| [effects of gtw and t4 from tripterygium wilfordii hook f. on lh cells in male rat pituitary glands]. | using anti-beta-lh monoclonal antibodies, studies were undertaken to assess the effects of the glycosides (gtw) and t4 from tripterygium wilfordii hook f. on lh cells in male rat pituitary glands using immunohistochemical methods and ultrastructural observation. the results showed that there were more vacuoles in the cytoplasm of lh cells and the color density of immunohistochemical staining was much stronger in the treated groups than that in the control group. electron microscopic results show ... | 1992 | 1299539 |
| [structure modification of triptolide, a diterpenoid from tripterygium wilfordii]. | in this paper, the structure modification of triptolide was studied and nine triptolide derivatives were synthesized. a preliminary test for the immunosuppression activity in vitro showed that tripchlorolide (2) and tripbromolide (3) have strong activity similar to triptolide, while their toxicity are much lower. the activity of other compounds was decreased significantly. a simple method for the preparation of tripchlorolide from triptolide in 92% yield was found by reacting triptolide with hcl ... | 1992 | 1300027 |
| the effect of multi-glycosides of tripterygium wilfordii hook f. (gtw) on the survival time of cardiac allografts in rats. | heterotopic heart transplantation was carried out in rats and the influence of multi-glycosides of tripterygium wilfordii hook f. (gtw) and a subtherapeutic dose of cyclosporine a (csa) on the mean survival time (mst) of the cardiac allografts was investigated. the results showed that the msts of cardiac allografts in both the gtw and csa-treated groups were significantly prolonged (p < 0.01 vs control). the rate of allograft rejection in the drug-treated groups was much lower than that in the c ... | 1992 | 1307500 |
| inhibitory effects of dihydroagarofuran sesquiterpenes on epstein-barr virus activation. | to search for possible antitumor promoters, we carried out a primary screening of thirty-seven dihydroagarofuran sesquiterpenes from tripterygium wilfordii hook fil. var. regelii makino and euonymus sieboldianus blume, using their possible inhibitory effects on the epstein-barr virus early antigen (ebv-ea) activation which is induced by 12-o-tetradecanoylphorbol-13-acetate (tpa) in raji cells. some of these sesquiterpenes, triptofordin f-2 (takaishi et al., 1988), 1,2,6,8,15-pentaacetoxy-9-benzo ... | 1992 | 1324784 |
| [the effect of glycoside tripterygium wilfordii hook f on the immune regulatory function of t lymphocyte]. | previously, we treated successfully patients with systemic lupus erythromatosus (sle) with glycoside tripterygium wilfordii hook f, a chinese medicinal herb. to evaluate the pharmacological mechanism of this herb, we studied its effects on the activation and proliferation facets of human t lymphocyte in vitro. the results revealed that this drug can markedly suppress the activation and proliferation facets of t lymphocytes. | 1992 | 1363218 |
| anti-aids agents, 6. salaspermic acid, an anti-hiv principle from tripterygium wilfordii, and the structure-activity correlation with its related compounds. | salaspermic acid [1], an inhibitor of hiv reverse transcriptase and hiv replication in h9 lymphocyte cells, was isolated from the roots of tripterygium wilfordii for the first time. the structure of 1 derived from spectral data was established unequivocally by an x-ray analysis of crystals of the monohydrate. a structure-activity correlation of 1 with ten related compounds indicated that the acetal linkage in ring a and the carboxyl group in ring e of 1 may be required for the anti-hiv activity. | 1992 | 1375626 |
| [treatment of purpuric nephritis in children with tripterygium wilfordii and radix salviae miltiorrhizae]. | this paper dealt with the data of tripterygium wilfordii polyoglucoside (1 mg/kg.d) combined with radix salvaie multiorrhizae (6-15 g/d) for treating purpuric nephritis (group-a), compared with the control group of using tripterygium wilfordii polyoglucoside treatment only (group-b). the average time of edema-disappearing and blood pressure-resuming to normal range were 8.72 +/- 3.07 and 7.44 +/- 5.17 days in group-a, which were much better than those in group-b (p < 0.05). the average time of b ... | 1992 | 1421974 |
| suppression of renal disease and arthritis, and prolongation of survival in mrl-lpr mice treated with an extract of tripterygium wilfordii hook f. | treatment of mrl-lpr/lpr mice with tripterygium wilfordii hook f (twhf) to evaluate its effects on mortality, renal disease, and arthritis. | 1992 | 1445458 |
| the suspension culture of tripterygium wilfordii. | in suspension culturing of tripterygium wilfordii, 18.4 mg/l of dry cells and 9.184 mg/l of diterpene-lactone compounds were obtained from 6,7-v liquid medium containing 1 mg/l naa. besides those within the cells, diterpene-lactone compounds were also found in the cultured liquid and the yield reached 30.16-43.14% of the total yield. the total yield of diterpene-lactone compounds in suspension culture (6,7-v medium containing 1 mg/l naa) was 12.19 times as much as that in the roots of the origin ... | 1992 | 1457723 |
