| crotalaria spectabilis poisoning in swine. | | 1974 | 4417665 |
| evagination of vascular smooth muscle cells during the early stages of crotalaria pulmonary hypertension. | fifteen adult female wistar albino rats were fed on a diet containing powdered crotalaria spectabilis seeds for periods of up to 5 wk. electron microscopic studies were carried out on the lungs of these animals and also of three control rats. both groups of animals showed protuberances of smooth muscle cells. in the control rats such protuberances were small and filled out spaces created by undulation of the internal elastic lamina produced by collapse of the vessel. these protuberances could be ... | 1978 | 722380 |
| medical thickness of pulmonary trunk in rats with cor pulmonale induced by ingestion of crotalaria spectabilis seeds. | | 1967 | 6060163 |
| observations on the pulmonary arteries and heart weight of rats fed on crotalaria spectabilis seeds. | | 1966 | 4225652 |
| mast cells in the lungs of rats fed on crotalaria spectabilis seeds. | | 1967 | 4229037 |
| right ventricular performance after monocrotaline-induced pulmonary hypertension. | chronic pulmonary hypertension leads to a compensatory hypertrophy of the right ventricle (rv). performance of the hypertrophied heart has been shown to vary depending on the type and severity of the overload, the species, age, and sex of the animal in which the hypertrophy is induced and the ventricle to which the overload is applied (left ventricle vs. right ventricle). in this study we employed two novel approaches to examine the performance of the hypertrophied right ventricle in male spragu ... | 1989 | 2524170 |
| pulmonary endothelial pavement patterns. | the appearance of the endothelial pavement pattern was studied in the pulmonary trunk, pulmonary veins, aorta, and inferior vena cava of the rat by means of silver staining of the cell borders. the endothelial cell in each of the four blood vessels was found to have its own distinctive shape, fusiform and pointed in the direction of blood flow in the case of the aorta and larger and more rectangular in the pulmonary trunk and pulmonary veins. detailed quantitation of the dimensions and surface a ... | 1980 | 7385090 |
| clinical signs and pathologic changes in crotalaria spectabilis-intoxicated rats. | | 1970 | 5430697 |
| [proceedings: hypertonic early reactions of lung vessels under the influence of crotalaria spectabilis -- an autoradiographic study]. | | 1974 | 4460567 |
| development of crotalaria pulmonary hypertension: hemodynamic and structural study. | in awake rats with indwelling catheters, the development of pulmonary hypertension after feeding crotalaria spectabilis seeds is followed. hypoxemia is excluded as a factor. other hemodynamic changes are found before hypertension. after 7 days, pulmonary artery pressure (ppa) is normal, 17.17 +/- 0.30 (se) mmhg and from 14 days significantly increased (p < 0.01). oxygen consumption (vo2) is significantly increased by day 7 (control 22.72 +/- 2.13 ml . min-1 . kg-1; crotalaria 42.47 +/- 2.95; p < ... | 1980 | 6449154 |
| monocrotaline-induced renal lesions. | monocrotaline, an alkaloid obtained from crotalaria spectabilis, provides an experimental model for studies of mesangiolysis as seen in habu venom poisoning and hemolytic-uremic syndrome. renal lesions induced in rats by a single intraperitoneal administration of monocrotaline were examined by light and electron microscopy. two weeks after the injection glomerular capillaries showed focal endothelial cell detachment and adhesion of platelets to the basal lamina. at 3 weeks there was no endotheli ... | 1983 | 6416892 |
| changes in pulmonary structure and function induced by monocrotaline intoxication. | monocrotaline, a pyrrolizidine alkaloid derived from crotalaria spectabilis, is known to be toxic to a variety of domestic and laboratory animals and to humans. major pathological effects induced by monocrotaline poisoning include hepatic cirrhosis and megalocytosis, venocclusive disease, pulmonary hypertension, and right ventricular hypertrophy. the present investigation explored the structural and functional relationships that exist between pulmonary artery pressure, small pulmonary artery med ... | 1981 | 6451183 |
| hepatic metabolism and pulmonary toxicity of monocrotaline using isolated perfused liver and lung. | monocrotaline is a pyrrolizidine alkaloid obtained from the seeds of crotalaria spectabilis. when perfused through an isolated liver, monocrotaline is metabolized to ehrlich reactive (e+) metabolites. metabolism of monocrotaline was faster in livers from male rats than female rats, was inducible with phenobarbital pretreatment, and was inhibited by coperfusion with the p-450 mixed-function oxidase inhibitor skf-525a, anoxic perfusion conditions, and low temperatures. when metabolites generated b ... | 1984 | 6087830 |
