| aspergillus calidoustus sp. nov., causative agent of human infections previously assigned to aspergillus ustus. | aspergillus ustus is a relatively rare human pathogen causing invasive infections in immunocompromised hosts. in this study isolates originating from clinical and other sources have been examined using molecular, morphological, and physiological approaches to clarify their species assignment. phylogenetic analysis of partial beta-tubulin, calmodulin, actin, and intergenic transcribed spacer sequences indicated that none of the clinical isolates recognized previously as a. ustus belongs to this s ... | 2008 | 18281596 |
| in vitro activity of nine antifungal agents against clinical isolates of aspergillus calidoustus. | this study analyzes aspergillus isolates from the spanish national centre for microbiology collection, which were identified morphologically as members of aspergillus section usti. strains were identified through the analysis of the internal transcribed spacer regions and partial beta tubulin gene sequences. one aspergillus pseudodeflectus isolate and eight aspergillus calidoustus isolates were detected in this panel of clinical strains. terbinafine and the echinocandins micafungin and anidulafu ... | 2010 | 19296366 |
| secondary metabolites from eurotium species, aspergillus calidoustus and a. insuetus common in canadian homes with a review of their chemistry and biological activities. | as part of studies of metabolites from fungi common in the built environment in canadian homes, we investigated metabolites from strains of three eurotium species, namely e. herbariorum, e. amstelodami, and e. rubrum as well as a number of isolates provisionally identified as aspergillus ustus. the latter have been recently assigned as the new species a. insuetus and a. calidoustus. e. amstelodami produced neoechinulin a and neoechinulin b, epiheveadride, flavoglaucin, auroglaucin, and isotetrah ... | 2009 | 19422073 |
| patterns of susceptibility of aspergillus isolates recovered from patients enrolled in the transplant-associated infection surveillance network. | we analyzed antifungal susceptibilities of 274 clinical aspergillus isolates from transplant recipients with proven or probable invasive aspergillosis collected as part of the transplant-associated infection surveillance network (transnet) and examined the relationship between mic and mortality at 6 or 12 weeks. antifungal susceptibility testing was performed by the clinical and laboratory standards institute (clsi) m38-a2 broth dilution method for amphotericin b (amb), itraconazole (itr), voric ... | 2009 | 19692558 |
| emerging pathogen aspergillus calidoustus colonizes water distribution systems. | recent studies have changed the taxonomy of aspergillus section usti, and a novel species, aspergillus calidoustus, has been erected. it was also demonstrated that clinical isolates previously identified as a. ustus actually belong to the emerging pathogen a. calidoustus. aspergillus ustus were frequently isolated from norwegian water systems, and due to the taxonomical progress, these waterborne strains could be identified more precisely. a mlst study including its, calmodulin, β-tubulin and ac ... | 2011 | 21208025 |
| New taxa in Aspergillus section Usti. | Based on phylogenetic analysis of sequence data, Aspergillus section Usti includes 21 species, inclucing two teleomorphic species Aspergillus heterothallicus (= Emericella heterothallica) and Fennellia monodii. Aspergillus germanicus sp. nov. was isolated from indoor air in Germany. This species has identical ITS sequences with A. insuetusCBS 119.27, but is clearly distinct from that species based on ß-tubulin and calmodulin sequence data. This species is unable to grow at 37 °C, similarly to A. ... | 2011 | 21892244 |
| does fungicide application in vineyards induce resistance to medical azoles in aspergillus species? | this study assessed if the use of sterol demethylase inhibitor fungicides in vineyard production can induce resistance to azoles in aspergillus strains and if it can induce selection of resistant species. we also tried to identify the aspergillus species most prevalent in the vineyards. two vineyards from northern portugal were selected from "vinhos verdes" and "douro" regions. the vineyards were divided into plots that were treated or not with penconazole (pen). in each vineyard, air, soil, and ... | 2014 | 24833021 |
| discovery of an extended austinoid biosynthetic pathway in aspergillus calidoustus. | filamentous fungi produce a wide range of natural products that are commonly used in various industrial contexts (e.g., pharmaceuticals and insecticides). meroterpenoids are natural products of interest because of their various biological activities. among the meroterpenoids, there is a group of insecticidal compounds known as the austinoids. these compounds have also been studied because of their intriguing spiro-lactone ring formation along with various modifications. here, we present an exten ... | 2017 | 28233494 |
| evaluation of the vitek ms matrix-assisted laser desorption ionization-time of flight mass spectrometry system for identification of clinically relevant filamentous fungi. | invasive fungal infections have a high rate of morbidity and mortality, and accurate identification is necessary to guide appropriate antifungal therapy. with the increasing incidence of invasive disease attributed to filamentous fungi, rapid and accurate species-level identification of these pathogens is necessary. traditional methods for identification of filamentous fungi can be slow and may lack resolution. matrix-assisted laser desorption ionization-time of flight mass spectrometry (maldi-t ... | 2016 | 27225405 |
| draft genome sequences of fungus aspergillus calidoustus. | here, we report the draft genome sequence of aspergillus calidoustus (strain sf006504). the functional annotation of a. calidoustus predicts a relatively large number of secondary metabolite gene clusters. the presented genome sequence builds the basis for further genome mining. | 2016 | 26966204 |