| [antitumor effect of tripterygium wilfordii]. | a new component of antitumor action tg has been isolated from the ethyl acetate extract of tripterygium wilfordii (besides triptolide, tripdiolide and triptonide). tg was shown in this study to have obvious antitumor effects. the average life span of h22, s180, eac and breast carcinoma-bearing mice treated with tg ip x 2 days were 100% more than those of the control mice (p less than 0.01) tg was able to inhibit tumor growth of s37-bearing mice at the dose of 150 mg/kg per day, ig x 3, its inhib ... | 1992 | 1504534 |
| effects of multiglycosides of tripterygium wilfordii (gtw) on rat fertility and leydig and sertoli cells. | primary cultures of rat leydig and sertoli cells were used to evaluate the direct effects of gtw on testicular cells and to compare these to the effects of gossypol acetate. both gtw and gossypol acetate can affect the survival of leydig and sertoli cells. but sertoli cells are much more sensitive than leydig cells, either to gossypol acetate or gtw. leydig and sertoli cells all died when they were exposed to gossypol acetate or gtw at a dose of 3.0 micrograms/ml or 30 micrograms/ml, respectivel ... | 1992 | 1511610 |
| anti-aids agents, 4. tripterifordin, a novel anti-hiv principle from tripterygium wilfordii: isolation and structural elucidation. | a new kaurane-type diterpene lactone, tripterifordin [1], has been isolated from the roots of tripterygium wilfordii. the structure of 1 was elucidated by spectroscopic methods, including the concerted application of a number of 2d nmr techniques that involved the 1h-1h cosy, heteronucleus-detected variants of the heteronuclear chemical shift correlation (hetcor), phase-sensitive noesy, and long-range hetcor. compound 1 shows anti-hiv replication activity in h9 lymphocyte cells with an ec50 of 1 ... | 1992 | 1602302 |
| inhibition of type ii collagen induced arthritis in mice by an immunosuppressive extract of tripterygium wilfordii hook f. | the effects of tripterygium wilfordii hook f (twhf), a chinese herbal remedy, on type ii collagen induced arthritis (cia) in dba/1lacj mice were determined. mice were divided into 4 groups receiving oral treatment for 63 days: group a, sham feedings; group b, twhf (78 mg/day); group c, twhf (140 mg/day); group d, twhf (140 mg/day) starting 21 days after collagen immunization. arthritis incidence was reduced and day of onset delayed in groups b and c compared with a. arthritic joint counts, arthr ... | 1992 | 1613695 |
| [summary of second national symposium of tripterygium wilfordii]. | | 1991 | 1687966 |
| prolonged survival of mrl-lpr/lpr mice treated with tripterygium wilfordii hook-f. | mrl-lpr/lpr mice were treated with tripterygium wilfordii hook-f (twhf), a chinese herbal medicine successfully used for human rheumatoid arthritis. dramatic prolongation of survival and the reduction of urinary protein were observed in mice treated with a high dose of twhf (20 mg/kg, three times a week) compared to the control animals receiving solvent alone. a slight but significant reduction was also seen in the degree of lymphadenopathy and arthritis with the high dose treatment. surprisingl ... | 1992 | 1728981 |
| inhibitory effect of triptolide on colony formation of breast and stomach cancer cell lines. | triptolide (tri) is a diterpenoid triepoxide isolated from tripterygium wilfordii hook f. the effects of tri on the colony formation of breast cancer cell lines mcf-7 and bt-20, stomach cancer cell lines mkn-45, mkn-7, and kato-iii, and promyelocytic leukemia cell line hl-60 were reported. using hamburger-salmon's double layer agar technique with certain modifications, cancer cells were cultured in 0.3% agar in a highly humidified atmosphere of 5% co2 at 37 degrees c for 14-21 d. colonies were c ... | 1991 | 1819894 |
| [inhibitory effect of tripterine on activities of il-1, il-2 and release of pge2]. | tripterine is one of the components isolated from tripterygium wilfordii hook. previous studies demonstrated that tripterine inhibited not only humoral and cellular immune responses but also some inflammatory responses. the present investigation attempted to observe effect of the drug on productions of il-1 from macrophages, il-2 from splenocytes and pge2 from synovial cells. the results showed that tripterine (0.1-1.0 microgram/ml) significantly inhibited il-1 activity of murine peritoneal macr ... | 1991 | 1821082 |
| [16-hydroxytriptolide, a new active diterpene isolated from tripterygium wilford ii]. | a new diterpene triepoxide, 16-hydroxytriptolide was isolated from the root and leaves of tripterygium wilfordii hook.f. 16-hydroxytriptolide was obtained as white cluster crystal, mp 232-233.5 degrees c. its molecular formula is c20h24o7. the structure and stereochemistry of 16-hydroxytriptolide was established as l2 on the basis of spectral data (ir, ms, uv, 1h-nmr, 13c-nmr, 2d-nmr, noe) and x-ray crystallographic analysis. in the pharmacologic screening, 16-hydroxytriptolide showed definite a ... | 1991 | 1823717 |
| [screening of active anti-inflammatory, immunosuppressive and antifertility components of tripterygium wilfordii. iii. a comparison of the antiinflammatory and immunosuppressive activities of 7 diterpene lactone epoxide compounds in vivo]. | the half-effective dose(ed50), therapeutic index(ti) and certain safety factor(csf) of 7 diterpene lactone epoxide compounds with antiinflammatory and immunosuppressive action extracted from tripterygium wilfordii (tw) were assayed using croton oil-induced ear swelling and hemolysin-antibody formation mouse models. the results indicated that triptolide(t10), tripchlorolide(t4), triptonide(t7), tripdiolide(t8), triptolidenol(t9) and 16-hydroxytriptolide(l2) possessed both anti-inflammatory and im ... | 1991 | 1838954 |
