| exophilin a, a new antibiotic from a marine microorganism exophiala pisciphila. | exophilin a, a new antibacterial compound, was discovered in the culture of the marine microorganism exophiala pisciphila ni10102, which was isolated from a marine sponge mycale adhaerens. the absolute chemical structure of exophilin a was elucidated as a trimer of (3r,5r)-3,5-dihydroxydecanoic acid by spectroscopic methods and analyses of a degradative product. exophilin a showed antimicrobial activity against gram-positive bacteria. | 1996 | 8982339 |
| 13-deoxytedanolide, a marine sponge-derived antitumor macrolide, binds to the 60s large ribosomal subunit. | 13-deoxytedanolide is a potent antitumor macrolide isolated from the marine sponge mycale adhaerens. in spite of its remarkable activity, the mode of action of 13-deoxytedanolide has not been elucidated. [11-3h]-(11s)-13-deoxydihydrotedanolide derived from the macrolide was used for identifying the target molecule from the yeast cell lysate. fractionation of the binding protein revealed that the labeled 13-deoxytedanolide derivative strongly bound to the 80s ribosome as well as to the 60s large ... | 2005 | 15598566 |
| structure-activity relationship study on 13-deoxytedanolide, a highly antitumor macrolide from the marine sponge mycale adhaerens. | to obtain information of structure-activity relationships (sars) of 13-deoxytedanolide, its chemical transformation has been carried out, targeting on such functional groups as an epoxide, hydroxyls, ketones, and olefins. a total of 10 derivatives have been prepared and their cytotoxicity against p388 murine leukemia cells and inhibitory activity of polypeptide elongation in yeast cell lysate provided some important sars; the southern hemisphere comprises the pharmacophore, while the epoxide-bea ... | 2005 | 15598567 |
| pseudoalteromonas spongiae sp. nov., a novel member of the gamma-proteobacteria isolated from the sponge mycale adhaerens in hong kong waters. | a gram-negative, non-spore-forming, short rod-shaped bacterium (ust010723-006(t)) was isolated from the surface of the sponge mycale adhaerens in hong kong waters. cells of ust010723-006(t) did not have flagella and were non-motile. colonies were pale orange in colour, 2-4 mm in diameter, convex with a smooth surface and an entire translucent margin. gas bubbles were observed in the colonies and also in the agar matrix underneath and adjacent to the colonies. ust010723-006(t) was heterotrophic, ... | 2005 | 16014487 |
| consistent bacterial community structure associated with the surface of the sponge mycale adhaerens bowerbank. | as a crucial step in the identification of possible association between bacteria and sponges, we investigated if a unique bacterial population community was consistently associated with the surface of the sponge mycale adhaerens, irrespective of environmental conditions. the composition of bacterial communities associated with the surface of sponges at three geographically distinctive sites in hong kong waters over four seasons was examined by analyzing terminal restriction fragment length polym ... | 2006 | 16909349 |