| identification and isolation of medicarpin and a substituted benzofuran as potent leukotriene inhibitors in an anti-inflammatory chinese herb. | in a search for new inhibitors of leukotriene formation, a methylene chloride extract of the plant dalbergia odorifera (jiangxiang) was found to be a potent inhibitor of ltc4 formation in ab-cxbg mct-1 mastocytoma cells. following lh-20 and reverse phase hplc chromatography, two compounds were isolated that had potent ltc4 inhibitory activity: medicarpin and 6-hydroxy-2-(2-hydroxy-4-methoxyphenyl) benzofuran (iv) with ic50s of 0.5 and 0.05 microm respectively. iv was shown to be a specific inhib ... | 1989 | 2559412 |
| inhibitors of prostaglandin biosynthesis from dalbergia odorifera. | | 1985 | 3833402 |
| endothelium-dependent relaxation of rat aorta by butein, a novel cyclic amp-specific phosphodiesterase inhibitor. | butein, isolated from dalbergia odorifera t. chen, caused endothelium-dependent relaxation of rat aorta precontracted with phenylephrine. this effect was abolished in endothelium-denuded aorta and in endothelium-intact aorta in the presence of ng-monomethyl-l-arginine, oxyhemoglobin and methylene blue, whereas the effect was unaltered by indomethacin or charybdotoxin. these results indicate that the vasorelaxant effect of butein depended on the endothelium and was mediated by endothelium-derived ... | 1995 | 7498256 |
| vasorelaxant effect of isoliquiritigenin, a novel soluble guanylate cyclase activator, in rat aorta. | 1. the vasorelaxant activity of isoliquiritigenin, isolated from dalbergia odorifera t, was investigated in the phenylephrine-precontracted rat aorta by measuring tension, guanylate and adenylate cyclase activities, guanosine 3':5'-cyclic monophosphate (cyclic gmp) and adenosine 3':5'-cyclic monophosphate (cyclic amp) levels. 2. isoliquiritigenin concentration-dependently relaxed rat aorta contracted with phenylephrine, kcl, u-46619, endothelin and 5-hydroxytryptamine, with ec50s of 7.4 +/- 1.6, ... | 1995 | 7599926 |
| three new flavonoids and antiallergic, anti-inflammatory constituents from the heartwood of dalbergia odorifera. | three new flavonoids, (3r)-4'-methoxy-2',3,7-trihydroxyisoflavanone (11), 7-methoxy-3,3',4',6-tetrahydroxyflavone (18), and 2',7-dihydroxy-4',5'-dimethoxyisoflavone (22), were isolated from the heartwood of dalbergia odorifera t. chen. (leguminosae), together with twenty-two known compounds, (s)-4-methoxydalbergione (1), cearoin (2), medicarpin (3), formononetin (4), sativanone (5), 3-hydroxy-9-methoxy-coumestan (6), meliotocarpan a (7), isoliquiritigenin (8), stevein (9), liquiritigenin (10), 3 ... | 1998 | 9525107 |
| antioxidant properties of butein isolated from dalbergia odorifera. | the antioxidant properties of butein, isolated from dalbergia odorifera t. chen, were investigated in this study. butein inhibited iron-induced lipid peroxidation in rat brain homogenate in a concentration-dependent manner with an ic50, 3.3+/-0.4 microm. it was as potent as alpha-tocopherol in reducing the stable free radical diphenyl-2-picrylhydrazyl (dpph) with an ic0.200, 9.2+/-1.8 microm. it also inhibited the activity of xanthine oxidase with an ic50, 5.9+/-0.3 microm. besides, butein scave ... | 1998 | 9630680 |
| cardiac effects of salvia miltiorrhiza/dalbergia odorifera mixture, an intravenously applicable chinese medicine widely used for patients with ischemic heart disease in china. | chronotropic, inotropic and coronary vasodilator actions of the clinically available ampoule preparation of salvia miltiorrhiza/dalbergia odorifera mixture were examined using canine isolated, blood-perfused heart preparations. the mixture slightly decreased the sinoatrial rate and significantly increased coronary blood flow, but hardly affected the developed tension of the papillary muscle. the effect on coronary blood flow was induced by at least a 10-fold smaller dose than that which induced ... | 2002 | 11999645 |
| angiogenesis and anti-angiogenesis activity of chinese medicinal herbal extracts. | the aqueous extracts of 24 herbs traditionally used as curing ischemic heart disease in clinic in china were screened for their in vitro angiogenic activity, another twenty-four traditionally used as anti-tumor or anti-inflammatory remedies in china were screened for their in vitro anti-angiogenic activity. the activity of angiogenesis was determined by quantitation of vessels on chick embryo chorioallantoic membrane (cam) model and cell proliferation of cultured bovine aortic endothelial cells ... | 2004 | 15010258 |
| identification and determination of major flavonoids in rat serum by hplc-uv and hplc-ms methods following oral administration of dalbergiaodorifera extract. | the major flavonoids in rat serum after oral administration of dalbergia odorifera extract were analyzed qualitatively and quantitatively by high performance liquid chromatography (hplc) and its coupling to mass spectrometry (hplc-ms). utilizing hplc-ms technique, 18 flavonoids including five isoflavones, four isoflavanones, four neoflavones, two flavanones, two chalcones, one isoflavanonol were identified in free form in serum sample based on comparison with the authentic standards. furthermore ... | 2005 | 16233995 |
