v) nacl and at 10-55 degrees c. the whole-cell hydrolysate contained meso-diaminopimelic acid and glucose as the whole ... | 2009 | 19406773 |
| murinocardiopsis flavida gen. nov., sp. nov., an actinomycete isolated from indoor walls. | two gram-stain-positive, mycelium-forming actinobacteria (strains 14-be-013t and 02-gi-014) were isolated from walls colonized with moulds and studied taxonomically. the isolates formed yellowish-pigmented substrate mycelium showing no fragmentation. comparative analysis of 16s rrna gene sequences showed that these bacteria are most closely related to genera within the family nocardiopsaceae, but form a separate lineage within this family. highest sequence similarities were to the type strains o ... | 2010 | 19734281 |
| marinactinones a-c, new γ-pyrones from marine actinomycete marinactinospora thermotolerans scsio 00606. | three new γ-pyrones named marinactinones a-c (1-3) were isolated from marine-derived actinomycete marinactinospora thermotolerans scsio 00606. these structures were elucidated by extensive spectroscopic methods. all three new compounds were evaluated for cytotoxic effects on six cancer cell lines and inhibitory activities of dna topoisomerase ii. compounds 1-3 exhibited moderate cytotoxicities against sw1990, hepg2 and smcc-7721 cell lines, and compound 2 showed weak dna topoisomerase ii inhibit ... | 2010 | 21157453 |
| spinactinospora alkalitolerans gen. nov. sp. nov., a novel marine actinomycete isolated from sediment near the yellow sea cold water mass, china. | a novel marine actinomycete, designated cxb654t, was isolated from a marine sediment collected at a depth of 17.5 m near the yellow sea cold water mass, china. optimal growth occurred at 37.0°c, ph 7.0-8.0 and 3-8% (w/v) nacl. the strain cxb654t formed branched substrate mycelium without fragmentation. abundant aerial mycelium differentiated into long or short chains of spores, and the spores were elliptic and cylindrical with spinous surface. strain cxb654t contained meso-diaminopimelic acid as ... | 2011 | 21216917 |
| antimalarial β-carboline and indolactam alkaloids from marinactinospora thermotolerans, a deep sea isolate. | four new β-carboline alkaloids, designated marinacarbolines a-d (1-4), two new indolactam alkaloids, 13-n-demethyl-methylpendolmycin (5) and methylpendolmycin-14-o-α-glucoside (6), and the three known compounds 1-acetyl-β-carboline (7), methylpendolmycin (8), and pendolmycin (9) were obtained from the fermentation broth of marinactinospora thermotolerans scsio 00652, a new actinomycete belonging to the family nocardiopsaceae. their structures were elucidated by extensive ms and 1d and 2d nmr spe ... | 2011 | 21977916 |
| discovery and engineered overproduction of antimicrobial nucleoside antibiotic a201a from the deep-sea marine actinomycete marinactinospora thermotolerans scsio 00652. | marinactinospora thermotolerans scsio 00652, originating from a deep-sea marine sediment of the south china sea, was discovered to produce antimicrobial nucleoside antibiotic a201a. whole-genome scanning and annotation strategies enabled us to localize the genes responsible for a201a biosynthesis and to experimentally identify the gene cluster; inactivation of mtdf, an oxidoreductase gene within the suspected gene cluster, abolished a201a production. bioinformatics analysis revealed that a gene ... | 2012 | 22064543 |