| coronavirus mhv-3-induced apoptosis in macrophages. | infection with mouse hepatitis virus strain 3 (mhv-3) results in lethal fulminant hepatic necrosis in fully susceptible balb/c mice compared to the minimal disease observed in resistant strain a/j mice. macrophages play a central role in the pathogenesis of mhv-3-induced hepatitis. in the present study we have shown that mhv-3 infection of macrophages induces these cells to undergo apoptosis. three methods to detect apoptosis were applied: flow cytometry analysis of nuclear dna content, fluoresc ... | 1998 | 9770418 |