| identification and determination of major flavonoids in rat urine by hplc-uv and hplc-ms methods following oral administration of dalbergia odorifera extract. | flavonoids are the main active constituents of dalbergia odorifera. the excretion of the major flavonoids in rat urine after oral administration of d. odorifera extract was investigated by hplc-uv and hplc-ms methods. utilizing the hplc-ms technique, 18 flavonoids, including five isoflavones, four isoflavanones, four neoflavones, two flavanones, two chalcones and one isoflavanonol were identified in free form in a urine sample based on the direct comparison of the corresponding tr, uv maximum ab ... | 2006 | 16252255 |
| co-administration of dalbergia odorifera increased bioavailability of salvia miltiorrhizae in rabbits. | this study was to investigate the effect of dalbergia odorifera (do) on the pharmacokinetics of danshensu in salvia miltiorrhiza (sm) in healthy rabbits and rabbits with qi-stagnancy and blood stasis. thirty two healthy rabbits were involved in the whole experiment. qi-stagnancy and blood stasis rabbits were obtained by treating the limbs of 16 adnephrin rabbits in an ice-bath for 6.0 min. the rest of rabbits were equally divided into 2 healthy groups. one healthy group and 8 qi-stagnancy and bl ... | 2007 | 17963322 |
| secondary metabolites from nonhost plants affect the motility and viability of phytopathogenic aphanomyces cochlioides zoospores. | the motile zoospores of the damping-off pathogen aphanomyces cochlioides aggregate on host plants (e.g., sugar beet, spinach) guided by the host-specific plant signal cochliophilin a before infection. to assess the potential role of secondary metabolites in nonhost resistance, acetone extracts of 200 nonhost traditional medicinal plants from chinese and bangladeshi origins were tested for the motility behaviour of a. cochlioides zoospores using a particle bioassay method. nearly one third of the ... | 2008 | 18533468 |
| bioactive sesquiterpenes isolated from the essential oil of dalbergia odorifera t. chen. | investigation of the essential oil from the heartwood of dalbergia odorifera t. chen afforded the sesquiterpenes 1 and 2, that both showed anti-platelet activity. their backbones were totally the same only with subtle difference in the chiral centre. additionally, antithrombotic and anti-platelet activities of these two compounds were measured. the results showed that the antithrombotic activity of these two compounds was poor, while their anti-platelet activity was strong at middle and high con ... | 2010 | 19969044 |
| yeast α-glucosidase inhibition by isoflavones from plants of leguminosae as an in vitro alternative to acarbose. | in the course of searching for new classes of α-glucosidase inhibitors originated from natural resources, 11 kinds of isoflavones, i.e., medicarpin (1), formononetin (2), mucronulatol (3), (3r)-calussequinone (5), (3r)-5'-methoxyvestitol (6), tectorigenin (7), biochanin a (8), tuberosin (9), calycosin (10), daidzein (11), and genistein (12), as well as a flavone, liquritigenin (4), were isolated as active principles responsible for the yeast α-glucosidase inhibitory activity from two leguminous ... | 2010 | 20734984 |
| antibacterial activity of the flavonoids from dalbergia odorifera on ralstonia solanacearum. | phytohemical investigation on the heartwood of dalbergia odorifera resulted in the isolation of nine flavonoids. their structures were elucidated as sativanone (1), (3r)-vestitone (2), (3r)-2',3',7-trihydroxy-4'-methoxyisoflavanone (3), (3r)-4'-methoxy-2',3,7-trihydroxyisoflavanone (4), carthamidin (5), liquiritigenin (6), isoliquiritigenin (7), (3r)-vestitol (8), and sulfuretin (9) based on their spectral data. all compounds were evaluated for their inhibitory activity against ralstonia solanac ... | 2011 | 22117168 |
| Involvement of heme oxygenase-1 induction in the cytoprotective and immunomodulatory activities of 6,4'-dihydroxy-7-methoxyflavanone in murine hippocampal and microglia cells. | 6,4'-Dihydroxy-7-methoxyflavanone (DMF), a biologically active compound, was isolated from the heartwood of Dalbergia odorifera T. Chen (Leguminosae). The present study proposed to examine the role of DMF as an anti-oxidative and anti-inflammatory heme oxygenase-1 (HO-1) inducer in mouse hippocampal HT22 cells and BV2 microglia cells. The effect of DMF on cell viability was determined by MTT assay and the effects of DMF on pro-inflammatory enzymes and cytokines were analyzed by western blot and ... | 2011 | 22119385 |
