| in vitro and in vivo studies of ribavirin action on brazilian orthobunyavirus. | oropouche, caraparu, guama, guaroa, and tacaiuma are viruses (genus orthobunyavirus) that cause human febrile illnesses and encephalitis. the goal of this study was to evaluate the antiviral action of ribavirin on these orthobunyaviruses to achieve a therapeutical agent to treat the diseases caused by these viruses. in vitro results showed that ribavirin (50 microg/ml) had antiviral activity only on the tacaiuma virus. addition of guanosine in the culture reversed the antiviral effect of ribavir ... | 2006 | 17124004 |
| in vitro study of antiviral activity of mycophenolic acid on brazilian orthobunyaviruses. | oropouche, caraparu, guama, guaroa and tacaiuma are ssrna viruses that belong to the genus orthobunyavirus and have been associated with human febrile illnesses and/or encephalitis. in this study, we evaluated the antiviral action of mycophenolic acid (mpa) on theseorthobunyaviruses to achieve a therapeutic agent to treat the diseases caused by these viruses. | 2007 | 17283446 |
| viruses in the anopheles a, anopheles b, and tete serogroups in the orthobunyavirus genus (family bunyaviridae) do not encode an nss protein. | viruses in the genus orthobunyavirus, family bunyaviridae, have a genome comprising three segments (called l, m, and s) of negative-sense rna. serological studies have classified the >170 named virus isolates into 18 serogroups, with a few additional as yet ungrouped viruses. until now, molecular studies and full-length s-segment nucleotide sequences were available for representatives of eight serogroups; in all cases, the s segment encodes two proteins, n (nucleocapsid) and nss (nonstructural), ... | 2009 | 19439468 |