| the electron microscopy of "fibrinoid necrosis" in pulmonary arteries. | fibrinoid necrosis was induced in the pulmonary arteries of five male wistar albino rats by feeding them on a diet adulterated by the addition of 0.07% ground crotalaria spectabilis seeds by weight. electron microscopy of the arteries affected by the process showed fibrin in the thrombus occluding their lumens and in the arterial intima, held up from further penetration of the media by the inner elastic lamina. naturally occurring gaps in this lamina were found, and it is postulated that they de ... | 1978 | 31704 |
| crotalaria-induced pulmonary hypertension. uptake of 3h-thymidine by the cells of the pulmonary circulation and alveolar walls. | feeding with crotalaria spectabilis seeds induces structural changes in the pulmonary arterial circulation characteristic of pulmonary hypertension: increased medial and adventitial thickness, the appearance of muscle in smaller arteries than normal, and reduction in the number of peripheral arteries. by autoradiographic techniques, after injection of 3h-thymidine into rats fed crotalaria for 3, 7, 14, 21, 28, or 35 days, the contribution of hyperplasia to these changes has been assessed at two ... | 1982 | 7055214 |
| blood 5-hydroxytryptamine in rats with pulmonary hypertension produced by ingestion of crotalaria spectabilis seeds. | | 1968 | 5721145 |
| pulmonary hypertension produced in rats by ingestion of crotalaria spectabilis seeds. | | 1967 | 6033385 |
| development of pulmonary arterial changes in rats fed crotalaria spectabilis. | the early changes in pulmonary artery structure and the timing and development of right ventricular hypertrophy were examined in rats after ingestion of crotalaria spectabilis; the arteries were distended with a micropaque--gelatin mixture. the earliest change, detected at day 3, is the appearance of new muscle in normally nonmuscular arteries. increased medial wall thickness of the normally muscular arteries is apparent from day 7, reaching significance in the smaller arteries from day 10 and i ... | 1979 | 153714 |
| renal and pulmonary vascular changes induced by crotalaria spectabilis in rats. | | 1965 | 5899497 |
| [pathogenesis of experimental pulmonary hypertension. model experiments in rats using crotalaria spectabilis]. | | 1972 | 4627440 |
| population dynamics of plant nematodes in cultivated soil: effect of summer cover crops in old agricultural land. | in a 6-year cover crop sequence study, nematode population densities varied with different cover crops. millet favored rapid increase of belonolaimus longicaudatus and supported relatively large numbers of pratylenchus brachyurus. beggarweed and 'coastal' bermudagrass favored rapid increase of b. iongicaudatus and to a lesser extent p. brachyurus and trichodorus christiei. hairy indigo and crotalaria supported relatively large numbers of p. brachyurus but suppressed b. longicaudatus. hairy indig ... | 1970 | 19322288 |
| arterial changes in crotalaria spectabilis-induced pulmonary hypertension in rats. | | 1974 | 4835803 |
| effects on cytokines and histology by treatment with the ace inhibitor captopril and the antioxidant retinoic acid in the monocrotaline model of experimentally induced lung fibrosis. | monocrotaline (mct), a pyrrolizidine alkaloid extracted from the shrub crotalaria spectabilis, induces in the lungs of many mammalian species severe hypertension and fibrosis. previous work with mct-induced lung disease in rats has shown that some of the steps to progressive fibrosis can be interrupted or decreased by intervention with retinoic acid (ra) or with the angiotensin converting enzyme inhibitor, captopril. this report emphasizes the pathology and cytokines present in lungs of rats in ... | 2007 | 17506718 |
| protective effect of beraprost sodium, a stable prostacyclin analogue, in development of monocrotaline-induced pulmonary hypertension. | experimental pulmonary hypertension (ph) was induced by a single injection of monocrotaline (mct), a pyrrolizidine alkaloid extracted from crotalaria spectabilis. the effect of beraprost sodium, a stable prostacyclin analogue, on the development of mct-induced ph in rats was studied. chronic administration of beraprost sodium at a dose of 30 micrograms/kg/day initiated on the same day as mct injection decreased the degree of ph determined by weight ratio of right ventricular free wall to that of ... | 1996 | 8656653 |