| two-way transfer of nitrogen between dalbergia odorifera and its hemiparasite santalum album is enhanced when the host is effectively nodulated and fixing nitrogen. | nutrient translocation from a host plant is vital to the growth and survival of its root parasitic plant, but few studies have investigated whether a parasitic plant is also able to transfer nutrients to its host. the role of n2-fixation in nitrogen (n) transfer between 7-month-old dalbergia odorifera t. chen nodulated with bradyrhizobium elkanii dg and its hemiparasite santalum album linn. was examined by external (15)n labeling in a pot study. four paired treatments were used, with (15)n given ... | 2013 | 23604744 |
| five new sesquiterpenoids from dalbergia odorifera. | five new sesquiterpenes (1-5) along with ten known ones were isolated from the heartwood of dalbergia odorifrea t. chen. their structures were determined by spectroscopic techniques including ms, uv, ir, 1d and 2d nmr. bioassay results showed that compounds 1 and 9 had inhibitory effect on candida albicans, and compound 9 exhibited inhibitory effects on staphylococcus aureus by paper disk diffusion method. | 2014 | 24613800 |
| [chemical constituents of dalbergia odorifera]. | fourteen compounds were isolated from dalbergia odoriferae and purified by repeated column chromatography on silica and sephadex lh-20 gel and structurally identified by spectral analysis. these compounds were identified as 4, 9-dimethoxy-3-hydroxypterocarpan (1), medicarpin (2), 2', 4', 5-trihydroxy-7-methoxyisoflavone (3), 2', 3', 7-trihydroxy-4'-methoxyisoflavan (4), formononetin (5), 3, 8-dihydroxy-9-methoxypterocarpan (6), koparin (7), 3-hydroxy-9-methoxypterocarp-6a-ene (8), 2'-hydroxyform ... | 2014 | 25095373 |
| screening and determination for potential α-glucosidase inhibitory constituents from dalbergia odorifera t. chen using ultrafiltration-lc/esi-ms(n). | in the present study, it was demonstrated that ethyl acetate soluble fraction partitioned from heartwood of dalbergia odorifera t. chen (hef) had a remarkable inhibitory effect on α-glucosidase. therefore hef was selected as a starting material for screening the potential α-glucosidase inhibitors using ultrafiltration liquid chromatography/mass spectrometry (uf-lc/ms). twenty-six compounds were identified with analysis of lc/ms. uf assay indicated that 18 compositions might be α-glucosidase inhi ... | 2013 | 23813551 |
| host-species-dependent physiological characteristics of hemiparasite santalum album in association with n2-fixing and non-n2-fixing hosts native to southern china. | understanding the interactions between the hemiparasite santalum album l. and its hosts has theoretical and practical significance in sandalwood plantations. in a pot study, we tested the effects of two non-n2-fixing (bischofia polycarpa (levl.) airy shaw and dracontomelon duperreranum pierre) and two n2-fixing hosts (acacia confusa merr. and dalbergia odorifera t. chen) on the growth characteristics and nitrogen (n) nutrition of s. album. biomass production of shoot, root and haustoria, n and t ... | 2014 | 25216726 |
| qishenyiqi dropping pill attenuates myocardial fibrosis in rats by inhibiting raas-mediated arachidonic acid inflammation. | in china, qishenyiqi dropping pill (qsdp), a chinese medicine formula containing astragalus membranaceus (fisch.) bunge, salvia miltiorrhiza bunge, panax notoginseng (burkill) f.h.chen and dalbergia odorifera t.c.chen, has been used frequently in traditional folk medicine for treatment of coronary heart diseases (chd) and heart failure (hf). | 2015 | 26590099 |
| a network pharmacology study of chinese medicine qishenyiqi to reveal its underlying multi-compound, multi-target, multi-pathway mode of action. | chinese medicine is a complex system guided by traditional chinese medicine (tcm) theories, which has proven to be especially effective in treating chronic and complex diseases. however, the underlying modes of action (moa) are not always systematically investigated. herein, a systematic study was designed to elucidate the multi-compound, multi-target and multi-pathway moa of a chinese medicine, qishenyiqi (qsyq), on myocardial infarction. qsyq is composed of astragalus membranaceus (huangqi), s ... | 2014 | 24817581 |
| metabolite profiling and pharmacokinetics of herbal compounds following oral administration of a cardiovascular multi-herb medicine (qishen yiqi pills) in rats. | qishen yiqi pills (qy pills) are a type of standardized cardiovascular herbal medicine, which contain four component herbs, i.e., astragalus membranaceus (huangqi), salvia miltiorrhiza (danshen), panax notoginseng (sanqi), and dalbergia odorifera (jiangxiang). after oral administration of qy pills, the in vivo exposure types of each component herb in rats were first uncovered and identified according to a target-directed strategy based on hyphenated chromatography techniques. the dominated metab ... | 2012 | 22292791 |