| [screening of active anti-inflammatory, immunosuppressive and antifertility components from tripterygium wilfordii. iv. a comparison of the male antifertility activities of 7 diterpene lactone epoxide compounds]. | the male antifertility activities under equal toxic dosages 1/10-1/60 ld50 and hemolysin antibody formation parameters under effective threshold dosages respectively of 7 diterpene lactone epoxide compounds extracted from tripterygium wilfordii (tw) were assayed in mice. the results indicated that among the 7 compounds, 6 (t10, t4, t7, t8, t9 and l2) showed antifertility activities, the effective thresholds of t7, t8, t10 and l2 were below 1/40 ld50, those of t4 and t9 were below 1/60 ld50, whil ... | 1991 | 1838955 |
| [antispermatogenic effects of multiglycosides of tripterygium wilfordii and monomer t4 in the testes and epididymal spermatozoa of rats]. | the antispermatogenic effects of the multiglycosides of tripterygium wilfordii (gtw) and monomer t4 isolated from gtw on the testes and epididymal spermatozoa of rats were examined microscopically following silver staining. the dosages of gtw and t4 were 10mg/kg.d and 0.05 mg/kg.d, respectively, fed for 7 weeks via gastric intubation. different degrees of damage to the testis and epididymal tubes were found in rats treated with gtw. deformed, round-headed sperms and exfoliated cells (mainly sper ... | 1991 | 1839514 |
| immunomodulating chinese herbal medicines. | traditional chinese medicine always pays close attention to the strengthening of the patient's general resistance against illness, there are many chinese herbs used for thousands of years are considered as tonics. animal experiments and modern clinical trails have shown that quite a number herbs are immunologically active, and most of the tonics are excellent immunomodulating agents, such as polysaccharides or saponins isolated from astragalus mongholicus, acanthopanax senticosus and panax notog ... | 1991 | 1841992 |
| some progress on the chemistry of natural bioactive terpenoids from chinese medicinal plants. | (1) pseudolaric acids--novel diterpenes, pseudolaric acid a, b, c and d were isolated from pseudolarix kaempferi gorden (pinaceae). their structures were assigned by spectroscopic data and chemical correlations. in the continuous studies, the absolute configurations, the conformations in the solutions, the fragmentation mechanisms of ms and assignments of all nmr spectral signals were also reported. they showed the antifungal and cytotoxic activities. (2)--daphnane diterpenes--in the further stu ... | 1991 | 1842005 |
| can ethnopharmacology contribute to the development of anti-fertility drugs? | china, one of the developing countries with approx. one-fifth of the world population, has been making great efforts in controlling her population size. one of the efforts being stressed is to look into the practicability of employing chinese herbal medicine for fertility control. the rich ethnopharmacological descriptions in the ancient books of herbal remedy and those scattered in the folklore medicine contribute the possibility of this approach. after a discussion concerning the facets of ant ... | 1991 | 1881154 |
| effect of an extract of the chinese herbal remedy tripterygium wilfordii hook f on human immune responsiveness. | tripterygium wilfordii hook f (twh) is a vine-like plant that grows in a wide area of south china. an alcohol extract of this plant known as t2 has been suggested to be effective in the treatment of rheumatoid arthritis (ra). to examine the mechanism by which this herbal remedy might be effective in ra, the capacity of t2 to alter human immune responsiveness in vitro was investigated. human peripheral blood mononuclear cells were obtained from normal adults and separated into purified population ... | 1991 | 1930317 |
| development of male-fertility-regulating agents. | steroidal, nonsteroidal, plant-derived, gonadotropin-related and immunological agents investigated for control of male fertility are reviewed with brief descriptions of their effects, and illustrations of their structures. the physiology of the male reproductive system is presented as an introduction: an ideal male antifertility agent would inhibit spermatogenesis at the level of the sertoli cells, without affecting endogenous androgen production by leydig cells, needed for libido and potency. a ... | 1991 | 1943328 |
| [the structure of tripterygone]. | three triterpene compounds have been isolated from the roots of tripterygium wilfordii hook f. the structure of the new compound, 3-hydroxy-25-norfriedel-3, 1 (10)-dien-2-one-30 oic acid named tripterygone (iii), and the identity of others, 3 beta, 22 beta-dihydroxy-delta 12-oleanen-29-oic acid (i) and 2 alpha, 3 alpha, 24-trihydroxy-delta 12-ursene-28-oic acid (ii) have been established by spectral data and physical properties. compound ii was isolated for the first time from the title plant. | 1991 | 1957683 |
| [immunosuppressive and antiinflammatory activities of tripterine]. | tripterine is one of the active components isolated from tripterygium wilfordii hook.f. in this study tripterine was shown to inhibit the antibody response of mouse splenocytes to srbc both in vitro and in vivo either by primary or secondary stimulation. tripterine was also found to significantly inhibit cotton pellet induced granuloma growth in rats and depress the delayed hypersensitive reaction of mouse skin to dinitrochlorobenzene (dncb). besides, it also increased the sleeping time of mouse ... | 1990 | 2082679 |
