| effect of polyacetylenes on the neurite outgrowth of neuronal culture cells and scopolamine-induced memory impairment in mice. | polyacetylenic alcohols and their linoleates isolated from panax ginseng c. a. meyer and cirsium japonicum dc., of which the lipophilic extracts had been found to affect the neuritogenesis of cultured paraneurons, were demonstrated to have a significant neuritogenic effect on pc12h and neuro2a cells. panaxynol and the acetylenic triol in particular were highly efficient at concentrations > or = 2 microm. panaxynol (20 mg/kg/d, i.p., for 3 d) was confirmed to improve scopolamine-induced memory de ... | 2001 | 11767118 |
| effects of methanol extract of cirsium japonicum var. ussuriense and its principle, hispidulin-7-o-neohesperidoside on hepatic alcohol-metabolizing enzymes and lipid peroxidation in ethanol-treated rats. | effects of the methanol extract of cirsium japonicum var. ussuriense and hispidulin 7-o-neohesperidoside isolated from the plant on hepatic alcohol-metabolizing enzymes and lipid peroxidation were studied in rats treated with ethanol. rats treated with 10% alcohol solution for 6 weeks were orally administered with 250 or 500 mg of methanol extract or 10 or 20 mg of hispidulin 7-o-neohesperidoside per kg body weight daily during the last week of ethanol treatment. the administration of the methan ... | 2004 | 14750195 |
| tumor inhibition and improved immunity in mice treated with flavone from cirsium japonicum dc. | the purpose of these experiments is to study the effects of flavone from cirsium japonicum dc (flcj) on tumor activity and on the regulation of the immune response in mice with s180 and h22 tumors. pectolinarin and 5, 7-dihydroxy-6, 4'-dimethoxyflavone are two major components of flcj. flcj, pectolinarin and 5, 7-dihydroxy-6, 4'-dimethoxyflavone can inhibit the growth of the implanted tumors s180 and h22 and promote cellular and humoral immune responses. flcj is stronger than pectolinarin and 5, ... | 2006 | 16846832 |
| anticancer activity and quantitative analysis of flavone of cirsium japonicum dc. | cirsium japonicum dc, a traditional chinese medicine, has been widely used as an antihemorrhagic and diuretic agent. the objective of this study was to perform quantitative analysis of flavone by reversed-phase hplc and examine the anticancer activity of c. japonicum dc in the s180 and h22 mice. cirsium japonicum dc was separated and purified with several chromatography techniques and two flavone compounds, pectolinarin and 5,7-dihydroxy-6,4'-dimethoxyflavone, were isolated. the content of these ... | 2007 | 17680503 |
| cirsium japonicum elicits endothelium-dependent relaxation via histamine h(1)-receptor in rat thoracic aorta. | cirsium japonicum de candole is widely used in traditional herbal medicine for the treatment of hemorrhage, hypertension or blood circulation in korea. in this work, we investigated the vasorelaxant activity of an aqueous extract of c. japonicum whole plant (cjex) and its possible mechanism in isolated rat thoracic aortic rings constricted with norepinephrine (ne; 300 nmol/l). cjex elicited an acute relaxation in endothelium-intact rings in a concentration-dependent manner (0.1-1.0 mg/ml). this ... | 2008 | 18242903 |
| phylogenetic analysis of carthamus species based on the nucleotide sequence of the nuclear sacpd gene and chloroplast trnl-trnf igs region. | to clarify the phylogenetic relationships of carthamus species, we performed sequence analysis of the nuclear stearoyl acyl carrier protein desaturase (sacpd) gene and the chloroplast intergenic spacer region between leucine and phenylalanine trna genes (trnl-trnf igs) in 13 taxa of carthamus. the previous division of the genus into 4 taxonomic sections and allocation of particular genomes to various taxa on the basis of morphological, cytogenetic, and biosystematic analyses is not supported by ... | 2008 | 18772950 |
| antidiabetic effect of flavones from cirsium japonicum dc in diabetic rats. | cirsium japonicum dc is a traditional chinese herb used along with other herbs to treat hypertension, traumatic hemorrhage, inflammation, and renal cellular injury. here, we isolated two flavones from cirsium japonicum dc, pectolinarin and 5,7-dihydroxy-6,4'-dimethoxy flavone (ddmf), and investigated their antidiabetic effect in diabetic rats established by intravenous injection with streptozotocin followed by feeding with high-carbohydrate/high-fat diet. both pectolinarin and ddmf showed antidi ... | 2010 | 20361298 |