| 4-parvifuran inhibits metastatic and invasive actions through the jak2/stat3 pathway in osteosarcoma cells. | this study was performed to examine the anticancer and anti-metastatic effects of 4-parvifuran (pvn), a novel flavonoid isolated from the heartwood of dalbergia odorifera, and to study its underlying signaling pathway in human osteosarcoma cells. in the present study, pvn was found to inhibit cell proliferation in a concentration- and time-dependent manner in the human osteosarcoma cell lines studied (mg-63 and u-2 os) and induce apoptosis, as evidenced by annexin v(+) and tunel(+) cells. cleave ... | 2017 | 28386742 |
| cearoin induces autophagy, erk activation and apoptosis via ros generation in sh-sy5y neuroblastoma cells. | neuroblastomas are the most common solid extracranial tumors in childhood. we investigated the anticancer effect of cearoin isolated from dalbergia odorifera in human neuroblastoma sh-sy5y cells. sh-sy5y cells were treated with various doses of cearoin. the viability was measured by mtt assay. dcfda fluorescence assay and griess assay were used for the measurement of intracellular reactive oxygen species (ros) and nitric oxide (no), respectively. western blot analysis was performed to clarify th ... | 2017 | 28178193 |
| metabonomic strategy to the evaluation of chinese medicine salvia miltiorrhiza and dalbergia odorifera interfering myocardial ischemia/reperfusion injury in rats. | extract of salvia miltiorrhiza and dalbergia odorifera (sm-doo) has been traditionally used for the prevention and treatment of cardiovascular diseases. however, information regarding the pharmacodyamic material basis and potential mechanism remain unknown. male sprague-dawley rats were divided into four groups: sham, model, diltiazem, and sm-doo group, n = 6. rats were pretreated with homologous drugs for 7 days, and then subjected to 30 minutes of ischemia followed by 180 minutes of reperfusio ... | 2017 | 28093038 |
| corrigendum to "inhibitory effect of 9-hydroxy-6,7-dimethoxydalbergiquinol from dalbergia odorifera on the nf-кb-related neuroinflammatory response in lipopolysaccharide-stimulated mouse bv2 microglial cells is mediated by heme oxygenase-1" [int immunopharmacol (2013) 828-835]. | | 2016 | 27852515 |
| efficient extraction and preparative separation of four main isoflavonoids from dalbergia odorifera t. chen leaves by deep eutectic solvents-based negative pressure cavitation extraction followed by macroporous resin column chromatography. | in this study, green and efficient deep eutectic solvent-based negative pressure cavitation-assisted extraction (des-npce) followed by macroporous resin column chromatography was developed to extract and separate four main isoflavonoids, i.e. prunetin, tectorigenin, genistein and biochanin a from dalbergia odorifera t. chen leaves. the extraction procedure was optimized systematically by single-factor experiments and a box-behnken experimental design combined with response surface methodology. t ... | 2016 | 27517524 |
| 4-methoxydalbergione suppresses growth and induces apoptosis in human osteosarcoma cells in vitro and in vivo xenograft model through down-regulation of the jak2/stat3 pathway. | although the heartwood of dalbergia odorifera t. chen (leguminosae) is an important source of traditional korean and chinese medicines, the effects of novel compound methoxydalbergione (4-md) isolated from dalbergia odorifera was not reported. herein, we investigated the effects of the 4-md in vitro and in vivo against osteosarcoma cells and its molecular mechanisms. 4-md inhibited the proliferation of osteosarcoma cells and induced apoptosis as evidenced by annexin v + and tunel + cells. this a ... | 2016 | 26755649 |
| 2,4,5-trimethoxyldalbergiquinol promotes osteoblastic differentiation and mineralization via the bmp and wnt/β-catenin pathway. | dalbergia odorifera has been traditionally used as a medicine to treat many diseases. however, the role of 2,4,5-trimethoxyldalbergiquinol (tmdq) isolated and extracted from d. odorifera in osteoblast function and the underlying molecular mechanisms remain poorly understood. the aim of this study was to investigate the effects and possible underlying mechanisms of tmdq on osteoblastic differentiation of primary cultures of mouse osteoblasts as an in vitro assay system. tmdq stimulated osteoblast ... | 2015 | 26181200 |
| qishenyiqi pills, a compound in chinese medicine, protects against pressure overload-induced cardiac hypertrophy through a multi-component and multi-target mode. | the present study aimed to explore the holistic mechanism for the antihypertrophic effect of a compound in chinese medicine, qishenyiqi pills (qsyq) and the contributions of its components to the effect in rats with cardiac hypertrophy (ch). after induction of ch by ascending aortic stenosis, rats were treated with qsyq, each identified active ingredient (astragaloside iv, 3, 4-dihydroxy-phenyl lactic acid or notoginsenoside r1) from its 3 major herb components or dalbergia odorifera, either alo ... | 2015 | 26136154 |
