| characterization of imjin virus, a newly isolated hantavirus from the ussuri white-toothed shrew (crocidura lasiura). | until recently, the single known exception to the rodent-hantavirus association was thottapalayam virus (tpmv), a long-unclassified virus isolated from the asian house shrew (suncus murinus). robust gene amplification techniques have now uncovered several genetically distinct hantaviruses from shrews in widely separated geographic regions. here, we report the characterization of a newly identified hantavirus, designated imjin virus (mjnv), isolated from the lung tissues of ussuri white-toothed s ... | 2009 | 19357167 |
| genetic diversity of imjin virus in the ussuri white-toothed shrew (crocidura lasiura) in the republic of korea, 2004-2010. | recently, imjin virus (mjnv), a genetically distinct hantavirus, was isolated from lung tissues of the ussuri white-toothed shrew (crocidura lasiura) captured near the demilitarized zone in the republic of korea. to clarify the genetic diversity of mjnv, partial m- and l-segment sequences were amplified from lung tissues of 12 of 37 (32.4%) anti-mjnv igg antibody-positive ussuri white-toothed shrews captured between 2004 and 2010. a 531-nucleotide region of the m segment (coordinates 2,255 to 2, ... | 2011 | 21303516 |
| a new subtype of thottapalayam virus carried by the asian house shrew (suncus murinus) in china. | recently, many novel hantavirus species carried by insectivore had been found. in order to know whether the insectivore-associated hantaviruses exist in china, asian house shrew (suncus murinus) were analyzed for the presence of hantaviruses. 362 asian house shrews were captured in wenzhou of zhejiang province. hantavirus-specific rna was detected by rt-pcr in lung tissue samples of six shrews. the complete hantavirus s and m segment sequences and also partial l segment sequences were successful ... | 2011 | 21801855 |
| molecular evolution of azagny virus, a newfound hantavirus harbored by the west african pygmy shrew (crocidura obscurior) in cote d'ivoire. | abstract: background: tanganya virus (tgnv), the only shrew-associated hantavirus reported to date from sub-saharan africa, is harbored by the therese's shrew (crocidura theresae), and is phylogenetically distinct from thottapalayam virus (tpmv) in the asian house shrew (suncus murinus) and imjin virus (mjnv) in the ussuri white-toothed shrew (crocidura lasiura). the existence of myriad soricid-borne hantaviruses in eurasia and north america would predict the presence of additional hantaviruses ... | 2011 | 21798050 |
| detection of imjin virus and seoul virus in crocidurine shrews in shandong province, china. | recently, hantaviruses have been discovered in insectivores in europe, asia, africa, and north america. imjin virus (mjnv) was first isolated from the lung tissues of ussuri white-toothed shrew (crocidura lasiura) from south korea in 2009. we aim to detect the species and prevalence of insectivore- and rodent-borne hantaviruses in shrews and rodents. | 2017 | 28287930 |
| hantaan virus surveillance targeting small mammals at nightmare range, a high elevation military training area, gyeonggi province, republic of korea. | rodent-borne disease surveillance was conducted at nightmare range (nm-r), near the demilitarized zone in northeast gyeonggi province, republic of korea, to identify hemorrhagic fever with renal syndrome (hfrs) risks for a mountainous high-elevation (500 m) military training site. monthly surveys were conducted from january 2008-december 2009. a total of 1,720 small mammals were captured belonging to the orders rodentia [families, sciuridae (1 species) and muridae (7 species)] and soricomorpha [ ... | 2015 | 25874643 |
| hantaviruses induce antiviral and pro-inflammatory innate immune responses in astrocytic cells and the brain. | although hantaviruses are not generally considered neurotropic, neurological complications have been reported occasionally in patients with hemorrhagic fever renal syndrome (hfrs). in this study, we analyzed innate immune responses to hantavirus infection in vitro in human astrocytic cells (a172) and in vivo in suckling icr mice. infection of a172 cells with pathogenic hantaan virus (htnv) or a novel shrew-borne hantavirus, known as imjin virus (mjnv), induced activation of antiviral genes and p ... | 2014 | 24937036 |
| biodiversity and evolution of imjin virus and thottapalayam virus in crocidurinae shrews in zhejiang province, china. | the recent discovery of numerous hantaviruses in insectivores has provided a new view of hantavirus biodiversity and evolution. to determine the presence and genetic diversity of imjin virus (mjnv) and thottapalayam virus (tpmv) in insectivores in zhejiang province, china, we captured and performed virus screening of 32 ussuri white-toothed shrews (crocidura lasiura) and 105 asian house shrews (suncus murinus) in different coastal regions. hantavirus genome (s, m, and l segments) sequences were ... | 2014 | 24874196 |
| distinct innate immune responses in human macrophages and endothelial cells infected with shrew-borne hantaviruses. | although hantaviruses have been previously considered as rodent-borne pathogens, recent studies demonstrate genetically distinct hantaviruses in evolutionarily distant non-rodent reservoirs, including shrews, moles and bats. the immunological responses to these newfound hantaviruses in humans are unknown. we compared the innate immune responses to imjin virus (mjnv) and thottapalayam virus (tpmv), two shrew-borne hantaviruses, with that toward two rodent-borne hantaviruses, pathogenic hantann vi ... | 2012 | 22944108 |
| divergent ancestral lineages of newfound hantaviruses harbored by phylogenetically related crocidurine shrew species in korea. | spurred by the recent isolation of a novel hantavirus, named imjin virus (mjnv), from the ussuri white-toothed shrew (crocidura lasiura), targeted trapping was conducted for the phylogenetically related asian lesser white-toothed shrew (crocidura shantungensis). pair-wise alignment and comparison of the s, m and l segments of a newfound hantavirus, designated jeju virus (jjuv), indicated remarkably low nucleotide and amino acid sequence similarity with mjnv. phylogenetic analyses, using maximum ... | 2012 | 22230701 |
| dynamic circulation and genetic exchange of a shrew-borne hantavirus, imjin virus, in the republic of korea. | hantaviruses (family bunyaviridae) are enveloped negative-sense tripartite rna viruses. the natural hosts of hantaviruses include rodents, shrews, moles, and bats. imjin virus (mjnv) is a shrew-borne hantavirus identified from the ussuri white-toothed shrews (crocidura lasiura) in the republic of korea (rok) and china. we have isolated mjnv and determined its prevalence and molecular diversity in gyeonggi province, rok. however, the distribution and phylogeography of mjnv in other regions of rok ... | 2017 | 28295052 |
| lethal disease in infant and juvenile syrian hamsters experimentally infected with imjin virus, a newfound crocidurine shrew-borne hantavirus. | to gain insights into the pathogenicity of imjin virus (mjnv), a newfound hantavirus isolated from the ussuri white-toothed shrew (crocidura lasiura), groups of syrian hamsters (mesocricetus auratus) of varying ages (<1, 5, 10, 14, 21, 35 and 56 days) were inoculated by the intraperitoneal route with 1000 pfu of mjnv strains 04-55 and 05-11. mjnv-infected syrian hamsters, aged 21 days or less, exhibited reduced activity, weight loss, respiratory distress, hind-limb paralysis and seizures. death ... | 2015 | 26371066 |