| experimental infection with scedosporium inflatum. | the experimental pathogenicity of scedosporium inflatum (three isolates) and scedosporium apiospermum (one strain) was determined following intraperitoneal and intravenous injection into immunosuppressed and normal mice. immunosuppressed animals were treated with cortisone acetate. the results show that the strains studied displayed positive tropism to kidney and brain. in the histopathological study of the first organ, we initially observed abscesses at the glomerular level and later in the ren ... | 1992 | 1287160 |
| [apropos of 2 cases of scedosporium apiospermum nasosinusal infection]. | we report two cases of nasosinusal infection caused by scedosporium apiospermum and involving the nasal fossa in one case and the maxillary sinus in the other. the course of the disease varied according to the patient's immune status. the otherwise healthy patient (case n. 1) was completely cured by surgery, whereas the immunosuppressed patient (case n. 2) had local extension with pseudotumoral symptoms and lysis of the inter-sinusonasal septum; an early surgical treatment combined with local ad ... | 1992 | 1410889 |
| clinical features of human infection with scedosporium inflatum. | we report on 17 australian cases of human infection or colonization with scedosporium inflatum. the spectrum of clinical manifestations was similar to that in infection caused by scedosporium apiospermum. the patients were classified into three groups. four immunocompetent patients who presented with localized infections of a joint, nail bed, eye, or sphenoidal sinus made up the first group. our first case, in a boy with posttraumatic septic arthritis, responded to surgical drainage with amphote ... | 1992 | 1534693 |
| [fungus-induced arthritis caused by scedosporium apiospermum (pseudallescheria boydii)]. | scedosporium (monosporium) apiospermum is the most common causative agent of maduro mycosis. recent research reports claim that this fungus can also induce arthritis. we report on the disease in a woman from a rural area who was admitted to our clinic because of arthritis symptoms. we were able to detect scedosporium apiospermum, i.e., it was probably a fungus-induced arthritis which had developed after an intraarticular steroid injection. | 1991 | 1746172 |
| keratomycosis due to scedosporium apiospermum. | although no overt injury occurred, a corneal abscess without hypopyon developed in a normal, 25-year-old female, living in a suburban area of madrid, following a period of intensive garden work. direct examination of the corneal scrapings on one occasion showed septate, branched hyphal elements. when scrapings were cultured on sabouraud glucose and brain heart infusion agars a pure culture of scedosporium apiospermum was repeatedly isolated. the patient responded successfully to treatment with m ... | 1991 | 1824418 |
| the first case of pseudallescheria boydii meningitis in china--electron microscopic study and antigenicity analysis of the agent. | reported in this paper is the first case of isolation of pseudallescheria boydii from cerebral spinal fluid of a boy with meningitis in china. morphology and culture were observed by light microscopy, electron scanning microscopy and transmission electron microscopy. in addition, mycelium antigen prepared by sds-page was compared with that of the other strain of scedosporium apiospermum. both of the strains showed more than 40 peptide lines. their molecular weight was very similar. on the cs-930 ... | 1990 | 2098578 |
| successful treatment of scedosporium apiospermum suppurative arthritis with itraconazole. | | 1990 | 2172910 |
| [clinical case of mycetoma caused by scedosporium apiospermum]. | the authors report a case of mycetoma from scedosporium apiospermum in a 19 years old patient affected by adult's cgd. they emphasize the importance of mycetes' identification from clinical specimens' isolates, to consent a correct interpretation of the bacteriological result from physician. | 1989 | 2490408 |
| potted plants in hospitals as reservoirs of pathogenic fungi. | the soils of five potted plants cultivated within a hospital were investigated for the presence of fungal opportunistic pathogens of humans. a total of 16 potentially pathogenic species were isolated, including aspergillus fumigatus at up to 53.5 colony-forming units (cfu) per gram dry soil and scedosporium apiospermum (pseudallescheria boydii) at up to 97.0 cfu/g. other common species included phialophora verrucosa and fusarium solani. scedosporium inflatum, a recently described emerging pathog ... | 1989 | 2671744 |
| [a case of prosthetic valve endocarditis due to scedosporium apiospermum]. | | 1989 | 2732604 |
| [cutaneous microabscesses caused by scedosporium apiospermum]. | | 1985 | 2931685 |
| a case of disseminated scedosporium apiospermum infection after bone marrow transplantation. | | 1987 | 3295538 |
| scedosporium inflatum, an emerging pathogen. | the salient morphologic and physiologic characteristics of 18 isolates of scedosporium inflatum, a newly reported human pathogen, were compared with those of the morphologically similar fungi scedosporium apiospermum, scopulariopsis brevicaulis, and scopulariopsis brumptii. the formation by s. inflatum of annelloconidia in wet clumps at the apices of annellides with swollen bases was found to be the most useful characteristic in differentiating this potential pathogen. | 1988 | 3356789 |
| [fungal mycotic aneurysms and multiple cerebral abscesses caused by scedosporium apiospermum. apropos of a case with review of the literature]. | the authors report a case of intracranial fungal aneurysm and brain abscesses. the compromised host was a young drowned woman. scedosporium apiospermum was isolated in fungal culture from abscess. radiological and clinical pictures are typical of the hyphal form. | 1985 | 3839532 |
| an atypical isolate of scedosporium apiospermum from a purulent meningitis in man. | | 1981 | 7197398 |