| diverse fungi associated with partial irregular heartwood of dalbergia odorifera. | dalbergia odorifera t. chen is a medium-sized evergreen tree that produces purple-brown heartwood called jiangxiang in traditional chinese medicine, the formation process of which takes several decades. in this study, a standard culture method was used to isolate fungi from the wounded and normal stems of d. odorifera aiming to investigate the difference between the two types of wood. to characterize the spatial colonisation of endophytic fungi, an anatomical study was undertaken using the two d ... | 2015 | 25682752 |
| dalbergia odorifera extract ameliorates uvb-induced wrinkle formation by modulating expression of extracellular matrix proteins. | preclinical research emerging evidence suggests that dalbergia odorifera t. chen (leguminosae), an indigenous medicinal herb, has therapeutic potential. this study examined the antiwrinkle effects of ethanol extracts of d. odorifera in uvb-irradiated human skin cells. ethanol extracts of d. odorifera and thier constituents, dalbergin and sativanone, induced expression of collagen type i and transforming growth factor (tgf)-β1 in human dermal fibroblasts. in hr-1 hairless mice exposed to uvb, the ... | 2015 | 25620496 |
| ethanol extract of dalbergia odorifera protects skin keratinocytes against ultraviolet b-induced photoaging by suppressing production of reactive oxygen species. | dalbergia odorifera t. chen (leguminosae), an indigenous medicinal herb, has been widely used in northern and eastern asia to treat diverse diseases. here, we investigated the anti-senescent effects of ethanolic extracts of dalbergia odorifera (eedo) in ultraviolet (uv) b-irradiated skin cells. eedo significantly inhibited uvb-induced senescence of human keratinocytes in a concentration-dependent manner, concomitant with inhibition of reactive oxygen species (ros) generation. uvb-induced increas ... | 2015 | 25560618 |
| three new phenolic compounds from dalbergia odorifera. | three new phenolic compounds (1-3) were isolated from the heartwood of dalbergia odorifera t. chen. (leguminosae). their structures were established based on spectroscopic methods including 1d and 2d nmr (hsqc, cosy, hmbc and roesy). compound 2 exhibited cytotoxicity against bel-7402 tumor cell lines. | 2014 | 25483266 |
| [cryopreservation study on seeds and embryos in dalbergia odorifera]. | the mature seeds and excised embryos of dalbergia odorifera were used as materials to study the effect of moisture content on their survival, as well as the effect of rapid freezing and vitrification freezing method on seeds and in vitro embryos cryopreservation. the results showed that the germination rate and vigor decreased from 82.67%, 85% to 18.35%, 25% respectively, when the seed moisture content decreased from 15.04% to 8.14%; and the germination rate decreased from 82.67% to 37.50%, 25.3 ... | 2014 | 25244756 |
| 9-hydroxy-6,7-dimethoxydalbergiquinol inhibits osteoclast differentiation through down-regulation of akt, c-fos and nfatc1. | recently, natural plant-derived products have been recognized as one of the main sources for drug discovery and development in human disease. 9-hydroxy-6,7-dimethoxydalbergiquinol (hddq) isolated from the heart wood of dalbergia odorifera is widely used in oriental medicine, however, the pharmacological effect of hddq in osteoclast-associated diseases remains unknown. in this study, hddq dose-dependently inhibited the early stage of rankl-mediated osteoclast differentiation in bone marrow macrop ... | 2014 | 24630975 |
| arylbenzofuran isolated from dalbergia odorifera suppresses lipopolysaccharide-induced mouse bv2 microglial cell activation, which protects mouse hippocampal ht22 cells death from neuroinflammation-mediated toxicity. | neuroinflammation is a key mechanism against infection, injury, and trauma in the central nervous system (cns). the heartwood of dalbergia odorifera t. chen is an important source of traditional korean and chinese medicines. (2r, 3r)-obtusafuran (1) and isoparvifuran (2) are arylbenzofuran compounds isolated from d. odorifera. this study determined the efficacy of (1) and (2) in modulating the regulation of anti-inflammatory activity through the upregulation of heme oxygenase (ho)-1 in bv2 micro ... | 2014 | 24485892 |
| the neoflavonoid latifolin isolated from meoh extract of dalbergia odorifera attenuates inflammatory responses by inhibiting nf-κb activation via nrf2-mediated heme oxygenase-1 expression. | in korea and china, the heartwood of dalbergia odorifera t. chen is an important traditional medicine used to treat blood disorders, ischemia, swelling, and epigastric pain. in this study, we investigated the inhibitory effects of latifolin, a major neoflavonoid component isolated from the meoh extract of d. odorifera, on the inflammatory reaction of thioglycollate-elicited peritoneal macrophages exposed to lipopolysaccharide, with a particular focus on heme oxygenase-1 (ho-1) expression and nuc ... | 2014 | 24474433 |
