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inhibitory effects on hiv-1 protease of tri-p-coumaroylspermidine from artemisia caruifolia and related amides.from a methanol extract of artemisia caruifolia, which showed a moderate inhibitory activity on hiv-1 protease in a preliminary screening, n1,n5,n10-tri-p-coumaroylspermidine and three dicaffeoylquinic acids were isolated. the former compound was found to appreciably inhibit hiv-1 protease. of related amides which were chemically synthesized, n1,n5,n10,n14-tetra-p-coumaroylspermine and n1,n4,n7,n10,n13-penta-p-coumaroylte-traethylenepentamine inhibited hiv-1 protease more potently than n1,n5,n10 ...200111456103
rol genes enhance the biosynthesis of antioxidants in artemisia carvifolia buch.the secondary metabolites of the artemisia genus are well known for their important therapeutic properties. this genus is one of the valuable sources of flavonoids and other polyphenols, but due to the low contents of these important metabolites, there is a need to either enhance their concentration in the original plant or seek alternative sources for them. the aim of the current study was to detect and enhance the yield of antioxidant compounds of artemisia carvifolia buch. hplc analysis was p ...201627251864
genetic transformation of artemisia carvifolia buch with rol genes enhances artemisinin accumulation.the potent antimalarial drug artemisinin has a high cost, since its only viable source to date is artemisia annua (0.01-0.8% dw). there is therefore an urgent need to design new strategies to increase its production or to find alternative sources. in the current study, artemisia carvifolia buch was selected with the aim of detecting artemisinin and then enhancing the production of the target compound and its derivatives. these metabolites were determined by lc-ms in the shoots of a. carvifolia w ...201526444558
rheum emodin inhibits enterovirus 71 viral replication and affects the host cell cycle environment.human enterovirus 71 (ev71) is the primary causative agent of recent large-scale outbreaks of hand, foot, and mouth disease (hfmd) in asia. currently, there are no drugs available for the prevention and treatment of hfmd. in this study, we compared the anti-ev71 activities of three natural compounds, rheum emodin, artemisinin and astragaloside extracted from chinese herbs chinese rhubarb, artemisia carvifolia and astragalus, respectively, which have been traditionally used for the treatment and ...201727840410
triterpenes and lignans from artemisia caruifolia and their cytotoxic effects on meth-a and llc tumor cell lines.one new triterpene, 3beta-hydroxy-29-norcycloart-24-one (1), and four new lignans, caruilignans (2-5), together with six known compounds were isolated from the aerial part of artemisia caruifolia buch.-ham. ex toxb. their structures were determined by various spectroscopic means. most of the isolated lignans were moderately cytotoxic to meth-a cells with ed50 values of 5-10 microg/ml, but not to lowis lung carcinoma (llc) cells. an oxime derivative of 1 showed more potent cytotoxic activity agai ...200111217106
guaiane dimers and germacranolide from artemisia caruifolia.one new germacranolide (named caruifolin a) and three new guaiane dimers (caruifolins b-d), together with six known compounds, were isolated from the aerial parts of artemisia caruifolia. the structures were determined by chemical and spectroscopic methods.200011141102
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