| annellated conidiogenous cells in petriellidium boydii (scedosporium apiospermum). | annellated conidiogenous cells of both the mononematous (scedosporium state) and synnematous (graphium state) conidiophores develop in the conidial state of petriellidium (= allescheria) boydii, scedosporium (= monosporium) apiospermum. conidiogenesis in this species is characterized by percurrent proliferation of the conidiogenous cells and the conidia are holoblastic and annellidic. | 1980 | 7455859 |
| ribosomal dna internal transcribed spacer analysis supports synonomy of scedosporium inflatum and lomentospora prolificans. | scedosporium inflatum is a dematiaceous opportunistic pathogen originally described by d. malloch and i.f. salkin (mycotaxon 21:247-255, 1984). however, e. gueho and g. s. de hoog (j. mycol. med. 118:3-9, 1991) recently suggested reducing this mold to synonomy with lomentospora prolificans on the basis of their similar morphological and molecular characteristics. we have investigated the ribosomal dna internal transcribed spacers (its), i.e., its i and its ii, of 18 isolates, including these two ... | 1994 | 7814476 |
| [severe keratomycosis. diagnosis and treatment]. | we reported three consecutive cases of severe fungal keratitis initially undiagnosed by corneal scrapping. corneal biopsy showed fungal elements of paecilomyces lilacinus, fusarium solani, scedosporium apiospermum. most cases of fungal keratitis could be treated successfully if adequate antifungal therapy were started early. early and accurate diagnosis is of major importance. the results of our cases confirm the superiority of corneal biopsy over corneal scrapping. corneal biopsy is a procedure ... | 1994 | 7822693 |
| phylogeny of dermatophytes and dimorphic fungi based on large subunit ribosomal rna sequence comparisons. | the phylogeny of dermatophytes and dimorphic fungi was considered using the large-subunit of ribosomal rna (25s rrna). aligned sequences of 595 nucleotides covering the two most divergent domains d1 and d2, permitted a comparison of phylogenetic relationships at different levels. the dimorphic species (onygenaceae) were significantly separated from dermatophytes (arthrodermataceae) and from a third group including geophilic or very weakly pathogenic species (onygenaceae and gymnoascaceae). on a ... | 1994 | 7844699 |
| fungal panophthalmitis secondary to scedosporium apiospermum (pseudallescheria boydii) keratitis. | | 1994 | 7943139 |
| [scedosporium apiospermum infection in a patient with myelomonocytic leukemia presenting as lympho-cutaneous sporotrichosis]. | 63 year old patient is presented with myelo-monocytic leukemia, in whom subcutaneous nodules developed at the lower limb, spreading along the lymph vessels, and partly ulcerating. by mycologic investigation scedosporium apiospermum was disclosed. attention is drawn to human infections brought about by opportunistic scedosporium species. | 1994 | 7970657 |
| fungal arthritis due to pseudallescheria boydii (scedosporium apiospermum). | musculoskeletal infections by fungal agents are uncommon conditions. pseudallescheria boydii is an ubiquitous saprophytic fungus frequently involved in maduromycosis but rarely in septic arthritis. we describe a case of pseudallescheria boydii destructive suppurative arthritis and osteomyelitis of the knee in an adult guadeloupean man. osteoarticular infections due to pseudallescheria boydii are reviewed. | 1994 | 8035409 |
| successful bone marrow transplantation in patients with previous invasive fungal infections: report of four cases. | patients with previous invasive fungal infections (ifi) are at high risk of reactivation of the infection during bmt, even after an apparently curative antifungal treatment. we report four patients who suffered an ifi after intensive chemotherapy for acute leukemia and were later submitted for bmt. one patient had developed a chronic systemic candidiasis during consolidation chemotherapy and received prophylactic oral or iv fluconazole (200 mg daily) throughout bmt. two patients developed an inv ... | 1994 | 8199569 |
| [disseminated infection due to scedosporium apiospermum in liver transplantation. differential diagnosis from invasive aspergillosis]. | a case of fatal disseminated infection due to scedosporium apiospermum occurring after liver transplantation is reported. diagnosis was made at autopsy, as numerous fungal colonies were found in the lungs, heart, brain, kidney, spleen and liver. scedosporium apiospermum was identified in pulmonary, cerebral and myocardial specimens by sabouraud's glucose agar cultures. infections due to scedosporium (s. apiospermum ou pseudallescheria boydii) occur in immunocompromised hosts, particularly after ... | 1993 | 8311860 |
| mycetoma: a retrospective study of 41 cases seen in são paulo, brazil, from 1978 to 1989. | clinical and epidemiological aspects of 41 cases of mycetoma seen in são paulo city from january 1978 to december 1989 are presented. twenty-eight cases (68%) were caused by actinomycetes, while 13 (32%) were caused by true fungi. in only 22 (78%) actinomycetoma cases was it possible to identify the agent. nocardia brasiliensis, by far the commonest actinomycete isolated, was responsible for 13 cases. among eumycetomata, madurella grisea was isolated from 3 cases, scedosporium apiospermum from 2 ... | 1993 | 8366881 |
| successful treatment of pneumonia due to scedosporium apiospermum with itraconazole: case report. | | 1993 | 8389611 |
| fungal mycotic aneurysms and visceral infection due to scedosporium apiospermum in a kidney transplant patient. | | 1993 | 8516902 |
| scedosporium apiospermum infection imitating lymphocutaneous sporotrichosis in a patient with myeloblastic-monocytic leukaemia. | a 63-year-old man with a history of myeloblastic-monocytic leukaemia developed partly suppurating cutaneous nodules on the lower left leg. the nodules proceeded to spread in a linear fashion up the limb, following the line of the lymphatic drainage. mycological examination of a skin biopsy demonstrated scedoporium apiospermum. this case highlights the potential for scedosporium species to act as opportunistic infections in immunosuppressed humans. | 1995 | 8555041 |
