| in vitro anti-influenza virus activity of the pavine alkaloid (-)-thalimonine isolated from thalictrum simplex l. | the pavine alkaloid (-)-thalimonine (thl), isolated from the mongolian plant thalictrum simplex inhibited markedly the reproduction of influenza virus a/germany/27, str. weybridge (h7n7) and a/germany/34, str. rostock (h7n1) in cell cultures of chicken embryo fibroblasts. in a number of assays at a non-toxic concentration range of 0.1-6.4 microm the alkaloid inhibited viral reproduction in a selective and specific way (selectivity index = 640, 106.6, respectively). expression of viral glycoprote ... | 2003 | 12856918 |
| two new pavine alkaloids from thalictrum simplex. | two new pavine alkaloids (-)-2-demethylthalimonine and (-)-9-demethylthalimonine together with the known argemonine have been isolated from the aerial parts of thalictrum simplex widespead in mongolia. the structures have been elucidated on the basis of ir, ei-ms, and (1)h-nmr analyses as well as chemical transformation, respectively. | 1993 | 17235968 |