| effect of feeding various levels of crotalaria spectabilis seed on the performance of chicks, turkeys, and pullets. | | 1963 | 13952865 |
| comparison of the toxic effects of crotalaria spectabilis and crotalaria giant striata as complete feed contaminants. | | 1960 | 13800572 |
| crotalaria spectabilis poisoning in louisiana livestock. | | 1946 | 21013338 |
| hypertensive pulmonary vascular disease in rats after prolonged feeding with crotalaria spectabilis seeds. | | 1970 | 4396343 |
| crotalaria spectabilis toxicity in chickens. | | 1960 | 13792760 |
| pathologic changes associated with feeding various levels of crotalaria spectabilis seed to poultry. | | 1963 | 13977554 |
| [monocrotaline-induced pulmonary hypertension in animals]. | monocrotaline (mct) is a pyrrolizidine alkaloid extracted from seeds of crotalaria spectabilis that has been used to induce structural changes in the pulmonary arteries associated with progressive pulmonary hypertension in rodents. recent studies have demonstrated that several mediators such as elastase, vasoconstrictors (endotheline-1), vasodilators (nitric oxide, pgi2) and cytokines (il-1, mcp-1) play important roles in mct-induced pulmonary hypertension, and that the changes in pulmonary hemo ... | 2001 | 11411116 |
| pulmonary arteritis produced in rat by feeding crotalaria spectabilis. | | 1961 | 13758395 |
| natural incidence of egg parasitoids of edessa meditabunda (f.) (hemiptera: pentatomidae) on crotalaria spectabilis in campo novo do parecis, mt, brazil. | egg parasitoids of the stink bug edessa meditabunda (f) were studied on rattlepod crotalaria spectabilis used in soybean crop rotation in campo novo do parecis, mato grosso state, central western brazil. seven species of parasitoids were found: two encyrtidae, one eurytomidae, and four platygastridae. the occurrence of trissolcus euchisti (ashmead) and trissolcus elimatus johnson (platygastridae) on eggs of e. meditabunda is recorded for the first time. moreover, this is the first record of t. e ... | 2011 | 22068950 |
| beneficial use of industrial by-products for phytoremediation of an arsenic-rich soil from a gold mining area. | this study investigated two industrial by-products - red mud (rm) and its mixture with phosphogypsum (rmg), as amendments in an as((5+))-contaminated soil from a gold mining area in brazil in order to grow three plant species: brachiaria decumbens, crotalaria spectabilis, and stylosanthes cv. campo grande. these amendments were applied to reach a soil ph of 6.0. using rm and rmg increased shoot dry matter (sdm) and root dry matter (rdm) of most plants, with rmg being more effective. adding rmg i ... | 2016 | 26710183 |
| fast and reliable detection of toxic crotalaria spectabilis roth. in thunbergia laurifolia lindl. herbal products using dna barcoding coupled with hrm analysis. | nowadays, medicinal plants are used as a popular alternative to synthetic drugs. many medicinal plant products have now been commercialized throughout various markets. these products are commonly sold in processed or modified forms such as powders, dried material and capsules, making it almost impossible to accurately identify the constituent species. the herbal plant known as 'rang chuet' in thai has been widely used as remedies for various ailments. however, two medicinal plants species, thunb ... | 2015 | 26024888 |
| toxicity of dietary heliotropium dolosum seed to japanese quail. | five groups of 30 male japanese quail, each 7-w-old, were fed diets containing 0, 1, 3, 5, or 10% (w/w) of dehulled h dolosum seed. half of the birds from the each group were killed at 6 and 24 w after beginning of the trial. at the end of 6th w, neither mortality nor clinical sign occurred in test groups. in the 5 and 10% inclusion levels, mild to moderate hepatic injury was detected as evidenced by mild karyomegaly, moderate fatty change, focal or portal fibrosis, bile duct hyperplasie, and ov ... | 2002 | 12361106 |
| courtship pheromone production and body size as correlates of larval diet in males of the arctiid moth,utetheisa ornatrix. | hydroxydanaidal, the corematal courtship pheromone of maleutetheisa ornatrix, shows pronounced quantitative variation in natural populations of the moth. males that, as larvae, fed on seed-bearing rather than immature food plants (crotalaria spectabilis orc. mucronata) produce higher levels of hydroxydanaidal. such males also have higher systemic loads of pyrrolizidine alkaloid, the known metabolic precursor of hydroxydanaidal, whichutetheisa sequester from their larval diet and which is concent ... | 1990 | 24263510 |
| crotalaria spectabilis intoxication in rhesus monkeys. | | 1965 | 14316796 |