| amphotericin b responsive scedosporium apiospermum infection in a patient with acute myeloid leukaemia. | a 71 year old man with newly diagnosed acute myelomonocytic leukaemia developed a soft tissue infection of his foot during his first course of chemotherapy. scedosporium apiospermum was isolated from the lesion, which resolved rapidly on treatment with intravenous amphotericin b despite being resistant in vitro to this agent. this observation suggests that sensitivity testing of s apiospermum should be interpreted with caution and that clinical response may be a better indicator of outcome. | 1996 | 8666698 |
| a 33 kda serine proteinase from scedosporium apiospermum. | an extracellular proteinase produced by the filamentous fungus scedosporium apiospermum has been purified and characterized. initially, in vitro conditions for enzyme synthesis were investigated. the highest yield of enzyme production was obtained when the fungus was cultivated in modified czapek-dox liquid medium supplemented with 0.1% bacteriological peptone and 1% (w/v) glucose as the nitrogen and carbon sources respectively. purification to homogeneity of the proteinase was accomplished by ( ... | 1996 | 8670095 |
| cerebral pseudallescheria mycosis after near-drowning. | scedosporium apiospermum, an anamorph of pseudallescheria boydii, is a hyalohyphomycete which can be mistaken, histologically, for aspergillus. s. apiospermum is clinically distinguished by resistance to most antifungals and its ability to cause invasive mycoses in immunocompetent patients. here we present a typical case of lethal cerebral pseudallescheria mycosis in a child after near-drowning. | 1995 | 8720198 |
| scedosporium apiospermum pneumonia after autologous bone marrow transplantation. | although opportunistic infections after bone marrow transplantation (bmt) are very common, only five cases of pseudallescheria boydii infection have been reported in the literature, two of which were autopsy findings. a case of scedosporium apiospermum infection after bmt, treated initially with amphotericin b (total dose of 2.5 g) and then with itraconazole (for 25 days), is reported here. when the patient failed to improve, scedosporium apiospermum pneumonia was diagnosed and therapy was chang ... | 1996 | 8874080 |
| [epidemiology of invasive mycoses. experience of a university hospital center in paris]. | the incidence of opportunistic fungal infections have dramatically increased during the past decades. data from a retrospective study conducted between january 1992 and december 1994 in necker-enfants malades hospital and a review of the literature were analyzed to assess the main epidemiological features of these infections. candidiasis remained largely the most frequent: candidemia and invasive candidiasis were diagnosed in respectively 71 and 11 patients. candida albicans was the agent the mo ... | 1996 | 8959131 |
| development of murine monoclonal antibodies for the immunohistochemical diagnosis of systemic bovine aspergillosis. | murine monoclonal antibodies (mabs) against water-soluble somatic antigens (wssa) and the wall fraction (wf) from aspergillus fumigatus were produced by fusion of splenocytes from immunized balb/c mice with mouse myeloma x63-ag 8.653 cells. the supernatants of in vitro cultured hybridomas were initially screened for reactivity with the wssa and the wf from a. fumigatus and wssa of other fungi in an enzyme-linked immunosorbent assay (elisa). supernatants reacting only with a. fumigatus antigens w ... | 1996 | 9026084 |
| pulmonary tuberculosis associated with invasive pseudallescheriasis. | a 54-year-old woman with pulmonary tuberculosis developed pneumonia caused by scedosporium apiospermum, the asexual stage of the fungus pseudallescheria boydii. mycobacterium tuberculosis and p boydii were cultured in bal fluid. the patient cleaned swimming pools in a spa health resort and was highly exposed to fungal conidia. she was successfully treated with antituberculosis drugs, miconazole nitrate and ketoconazole, leading to remission of her pulmonary infection. invasive pulmonary pseudall ... | 1997 | 9042007 |
| in vitro studies of activity of voriconazole (uk-109,496), a new triazole antifungal agent, against emerging and less-common mold pathogens. | the in vitro activity of voriconazole was compared with that of itraconazole. eighty-six isolates of pathogenic molds belonging to 23 species were tested by an agar dilution method in high resolution medium. voriconazole was more active than itraconazole against a number of hyaline molds, including several fusarium spp. and scedosporium prolificans. voriconazole and itraconazole showed comparable good activity against several hyaline molds, including penicillium marneffei and scedosporium apiosp ... | 1997 | 9087501 |
| scedosporium apiospermum skin infection in a patient with nephrotic syndrome. | | 1997 | 9111845 |
| in vitro antifungal activity of pneumocandin l-743,872 against a variety of clinically important molds. | the in vitro activity of the new antifungal drug pneumocandin l-743,872 against 55 isolates of clinically important molds was examined by an adapted macrobroth dilution method for yeasts. pneumocandin l-743,872 exhibited in vitro antifungal activity against alternaria sp., aspergillus flavus, aspergillus fumigatus, curvularia lunata, exophiala jeanselmei, fonsecaea pedrosoi, paecilomyces variotii, and scedosporium apiospermum. the drug appeared to lack significant in vitro inhibitory activity ag ... | 1997 | 9257774 |
