| chemical forms of radioactive iodine in seawater and its effects upon marine organisms. | chemical forms of radioactive iodine and its effects upon marine organisms were studied by the tracer experiments. seaweeds or fish were held in the aquarium in which the 125i tracer in either iodide or iodate form was inoculated. iodide form of 125i was taken by dorome (chasmichthys gulosus) with the concentration factor of about 10 and excreted with the biological half-life of 15 days, while iodate form of 125i was not taken up appreciably and the concentration factor did not greatly exceed un ... | 1983 | 6658018 |
| [study on the apoptosis of hl-60 human promyeloid leukaemia cells induced by sfps]. | the inhibition effects of sargassum fusiforme polysaccharides (sfps) on proliferation of human hl-60 promyeloid leukemia cells were measured by mtt assay. sfps-induced apoptosis in hl-60 cells was observed by electron microscopy, flow cytometry and dna electrophoresis. the results revealed that sfps exhibited antiproliferative activity which depended on dosage and time. after incubation for 24, 36, 48 and 72 h, sfps had growth inhibitory effect on hl-60 cells with ic50 of 390, 362, 402 and 421 m ... | 2004 | 15259985 |
| the effect of sargassum fusiforme polysaccharide extracts on vibriosis resistance and immune activity of the shrimp, fenneropenaeus chinensis. | immunostimulants are valuable for control of shrimp diseases and the immunostimulatory effects of some polysaccharide additives for shrimp have been reported. in this study, the sargassum fusiforme polysaccharide extract (sfpse) was assessed as a feed additive when supplemented in the diet (0%, 0.5%, 1.0%, and 2.0%) for juvenile shrimp, fenneropenaeus chinensis, in order to study the effects of sfpse on vibriosis resistance and immune activity. shrimp were cultured in the same pond with cages. t ... | 2006 | 16326114 |
| structural investigation of a fucoidan containing a fucose-free core from the brown seaweed, hizikia fusiforme. | a fucoidan, obtained from the hot-water extract of the brown seaweed, hizikia fusiforme, was separated into five fractions by deae sepharose cl-6b and sepharose cl-6b column chromatography. all five fractions contained predominantly fucose, mannose and galactose and also contained sulfate groups and uronic acid. the fucoidans had mws from 25 to 950 kda. the structure of fraction f32 was investigated by desulfation, carboxyl-group reduction, partial hydrolysis, methylation analysis and nmr spectr ... | 2006 | 16643873 |
| inhibition of highly productive hiv-1 infection in t cells, primary human macrophages, microglia, and astrocytes by sargassum fusiforme. | the high rate of hiv-1 mutation and increasing resistance to currently available antiretroviral (art) therapies highlight the need for new antiviral agents. products derived from natural sources have been shown to inhibit hiv-1 replication during various stages of the virus life cycle, and therefore represent a potential source of novel therapeutic agents. to expand our arsenal of therapeutics against hiv-1 infection, we investigated aqueous extract from sargassum fusiforme (s. fusiforme) for ab ... | 2006 | 16725040 |
| [effect of sargassum fusiforme polysaccharides on the complex mobility of erythrocytes in tumor-bearing organisms using high performance capillary electrophoresis]. | this study analyzed the effect of sargassum fusiforme polysaccharides (sfps) on the complex mobility of erythrocytes in tumor-bearing organisms. a mouse tumor model was developed in which mice were intraperitoneally injected with high, medium, and low dosages of sfps for 7 d. the erythrocytes were collected and prepared into suspensions, and the complex mobilities of cells were measured using high performance capillary electrophoresis (hpce). experimental conditions included the following: capil ... | 2007 | 17679421 |
| sargassum fusiforme fraction is a potent and specific inhibitor of hiv-1 fusion and reverse transcriptase. | sargassum fusiforme (harvey) setchell has been shown to be a highly effective inhibitor of hiv-1 infection. to identify its mechanism of action, we performed bioactivity-guided fractionation on sargassum fusiforme mixture. here, we report isolation of a bioactive fraction sp4-2 (s. fusiforme), which at 8 mug/ml inhibited hiv-1 infection by 86.9%, with ic50 value of 3.7 mug. that represents 230-fold enhancement of antiretroviral potency as compared to the whole extract. inhibition was mediated ag ... | 2008 | 18197976 |
| ethyl alcohol extracts of hizikia fusiforme sensitize ags human gastric adenocarcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis. | resistance to tumor necrosis factor-related apoptosis-inducing ligand (trail)-induced apoptosis has been reported in some cancer cells, including ags human gastric adenocarcinoma cells. hizikia fusiforme is a commonly used brown seaweed species in korea that possesses potent antibacterial, antifungal, and anti-inflammatory activities. in this study, we demonstrated that treatment with trail in combination with subtoxic concentrations of ethyl alcohol extract of h. fusiforme (eahf) sensitized tra ... | 2009 | 19735177 |
| palmitic acid is a novel cd4 fusion inhibitor that blocks hiv entry and infection. | the high rate of hiv-1 mutation and the frequent sexual transmission highlight the need for novel therapeutic modalities with broad activity against both cxcr4 (x4) and ccr5 (r5)-tropic viruses. we investigated a large number of natural products, and from sargassum fusiforme we isolated and identified palmitic acid (pa) as a natural small bioactive molecule with activity against hiv-1 infection. treatment with 100 microm pa inhibited both x4 and r5 independent infection in the t cell line up to ... | 2009 | 20001317 |