| aspergillus mediastinitis after orthotopic heart transplantation: a case report. | a 55-year-old woman was admitted for orthotopic heart transplantation. her medical history was notable for multiple cardiovascular problems, including ischemic cardiomyopathy that necessitated circulatory support with a left ventricular assist device. five weeks after undergoing orthotopic heart transplantation, she developed aspergillus calidoustus mediastinitis, for which she underwent a prolonged course of antifungal treatment that comprised (in sequence) posaconazole for 11 days, voriconazol ... | 2015 | 26504444 |
| biological activities of ophiobolin k and 6-epi-ophiobolin k produced by the endophytic fungus aspergillus calidoustus. | endophytic fungi represent ubiquitous microbial organisms able to live in the tissues of different plants around the world and represent a prolific source of bioactive metabolites. in the present study, the endophytic fungus aspergillus calidoustus was isolated from the medicinal plant acanthospermum australe (asteraceae), and identified using molecular, physiological and morphological methods. a methylene chloride crude extract of a. calidoustus has been produced and subjected to antifungal bio ... | 2016 | 25812930 |
| antifungal susceptibility profile of cryptic species of aspergillus. | the use of molecular tools has led to the description of new cryptic species among different aspergillus species complexes. their frequency in the clinical setting has been reported to be between 10 and 15%. the susceptibility to azoles and amphotericin b of many of these species is low, and some of them, such as aspergillus calidoustus or aspergillus lentulus, are considered multi-resistant. the changing epidemiology, the frequency of cryptic species, and the different susceptibility profiles m ... | 2014 | 24972670 |
| multi-resistant aspergillosis due to cryptic species. | reports of cryptic species causing aspergillosis in humans are increasing in the literature. cryptic species are defined as those which are morphologically indistinguishable, although their identifications can be confirmed using molecular or other techniques which continue to become more widely available in the clinical setting. antifungal resistance has often been noted in these cases, and indeed there does appear to be a higher prevalence of reduced susceptibility in cryptic species. many of t ... | 2014 | 24969615 |
| aerial prevalence of aspergillus calidoustus isolates in and around a tertiary care hospital in kuwait and assessment of their pathogenicity. | seven aspergillus calidoustus isolates from 486 aspergillus spp. isolates (1.4% overall prevalence) from outdoor/indoor air samples and one isolate from the bronchoalveolar lavage fluid of a patient with pneumonia were obtained. these 8 isolates exhibited reduced susceptibility to triazoles. preliminary pathogenicity data from balb/c mice suggest that a. calidoustus can persist in tissues for long periods without causing mortality. further studies using graded doses of inoculum and immunosuppres ... | 2014 | 24920775 |
| [microecological mechanisms of red-leaf disease occurrence in salvia miltiorrhiza bge]. | a comparative study was made on the nutrient content in rhizosphere soil and the microflora in rhizosphere soil and on rhizoplane of healthy and red-leaf diseased salvia miltiorrhiza plants, aimed to approach the microecological mechanisms of red-leaf disease occurrence in s. miltiorrhiza. the n, p, k, and mn contents in the diseased plant leaves were significantly lower than those in the healthy plant leaves (p < 0.05). no significant difference was observed in the available p content in the rh ... | 2013 | 24175532 |
| invasive aspergillosis caused by cryptic aspergillus species: a report of two consecutive episodes in a patient with leukaemia. | we report a case of two consecutive episodes of invasive aspergillosis caused by cryptic aspergillus species in a patient with leukaemia. a first episode of pulmonary infection was caused by aspergillus calidoustus and aspergillus novofumigatus, and the second episode by a. novofumigatus and aspergillus viridinutans. fungal isolates were identified to species level using traditional and sequencing-based molecular methods. | 2013 | 23161769 |
| emergence of aspergillus calidoustus infection in the era of posttransplantation azole prophylaxis. | universal antifungal prophylaxis with azoles is commonly used after lung transplantation. we noted an increase in isolates of aspergillus calidoustus in our transplant population and hypothesized that increasing azole use (universal prophylaxis since 2008) may be promoting this infection. | 2012 | 22805441 |
| aspergillus calidoustus case series and review of the literature. | aspergillus calidoustus, previously classified as aspergillus ustus, is an emerging pathogen in immunocompromised persons. we describe four recent cases of a. calidoustus and review 37 additional cases of a. calidoustus (n=16) or a. ustus (n=25) published through june 2016. twenty (49%) cases occurred in patients with hematologic malignancy and/or receipt of hematopoietic cell transplantation, and 13 (32%) occurred in solid organ transplant recipients. antifungal susceptibility was reported in 4 ... | 2017 | 28741738 |
| in vitro activity of the novel antifungal compound f901318 against difficult-to-treat aspergillus isolates. | f901318 is a new antifungal agent with a novel mechanism of action with activity against aspergillus species. we investigated the in vitro activity of f901318 against a collection of aspergillus isolates. | 2017 | 28605488 |
| antifungal susceptibility testing of aspergillus spp. by using a composite correlation index (cci)-based matrix-assisted laser desorption ionization-time of flight mass spectrometry method appears to not offer benefit over traditional broth microdilution testing. | aspergillus spp. cause serious invasive lung infections, and aspergillus fumigatus is the most commonly encountered clinically significant species. voriconazole is considered to be the drug of choice for treating a. fumigatus infections; however, rising resistance rates have been reported. we evaluated a matrix-assisted laser desorption ionization-time of flight mass spectrometry (maldi-tof ms)-based method for the differentiation between wild-type and non-wild-type isolates of 20 aspergillus sp ... | 2017 | 28404678 |