| deep infections caused by scedosporium prolificans. a report on 16 cases in spain and a review of the literature. scedosporium prolificans spanish study group. | scedosporium prolificans, a mold morphologically similar to scedosporium apiospermum, may cause asymptomatic colonization or localized or disseminated infection following trauma, surgery, and immunosuppression. s. prolificans is normally resistant to available antifungal agents, and prognosis depends largely on the host's immune status, extent of infection, and feasibility of surgical debridement. we report on 16 patients with deep s. prolificans infections, focusing on predisposing factors, cli ... | 1997 | 9279332 |
| new polyazole derivatives from 2-(2,4-dichlorophenyl)-1,3-dioxolane. antifungal activity. structure-activity relationships. | six new polyazole derivatives from 2-(2,4-dichlorophenyl)-1,3-dioxolane were studied for their antifungal activity against pathogenic fungi for humans and animals. the antimycotic effect was largely restricted to the filamentous fungi with aspergillus fumigatus and scedosporium apiospermum being remarkably susceptible. three compounds were as effective as the two references, ketoconazole and oxiconazole. the structure-activity relationships revealed than an 'oxime group' combined with four chlor ... | 1997 | 9299755 |
| lymphocutaneous infection due to scedosporium apiospermum. | | 1997 | 9352411 |
| [mycotic keratitis with uveitis cause by scedosporium apiospermum]. | mycotic keratitis with induced uveitis caused by scedosporium apiospermum. in the work the case of mycotic keratitis with induced uveitis is descriped. affected is young healthy woman working in a fruit and vegetable store. affection arised on cornea in the area of previous erosion. current antibiotics did not have any effect on the affection after repeated negative cultivative examinations. the culture of fibrous mikromycete was gained out of cultivation done on sabouraud's glucose agar and was ... | 1997 | 9377319 |
| cutaneous infection by scedosporium apiospermum and its successful treatment with itraconazole. | we report the case of a 42-year-old man with a 13-year history of bilateral faciocervical infiltrative erythema, which had been misdiagnosed as tuberculoderma and which had failed to respond to treatment with adrenal corticosteroids and antituberculotics. on admission to the department, scedosporium apiospermum was identified on lesion biopsies and fungus cultures as the causative agent and a diagnosis of cutaneous infection by s. apiospermum was made. this is the first report of chronic skin gr ... | 1997 | 9499613 |
| scedosporium apiospermum (pseudallescheria boydii) infection in a heart transplant recipient: a case of mistaken identity. | we report a case of fatal central nervous system infection with scedosporium apiospermum (pseudallescheria boydii) in a heart transplant recipient. this ubiquitous fungus is known to cause mycetoma and localized infections in patients with otherwise normal conditions. disseminated infections occur rarely and are seen primarily in patients who are receiving immunosuppressive medications or who have neutropenia. often life-threatening when infection is disseminated and involves the central nervous ... | 1998 | 9563611 |
| use of voriconazole in treatment of scedosporium apiospermum infection: case report. | we report a case of disseminated scedosporium apiospermum infection in a neutropenic patient with acute myeloid leukemia. due to progression of the mycosis after 7 days of amphotericin b lipid complex therapy and to high susceptibility of the mold to voriconazole in vitro, the patient was treated with intravenous voriconazole. after a few days of therapy, fever disappeared and skin lesions improved. however, the patient died after 1 month due to intestinal bleeding. despite a negative outcome, t ... | 1998 | 9574724 |
| [sensitivity to disinfectants in certain rare micromycetes]. | the authors investigated the effectiveness of 6 different disinfectants at recommended concentrations on strains of rare types of filamentous micromycetes: scedosporium apiospermum and exophiala dermatitidis (isolated from ophthalmomycoses), fusarium dimerum (isolates from nosocomial fungaemia) and strains of fusarium moniliforme and stachybotrys alternans (isolates from the environment and potential producers of mycotoxins). the tested strains were mostly sensitive also to an alcoholic solution ... | 1998 | 9611894 |
| subcutaneous scedosporiosis. report of two cases and review of the literature. | two cases of subcutaneous scedosporiosis, caused by scedosporium apiospermum, are reported. both patients had lesions localized in the forearm: a solitary ulceration in one and a sporotrichoid-like lesion in the other. the literature is reviewed. | 1997 | 9640787 |
| nasal granuloma caused by scedosporium apiospermum in a dog. | a 10-month-old male american staffordshire terrier was presented to the autonomous university of barcelona veterinary teaching hospital because of a 6-month history of a mucopurulent bilateral nasal discharge. the dog had not responded to antibiotics. a follow-up x ray revealed a mixed pattern of osteolysis and increased radiodensity confined to the nasal cavity. histologic sections of the biopsy specimens revealed the presence of granules containing numerous septate hyphae that were hyaline to ... | 1998 | 9705431 |
| scedosporium apiospermum skin infection: a case report and review of the literature. | | 1998 | 9738792 |
| polypoid bronchial lesions due to scedosporium apiospermum in a patient with mycobacterium avium complex pulmonary disease. | a 69 yr old female was hospitalized for further examination of abnormal shadows on chest radiographs. she had a history of tuberculous pleurisy, rheumatoid arthritis and gold-induced interstitial pneumonia. on admission she still suffered from rheumatoid arthritis. a chest computed tomography scan on admission showed clusters of small nodules in subpleural regions of both lungs combined with bronchiectasis. mycobacterium avium complex was cultured repeatedly from the sputum. bronchoscopic examin ... | 1998 | 9762808 |