| extraction of monocrotaline from crotalaria spectabilis using supercritical carbon dioxide and carbon dioxide-ethanol mixtures. | monocrotaline, a pyrrolizidine alkaloid of chemotherapeutic interest, was successfully extracted from the crushed seeds of crotalaria spectabilis using supercritical carbon dioxide and ethanol mixtures. overall solubilities of the plant material in the supercritical fluid phase were as high as 1.1 mass percent, and monocrotaline solubilities were as high as 0.07 mass percent. the solubility of monocrotaline in the presence of other plant material was smaller by 50 to 98% compared with the solubi ... | 1989 | 18588078 |
| synthesis of pyrrolizidine alkaloids indicine, intermedine, lycopsamine, and analogues and their n-oxides. potential antitumor agents. | (-)- and (+)-trachelanthic and (-)- and (+)-viridifloric acids were synthesized and their isopropylidene derivatives were regiospecifically coupled, at c-9, with (-)-retronecine obtained by hydrolysis of monocrotaline, isolated from crotalaria spectabilis. hydrolysis, followed by oxidation, led to the n-oxides of indicine, intermedine, lycopsamine, and the new nonnatural product, respectively. each of these analogues was screened in the p388 lymphocytic leukemia system at the same time as indici ... | 1985 | 4009589 |
| hypercholeresis in turkeys following the ingestion of crotalaria spectabilis seeds. | young female turkeys received diets containing crotalaria spectabilis seeds for 18 weeks. mean values for total bile flow, biliary bile acid excretion, bile acid-dependent flow and bile acid-independent flow were significantly higher in crotalaria-fed turkeys than in controls. the hypercholeresis observed in crotalaria-fed birds involved both bile acid-dependent and bile acid-independent components of bile. crotalaria-fed turkeys developed biliary hyperplasia. liver weights were similar in the t ... | 1976 | 975841 |
| crotalaria spectabilis toxicity studies in turkeys. | | 1963 | 5888523 |
| crotalaria spectabilis-induced cirrhosis in turkeys. | | 1963 | 14012127 |
| host suitability of potential cover crops for root-knot nematodes. | several potential cover crops were evaluated for their susceptibility to meloidogyne arenaria race 1, m. incognita race 1, and m. javanica in a series of five greenhouse experiments. no galls or egg masses were observed on roots of castor (ricinus communis), cowpea (vigna unguiculata cv. iron clay), crotalaria (crotalaria spectabilis), or american jointvetch (aeschynomene americana). occasional egg masses (rating </=1.0 on 0-5 scale) were observed on marigold (tagetes minuta) in one test with m. ... | 1999 | 19270926 |
| [studies on experimentally induced pulmonary hypertension due to seeds of crotalaria spectabilis]. | | 1972 | 4663541 |
| augmented adrenomedullin concentrations in right ventricle and plasma of experimental pulmonary hypertension. | adrenomedullin is a strong vasorelaxing peptide discovered in pheochromocytoma tissue. monocrotaline, a pyrrolizidine alkaloid derived from crotalaria spectabilis, is known to cause pulmonary hypertension. to test the hypothesis that adrenomedullin plays a role similar to that of atrial natriuretic peptide or brain natriuretic peptide in modulating right ventricular responses to pulmonary hypertension, we have compared concentrations of immunoreactive rat adrenomedullin and adrenomedullin messen ... | 1995 | 7475919 |
| influence of selenium on aflatoxin b1 or crotalaria toxicity in turkey poults. | this research compared the toxic effects of aflatoxin b1 and monocrotaline, the active principle of crotalaria spectabilis, and the additive effect between aflatoxin b1 and monocrotaline in turkey poults. it was of interest whether selenium fed at dosage levels of 0.1, 5, or 10 micrograms/g of feed would protect against the toxic effect of aflatoxin and/or monocrotaline, and whether the toxicants would result in detectable residues in poult tissues. a total of 180 healthy 1-day-old male turkey p ... | 1983 | 6414348 |
| effects of tropical rotation crops on meloidogyne arenaria population densities and vegetable yields in microplots. | the effects of 12 summer crop rotation treatments on population densities of meloidogyne arenaria race 1 and on yields of subsequent spring vegetable crops were determined in microplots. the crop sequence was: (i) rotation crops during summer 1991 ; (ii) cover crop of rye (secale cereale) during winter 1991-92; (iii) squash (cucurbita pepo) during spring 1992; (iv) rotation crops during summer 1992; (v) rye during winter 1992-93; (vi) eggplant (solanum melongena) during spring 1993. the 12 rotat ... | 1994 | 19279880 |