| [structure revision of triptophenolide]. | a diterpenoid-lactone, white thin crystals, c20h24o3, m/z: 312 (m+), mp 222-223 degrees c, uv lambda max (etoh) 217 (log epsilon 4.36) nm, has been isolated from the ethyl acetate extract of the roots of tripterygium wilfordii hook. f., in a yield of 0.025%. its structure was elucidated by spectral analysis (uv, ir, ms, 1hnmr and 13cnmr) and x-ray scd. it is the known triptophenolide with revision of structure. triptophenlolide was shown to have obvious inhibiting effects on lymphocyte and igg ( ... | 1990 | 2104474 |
| [immunoregulatory effects of monomer t4 from tripterygium wilfordii hook. i. immunoregulatory effects of t4 on nk activity of mouse splenocytes]. | effects of monomer t4 on nk activity of mouse splenocytes were determined both in vitro and in vivo by means of a classical i-udr release assay. the results showed that monomer t4 exhibited dose-dependent double-regulatory inhibiting enhancing effects, ie, t4 of low dosage enhanced the percentage of nk cytotoxicity and lu numbers, while a high dosage showed dose-dependent inhibition. the double-regulatory effects of monomer t4 might be important for evaluation of the therapeutic effects of tript ... | 1990 | 2143110 |
| [the isolation and structure of tripchlorolide (t4) from tripterygium wilfordii]. | a new compound named tripchlorolide was isolated from total glucosides (t ii) extracted from the woody part of the root of tripterygium wilfordii hook. f. tripchlorolide (t4) was obtained as white needle-like crystals, mp 256-258 degrees c. its molecular formula is c20h25o6cl. the structure of t4 was elucidated on the basis of spectral (uv, ir, ms, ftms/sci, 1h-nmr, 13c-nmr, 1h-1h cosy, 13c-1h cosy) analyses, x-ray and chemical evidence. in preliminary pharmacologic assay, tripchlorolide showed ... | 1990 | 2150350 |
| [effect of glycosides of tripterygium wilfordii hook on the reproductive system and major organs of male rats]. | spermatogenesis and turnover of basic nuclear protein synthesis in late elongated spermatids of rat testis were found to be significantly inhibited by glycosides of tripterygium wilfordii hook (t ii) at a daily dosage of 10 mg/kg for 7 or 13 weeks and 20 mg/kg for 4 or 10 weeks. the number of spermatozoa in the epididymis was found to be reduced and the remaining spermatozoa deformed, showing head swelling, head and tail separation and severe curling of the middle piece. these changes differed f ... | 1990 | 2150357 |
| [mechanism of treating rheumatoid arthritis with polyglycosides of tripterygium wilfordii hook (t ii). iii. study on inhibitory effect of t ii on in vitro ig secreted by peripheral blood mononuclear cells from normal controls and ra patients]. | the in vitro effects of polyglycosides of tripterygium wilfordii hook (t ii) on immunoglobulin (ig) production by peripheral blood mononuclear cells (pb-mc) from seventeen healthy persons and eight rheumatoid arthritis (ra) patients were studied. pbmcs, monocytes and lymphocytes were treated separately with different doses of t ii for different periods of time. cells in different combinations were cultured for two weeks under pokeweed mitogen (pwm) stimulation and the igg and igm content of cult ... | 1990 | 2150359 |
| [comparative studies on antifertility mechanism and toxicology of tripterygium wilfordii monomer t4 and gossypol]. | inhibition of spermatogenesis and turnover of basic nuclear protein in late elongated spermatids of rat testis by tripterygium wilfordii monomer t4 was more obvious than that by gossypol. clustered positive deposits of gamma-gt, alp reaction were found in the inner edges of epididymal epithelium. head and tail separation, mid-piece coiling and axial fiber dislocation of epididymal spermatozoa in t4 treated rats were more obvious than those of gossypol-treated rats. mitochondrial ldh, ldh-x and m ... | 1990 | 2151263 |
| radix tripterygium wilfordii--a chinese herbal medicine with potent immunosuppressive properties. | radix tripterygium wilfordii hook-f (tw) is a chinese herbal medicine that has been reported to be effective in the treatment of various autoimmune disorders in experimental animals and man. little is known about the immunosuppressive mechanism of action of this medicine. we demonstrate herein that tw is capable of inhibiting several afferent immune functions including the in vitro response of human peripheral blood mononuclear cells to both mitogen and alloantigen, and the generation of cytotox ... | 1990 | 2368155 |
| [comparative clinical study of rheumatoid arthritis treated by triptolide and an ethyl acetate extract of tripterygium wilfordii]. | it was satisfactory using the ethyl acetate extract of tripterygium wilfordii (tw) to treat rheumatoid arthritis (ra). the results showed that the ethyl acetate extract of tw was the effective component part of tw. although the therapeutic effect of 15 cases with ra cured by triptolide was as effective as the ethyl acetate extract of tw, triptolide could impair some patients' hearts. this suggested that triptolide was one of the main effective elements of tw, but it was also one of the main toxi ... | 1990 | 2379295 |
| [treatment of rheumatoid arthritis with low doses of multi-glycosides of tripterygium wilfordii]. | thirty two cases of rheumatoid arthritis were treated with multi-glycosides of tripterygium wilfordii (t2) in a dosage of 30 mg daily for 12 weeks. significant improvements in clinical and laboratory variables were observed. in comparison with the results of routine dose of t2 (60 mg per day) treatment, there was no significant difference to be seen between the two treatment plans. meanwhile, symptom of rash and slightly alimentary canal lower incidences and milder manifestations of side effects ... | 1990 | 2397546 |