| biodegradation of phenol and p-cresol by the hyphomycete scedosporium apiospermum. | a hyphomycete with the ability to utilize phenol and p-cresol as carbon and energy source was isolated from soil and subsequently identified as scedesporium apiospermum. the identification of degradation metabolites and the detection of the corresponding catabolic enzymes in crude extracts enabled us to propose different pathways for the degradation of both phenol and p-cresol in this organism. generally, the catabolism proceeded via three different dihydroxylated intermediates (catechol, hydrox ... | 1998 | 9766239 |
| pcr-based identification of clinically relevant pseudallescheria/scedosporium strains. | pseudallescheria boydii (anamorph: scedosporium apiospermum) and s. prolificans can cause severe infections in both the immunocompromized host and accidentally injured people. a species-specific polymerase chain reaction (pcr) enabling detection and discrimination of these fungi has not been available to date. in view of the difficult treatment especially of s. prolificans infections, a pcr-based detection system has been developed. based on results of partial sequencing of ribosomal dna, scedos ... | 1998 | 9776815 |
| pathology of hyalohyphomycosis caused by scedosporium apiospermum (pseudallescheria boydii): an emerging mycosis. | the genus scedosporium contains two medically significant species of emerging mycotic agents, s. apiospermum and s. prolificans, which have received scant attention. scedosporium apiospermum is the anamorph, or asexual state, of the cosmopolitan fungus pseudallescheria boydii, with both sharing the same risk factors for infection, clinical spectrum, and histopathologic features. scedosporium prolificans is a recently recognized agent of bone, soft tissue, and joint infections that occurs with hi ... | 1998 | 9824105 |
| [cutaneous scedosporium infection revealed by bullous-necrotic purpura]. | non-mycetomatous cutaneous scedosprium is an uncommon mycosis observed in immunodepressed subjects. we report a case with an inaugural presentation of bullous and necrotic purpura. | 1998 | 9835962 |
| invasive pulmonary infection due to scedosporium apiospermum in two children with chronic granulomatous disease. | scedosporium apiospermum is an opportunistic fungus in humans. the incidence of s. apiospermum infection in patients with acquired neutropenia (e.g., patients receiving chemotherapy and bone marrow transplant recipients) is steadily increasing. s. apiospermum has poor in vitro susceptibility to "conventional" antifungal agents, rendering the management of infections complex. patients with chronic granulomatous disease (cgd) are highly susceptible to fungal infections, which are mostly due to asp ... | 1998 | 9868657 |
| true fungal mycotic aneurysm of the basilar artery: a clinical and surgical dilemma. | mycotic aneurysms of the intracranial circulation of true fungal etiology are extremely rare and are associated with a very high mortality. we report a case of a fatal aneurysm of the basilar artery secondary to scedosporium apiospermum infection. the medical and surgical treatments are presented to demonstrate the difficulties associated with these lesions. | 1999 | 9873163 |
| pulmonary scedosporiosis. | a case of a solitary pulmonary nodule due to scedosporium apiospermum (pseudallescheria boydii) is related. a review of the pertinent literature was done and, in addition, similar lesions caused by other opportunistic fungi are commented. | 1998 | 9876438 |
| [rare pulmonary mycoses in patients with hematologic diseases]. | patients with hematology disease in post-chemotherapy medullary aplasia are susceptible to life-threatening bronchopulmonary mycoses, especially aspergillosis. other less common pulmonary mycoses are also observed. we report 4 cases due to penicillium purpurogenum, acromonium strictum and scedosporium apiospermum (n = 2) infections. these unusual fungi appear to be emerging as pathogens in this population. they have common ubiquitous, opportunistic and low pathogenicity characteristics in immuno ... | 1998 | 9894280 |
| onychomycosis in white line disease in horses: pathology, mycology and clinical features. | this paper describes onychomycosis in horses and reports the pathological findings, associated fungi and incidence of concurrent white line disease. in addition to these observations, relevance between post mortem and clinical findings of onychomycosis are discussed in 3 necropsied horses. samples were collected from 100 hooves from a total of 51 thoroughbreds suffering from white line disease. of these, 15 hooves from 13 horses were also complicated with severe hoof wall fissure formation. prep ... | 1998 | 9932091 |
| scedosporium apiospermum sinusitis after bone marrow transplantation: report of a case. | a forty-year-old man underwent an allogeneic bmt from his hla identical sister. gvhd prophylaxis was done with cyclosporine (cya), methotrexate and prednisone (pdn). on day +90 extensive gvhd was noted and higher doses of immunosuppressive drugs alternating cya with pdn were initiated. patient's follow-up was complicated by intermittent episodes of leukopenia and monthly episodes of sinusitis or pneumonia. one year after bmt, the patient developed hoarseness and nasal voice. no etiologic agent c ... | 1998 | 10030078 |
| scedosporium apiospermum of the orbit. | | 1999 | 10037582 |
| in-vitro activity of voriconazole, itraconazole and amphotericin b against filamentous fungi. | the in-vitro fungistatic and fungicidal activities of voriconazole were compared with those of itraconazole and amphotericin b. mics for 110 isolates belonging to 11 species of filamentous fungi were determined by a broth microdilution adaptation of the method recommended by the national committee for clinical laboratory standards. minimum lethal concentrations (mlcs) of the three antifungal agents were also determined. the mic ranges of the three compounds were comparable for aspergillus flavus ... | 1998 | 10052897 |