| interactions between six warm-season legumes and three species of root-knot nematodes. | | 1985 | 19294109 |
| genetic diversity of crotalaria germplasm assessed through phylogenetic analysis of est-ssr markers. | the genetic diversity of the genus crotalaria is unknown even though many species in this genus are economically valuable. we report the first study in which polymorphic expressed sequence tag-simple sequence repeat (est-ssr) markers derived from medicago and soybean were used to assess the genetic diversity of the crotalaria germplasm collection. this collection consisted of 26 accessions representing 4 morphologically characterized species. phylogenetic analysis partitioned accessions into 4 m ... | 2006 | 16936850 |
| leguminosae native nodulating bacteria from a gold mine as-contaminated soil: multi-resistance to trace elements, and possible role in plant growth and mineral nutrition. | efficient n2-fixing leguminosae nodulating bacteria resistant to as may facilitate plant growth on as-contaminated sites. in order to identify bacteria possessing these features, 24 strains were isolated from nodules of the trap species crotalaria spectabilis (12) and stizolobium aterrimum (12) growing on an as-contaminated gold mine site. 16s rrna gene sequencing revealed that most of the strains belonged to the group of α-proteobacteria, being representatives of the genera bradyrhizobium, rhiz ... | 2017 | 28323446 |
| relative fitness of helicoverpa armigera (lepidoptera: noctuidae) on seven host plants: a perspective for ipm in brazil. | the cotton bollworm helicoverpa armigera (hübner) (lepidoptera: noctuidae) is a widespread pest of many cultivated and wild plants in europe, africa, asia, and australia. in 2013, this species was reported in brazil, attacking various host crops in the midwestern and northeastern regions of the country and is now found countrywide. aiming to understand the effects of different host plants on the life cycle of h. armigera, we selected seven species of host plants that mature in different seasons ... | 2016 | 26798139 |
| study of the proteolytic activity of the tropical legume crotalaria spectabilis. | the characterization of legume proteases contributes to the understanding of the physiology of plants and their interaction with the environment. thirteen extracts from various parts of crotalaria spectabilis were made using different extraction systems. the highest protein content was found in seeds, and the most pronounced proteolytic activity was observed in leaf extracts, with an optimal ph value in the alkaline range. proteases in extracts from roots, stems, and flowers were active in vario ... | 2012 | 23198408 |
| potential of leguminous cover crops in management of a mixed population of root-knot nematodes (meloidogyne spp.). | root-knot nematode is an important pest in agricultural production worldwide. crop rotation is the only management strategy in some production systems, especially for resource poor farmers in developing countries. a series of experiments was conducted in the laboratory with several leguminous cover crops to investigate their potential for managing a mixture of root-knot nematodes (meloidogyne arenaria, m. incognita, m. javanica). the root-knot nematode mixture failed to multiply on mucuna prurie ... | 2010 | 22736854 |
| crotalaria spectabilis toxicity in swine: characterization of the renal glomerular lesion. | | 1975 | 1141458 |
| feeding and oviposition preference of phyllophaga cuyabana (moser) (coleoptera: melolonthidae) on several crops. | laboratory and greenhouse experiments were carried out to study food and oviposition preference by phyllophaga cuyabana (moser) on different plant species as cajanus cajan l. (pigeon pea), crotalaria juncea l. (sun hemp), crotalaria spectabilis roth (showy crotalaria), crotalaria ochroleuca g. don (slenderleaf rattlebox), glycine max [l.] merrill (soybean), gossypium hirsutum l. (cotton), helianthus annuus l. (sunflower), stizolobium aterrimum [mucuna aterrima] piper tracey (velvetbean) and zea ... | 2007 | 18060303 |
| lectin, hemolysin and protease inhibitors in seed fractions with ovicidal activity against haemonchus contortus. | bioactive molecules of plant species are promising alternatives for the chemical control of gastrointestinal nematodes in ruminants. extracts of native and exotic seed species from brazil's semi-arid region were tested in vitro in an egg hatch assay and the bioactivity of their proteins was investigated. each seed species was subjected to three extractions with three types of solvents. all the seeds showed ovicidal activity, which varied according to the solvents. higher ovicidal activity was fo ... | 2014 | 25054490 |