| [multiple sclerosis treated with tripterygium wilfordii tablets]. | | 1988 | 2457453 |
| [mechanism of treating rheumatoid arthritis with tripterygium wilfordii hook. ii. effect on pge2 secretion]. | pbmc from normal adults and patients with rheumatoid arthritis (ra) were cultured in the absence or presence of various concentrations of t2, indomethacin, dexamethasone for certain periods of time. the amounts of pge2 in the cell-free supernatants were measured by radioimmunoassay, and a significant reduction of pge2 production by pbmc cultured with 2-50 micrograms/ml of t2 was found. the percentages of inhibition of pge2 production in the cultures with 2 micrograms/ml, 10 micrograms/ml and 50 ... | 1989 | 2527628 |
| [cause of amenorrhea after treatment with tripterygium wilfordii f]. | fourteen female patients with rheumatoid arthritis who developed amenorrhea after treatment with t2 were investigated endocrinologically. fsh and lh levels began to rise after 2-3 mon and reached menopausal levels at 4-5 mon of treatment. e2 levels began to drop after 3-4 mon and reached very low levels at 5 mon of treatment. this indicates that the site of action of t2 is the ovary. the factors effecting amenorrhea may be related to dosage and the status of reproductive function. cytotoxicity m ... | 1989 | 2528424 |
| [studies on triterpenoids of total glucosides of tripterygium wilfordii (t ii)]. | five triterpenoids were isolated from total glucosides of tripterygium wilfordii (t ii). t1 was identified as wilforlide a; t2 a new triterpenic acid, as 3 beta-22 beta-dihydroxy-delta 12-oleanen-29-oic acid, named triptotriterpenic acid b; t6 as orthosphenic acid; t3 and t28 had been reported in other papers. t2, t6 and t28 have been further confirmed by x-ray analysis. all of them were shown to have anti-inflammatory action except t1 wasn't examined. | 1989 | 2534610 |
| screening of 5 monomers from total glucosides of tripterygium wilfordii. | | 1989 | 2594742 |
| [immunosuppresive effects of wilfortrine and euonine]. | wifortrine and euonine isolated from tripterygium wilfordii hook. f. wilfortrine and euonine (40.80 mg/(kg.d) x 4d ip) showed marked depressant effects on humoral mediated immunity using the hemolysin reaction as indices. wilfortrine (160 mg/kg.d x 9d ip) exhibited a depressant effect on graft vs host reaction (gvhr), but wilfortrine (80 mg/(kg.d) x 9d ip) showed no definite effect. euonine (80 mg/(kg.d) x 10d ip) showed marked suppressant effects on dncb induced delayed hypersensitivity reactio ... | 1989 | 2618700 |
| [histopathologic observation on the therapeutic effect of tripterygium wilfordii in treating experimental allergic encephalomyelitis]. | the tripterygium wilfordii (tw) was used to treat experimental allergic encephalomyelitis (eae) in guinea-pig. the morphological change was observed by using light microscope. lymphocytic histochemical staining was performed on the spinal cord from eae in guinea-pig. the results were: the incidence of inflammatory reaction, neuraxial swelling, break and neuronal necrosis in the treatment group was lower than that in the control group (p less than 0.01-0.005); the variation of incidence of neurof ... | 1989 | 2786771 |
| [a tablet of tripterygium wilfordii in treating lupus erythematosus]. | twenty-three cases of lupus erythematosus, including 15 cases of sle and 8 cases of dle treated with tripterygium wilfordii (tw, three tablets thrice a day, each tablet contains 5 gm of crude tw) were reported. as controls, 19 cases of sle were treated with prednisone alone at the same time. 9/15 cases in the former group and 6/19 in the latter got improvement after treatment. there was no significant difference between the two groups (p greater than 0.10). however, tw had beneficial effects to ... | 1989 | 2791160 |
| effect of rhodamine 123 and total glycosides from tripterygium wilfordii (gtw) on ultrastructures, survival and fertilizing capacity of human sperm in vitro. | human sperms were treated with rhodamine 123 or gtw in vitro. comparisons were made of survival, fertilizing capacity and ultrastructures of sperms which had been exposed to different concentrations and treatment durations of the agents. the results showed that no prominent change could be observed when treated with lower doses. however, at higher concentrations of rhodamine 123, mitochondria were found to be swollen, vacuolated and deranged instead of surrounding the flagellar axoneme in the no ... | 1989 | 2798404 |
| [the isolation and structure identification of triptotriterpenic acid c]. | a new ursolic-type acid named triptotriterpenic acid c was obtained from the total glycosides extracted from the root of tripterygium wilfordii hook.f. its structure was inferred from chemical reaction, ir, 1hnmr, 13cnmr and ms spectral data. the structure and stereochemistry of this compound was confirmed to be 3 beta,22 alpha-dihydroxy-delta 12-ursene-30-oic acid by x-ray crystallo-diffraction analysis of its methyl ester. | 1989 | 2816380 |
| [effects of total glycosides of tripterygium wilfordii on the reproductive organs of experimental animals. iii. dynamic observations on the reproductive organs and fertility in mice]. | | 1986 | 2943438 |