| comparison of e-test and broth microdilution methods for antifungal drug susceptibility testing of molds. | we compared the e test with a broth microdilution method, performed according to national committee for clinical laboratory standards document m27-a guidelines, for determining the in vitro susceptibilities of 90 isolates of pathogenic molds (10 absidia corymbifera, 10 aspergillus flavus, 10 aspergillus fumigatus, 10 aspergillus niger, 10 aspergillus terreus, 10 exophiala dermatitidis, 10 fusarium solani, 10 scedosporium apiospermum, 5 scedosporium prolificans, and 5 scopulariopsis brevicaulis). ... | 1999 | 10203509 |
| in vitro activity of syn-2869, a novel triazole agent, against emerging and less common mold pathogens. | the in vitro activity of syn-2869 was compared with that of amphotericin b and itraconazole. mics for 100 isolates of pathogenic molds belonging to 12 species were determined by a broth microdilution adaptation of the method recommended by the national committee for clinical laboratory standards. syn-2869 and itraconazole showed comparable, good activity against the dematiaceous molds cladophialophora bantiana, cladophialophora carrionii, exophiala dermatitidis, fonsecaea pedrosoi, phialophora p ... | 1999 | 10223947 |
| comparative in-vitro activity of voriconazole (uk-109,496) and six other antifungal agents against clinical isolates of scedosporium prolificans and scedosporium apiospermum. | we report the in-vitro susceptibility of 27 clinical isolates of scedosporium apiospermum and 43 of scedosporium prolificans. s. apiospermum was resistant to fluconazole and flucytosine, with variable susceptibility to amphotericin b, itraconazole, ketoconazole and susceptible to miconazole. voriconazole was much more active than fluconazole and flucytosine, more active than amphotericin b, itraconazole and ketoconazole and was as active as miconazole against s. apiospermum isolates. voriconazol ... | 1999 | 10381115 |
| fatal native valve endocarditis due to scedosporium apiospermum (pseudallescheria boydii) following trauma. | | 1999 | 10421053 |
| invasive fungal sinusitis due to scedosporium apiospermum in a patient with aids. | | 1999 | 10433595 |
| biodegradation of phenylbenzoate and some of its derivatives by scedosporium apiospermum. | scedosporium apiospermum, a recently isolated phenol-degrading hyphomycete, was shown to be able to productively utilise the diaryl ester phenylbenzoate as its sole source of carbon and energy. the characterisation of degradation intermediates together with the detection of the corresponding catabolic enzymes in crude extracts enabled us to propose a pathway for the degradation of this diaryl ester. according to our results, an inducible esterase initiated the biodegradation of phenylbenzoate by ... | 1999 | 10466410 |
| cutaneous infection with scedosporium apiospermum in a patient treated with corticosteroids. | | 1999 | 10494733 |
| peritonitis by scedosporium apiospermum in a patient undergoing continuous ambulatory peritoneal dialysis. | a case of peritonitis due to scedosporium apiospermum in a boy undergoing continuous ambulatory peritoneal dialysis is reported. the finding of suggestive tissual form of the fungus in the effluent hastened the diagnosis of the infection. | 1999 | 10564923 |
| localized skin infection due to scedosporium apiospermum: report of two cases. | | 1999 | 10583102 |
| cutaneous scedosporium apiospermum infection in an immunocompromised patient. | scedosporium apiospermum infection occurred in the left forearm of a patient who was taking oral prednisolone for pulmonary fibrosis. the infection appeared to follow a scratch from a blackcurrant bush. this is the first reported case in the united kingdom of a cutaneous infection from scedosporium apiospermum in an immunocompromised patient. | 1999 | 10690177 |
| clinical significance of scedosporium apiospermum in patients with cystic fibrosis. | the incidence of airway colonization by scedosporium apiospermum and of related sensitization was investigated prospectively in 128 patients with cystic fibrosis over a 5-year period, and results were compared with clinical data. scedosporium apio-spermum, recovered from sputum samples in 11 of 128 (8.6%) patients, was the most frequent filamentous fungus after aspergillus fumigatus. counterimmuno-electrophoresis, used to detect scedosporiosis serologically, was positive in 27 of 128 (21.1%) pat ... | 2000 | 10706182 |
| fungal keratitis after laser in situ keratomileusis. | a 22-year-old woman presented with pain, redness, watering, and decrease in vision in her left eye 15 days after laser in situ keratomileusis for myopia. slitlamp examination showed a central full-thickness infiltrate with hyphate edges. microscopic examination of corneal scrapings from the edge and underneath the flap showed fungal filaments, and the growth on culture media was identified as scedosporium apiospermum. | 2000 | 10771240 |
| comparison of nccls and 3-(4,5-dimethyl-2-thiazyl)-2, 5-diphenyl-2h-tetrazolium bromide (mtt) methods of in vitro susceptibility testing of filamentous fungi and development of a new simplified method. | the susceptibility of 30 clinical isolates belonging to six different species of filamentous fungi (aspergillus fumigatus, aspergillus flavus, scedosporium prolificans, scedosporium apiospermum, fusarium solani, and fusarium oxysporum) was tested against six antifungal drugs (miconazole, voriconazole, itraconazole, ur9825, terbinafine, and amphotericin b) with the microdilution method recommended by the national committee for clinical laboratory standards (nccls) (m38-p). the mics were compared ... | 2000 | 10921957 |
