| characterization of a cross-reactive monoclonal antibody against norovirus genogroups i, ii, iii and v. | noroviruses cause the majority of epidemic outbreaks of acute viral gastroenteritis worldwide. in a previous study of monoclonal antibodies against norovirus gii/4 strain, we identified a continuous epitope (55)wirnnf(60) that was recognized by mab n2c3. subsequent studies found that this mab could recognize several different strains of noroviruses, not just gii/4. in the present study, we used homology modeling to confirm that the epitope of n2c3 was exposed on the surface of gii/4 capsid prote ... | 2010 | 20417671 |