| [a pentacyclic triterpene acid from tripterygium wilfordii]. | | 1986 | 2946459 |
| [tripterygium wilfordii in the treatment of the nephritis of anaphylactoid purpura]. | | 1987 | 2966011 |
| [screening of active anti-inflammatory-immunosuppressive and antifertile compositions from tripterygium wilfordii. i. screening of 8 components from total glucosides of tripterygium wilfordii (tii)]. | | 1987 | 2968853 |
| [screening of active anti-inflammatory-immunosuppressive and antifertile components from tripterygium wilfordii. ii. screening of 5 monomers from total glucosides of tripterygium wilfordii (tii)]. | | 1987 | 2968854 |
| [treatment of rheumatoid arthritis with tripterygium wilfordii hook. i. effect on secretion of total igm and igm-rf by peripheral blood mononuclear cells (pbmc)]. | | 1988 | 2978257 |
| [summary on the clinical uses and study of tripterygium wilfordii]. | | 1988 | 3061673 |
| radix tripterygium wilfordii hook f in rheumatoid arthritis, ankylosing spondylitis and juvenile rheumatoid arthritis. | | 1986 | 3098512 |
| [effect of tripterygium wilfordii on the remission of proteinuria in patients with nephrotic syndrome]. | | 1985 | 3157498 |
| [effects of total glycosides of tripterygium wilfordii on animal reproductive organs i. experiments of male rats]. | | 1985 | 3158412 |
| [effects of tripterygium wilfordii on rheumatoid arthritis--analysis of 165 cases]. | | 1985 | 3159496 |
| future developments in contraception. | research in the improvement of current contraceptive methods includes the development of longacting, biodegradable steroid delivery systems; antiviral spermicides; and condoms made of better materials than latex rubber. at the forefront of research are the development of male contraceptive pills and contraceptive vaccines. progestagens cannot be used to suppress spermatogenesis without suppressing libido unless they are accompanied by replacement androgen therapy. moreover, it is extremely di ... | 1988 | 3217321 |
| structural elucidation of triptofordins f-1, f-2, f-3, and f-4, new sesquiterpenes polyesters from tripterygium wilfordii hook fil. var. regelii makino. | | 1988 | 3246002 |
| [studies on the chemical constituents of the stem and leaves of tripterygium wilfordii hook]. | | 1988 | 3252988 |
| [tripterygium wilfordii on prolonging the survival time of myocardial allografts in mice]. | | 1988 | 3289766 |
| tripterygium wilfordii, a chinese herb effective in male fertility regulation. | a refined extract from the root xylem of tripterygium wilfordii hook. f. (the so-called multi-glycosides of the plant), available in the market as tablets for the long-term treatment of rheumatoid arthritis and various skin disorders, has recently been shown to possess a powerful antifertility effect in male rats and in men after oral administration at dose levels not showing apparent toxicity or side effects. fertility appears to be reversible after cessation of treatment. moreover, preliminary ... | 1987 | 3315438 |
| effect of tripterygium wilfordii on nephritis of anaphylactoid purpura. | | 1987 | 3432251 |
| [the effect of combined use of gossypol and tripterygium wilfordii on the fertility of male rats]. | | 1987 | 3452960 |
| [studies on triterpenoids of tripterygium wilfordii hood-f]. | | 1986 | 3811953 |
| triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from tripterygium wilfordii. | | 1972 | 5072337 |
| [studies on pharmacological actions of total glycosides in tripterygium wilfordii]. | | 1983 | 6226379 |
| [toxicity of total glycosides in tripterygium wilfordii]. | | 1983 | 6226402 |
| [clinical analysis of 84 cases of glomerulonephritis treated with tripterygium wilfordii]. | | 1984 | 6240328 |
| studies on total glycosides of tripterygium wilfordii hook f in dermatoses. tripterygium wilfordii hook f research group. | | 1984 | 6443299 |
| clinical observation of 144 cases of rheumatoid arthritis treated with glycoside of radix tripterygium wilfordii. | | 1983 | 6555445 |
| clinical observations on tripterygium wilfordii in treatment of 26 cases of discoid lupus erythematosus. | | 1983 | 6555446 |
| effects of tripterygium wilfordii on the menstruation of 50 patients suffering from rheumatoid arthritis--with a summary of its therapeutic effects in 12 cases of menorrhagia. | | 1984 | 6570157 |
| an experimental pathological study of acute lei gong teng (tripterygium wilfordii hook) intoxication in rats. | | 1984 | 6738988 |
| tripterygium wilfordii hook f in rheumatoid arthritis and ankylosing spondylitis. preliminary report. | | 1981 | 6796344 |
| tripterygium wilfordii hook f in systemic lupus erythematosus: report of 103 cases. | | 1981 | 6800725 |
| [clinical and experimental studies on the effect of tripterygium wilfordii hook in the treatment of nephritis]. | | 1982 | 6817881 |
| [studies on the chemical constituents of tripterygium wilfordii hook. f. iii. the isolation and structure of two new diterpenoid-lactones, triptophenolide methyl ether and neotriptophenolide (author's transl)]. | | 1982 | 7102323 |
| [clinical analysis of 31 cases of poisoning with tripterygium wilfordii hook. f., a chinese traditional herb medicine]. | | 1982 | 7128303 |
| [studies on the chemical constituents of tripterygium wilfordii hook. ii. the structure of triptonolide, a new diterpenoid lactone (author's transl)]. | | 1981 | 7304185 |
| [clinical study of tripterygium wilfordii hook in treating glomerulonephritis (author's transl)]. | | 1981 | 7307746 |