| pneumonia due to scedosporium apiospermum in a patient with hiv infection. | a 29-y-old woman from congo democratic republic was admitted to hospital with dyspnoea of 5-months duration. chest x-ray showed left white lung and infiltrates of the right superior lobe. the patient underwent left pneumonectomy. histopathological examination showed pulmonary cavitary lesions and bronchectasis full of branching septated fungi. cultures yielded scedosperium apiospermum. | 2000 | 10959662 |
| molecular variability of pseudallescheria boydii, a neurotropic opportunist. | the sequences of the internal transcribed spacer (its) ribosomal dna (rdna) domain data obtained by restriction fragment length polymorphism analysis with 18s rdna and fingerprinting (m13) for clinical and environmental strains of pseudallescheria boydii (anamorph, scedosporium apiospermum) were compared to those for related species of pseudallescheria, petriella, and scedosporium. the infraspecific variability of p. boydii was considerable. there were five different lengths in the 18s rdnas wit ... | 2000 | 10970369 |
| pseudallescheria boydii brain abscess successfully treated with voriconazole and surgical drainage: case report and literature review of central nervous system pseudallescheriasis. | pseudallescheria boydii and its asexual form, scedosporium apiospermum, are ubiquitous, saprophytic fungi that commonly cause cutaneous infection. however, in certain circumstances, p. boydii can also cause invasive disease, which can involve the central nervous system (cns). when the cns becomes involved, treatment is difficult, therapeutic options are limited, and the prognosis is poor. we report a case of pseudallescheria brain abscess successfully treated with surgical drainage and systemic ... | 2000 | 11017814 |
| successful outcome of scedosporium apiospermum disseminated infection treated with voriconazole in a patient receiving corticosteroid therapy. | a disseminated scedosporium apiospermum infection was diagnosed in a woman with severe asthma and treated with corticosteroids. this fungi is resistant to fluconazole and amphotericin b. the infection was refractory to itraconazole, but responded successfully to voriconazole. a review of the literature is provided. | 2000 | 11096022 |
| fungal keratitis caused by pseudallescheria boydii (scedosporium apiospermum). | keratitis is rarely caused by fungi. filamentous fungal keratitis is often preceded by corneal trauma and occurs mostly in previously healthy individuals. we studied a case of posttraumatic keratitis caused by pseudallescheria boydii, which belongs to the group of filamentous fungi. | 2000 | 11126674 |
| molecular epidemiology of scedosporium apiospermum infection determined by pcr amplification of ribosomal intergenic spacer sequences in patients with chronic lung disease. | respiratory tract colonization with scedosporium apiospermum in patients with chronic suppurative lung disease is a significant concern for lung transplantation candidates, since scedosporium infections occurring posttransplantation are usually untreatable. up to 10% of patients with cystic fibrosis attending our respiratory medicine unit have had scedosporium organisms isolated from sputum samples. we therefore developed a molecular typing method to examine these isolates. typing by pcr amplifi ... | 2001 | 11136746 |
| lymphadenitis caused by scedosporium apiospermum in an immunocompetent patient. | a case of lymphadenitis caused by scedosporium apiospermum in a 25-year-old immunocompetent woman had been misdiagnosed as tuberculous lymphadenitis. clinical response to itraconazole therapy was obtained in 6 months; to our knowledge, this is the first report of lymphadenitis caused by s. apiospermum in humans. | 2001 | 11170973 |
| corneal co-infection with scedosporium apiospermum and acanthamoeba after sewage-contaminated ocular injury. | to describe a corneal co-infection with the fungus scedosporium apiospermum and acanthamoeba that result in spontaneous corneal perforation. | 2001 | 11188993 |
| in vitro fungicidal activities of voriconazole, itraconazole, and amphotericin b against opportunistic moniliaceous and dematiaceous fungi. | the nccls proposed standard m38-p describes standard parameters for testing the fungistatic antifungal activities (mics) of established agents against filamentous fungi (molds); however, standard conditions are not available for testing their fungicidal activities (minimum fungicidal or lethal concentrations [mfcs]). this study evaluated the in vitro fungistatic and fungicidal activities of voriconazole, itraconazole, and amphotericin b against 260 common and emerging molds (174 aspergillus sp. ... | 2001 | 11230410 |
| [scedosporiosis of the brain with fatal outcome after traumatizatio of the foot. case report]. | a 33 year old german man suffered from a wound of his foot after an accident. he developed an osteomyelitis. from wound probes scedosporium apiospermum could be isolated for several times. some weeks later a cerebral lesion could be diagnosed. the lesion was extirpated and again s. apiospermum could be cultured from the cerebral probes. a few weeks later the patient died and some new cerebral lesions could be diagnosed by ct-scan. | 2000 | 11291574 |
| acanthamoeba keratitis associated with fungal keratitis. | to report fungal infection complicating acanthamoeba keratitis. | 2001 | 11292419 |
| fungal malignant otitis externa due to scedosporium apiospermum. | malignant otitis externa (moe) is an infection of the external auditory canal that invades the skull base. aspergillus species fungi were the pathological organism in 21 of 23 reported cases of fungal moe. we report on a 21-year-old man with end-stage acquired immunodeficiency syndrome (aids) and fungal moe caused by scedosporium apiospermum. fungal moe is most common in patients with end-stage aids and hematologic malignancies. granulation tissue is not a common finding in these patients, and t ... | 2001 | 11307916 |