| fisetin inhibits matrix metalloproteinases and reduces tumor cell invasiveness and endothelial cell tube formation. | matrix metalloproteinases (mmps) play an important role in tissue remodeling during normal physiological situations and pathological implications such as tumor invasion and metastasis. mmp inhibitors were screened from extracts of medicinal herbs by an enzymatic assay using the mmp-14 catalytic domain. among samples tested, a methanol extract of the root of dalbergia odorifera t. chen (leguminosae) showed the strongest inhibitory activity. the inhibitory component was purified through fractionat ... | 2013 | 24099040 |
| inhibitory effect of 9-hydroxy-6,7-dimethoxydalbergiquinol from dalbergia odorifera on the nf-κb-related neuroinflammatory response in lipopolysaccharide-stimulated mouse bv2 microglial cells is mediated by heme oxygenase-1. | the heartwood of dalbergia odorifera t. chen (leguminosae) is an important source of traditional korean and chinese medicines. 9-hydroxy-6,7-dimethoxydalbergiquinol (hddq), a compound isolated from d. odorifera, has various biological activities. the aim of this study was to determine the efficacy of hddq in modulating the regulation of anti-inflammatory activity through the upregulation of heme oxygenase (ho)-1 in bv2 microglia. hddq inhibited the protein expression of inducible nitric oxide sy ... | 2013 | 24055019 |
| [anti-inflammation of flavonoid compounds from dalbergia odorifera t. chen in lipopolysaccharide stimulated raw264.7 macrophages]. | to screen, isolate and identify the compounds with anti-inflammatory activity from dalbergia odorifera t. chen. | 2013 | 23837974 |
| [chromatographic evaluation of multi-mode retention behavior of thiol-ene click chemistry based beta-cyclodextrin stationary phase]. | a native beta-cyclodextrin (beta-cd) stationary phase was prepared by covalent bonding of beta-cd on silica particles via thiol-ene click chemistry. the resulting beta-cd bonded silica (click te-cd) was characterized by elemental analysis, which proved the successful immobilization of beta-cd on the silica support with thiol-ene click chemistry. click te-cd was chromatographically evaluated with a set of flavone glycosides under hydrophilic interaction chromatography (hilic) mode, reversed-phase ... | 2013 | 23785988 |
| inhibitory constituents of the heartwood of dalbergia odorifera on nitric oxide production in raw 264.7 macrophages. | two new isoflavanones (1 and 13), along with 25 known compounds (2-12, 14-27), were isolated from the etoac-soluble fraction of the heartwood of dalbergia odorifera by following their potential to inhibit the lps-induced nitric oxide production in raw 264.7 cells. the structures of the isolated compounds were established by spectroscopic data such as (1)d, (2)d nmr and ms spectrometry. among the isolated compounds, (2s)-pinocembrin (26), showed the most potent inhibitory effect with ic50 value o ... | 2013 | 23743282 |
| 4,2',5'-trihydroxy-4'-methoxychalcone from dalbergia odorifera exhibits anti-inflammatory properties by inducing heme oxygenase-1 in murine macrophages. | dalbergia odorifera t. chen (leguminosae) has traditionally been used as an ingredient in east asian medicines to treat various diseases. in the present study, 4,2',5'-trihydroxy-4'-methoxychalcone (tmc), a biologically active chalcone isolated from the heartwood of d. odorifera, inhibited cyclooxygenase-2 (cox-2) and inducible nitric oxide synthase (inos) expression, leading to a reduction in cox-2-induced prostaglandin e2 (pge2) and inos-induced nitric oxide (no) production in lipopolysacchari ... | 2013 | 23566812 |
| 6,4'-dihydroxy-7-methoxyflavanone inhibits osteoclast differentiation and function. | 6,4'-dihydroxy-7-methoxyflavanone (dmf) is a flavonoid isolated from heartwood dalbergia odorifera. it has been known that dmf has antioxidant, anti-inflammatory and neuroprotective effects. dmf, however, the efficacy of bone related diseases has not been reported. in this study, we determined dmf's efficacy on osteoclasts differentiation and function using in vitro bone marrow macrophage osteoclast differentiation culture system. dmf inhibited receptor activators of nuclear factor kappa-b ligan ... | 2013 | 23420617 |
| a systems biology approach to understanding the mechanisms of action of chinese herbs for treatment of cardiovascular disease. | traditional chinese medicine (tcm) involves a broad range of empirical testing and refinement and plays an important role in the health maintenance for people all over the world. however, due to the complexity of chinese herbs, a full understanding of tcm's action mechanisms is still unavailable despite plenty of successful applications of tcm in the treatment of various diseases, including especially cardiovascular diseases (cvd), one of the leading causes of death. thus in the present work, by ... | 2012 | 23202964 |