| cirsium japonicum extract induces apoptosis and anti-proliferation in the human breast cancer cell line mcf-7. | cirsium japonicum is a wild perennial herb that has been used as an anti-hemorrhagic, anti-hypertensive and uretic agent in traditional chinese medicine. recently, it was reported that c. japonicum inhibits the growth of implanted cancer cells. however, the molecular mechanisms underlying the anti-cancer properties of c. japonicum are not fully understood. in this study, we investigated the effect of a methanol extract of c. japonicum on cell growth in the human breast cancer cell line mcf-7. c. ... | 2010 | 21472257 |
| Protective effects of luteolin against apoptotic liver damage induced by D-galactosamine/lipopolysaccharide in mice. | In this study, the protective effects of luteolin (1, a major component of Cirsium japonicum) were examined against d-galactosamine (GalN)/lipopolysaccharide (LPS)-induced fulminant hepatic failure. Mice received an intraperitoneal injection of 1 (25, 50, 100, and 200 mg·kg(-1)) 1 h before treatment with GalN (700 mg·kg(-1))/LPS (10 µg·kg(-1)). Treatment with GalN/LPS resulted in increased mortality and serum aminotransferase activity. These increases were attenuated by pretreatment with 1. Trea ... | 2011 | 21899269 |
| effects of medicinal herb extracts and their components on steatogenic hepatotoxicity in sk-hep1 cells. | herbal medicines are widely used in many countries for the treatment of many diseases. although the use of herb extracts as alternative medicine is growing, their toxicological properties have not been thoroughly investigated. in this study, we have investigated the effects of water and ethanol extracts of 18 herbs on the hepatic lipid metabolism and steatogenic hepatotoxicity. ethanol extracts of cirsium japonicum, carthamus tinctorius, rehmanniae glutinosa (preparata), polygala tenuifolia, foe ... | 2011 | 24278574 |
| protective effect of cirsimaritin against streptozotocin-induced apoptosis in pancreatic beta cells. | maintaining glucose homoeostasis is essential for the survival of cells. despite the various health benefits of korean thistle (cirsium japonicum var. maackii), their effects on pancreatic β-cell apoptosis in type 1 diabetes mellitus and the underlying mechanisms remain unclear, and experimentally investigated in this study. | 2017 | 28397263 |
| cytotoxic phenylpropanoid glycosides from cirsium japonicum. | three new phenylpropanoid glycosides 1-3, along with nine known phenylpropanoid glycosides 4-12, were isolated from the aerial parts of cirsium japonicum. the structures of isolated compounds were elucidated by chemical and spectroscopic methods. compounds 1, 3, 6, 8, and 11 showed moderate cytotoxicities against mcf-7, u87, hct116, and a549 cell lines with ic50 values in the range of 1.35-11.32 μm. the known compounds 4-12 were obtained from this plant for the first time. | 2016 | 27308841 |
| hepatoprotective effect of flavonoids from cirsium japonicum dc on hepatotoxicity in comparison with silymarin. | cirsium japonicum dc is a perennial plant that is widely distributed throughout china. flavonoids are the major active constituents of c. japonicum, which has been reported to possess many bioactivities. this study was designed to investigate the protective effects of flavonoids from c. japonicum against liver injury using carbon tetrachloride (ccl4)-induced hepatocyte injury, with silymarin as a positive control. silymarin is a mixture of flavonoids from silybum marianum, a traditional european ... | 2016 | 27094923 |
| ethanol extract of cirsium japonicum var. ussuriense kitamura exhibits the activation of nuclear factor erythroid 2-related factor 2-dependent antioxidant response element and protects human keratinocyte hacat cells against oxidative dna damage. | keratinocytes are constantly exposed to extracellular insults, such as ultraviolet b, toxic chemicals and mechanical stress, all of which can facilitate the aging of keratinocytes via the generation of intracellular reactive oxygen species (ros). nuclear factor erythroid 2-related factor 2 (nrf2) is a transcription factor that plays a critical role in protecting keratinocytes against oxidants and xenobiotics by binding to the antioxidant response element (are), a cis-acting element existing in t ... | 2016 | 27051652 |
| the natural substance ms-10 improves and prevents menopausal symptoms, including colpoxerosis, in clinical research. | many natural substances were screened to develop nutraceuticals that reduce menopausal symptoms. a complex of cirsium japonicum var. maackii and thymus vulgaris extracts, named ms-10, had significant positive effects. under a low concentration of estrogen, which represents postmenopausal physiological conditions, ms-10 had beneficial effects on estrogen receptor-expressing mcf-7 cells by reversibly enhancing estrogen activity. in addition, in the ovariectomized rat model, changes in bone-specifi ... | 2016 | 26848802 |