| isolation, purification, and characterization of immunosuppressive compounds from tripterygium: triptolide and tripdiolide. | crude extracts derived from the root of tripterygium wilfordii hook f (twhf) have previously been demonstrated to have immunosuppressive properties and have been used as anti-rheumatic therapy in chinese traditional medicine. although these extracts contain a large number of chemical components, the precise nature of the compound(s) responsible for this therapeutic effect has not been established with certainty. an aqueous extract of twhf was resolved into chemical components by medium-pressure ... | 1995 | 7591358 |
| hypovolemic shock and mortality after ingestion of tripterygium wilfordii hook f.: a case report. | tripterygium wilfordii hook f (twhf) is a kind of chinese herbal medicine used for 2000 years. it was applied externally for treatment of arthritis and inflammatory tissue swelling in early years. recently, this drug has been found to have immunosuppressive effects which could successfully induce remission of some autoimmune disorders without obvious adverse effects. although there are side effects of gastrointestinal upset, infertility and suppression of lymphocyte proliferation, little informa ... | 1995 | 7628889 |
| [in vitro inhibition of celastrol on spermatozoa fertilization ability of guinea pig]. | the effects of celastrol (cel), isolated from tripterygium wilfordii, on guinea pig sperm forward motility (fm), capacitation (cap), the acrosome reaction (ar) and sperm penetration assay (spa) were assessed in vitro. cel (5 micrograms.ml-1) was found to inhibit these spermatozoal functions, and the inhibitions were proportional to the concentrations of cel used. the potency of inhibition of cel on the fertilizing ability in guinea pig spermatozoa in vitro seems to follow the order: cap > fm > s ... | 1995 | 7660802 |
| the effects of tripterygium wilfordii extract on adjuvant arthritis in rats. | the effects of the extract of tripterygium wilfordii. (twe) on experimental adjuvant arthritis (aa) in the rat was studied. lewis rats induced with aa were administered with twe at 50 mg/kg/day for 10 weeks. the paw volume, its ratio to the body weight (paw ratio) and the radiologic changes in the feet of the rats with aa taking twe were compared with those in the rats taking indomethacin (0.5 mg/kg/day) and no additional drugs. the rats taking twe showed a smaller paw volume, a lower paw ratio ... | 1995 | 7698717 |
| [anti-inflammatory effect of triptolide]. | triptolide (tri) was isolated from tripterygium wilfordii hook f. tri 0.1-0.2 mg.kg-1 sc or 0.15-0.3 mg.kg-1 ig inhibited markedly the increased vascular permeability induced by ip 0.7% hac in mice. tri 0.05-0.1 mg.kg-1 ip or 0.15-0.3 mg.kg-1 ig inhibited hind paws swelling induced by sc 0.15 ml carrageenan and also inhibited the same swelling induced by sc 2.5% formaldehyde 0.1 ml in rats. tri 0.05-0.1 mg.kg-1 ip inhibited markedly proliferation of granuloma induced by sc implantation of cotton ... | 1994 | 7709756 |
| [effects of tripchlorolide (t4) of tripterygium wilfordii hook on the proliferation of peripheral blood mononuclear cells of rheumatoid arthritis patients]. | tripchlorolide (t4) is a single active ingredient recently isolated from tripterygium wilfordii hook. the effects of t4 on the proliferation of peripheral blood mononuclear cells (pbmc) of rheumatoid arthritis (ra) patients and normal subjects were studied, ra patients and sex- and age-matched normal subjects (each 8 cases) were selected. pbmc were incubated with t4 of various doses (10, 20, 30 and 40 ng/ml) in the presence or absence of pha for 72 hours. the results were as follows: t4 remarkab ... | 1994 | 7720126 |
| [studies on triterpenoids of total glucosides of tripterygium wilfordii]. | three more triterpenoids were isolated from total glucosides of tripterygium wilfordii (t1). t16 and t17 were identified as salaspermic acid and as wilforlide b. t18 was a new compound. the structure of t18 was determined, as 3-oxo-22 alpha-hydroxy-delta 12-oleanen-29-oic acid by detail spectroscopic and chemical analysis, and named triptotriterpenonic acid a. | 1994 | 7720147 |
| adverse effect of tripterygium wilfordii extract on mouse embryonic development. | tripterygium wilfordii hook f. is a medicinal plant which possesses anti-fertility activity in males and has been used in china for the treatment of rheumatoid arthritis, chronic nephritis and other pulmonary diseases for years. the effect of tripterygium wilfordii extract on in vitro development in day 9 and day 10 mouse embryos was examined. the embryotoxicity of t. wilfordii extract was obvious on day 9 and day 10 embryos at doses of 50 and 100 micrograms/ml, respectively. the embryonic abnor ... | 1995 | 7750287 |
| recent progress in research on tripterygium: a male antifertility plant. | the discovery of the reversible antifertility action of an extract from tripterygium wilfordii both in male rats and in men in 1986 stimulated worldwide interest. international and national collaborations aimed at the bioassay-directed sub-fractionation of materials extracted from the plant was then organized and to date, a series of six male antifertility diterpene epoxides have been isolated. their chemical structures have been identified and found to be triptolide, tripdiolide, triptolidenol, ... | 1995 | 7750290 |
