| comparative sequence analysis of mycobacterium leprae and the new leprosy-causing mycobacterium lepromatosis. | mycobacterium lepromatosis is a newly discovered leprosy-causing organism. preliminary phylogenetic analysis of its 16s rrna gene and a few other gene segments revealed significant divergence from mycobacterium leprae, a well-known cause of leprosy, that justifies the status of m. lepromatosis as a new species. in this study we analyzed the sequences of 20 genes and pseudogenes (22,814 nucleotides). overall, the level of matching of these sequences with m. leprae sequences was 90.9%, which subst ... | 2009 | 19633074 |
| characterization of mycobacterium leprae genotypes in china--identification of a new polymorphism c251t in the 16s rrna gene. | leprosy continues to be prevalent in some mountainous regions of china, and genotypes of leprosy strains endemic to the country are not known. mycobacterium lepromatosis is a new species that was discovered in mexico in 2008, and it remains unclear whether this species exists in china. here, we conducted pcr- restriction fragment length polymorphism (rflp) analysis to classify genotypes of 85 dna samples collected from patients from 18 different provinces. all 171 dna samples from skin biopsies ... | 2015 | 26196543 |
| new findings in the pathogenesis of leprosy and implications for the management of leprosy. | this review focuses on recent work in leprosy pathogenesis. new research of both innate and adaptive immune responses to mycobacterium leprae is described. the proposition that mycobacterium lepromatosis is a new species causing leprosy is discussed. | 2013 | 23982232 |
| severe leprosy reactions due to mycobacterium lepromatosis. | leprosy is caused by the well-known mycobacterium leprae and the newly discovered m lepromatosis. here, the authors describe 2 cases of leprosy with unusual clinical presentation caused by m lepromatosis. the patients, a 32-year-old man and a 50-year-old woman, both of mexican origin, manifested high fever, lymphadenopathy and florid skin lesions in the form of erythema nodosum and lucio's phenomenon as the first clinical presentation. heavy infiltration of acid-fast bacilli was identified in th ... | 2013 | 23111393 |
| mycobacterium leprae: pathogenic agent in leprosy. discovery of new species mycobacterium lepromatosis. perspectives in research and diagnosis of leprosy. | m. leprae was presumed as an aetiologic agent in dll, without specific microbiologic studios in the past. the sequencing of the genome through genetic testing led to the discovery of a new species m. lepromatosis by han et al. in 2008. | 2012 | 24595978 |
| on the age of leprosy. | leprosy is a chronic infection of the skin and nerves caused by mycobacterium leprae and the newly discovered mycobacterium lepromatosis. human leprosy has been documented for millennia in ancient cultures. recent genomic studies of worldwide m. leprae strains have further traced it along global human dispersals during the past ∼ 100,000 years. because leprosy bacilli are strictly intracellular, we wonder how long humans have been affected by this disease-causing parasite. based on recently publ ... | 2014 | 24551248 |
| analysis of the leprosy agents mycobacterium leprae and mycobacterium lepromatosis in four countries. | to differentiate the leprosy agents mycobacterium leprae and mycobacterium lepromatosis and correlate them with geographic distribution and clinicopathologic features. | 2014 | 25239420 |
| bone changes in an italian ancient human skeleton--possibly caused by leprosy. | leprosy is an infectious disease caused by mycobacterium leprae and mycobacterium lepromatosis. in the last stage it can afflict the skeleton with a series of specific and non-specific bone changes. the possibility of studyingthe skeleton of an individual who lived in the pre-antibiotic era (roman period) with skeletal changes in the rhino-maxillary region and hand and foot bones, permitted skeletal lesions to be analyzed directly. in addition, the localization and the complexity of the bony les ... | 2016 | 27506007 |