| lc-ms/ms determination and pharmacokinetic study of seven flavonoids in rat plasma after oral administration of cirsium japonicum dc. extract. | cirsium japonicum dc., a traditional chinese medicine, has the curative effect of antihemorrhagic and antitumor. pharmacological studies prove that the curative effect may relate to the flavonoids. a simple and rapid resolution liquid chromatography-tandem mass spectrometry (lc-ms/ms) method was first developed and validated for the quantification of seven flavonoids including pectolinarin, linarin, pectolinarigenin, hispidulin, diosmetin, acacetin and apigenin in rat plasma after oral administr ... | 2014 | 25456423 |
| bioactive constituents of cirsium japonicum var. australe. | cirsium japonicum var. australe, used as a folk medicine in taiwan, has been employed traditionally in the treatment of diabetes and inflammatory symptoms. bioactivity-guided fractionation of its ethanolic extract, utilizing centrifugal partition chromatography monitored by dpph-tlc analysis, led to the isolation of three new acetylenic phenylacrylic acid esters (1-3) and two new polyacetylenes (4 and 5), together with seven known compounds (6-12). the structures of 1-5 were elucidated by spectr ... | 2014 | 25025240 |
| ethanol extract of cirsium japonicum attenuates hepatic lipid accumulation via ampk activation in human hepg2 cells. | one of the most common causes of chronic liver disease, nonalcoholic fatty liver disease (nafld), is strongly associated with obesity and dysregulated insulin action in the liver. however, there are no pharmacological agents currently established for the treatment of nafld. a flowering plant in the asteraceae family, cirsium japonicum (cj), exhibits a variety of pharmacological and antioxidative properties that promote hepatoprotection. in the present study, cj ethanol extract was shown to reduc ... | 2014 | 24944601 |
| effects and treatment methods of acupuncture and herbal medicine for premenstrual syndrome/premenstrual dysphoric disorder: systematic review. | during their reproductive years about 10% of women experience some kind of symptoms before menstruation (pms) in a degree that affects their quality of life (qol). acupuncture and herbal medicine has been a recent favorable therapeutic approach. thus we aimed to review the effects of acupuncture and herbal medicine in the past decade as a preceding research in order to further investigate the most effective korean medicine treatment for pms/pmdd. | 2014 | 24410911 |
| silibinin inhibits the production of pro-inflammatory cytokines through inhibition of nf-κb signaling pathway in hmc-1 human mast cells. | silibinin is the major active molecule of silymarin, the mixture of flavonolignans extracted from cirsium japonicum. it has been used for the treatment of hepatitis and inflammation-related diseases. in the present study, the effects of silibinin on allergic inflammation and its signaling were investigated in the induced human mast cells. | 2013 | 24045679 |
| luteolin mediates the antidepressant-like effects of cirsium japonicum in mice, possibly through modulation of the gabaa receptor. | cirsium japonicum (cj) has been shown to possess antidepressant-like properties. in the present study, we sought to identify which constituent of cj might be responsible for its antidepressant effects and determine probable mechanism of action. the ethanol extract of cj was administered to mice then behavioral changes were evaluated in the forced-swimming test (fst) and open-field test (oft). in addition, its effects on norepinephrine (ne) reuptake and intracellular chloride (cl(-)) flux were de ... | 2014 | 23925560 |
| [content comparison of buddleoside and pectolinarin in cirsium japonicum, c. leo and c. leducei]. | to compare cirsium japonicum characteristics with c. leo and c. leducei, along with the content of buddleoside and pectolinarin, and lay the foundation for the quality control of c. japonicum. | 2013 | 23724673 |
| the ethanol extract of cirsium japonicum increased chloride ion influx through stimulating gaba(a) receptor in human neuroblastoma cells and exhibited anxiolytic-like effects in mice. | the aim of the present study was to evaluate the anxiolytic effects of the ethanol extract of cirsium japonicum (cj) in mice. the extract was orally administered at dosages of 50, 100, 200, or 400 mg/kg of body weight. the cj-induced behavioral changes were assessed using the open-field and elevated-plus maze test. the ethanol extract of cj did not affect overall locomotor activity of mice in the open-field test, however, it showed increase exploration in the unprotected center zone, which is th ... | 2013 | 23524939 |