| oxidation and glucose conjugation of synthetic abietane diterpenes by cunninghamella sp. ii. novel routes to the family of diterpenes from tripterygium wilfordii. | abietane diterpenes from the perennial herb, tripterygium wilfordii, have been shown to possess antiinflammatory activity. to obtain novel analogues of these diterpenes, two synthetic diterpenes, isotriptophenolide [1] (12,19-dihydroxy-18(4-->3)abeo-abieta-3,8,11,13-tetraen++ +-18-oic acid lactone) and triptophenolide [3] (14,19-dihydroxy-18(4-->3)abeo-abieta-3,8,11,13-tetraen++ +-18-oic acid lactone) were incubated with the filamentous fungi, cunningbamella echinulata and c. elegans. the struct ... | 1995 | 7760079 |
| [experimental and clinical studies of small bowel allotransplantation]. | the pigs with allograft were divided into 5 groups according to the different immunosuppressive regimens. acute rejection of allograft occurred in animals not treated with immunosuppressive agents or treated with low dose of cyclosporine (csa). there was no rejection developed in the pigs treated with high dose csa or low dose csa and tripterygium wilfordii (tw). no evidence of chronic rejection was detected in animals with continued administration of tw after living longer than 100 days when th ... | 1995 | 7774436 |
| observations on therapeutic effects of huangdan decoction and tripterygium wilfordii compound tablet on membranous glomerulonephritis in rats. | the model of membranous glomerulonephritis (mgn) in rats was successfully established using self-made cationic bovine serum albumin (c-bsa) and treated with huangdan decoction (hdd) and tripterygium wilfordii co. tablet (tw). results indicated that the levels of urinary protein, blood urea nitrogen (bun) and serum creatinine (scr) in treated groups (groups a, b and c) were significantly decreased as compared with the control group (group d) (p < 0.01). by light and electron microscope and immuno ... | 1995 | 7783260 |
| low-dose cyclosporin a and tripterygium wilfordii inhibited porcine intestinal allograft rejection. | the aim of this study was to evaluate whether tripterygium wilfordii (tw) could be used as an immunosuppressant, and whether antirejection therapy with low-dose cyclosporin a (csa) and tw was better than the treatment with large-dose csa alone in intestinal transplantation in pigs. 100 cm intestines were transplanted by using two-step models. four pigs which received large-dose csa for 100 days and then were given tw survived 251.5 +/- 181.5 days; 2 of these died of pneumonia 92 and 97 days afte ... | 1994 | 7805458 |
| effect of tripterygium wilfordii on adrenal cortex in rat with adjuvant arthritis. | this paper reports the effects of tripterygium wilfordii (tw) on adrenal cortex in rats with adjuvant arthritis. forty rats were divided into 5 groups. adjuvant arthritis (aa) models were made with complete freund's adjuvant (cfa) in groups i-iv. each of which was treated with sodium carboxyl methyl cellulose, tw, prednisone and cyclophosphamide respectively. the untreated rats allocated to group v served as normal controls. the swelling of aa markedly subsided in group ii, iii and iv as compare ... | 1994 | 7807601 |
| [clinical study on the use of multiglycosides of tripterygium wilfordii after cadaveric kidney transplantation]. | based on the animal experiments, we first used the multiglycosides of tripterygium wilfordii (gtw) as a main immunosuppressive agent to treat the patients with cadaveric kidney transplantation instead of azathioprine (aza) from 1990. by clinical observation and 3-year follow-up, the result showed the gtw having a satisfactory immunosuppressive effect. in this study, there were 85 cases in control group (aza+csa+pred) and 87 cases in therapeutic group (gtw+csa+pred). the normalizing times of graf ... | 1994 | 7842911 |
| [inhibitory effects of monomer t4 from tripterygium wilfordii hook on cultured mesangial cells proliferation and il-1 production]. | the cultured mesangial cells (msc) went through three serial passages before being using. quantitation of msc growth rate was obtained by measuring the ratio of 3h-tdr uptake in a medium containing various concentrations of t4. il-1 activity was tested by 3h-tdr incorporation in c57bl/c mice thymocytes. the results show that t4 inhibited msc proliferation and il-1 production. | 1994 | 7867094 |
| [effects of tripchlorolide (t4) of tripterygium wilfordii hook on the production of prostaglandin e2 by synovial cells of rheumatoid arthritis]. | the effects of tripchlorolide, an active ingredient (t4) of tripterygium wilfordii hook on the production of prostaglandin e2(pge2) by synovial cells of rheumatoid arthritis (ra) patients were investigated. six cases of definite ra (female 5, male 1, mean age 45 with an average course of disease of 9 years) were selected. surgically obtained synovium specimen were dissociated into digested synovial single cells (dssc). the cells were incubated with various concentrations of t4 for 48 hours. usin ... | 1994 | 7871999 |
| inhibition of il-1 release from human monocytes and suppression of streptococcal cell wall and adjuvant-induced arthritis in rats by an extract of tripterygium wilfordii hook. | 1. it was investigated whether an extract of tripterygium wilfordii hook f (tw) inhibits il-1 production by monocytes and suppresses the development of il-1-dependent arthritis induced in rats with streptococcal cell wall and adjuvant. 2. tw preferentially inhibited il-1 alpha and il-1 beta production by bacterial lipopolysaccharide (lps)-stimulated human monocytes with ic50 of approximately 1 microgram/ml. 3. oral administration of tw dose-dependently suppressed joint swelling and structural da ... | 1994 | 7875533 |