| [analyze on chemical compositions of dalbergia odorifera essential oils extracted by co2-supercritical-fluid-extraction and steam distillation extraction]. | to analyze the chemical compositions of dalbergia odorifera essential oils extacted by co2-supercritical-fluid-extraction (sfe-co2) and steam distillation extraction (sd). | 2011 | 22506398 |
| selective separation of flavonoid glycosides in dalbergia odorifera by matrix solid-phase dispersion using titania. | dalbergia odorifera contains high concentrations of flavonoid aglycones and trace flavonoid glycosides. in this study, trace flavonoid glycosides were separated from d. odorifera by titania with matrix solid-phase dispersion (mspd). before the mspd experiment, four standards, including two isoflavone glycosides (genistin and formononetin-8-c-apiosyl (1-6)-glucoside) and their aglycones (genistein and formononetin), were used to compare their retention on a titania column. the effect of acetonitr ... | 2011 | 21491599 |
| a new method for chemical identification based on orthogonal parallel liquid chromatography separation and accurate molecular weight confirmation. | recent advances in the theory and application of orthogonal lc separation have allowed for the establishment of a more effective method for the chemical identification of target compounds in complex samples, especially structurally similar compounds. in this study, a new chemical identification method based on orthogonal parallel separation and accurate molecular weight confirmation was developed. an orthogonal separation system consisting of an xterra ms c(18) column, a home-made click oeg colu ... | 2011 | 21333299 |
| purification of compounds from lignum dalbergia odorifera using two-dimensional preparative chromatography with click oligo (ethylene glycol) and c18 column. | purification of compounds from traditional chinese medicines (tcms) is an important task for understanding the chemical composition of tcms. however, it is difficult to obtain compounds with high enough purity for identification by nmr due to the complexity of tcms in chemical composition. in this study, a two-dimensional purification method based on a click oligo (ethylene glycol) column and a c18 column was developed to realize an orthogonal separation in preparative level for purifying compou ... | 2011 | 21268253 |
| cyclic electron flow plays an important role in photoprotection of tropical trees illuminated at temporal chilling temperature. | our previous study indicated that psii is more sensitive to chilling and light stress than psi in tropical trees, and erythrophleum guineense is more sensitive to chilling stress than dalbergia odorifera and khaya ivorensis, but the underlying physiological mechanisms are unclear. although recent studies have reported that cyclic electron flow (cef) plays an important role in photoprotection, the role of cef in protecting psi and psii of tropical tree species remains unclear. we investigated the ... | 2011 | 21062868 |
| stimulation of cyclic electron flow during recovery after chilling-induced photoinhibition of psii. | although cyclic electron flow (cef) is essential for repair of psii, it is unclear whether the cef is stimulated and what the role of stability of psi is during the recovery. in order to explore these two questions, mature leaves of dalbergia odorifera were treated with the chilling temperature of 4°c under a photosynthetic flux density (pfd) of 650 μmol m(-2) s(-1) for 2 h and then were transferred to 25°c under a pfd of 100 μmol m(-2) s(-1) for recovery. the maximum quantum yield of psii (f(v) ... | 2010 | 20861006 |
| off-line 2-d rplc/rplc method for separation of components in dalbergia odorifera t. chen. | an off-line 2-d rplc/rplc system incorporating a beta-cd based column and a beh c18 column was developed in the separation of components in dalbergia odorifera t. chen. (jiang xiang). both orthogonality and van deemter curves of the two columns were investigated. the orthogonality was about 57%, which was evaluated with 40 standard solutes. optimized column efficiency could be achieved under optimal linear velocity (0.04 cm/s) on the cd column or under high linear velocity (0.32 cm/s) on the beh ... | 2010 | 20235132 |
| the different effects of chilling stress under moderate light intensity on photosystem ii compared with photosystem i and subsequent recovery in tropical tree species. | tropical plants are sensitive to chilling temperatures above zero but it is still unclear whether photosystem i (psi) or photosystem ii (psii) of tropical plants is mainly affected by chilling temperatures. in this study, the effect of 4 degrees c associated with various light densities on psii and psi was studied in the potted seedlings of four tropical evergreen tree species grown in an open field, khaya ivorensis, pometia tomentosa, dalbergia odorifera, and erythrophleum guineense. after 8 h ... | 2010 | 20221850 |