| luteolin attenuates diabetes-associated cognitive decline in rats. | diabetes mellitus can cause dysfunction of the central nervous system called "diabetic encephalopathy". although various oral drugs are used to treat diabetes, they do not prevent the development of diabetes-associated cognitive decline in rats, and novel strategies for the prevention and treatment are urgently needed. luteolin, a flavonoid isolated from cirsium japonicum, has antioxidant, anti-inflammatory and neuroprotective activities. however, no report is available on influence of luteolin ... | 2013 | 23415807 |
| molecular phylogenetic status of korean strain of podosphaera xanthii, a causal pathogen of powdery mildew on japanese thistle (cirsium japonicum) in korea. | powdery mildew diseases are sensitive to climate change and spread can be favored by increased temperature and low moisture. during 2011 to 2012, a powdery mildew disease by a podosphaera species was observed on the leaves of japanese thistle (cirsium japonicum) in korea. the initial sign of this disease included scattered superficial white mycelia on leaves. as the disease progressed, abundant necrotic black spots exhibiting chasmothecia were formed on the leaves. rdna its and 28s homologies of ... | 2012 | 23275000 |
| polyacetylene compound from cirsium japonicum var. ussuriense inhibited caspase-1-mediated il-1β expression. | our previous report showed that polyacetylene compound, 1-heptadecene-11, 13-diyne-8, 9, 10-triol (pa) from the root of cirsium japonicum var. ussuriense has anti-inflammatory activity. in this study we investigated the role of the pa as inhibitor of caspase-1, which converts prointerleukin-1β (proil-1β) to active il-1β and is activated by inflammasome involved in the inflammatory process. we tested the effect of pa on the production of pro-inflammatory cytokines, il-1β in murine macrophage cell ... | 2012 | 23213315 |
| protection of apigenin against kainate-induced excitotoxicity by anti-oxidative effects. | apigenin (5,7,4'-trihydroxyflavone) is a principal ingredient of cirsium japonicum. these experiments were performed to determine whether apigenin has neuroprotective effects against kainic acid (ka)-induced excitotoxicity in vitro and in vivo. intraperitoneal (i.p.) administration of apigenin (25, 50 mg/kg) decreased the seizure scores induced by ka injection (40 mg/kg, i.p.) in mice. in addition, the convulsion onset time was significantly delayed by apigenin administration. moreover, we found ... | 2012 | 22975493 |
| cirsium japonicum flavones enhance adipocyte differentiation and glucose uptake in 3t3-l1 cells. | cirsium japonicum flavones have been demonstrated to possess anti-diabetic effects in diabetic rats, but the functional mechanism remains unknown. the nuclear receptor peroxisome proliferator-activated receptor γ (pparγ) plays an important role in glucose and lipid homeostasis. in this study, we report the effects of cirsium japonicum flavones (pectolinarin and 5,7-dihydroxy-6,4-dimethoxy flavone) on pparγ activation, adipocyte differentiation, and glucose uptake in 3t3-l1 cells. reporter gene a ... | 2012 | 22687475 |
| simultaneous determination of bioactive flavonoids in some selected korean thistles by high-performance liquid chromatography. | in order to facilitate the quality control of some selected korean thistles (cirsii herb), cirsium japonicum var ussuriense, c. japonium var spinosissimum, c. setidens, c. pendulum, c. nipponicum, carduus crispus, and breea segetum, a simple, accurate and reliable high performance liguid chromatography method was developed for the simultaneous determination of the six flavonoids: luteolin 5-o-glucoside (1), luteolin 7-o-glucoside (2), hispidulin 7-o-neohesperidoside (3), luteolin (4), pectolinar ... | 2011 | 21547678 |
| effects of elsholtzia splendens and cirsium japonicum on premenstrual syndrome. | premenstrual syndrome is a common chronic disorder in most women of reproductive age. the main symptoms are depression, anxiety, tension, feeling out of control, and mastalgia. in premenstrual syndrome, the effects of aromatic edible elsholtzia splendens and cirsium japonicum were investigated for over 3 months in 30 women participants in their twenties. in the elsholtzia splendens capsule treated group, scores of depression and anxiety were significantly lower than those in the cirsium japonicu ... | 2010 | 20827344 |