| draft genome sequence of new leprosy agent mycobacterium lepromatosis. | mycobacterium lepromatosis is a newly discovered cause of leprosy. here, we present a near-complete genome of m. lepromatosis from strain fj924 obtained from a patient who died of leprosy. the genome contained 3,215,823 nucleotides and matched ~87% with the mycobacterium leprae genome. this genome is likely the smallest of all mycobacterial genomes known to date. | 2015 | 25999555 |
| leprosy agents mycobacterium lepromatosis and mycobacterium leprae in mexico: a clarification. | | 2015 | 26224842 |
| diffuse lepromatous leprosy due to mycobacterium lepromatosis in quintana roo, mexico. | a 43-year-old woman of mayan origin from quintana roo, mexico, was diagnosed with diffuse lepromatous leprosy. the etiologic bacillus was determined to be mycobacterium lepromatosis instead of mycobacterium leprae. this case likely represents the first report of this leprosy form and its agent in the southeastern tip of mexico. | 2015 | 26311856 |
| soil-transmitted helminth infections and leprosy: a cross-sectional study of the association between two major neglected tropical diseases in indonesia. | the clinical spectrum of leprosy is dependent on the host immune response against mycobacterium leprae or the newly discovered mycobacterium lepromatosis antigen. helminth infections have been shown to affect the development of several diseases through immune regulation and thus may play a role in the clinical manifestations of leprosy and leprosy reactions. the purpose of this study is to determine the proportion of helminth infections in leprosy and its association with the type of leprosy and ... | 2016 | 27278453 |
| mutations in the drug resistance-determining region of mycobacterium lepromatosis isolated from leprosy patients in mexico. | mycobacterium lepromatosis, an independent species from mycobacterium leprae, has been found to be a causative agent for diffuse lepromatous leprosy (dll) in mexico, but remains poorly studied. here, the drug resistance-determining regions (drdr) of folp1, rpob and gyra (conferring resistance to dapsone, rifampicin and quinolone, respectively) in m. lepromatosis from leprosy patients in mexico were characterized. no mutations or silent mutations were found at previously characterized major sites ... | 2016 | 27345334 |
| red squirrels in the british isles are infected with leprosy bacilli. | leprosy, caused by infection with mycobacterium leprae or the recently discovered mycobacterium lepromatosis, was once endemic in humans in the british isles. red squirrels in great britain (sciurus vulgaris) have increasingly been observed with leprosy-like lesions on the head and limbs. using genomics, histopathology, and serology, we found m. lepromatosis in squirrels from england, ireland, and scotland, and m. leprae in squirrels from brownsea island, england. infection was detected in overt ... | 2016 | 27846605 |
| identification of the leprosy agent mycobacterium lepromatosis in singapore. | background: a new leprosy-causing species, namely mycobacterium lepromatosis, was discovered recently to be the cause of diffuse lepromatous leprosy (dll) in mexico. it is unknown whether this organism exists beyond mexico. methods: we sought to determine the identity of the mycobacteria in the skin tissue of two patients from singapore who died of dll. dna was extracted from archived biopsy tissue, and conserved polymerase chain reaction primers were used to amplify and sequence two to three my ... | 2012 | 22270197 |
| what is the evidence that the putative mycobacterium lepromatosis species causes diffuse lepromatous leprosy? | han et al. have made a retrospective isolation of dna from two patients with fatal lucio's phenomenon. this dna does have some molecular differences to m. leprae and may constitute a variant of m. leprae. however the experiments and data needed to confirm that this is a new leprosy-causing species have not yet been done. we have outlined the work that does need to be done. for the moment the assertion that 'm. lepromatosis' is a new leprosy-causing species is not proven. | 2011 | 22125927 |