| toluene biofiltration by the fungus scedosporium apiospermum tb1. | the performance of biofilters inoculated with the fungus scedosporium apiospermum was evaluated. this fungus was isolated from a biofilter which operated with toluene for more than 6 months. the experiments were performed in a 2.9 l reactor packed with vermiculite or with vermiculite-granular activated carbon as packing material. the initial moisture content of the support and the inlet concentration of toluene were 70% and 6 g/m3, respectively. as the pressure drop increased from 5-40 mm h2o a ... | 2001 | 11400107 |
| in vitro activities of four novel triazoles against scedosporium spp. | in order to develop new approaches to the treatment of the severe and usually fatal infections caused by scedosporium spp., the in vitro antifungal activities of four novel triazoles (posaconazole, ravuconazole, voriconazole, and ur-9825) and some current antifungals (amphotericin b, ketoconazole, itraconazole, and nystatin) were determined. the latter group was clearly ineffective against the two species tested. the four new antifungals showed activity against scedosporium apiospermum, and ur-9 ... | 2001 | 11408242 |
| invasive scedosporium apiospermum infection in a heart transplant recipient presenting with multiple skin nodules and a pulmonary consolidation. | | 2000 | 11429031 |
| scedosporium apiospermum chorioretinitis. | a case of a 24-year-old immunocompetent woman who developed unilateral scedosporium apiospermum chorioretinitis and diffuse cervical lymphadenitis 10 years after facial steroid injection is described. | 2001 | 11594997 |
| typing of scedosporium apiospermum by multilocus enzyme electrophoresis and random amplification of polymorphic dna. | the genetic diversity among epidemiologically unrelated strains of the human pathogenic fungus scedosporium apiospermum or its teleomorph, pseudallescheria boydii, from different areas in europe, was investigated by multilocus enzyme electrophoresis (mlee) and random amplification of polymorphic dna (rapd). fourteen enzyme activities were analysed by starch gel electrophoresis, corresponding to 27 polymorphic loci and 43 iso-enzymes. among the enzymes studied, propionate esterase, carboxyl ester ... | 2001 | 11599744 |
| antifungal activities and cytotoxicity studies of six new azasordarins. | gw 471552, gw 471558, gw 479821, gw 515716, gw 570009, and gw 587270 are members of a new family of sordarin derivatives called azasordarins. the in vitro activities of these compounds were evaluated against clinical isolates of yeasts, including candida albicans, candida non-albicans, and cryptococcus neoformans strains. activities against pneumocystis carinii, aspergillus spp., less common molds, and dermatophytes were also investigated. azasordarin derivatives displayed significant activities ... | 2001 | 11600368 |
| lymphocutaneous syndrome due to scedosporium apiospermum. | | 2001 | 11737093 |
| in vitro activities of new and conventional antifungal agents against clinical scedosporium isolates. | the susceptibilities of 13 clinical isolates of scedosporium apiospermum and 55 clinical isolates of s. prolificans to new and conventional drugs belonging to three different classes of antifungal agents, the azoles (miconazole, itraconazole, voriconazole, ur-9825, posaconazole), the polyenes (amphotericin b, nystatin and liposomal nystatin), and allylamines (terbinafine), were studied by use of proposed standard m38-p of nccls. low growth-inhibitory antifungal activities were found in vitro for ... | 2002 | 11751112 |
| septic arthritis due to scedosporium apiospermum: case report and review. | septic arthritis is a relatively common disease, but reports of septic arthritis caused by fungi are still rare and it is often associated with predisposing factors that reduce cellular immunity (alcoholism, cancer, endogenous or exogenous hypercortisolism, intravenous drug abuse). articular conditions caused by scedosporium apiospermum are uncommon. here we report the case of a 32-year-old immunocompetent male with septic arthritis caused by s. apiospermum and review 12 other cases. | 2001 | 11798262 |
| amphotericin b: spectrum and resistance. | amphotericin b is a polyene macrolide antibiotic derived from the actinomycete streptomyces nodosus. of the 200 known polyene agents, amphotericin b is the only one with toxicities that are sufficiently limited to permit intravenous administration. all polyenes have a common mechanism of action in that they preferentially bind to ergosterol, the primary sterol in the fungal cell membrane. the consequence of this binding includes disruption of the osmotic integrity of the membrane, with leakage o ... | 2002 | 11801575 |
| central nervous system aspergillosis: a 20-year retrospective series. | over the past 20 years at my institution, 71 patients with invasive necrotizing aspergillosis have been encountered; 42 have shown central nervous system (cns) involvement by autopsy (40) or surgical biopsy (2). most non-cns aspergillosis patients had invasive disease confined to the lung, and only 2 with dissemination to 3 or more organs did not have spread to the cns. in addition to the expected post-transplantation and hematologic malignancy cases, other risk groups identified included those ... | 2002 | 11823982 |
| cutaneous infection showing sporotrichoid spread caused by pseudallescheria boydii (scedosporium apiospermum): successful detection of fungal dna in formalin-fixed, paraffin-embedded sections by seminested pcr. | | 2002 | 11843660 |
| review of the safety and efficacy of voriconazole. | voriconazole is a new triazole antifungal agent structurally related to fluconazole, but with improved potency and spectrum of activity. voriconazole has good in vitro activity against candida species, cryptococcus neoformans, aspergillus spp. and other mould spp. initial clinical studies and case reports demonstrate efficacy with voriconazole against invasive aspergillosis and infections caused by c. neoformans, scedosporium apiospermum, blastomyces dermatitidis, coccidioides immitis and histop ... | 2002 | 11866669 |