| complete genome sequence of haemophilus parasuis sh0165. | haemophilus parasuis is the causative agent of glässer's disease, which produces big losses in swine populations worldwide. h. parasuis sh0165, belonging to the dominant serovar 5 in china, is a clinically isolated strain with high-level virulence. here, we report the first completed genome sequence of this species. | 2009 | 19074396 |
| evaluation of recombinant proteins of haemophilus parasuis strain sh0165 as vaccine candidates in a mouse model. | the recently completed genome sequence of haemophilus parasuis strain sh0165 allowed us to screen putative omps for the development of recombinant vaccines. the objective of this study was to evaluate the immunogenicity and protective efficacy of three omps of h. parasuis. three putative omps (smpa, ygiw and fog) were cloned, expressed and purified by ni affinity chromatography using nitriloacetic acid resin. mice were immunized either individually (individual protein, ip) or synergistically (sy ... | 2011 | 21596404 |
| genomic characterization of haemophilus parasuis sh0165, a highly virulent strain of serovar 5 prevalent in china. | haemophilus parasuis can be either a commensal bacterium of the porcine respiratory tract or an opportunistic pathogen causing glässer's disease, a severe systemic disease that has led to significant economical losses in the pig industry worldwide. we determined the complete genomic sequence of h. parasuis sh0165, a highly virulent strain of serovar 5, which was isolated from a hog pen in north china. the single circular chromosome was 2,269,156 base pairs in length and contained 2,031 protein-c ... | 2011 | 21611187 |
| cytolethal distending toxin (cdt) of the haemophilus parasuis sc096 strain contributes to serum resistance and adherence to and invasion of pk-15 and puvec cells. | cytolethal distending toxin (cdt) is proposed to be an important virulence determinant of many pathogens. although two cdt gene cluster loci have been identified in haemophilus parasuis strain sh0165, the characteristics of cdts associated with pathogenesis remain unclear. in this study, three cdt-deficient mutants, cdt-1, cdt-2 and the double-knockout cdt-1cdt-2 (δcdt-1, δcdt-2 and δcdt-1δcdt-2, respectively), were obtained in the h. parasuis serovar 4 clinical strain sc096 using a natural tran ... | 2011 | 22221379 |