| mariannaepyrone--a new inhibitor of thromboxane a2 induced platelet aggregation. | mariannaeapyrone ((e)-2-(1,3,5,7-tetramethyl-5-nonenyl)-3,5-dimethyl-6-hydroxy-4h-pyran-4-one) is a new fungal metabolite isolated from fermentations of the common mycophilic deuteromycete mariannaea elegans. the chemical structure of the 4-pyrone was determined by spectroscopic techniques. mariannaeapyrone is a selective inhibitor of the thromboxane a2 induced aggregation of human platelets, whereas only weak cytotoxic and antimicrobial effects could be observed. | 2001 | 11302199 |
| trichodermamide a and aspergillazine a, two cytotoxic modified dipeptides from a marine-derived fungus spicaria elegans. | two known modified dipeptides, trichodermamide a (1) and aspergillazine a (2), were isolated from an ethyl acetate extract of the metabolite of a marine-derived fungus spicaria elegans, and were found to have a weak cytotoxic effect on three cancer cell lines p388, a-549, and hl-60 agreed. to our knowledge, this is the first report on the isolation of compounds 1 and 2 from the fungus spicaria elegans and their cytotoxic effect. | 2005 | 16212235 |
| 10-phenyl-[12]-cytochalasins z7, z8, and z9 from the marine-derived fungus spicaria elegans. | the three new 10-phenyl-[12]-cytochalasins z7, z8, and z9 (1-3), together with two known analogues, cytochalasins e (4) and k (5), were isolated from the marine-derived fungus spicaria elegans. this is only the second report to date that cytochalasins contain a 12-membered macrocyclic ring. the structures of the three new cytochalasins were elucidated by spectroscopic methods, and their absolute configurations were determined for the first time by the modified mosher's method. all five cytochala ... | 2006 | 16792402 |
| diversity of cutaneous bacteria with antifungal activity isolated from female four-toed salamanders. | among the microbiota of amphibian skin are bacteria that produce antifungal compounds. we isolated cutaneous bacteria from the skins of three populations of the nest-attending plethodontid salamander hemidactylium scutatum and subsequently tested the bacterial isolates against two different fungi (related to mariannaea elegans and rhizomucor variabilis) that were obtained from dead salamander eggs. the culturable antifungal bacteria were phylogenetically characterized based on 16s rrna phylogeny ... | 2008 | 18079731 |
| novel open-chain cytochalsins from the marine-derived fungus spicaria elegans. | six novel open-chain cytochalasins (1-6) and one known [12]-cytochalasin (7) have been isolated from the fermentation broth of a marine-derived fungus, spicaria elegans. cytochalasins z10-z15 (1-6) are the first reported cytochalasins that contain an open chain to date. the structures of these new compounds were elucidated by spectroscopic methods. the cytotoxic effects on p388, a-549, hl-60, and bel-7402 cell lines of all compounds were evaluated by the mtt method. | 2008 | 18507474 |
| [osmac (one strain many compounds) approach in the research of microbial metabolites--a review]. | microbial secondary metabolites have a wide range of biological activities due to their structural diversity and have been proved a major source for drug lead compounds. however,the traditional method of a single culture restricts the metabolic pathways of microorganisms and as a result many metabolites cannot be formed. recently,it has attracted much attention to use various techniques to activate those metabolic pathways restricted by the traditional method to get metabolic products with rich ... | 2010 | 20687332 |
| three new cytochalasins from the marine-derived fungus spicaria elegans kla03 by supplementing the cultures with l- and d-tryptophan. | three new cytochalasins z(21) -z(23) (1-3, resp.), together with five analogs, 4-8, were isolated from spicaria elegans kla03 by the osmac (one strain-many compounds) approach with adding l- and d-tryptophan during its cultivation. the structures of new cytochalasins were elucidated on the basis of comprehensive 1d- and 2d-nmr and hr-esi-ms analyses. cytochalasins z(21) and z(22) (1 and 2, resp.), and compound 5 showed cytotoxic activities against a-549 cell lines with ic(50) values of 8.2, 20.0 ... | 2011 | 21560237 |
| effects of high salt stress on secondary metabolite production in the marine-derived fungus spicaria elegans. | to obtain structurally novel and bioactive natural compounds from marine-derived microorganisms, the effect of high salt stress on secondary metabolite production in the marine-derived fungal strain, spicaria elegans kla-03, was investigated. the organism, which was isolated from marine sediment, produced different secondary metabolites when cultured in 3% and 10% saline conditions. four characteristic metabolites, only produced in the 10% salinity culture, were isolated, and their structures we ... | 2011 | 21731548 |
| eleganketal a, a highly oxygenated dibenzospiroketal from the marine-derived fungus spicaria elegans kla03. | eleganketal a (1), a naturally occurring aromatic polyketide possessing a rare highly oxygenated spiro[isobenzofuran-1,3'-isochroman] ring system, was isolated from the fungus spicaria elegans kla03 by culturing it in a modified mannitol-based medium. the structure of 1 including the absolute configuration was determined by combining spectroscopic analysis, synthesis of the racemic permethylated analogue, chiral-phase hplc separation, and tddft-ecd analysis. | 2014 | 24967847 |
| novel neogala-series glycosphingolipids with a terminal glucose residue from the fungus mariannaea elegans. | glycosphingolipids (gsls) are essential membrane components of eukaryotic cells. recently, a new type of fungal neogala-series gsl was identified in aureobasidin a-resistant fungi. in this study, we analyzed gsls from four pathogenic fungal strains belonging to the order hypocreales, and found that mariannaea elegans contained both acidic gsls and neutral gsls with mono- and di-saccharides. the structures of the neutral gsls of m. elegans were determined by compositional sugar, fatty acid, and s ... | 2013 | 23563544 |
| new record of mariannaea elegans var. elegans in korea. | a mariannaea fungus was isolated during investigation of an elm tree infested with unidentified beetles. based on morphological characteristics and molecular analysis of the internal transcribed spacer rdna sequence, the fungus was identified as mariannaea elegans var. elegans. fungal growth was better on malt extract agar than on potato dextrose agar and oatmeal agar. optimal temperature and ph for growth of the fungus were 30℃ and ph 7.0, respectively. the fungus was found to have the ability ... | 2012 | 22783129 |