| [study on the preparation process of inclusion complex of volatile oil of dalbergia odorifera-beta-cyclodextrin]. | to study the optimum preparation process of the volatile oil of dalbergia odorifera-beta-cyclodextrin. | 2009 | 19445135 |
| isoliquiritigenin, from dalbergia odorifera, up-regulates anti-inflammatory heme oxygenase-1 expression in raw264.7 macrophages. | isoliquiritigenin (isl), one of the major constituents of dalbergia odorifera t. chen (leguminosae), is reported to exert anti-inflammatory effects, but the relevant anti-inflammatory mechanisms are not completely understood. heme oxygenase-1 (ho-1) has been proven to be involved in the resolution of inflammatory responses. in this study, we investigated whether isl could induce ho-1 expression in raw264.7 macrophages, and if so, whether ho-1 could mediate the anti-inflammatory effects of isl. | 2009 | 19169644 |
| flavonoids from the heartwood of dalbergia odorifera and their protective effect on glutamate-induced oxidative injury in ht22 cells. | two flavonoids, 4,2',5'-trihydroxy-4'-methoxychalcone (1) and (2s)-6,7,4'-trihydroxyflavan (2), along with fourteen known flavonoids and two other known arylbenzofurans were isolated from the heartwood of dalbergia odorifera. the structure of compounds 1 and 2 were established by spectroscopic (nmr and ms) analyses. of the isolates, eight compounds (1, 4, 7, 10, 12, 14, 15, 17) were found to have potent protective effect on glutamate-induced oxidative injury in ht22 cells. | 2008 | 19043246 |
| [chromatographic fingerprint of dalbergia odorifera and its application in the identification of the crude drugs of different origins]. | to establish the method of hplc-fingerprint analysis for the quality control of dalbergia odorifera and identify its main constituents by hplc-ms. | 2005 | 16499085 |
| [determination of nerolidol in volatile oil of dalbergia odorifera by gc]. | to develop a method for determination of nerolidol in the volatile oil of dalbergia odorifera. | 2005 | 16124604 |
| simultaneous determination of 10 major flavonoids in dalbergia odorifera by high performance liquid chromatography. | a reversed-phase liquid chromatographic method was developed for the simultaneous quantification of 10 major flavonoids, namely butin, (3r)-4'-methoxy-2',3,7-trihydroxyisoflavanone, liquiritigenin, melanettin, violanone, vistitone, formononetin, dalbergin, sativanone and medicarpin in the heartwood of dalbergia odorifera, an important traditional chinese medicine. samples were extracted with 60% methanol. the optimal conditions of separation and detection were achieved on an agilent zorbax sb-c1 ... | 2005 | 15935596 |
| liquid chromatography/electrospray ionization mass spectrometry for the characterization of twenty-three flavonoids in the extract of dalbergia odorifera. | a method incorporating high-performance liquid chromatography (hplc) with electrospray ionization and tandem mass spectrometry, with parallel analysis by hplc with uv detection using a diode-array detector, was developed for the qualitative characterization of flavonoids in d. odorifera. twenty-three flavonoids, including six isoflavones, six neoflavones, four isoflavanones, three flavanones, two chalcones, one isoflavanonol and one pterocarpan, were unambiguously identified by comparing their r ... | 2005 | 15880612 |
| [studies on the chemical constituents of the essential oil from the leaves of dalbergia odorifera t. chen]. | to study the constituents of the essential oil from the leaves of dalbergia odorifera t. chen. | 2004 | 15850354 |
| [a study on the quality of various species of dalbergia]. | the content and main components of volatile oil and the content of totalflavone in various species of dalbergia (da) are studied by steam-distillation, gas chromatography-mas spectroscopy and spectrophotometry. the results show that the content of volatile oil in dalbergia odorifera (do) is 3.61-3.79%, and the content of total flavone is 2.51-5.82%. the content of volatile oil of other species of da is less than 1.50%, their content of total flavone is markedly different from that of do. | 1997 | 12572437 |
| inhibitors of prostaglandin biosynthesis from dalbergia odorifera. | the root heartwood of dalbergia odorifera t. chen (leguminosae) is a chinese medicinal drug (japanese name koshinko) used for a stagnant blood syndrome (stagnation of disordered blood; japanese, oketsu). in addition to 10 known compounds, five new phenolic compounds, isomucronustyrene and hydroxyobtustyrene (cinnamylphenols), (+)-isoduartin (isoflavan), odoriflavene (isoflav-3-ene) and (-)-odoricarpan (pterocarpan) were isolated and their structures were elucidated on the basis of chemical and s ... | 1992 | 1446367 |