| a new mycobacterium species causing diffuse lepromatous leprosy. | mycobacterium leprae causes leprosy. m leprae strains collected worldwide have been genetically clonal, which poorly explains the varying severity and clinical features of the disease. we discovered a new mycobacterium species from 2 patients who died of diffuse lepromatous leprosy (dll). the mycobacterium was purified from heavily infected, freshly frozen autopsy liver tissue followed by dna extraction in 1 case. paraffin-embedded skin tissue was used for dna extraction in another case. six gen ... | 2008 | 19019760 |
| feline leprosy due to candidatus 'mycobacterium lepraefelis': further clinical and molecular characterisation of eight previously reported cases and an additional 30 cases. | this paper, the last in a series of three on 'feline leprosy', provides a detailed description of disease referable to the previously unnamed species, candidatus 'mycobacterium lepraefelis', a close relative of the human pathogens mycobacterium leprae and mycobacterium lepromatosis. | 2017 | 28838294 |
| leprosy-like illness in a patient with mycobacterium lepromatosis from ontario, canada. | here we present the first case of a patient from ottawa canada, presenting with leprosy-like illness associated with mycobacterium lepromatosis. the patient had no history of travel to leprosy-endemic areas or any obvious risk factors. clinically, the patient presented with an anesthetic maculopapular rash on the trunk, back, and extremities. a skin biopsy of a lesion revealed a dermal lymphohistiocytic infiltration involving the vessels with an inflammatory process extending to the nerves. a ne ... | 2012 | 22270208 |
| mycobacterium lepromatosis: emerging strain or species? | | 2012 | 22402645 |
| mycobacterium lepromatosis infections in nuevo león, mexico. | the frequency of infection caused by the recently described pathogen mycobacterium lepromatosis is unknown. here, we describe the demographics, clinical characteristics, and therapeutic outcomes of five lepromatous leprosy patients suffering from m. lepromatosis infection in nuevo léon, mexico. diagnosis was facilitated by a new highly specific pcr procedure. | 2015 | 25809978 |
| failure to detect mycobacterium lepromatosis as a cause of leprosy in 85 chinese patients. | | 2015 | 26261139 |
| "lucio's phenomenon" associated with mycobacterium lepromatosis. | | 2016 | 26936990 |
| two cases of leprosy in siblings caused by mycobacterium lepromatosis and review of the literature. | we describe two leprosy cases in mexican siblings caused by a new species mycobacterium lepromatosis this is likely the first report of family clustering of this infection. the patients showed severe prolonged leprosy reactions after antimicrobial treatment, raising a challenge for clinical management. the current status of m. lepromatosis infection is reviewed. | 2016 | 27402522 |
| infection with mycobacterium lepromatosis. | | 2016 | 27430540 |
| detection of the leprosy agent mycobacterium lepromatosis in south america and europe. | | 2017 | 27879462 |
| the leprosy agents mycobacterium lepromatosis and mycobacterium leprae in mexico. | mycobacterium leprae was the only known cause of leprosy until 2008, when a new species, named mycobacterium lepromatosis, was found to cause diffuse lepromatous leprosy (dll), a unique form of leprosy endemic in mexico. | 2012 | 22788812 |
| insight into the evolution and origin of leprosy bacilli from the genome sequence of mycobacterium lepromatosis. | mycobacterium lepromatosis is an uncultured human pathogen associated with diffuse lepromatous leprosy and a reactional state known as lucio's phenomenon. by using deep sequencing with and without dna enrichment, we obtained the near-complete genome sequence of m. lepromatosis present in a skin biopsy from a mexican patient, and compared it with that of mycobacterium leprae, which has undergone extensive reductive evolution. the genomes display extensive synteny and are similar in size (∼3.27 mb ... | 2015 | 25831531 |
| Case of Diffuse Lepromatous Leprosy Associated with "Mycobacterium lepromatosis". | An 86-year-old female patient from northeast Mexico presented with diffuse lepromatous leprosy (DLL). Sequence analysis of four genes (rrs, rpoB, sigA, and hsp65) from the skin biopsy specimen identified "Mycobacterium lepromatosis." This is the first independent confirmation of a case of DLL due to M. lepromatosis. | 2011 | 22012006 |