| modulation of the genomic estrogen receptor pathway by water extracts of cirsium japonicum. | we investigated the estrogenic activity of cirsium japonicum water extracts, which have long been used to treat vascular-related diseases. the activity of the extracts was characterized in a transient transfection system, using estrogen receptor isoforms and estrogen-responsive luciferase plasmids in hek 293 cells. the extract activated both and estrogen receptors. activation was inhibited by the estrogen receptor antagonist ici 182,780, indicating that the effects were mediated through the estr ... | 2008 | 18365694 |
| comparative antioxidant activity and hplc profiles of some selected korean thistles. | as yet, no comparative analyses have been conducted regarding the comparative antioxidant activities and hplc profiles of thistles distributed in korea. thus, this study was performed in order to evaluate the antioxidant potentials of seven korean thistles: cirsium lineare, cirsium chanroenicum, cirsium setidens, cirsium japonicum var. ussuriense, cirsium nipponicum, cirslum pendulum and carduus crispus, via peroxynitrite and dpph free radical assays. among seven korean thistles, carduus crispus ... | 2008 | 18277604 |
| antioxidant and antidiabetic activities of extracts from cirsium japonicum roots. | this study investigated the antioxidant activity of methanol (meoh) and water extracts from roots of cirsium japonicumin vitro. meoh extract showed a stronger free radical scavenging activity than water extract. however, both of extracts showed a concentration dependent hydroxyl radical scavenging activity, reducing power and metal chelating ability. meoh extract had greater phenolic and flavonoid contents than water extract. the antidiabetic activity of these two extracts was evaluated by the a ... | 2008 | 20016726 |
| differentiation of cirsium japonicum and c. setosum by tlc and hplc-ms. | the chinese pharmacopoeia indicates the use of field thistle (cirsium setosum) and japanese field thistle (c. japonicum) in the treatment of bleeding and inflammation. in the absence of an analytical method for the differentiation and analysis of these two species, tlc and hplc-ms methods have been developed for this purpose. both species could be readily distinguished by their flavonoid pattern as revealed by tlc on silica gel layers eluted with ethyl acetate:formic acid:acetic acid:water. the ... | 2015 | 15997854 |
| priority of color over scent during flower visitation by adult vanessa indica butterflies. | most flower visitors innately prefer a particular color and scent, and use them as cues for flower recognition and selection. however, in most cases, since color and scent serve as a combined signal, not only does the preference for an individual cue, but also the preference hierarchy among different cues, influence their flower visitation. in the present study, we attempted to reveal (1) the chromatic and (2) the olfactory cues that stimulate flower visiting, and (3) the preference hierarchy be ... | 2005 | 15688217 |
| oviposition-stimulatory activity against ostrinia zealis by essential oil of root part from cirsium japonicum dc. | the essential oil components from root part of cirsium japonicum and oviposition-stimulatory activity against ostrinia zealis by root essential oil were investigated. the main component of fresh root essential oil was aplotaxene (75.14%) and of dried root stock was found to be palmitic acid (14.42%). the root oil was significantly more active than the control against o. zealis. | 2003 | 14526913 |
| [studies on the chemical constituents of cirsium japonicum dc]. | in order to look for new bioactive compounds, investigation on the chemical constituents, especially on the typical polyacetylenes from the rhizomes of cirsium japonicum dc. was carried out. | 2003 | 14513805 |
| [the technology of processing carbonized cirsium japonicum and quality standards of its prepared pieces]. | the technology of processing carbonized cirsium japonicum was selected by using orthogonal experiment design. the result shows that the best way is to bake of 10 min at 220 degrees c. the contents of macro and trace elements in the prepared pieces significantly increased. | 1998 | 12569819 |
| [chemical constituents of cirsium japonicum d. c]. | | 1992 | 1482537 |
| studies on antihemorrhagic substances in herbs classified as hemostatics in chinese medicine. vii. on the antihemorrhagic principle in cirsium japonicum dc. | | 1987 | 3594697 |