| isolation and characterization of whitewater arroyo virus, a novel north american arenavirus. | rodents are principal hosts for each of the well-characterized arenaviruses. prior to the present study, tamiami (tam) virus was the sole arenavirus known to be indigenous to north america; it has been isolated only from southern florida where its primary host is the cotton rat sigmodon hispidus. recently, arenavirus antibody was found in neotoma albigula woodrats collected from the southwestern united states. the purpose of the present study was to isolate and characterize the arenavirus associ ... | 1996 | 8862405 |
| experimental infection of neotoma albigula (muridae) with whitewater arroyo virus (arenaviridae). | the whitewater arroyo virus (wwa) is a newly described north american arenavirus. the purpose of this study was to elucidate the biology of this virus in its natural rodent host, neotoma albigula (white-throated woodrat). thirteen adult, 7 juvenile, and 8 newborn woodrats each were inoculated subcutaneously with 1,000 cell culture infectious dose50 of the wwa virus prototype strain av 9310135. all 28 animals became infected (as measured by the recovery of infectious virus and/or seroconversion) ... | 2001 | 11508391 |
| phylogeny of new world arenaviruses based on the complete coding sequences of the small genomic segment identified an evolutionary lineage produced by intrasegmental recombination. | previous studies suggested that the small genomic segments (s-rna) of the south american arenaviruses (sa-avs) represent three phylogenetic lineages (designated a, b, and c) and indicated that the s-rna of whitewater arroyo virus (wwav) (a north american arenavirus [na-av]) is a product of genetic recombination between a lineage a and lineage b virus. the purpose of this study was to extend our knowledge on the phylogenetic relationships between wwav, the two other na-avs (tamiami and bear canyo ... | 2002 | 12207889 |
| human and host species transferrin receptor 1 use by north american arenaviruses. | at least five new world (nw) arenaviruses cause hemorrhagic fevers in south america. these pathogenic clade b viruses, as well as nonpathogenic arenaviruses of the same clade, use transferrin receptor 1 (tfr1) of their host species to enter cells. pathogenic viruses are distinguished from closely related nonpathogenic ones by their additional ability to utilize human tfr1 (htfr1). here, we investigate the receptor usage of north american arenaviruses, whose entry proteins share greatest similari ... | 2014 | 24920811 |