| the ethyl alcohol extract of hizikia fusiforme inhibits matrix metalloproteinase activity and regulates tight junction related protein expression in hep3b human hepatocarcinoma cells. | we tested the correlation between the tightness of tight junctions (tjs) and the anti-invasive activity of the ethyl alcohol extract of hizikia fusiforme (ehf) in hep3b human hepatocarcinoma cells. ehf inhibited cell proliferation, motility, and invasiveness, which were associated with increased tj tightness, as demonstrated by an increase in transepithelial electrical resistance. ehf dose-dependently decreased the secretion of matrix metalloprotease-2 and -9, which correlated with a decrease in ... | 2010 | 20136433 |
| effects of modified haizao yuhu decoction in experimental autoimmune thyroiditis rats. | modified haizao yuhu decoction (mhyd), based on clinical experience, has been used for approximately 500 years and famous for its efficiency in treating thyroid-related diseases. | 2011 | 21397681 |
| immunohistochemical localization of endogenous d-aspartate in the marine brown alga sargassum fusiforme. | immunohistochemical localization (cellular localization) of endogenous d-aspartate in the marine brown alga sargassum fusiforme was investigated by the use of a specific polyclonal antibody raised against d-aspartate. d-aspartate immunoreactivity was evident in the medullary layer in the blade of the alga, and weak staining was found in the cortical layer, whereas epidermal cells were found to lack d-aspartate. within the cells of the layers, immunoreactivity was confirmed only in the cytosol an ... | 2011 | 21821953 |
| extracts of marine algae show inhibitory activity against osteoclast differentiation. | osteoclasts are multinucleated cells that play a crucial role in bone resorption. the imbalance between bone resorption and bone formation results in osteoporosis. therefore, substances that can suppress osteoclast formation are potential candidate materials for drug development or functional foods. there have been reports that extracts or purified compounds from marine micro- and macroalgae can suppress osteoclast differentiation. symbioimine, isolated from the cultured dinoflagellate symbiodin ... | 2011 | 22054967 |
| antitumor and immunomodulatory activity of polysaccharides from sargassum fusiforme. | sargassum fusiforme (harv.) setchel is an ingredient of chinese herbal medicine that has been applied for thousands of years. this study was set up to evaluate the in vivo and in vitro anti-tumor potential of the polysaccharide (sfps) from s. fusiforme and the immune response in tumor-bearing mice. sfps was isolated by hot water extraction and ethanol precipitation. the mice inoculated with a549 cells were orally administrated with sfps at the doses of 100 and 200mg/kg body weight for 28days. th ... | 2011 | 22120506 |
| aspewentins a-c, norditerpenes from a cryptic pathway in an algicolous strain of aspergillus wentii. | through addition of suberoylanilide hydroxamic acid, two new aromatic norditerpenes, aspewentins a (1) and b (2), along with an oxygenated derivative, aspewentin c (3), were obtained from the culture of an aspergillus wentii strain (na-3) isolated from the tissue of the brown alga sargassum fusiforme. the structures and absolute configurations were unambiguously elucidated by spectroscopic analyses and quantum chemical calculations. aspewentins a-c were produced before sporulation and exhibited ... | 2014 | 24499164 |
| levels, profiles and dietary sources of hydroxylated pcbs and hydroxylated and methoxylated pbdes in japanese women serum samples. | human exposure to polychlorinated biphenyls (pcbs) and polybrominated diphenyl ethers (pbdes) may result in retention of specific congeners of hydroxylated pcbs (oh-pcbs) and hydroxylated/methoxylated pbdes (oh-/meo-pbdes) in serum. however, dietary sources and biotransformation of oh-/meo-pbdes in humans are poorly understood. therefore, this study was conducted to investigate the levels, profiles, and exposure sources of oh-/meo-pbdes along with oh-pcbs present in human serum. twenty serum sam ... | 2016 | 27615405 |
| nutritional and toxicological importance of macro, trace, and ultra-trace elements in algae food products. | the content of 5 macro elements (na, k, ca, mg, and p), 6 trace elements (fe, mn, zn, cu, se, and i), and 4 ultra-trace elements (as, pb, cd, and hg) in 34 edible dried seaweed products of brown algae (laminaria sp., undaria pinnatifida, and hizikia fusiforme) and red algae (porphyra sp.) originated from china, japan, and korea and bought by retail in germany was determined. the content of these elements was analyzed by spectrometric methods (icp-aes, icp-ms, hgaas, and cvaas). assuming a daily ... | 2007 | 17994690 |
| arsenosugars in raw and cooked edible seaweed: characterization and bioaccessibility. | the aim of this study was to examine arsenic species contents in raw and cooked edible seaweed and the bioaccessibility (maximum soluble concentration in gastrointestinal medium) of arsenosugars (glycerol ribose, phosphate ribose, sulfonate ribose, and sulfate ribose). for the analysis, a new chromatographic separation was developed in anion exchange, coupled with thermooxidation-hydride generation-atomic fluorescence spectrometry. an in vitro digestion (pepsin, ph 2; pancreatin-bile extract, ph ... | 2005 | 16131152 |
| estimation of arsenic bioaccessibility in edible seaweed by an in vitro digestion method. | the aim of this study was to examine the bioaccessibility (maximum soluble concentration in gastrointestinal medium) of total (ast) and inorganic (asi) arsenic contents and the effect on them of cooking edible seaweed, a food of great interest because of its high as content. an in vitro gastrointestinal digestion (pepsin, ph 2, and pancreatin-bile extract, ph 7) was applied to obtain the mineral soluble fraction of three seaweeds (hizikia fusiforme, porphyra sp., and enteromorpha sp.). ast was d ... | 2003 | 13129320 |