| the sensitizing capacity of compositae plants. i. occupational contact dermatitis from arnica longifolia eaton. | three patients with occupational contact dermatitis due to arnica longifolia eaton and arnica montana l. are reported. during cultivation, harvesting of the flower heads, chemical investigation of the sesquiterpene lactone constituents and preparation of therapeutic tinctures, they had frequent contact with the plant materials. patch tests with the two sesquiterpene lactones carabron and helenalin, isolated during investigation from a. longifolia eaton, were positive in all three patients, thoug ... | 1978 | 148995 |
| identification of the allergens of arnica montana l. | | 1978 | 154377 |
| helenalinmethacrylate, a new pseudoguaianolide from the flowers of arnica montana l. and the sensitizing capacity of their sesquiterpene lactones. | | 1978 | 704699 |
| [immunologic studies of plant combination preparations. in-vitro and in-vivo studies on the stimulation of phagocytosis]. | the activity of phagocytosis was tested in the in vitro granulocyte test and the in vivo carbon-clearance-test in the mouse for an extract combination consisting of four plant extracts (echinacea angustifolia, eupatorium perfoliatum, baptisia tinctoria and arnica montana). in both immune models, a step by step stimulation of the activity of phagocytosis by the addition of the four plant extracts was shown with an increase in effectiveness of partially over 50% in comparison to the pure echinacea ... | 1991 | 1799388 |
| helenalin and 11 alpha,13-dihydrohelenalin, two constituents from arnica montana l., inhibit human platelet function via thiol-dependent pathways. | this study investigates the effect on human platelet function of two sesquiterpene lactones from arnica montana l., helenalin (h) and 11 alpha,13-dihydrohelenalin (dh). both compounds inhibited collagen-induced platelet aggregation, thromboxane formation and 5-hydroxytryptamine secretion in a concentration-dependent manner at 3-300 microm. when arachidonic acid was used as stimulus, thromboxane formation remained unaffected despite of inhibition of platelet aggregation. both h and dh reduced the ... | 1990 | 2116680 |
| [new components of blossoms from arnica montana l]. | | 1974 | 4134079 |
| [efficacy of the phenol compounds of arnica in toxic lesion of the liver]. | experiments on rats with toxic liver injury induced by carbon tetrachloride have shown that the preparation presenting a sum of phenolic compounds of arnica montana and foliated arnica favours a more complete recovery of the bile secretion intensity, synthesis and excretion with bile of bile acids and bilirubin, and cholesterol excretion. it also accelerates the recovery of activity of serum enzymes. | 1983 | 6852212 |
| [arnica allergy]. | arnica montana l. (plant family: compositae) is one of the oldest and most important drug plants. besides its healing effects it also reveals sensitizing properties. from the literature more than 35 references with more than 100 cases of contact dermatitis could be cited, completed by four own cases. in most cases sensitization was induced by self treatment with tincture of arnica, whereas occupational contact dermatitis in drug sellers of pharmacists is rare. chemical and animal experimental in ... | 1980 | 6993423 |
| contact dermatitis caused by sesquiterpene lactones. | compositae dermatitis involves workers such as gardeners, florists, and farmers, and less commonly people not employed in occupations at risk. | 1998 | 9471988 |
| [effect of arnica montana on the state of lipid peroxidation and protective glutathione system of rat liver in experimental toxic hepatitis]. | effects of tinctura arnica on lipids peroxidation and on the protective glutathions system of liver in rats in case of experimental toxic hepatitis have been studied. toxic hepatitis is accompanied by deep alterations of the oxidant-antioxidant status of the body. intoxication of the body by ccl4 results in intensification of the free radicals formation particularly in liver: accumulation of lipids peroxidation molecular products, glutathione system enzyme activity inhibition in early terms and ... | 1998 | 9848164 |
| [effect of arnica montana tincture on some hydrolytic enzyme activities of rat liver in experimental toxic hepatitis]. | effects of tinctura arnica on arginase, adenosine triphosphatase, glucose-6-phosphatase and 5'-nucleotidase activities of rats liver in case of experimental toxic hepatitis have been studied. toxic hepatitis was caused by 2 times interstomach administration of 0.25 ml oil solution of carbon tetrachloride per 100 g of animal weight. 20 mkl/100 g of tinctura arnica was administered every day per os for 14 days. the enzyme activities have been investigated at 3, 7 and 17 days. a significant dementi ... | 1998 | 10402655 |
| effect of traumeel s, a homeopathic formulation, on blood-induced inflammation in rats. | to evaluate the activity of traumeel s (trs), a homeopathic formulation containing arnica montana and other plant extracts and minerals on an animal model of traumatic inflammation. | 1999 | 10709306 |
| in vitro antimicrobial activity of propolis and arnica montana against oral pathogens. | arnica and propolis have been used for thousands of years in folk medicine for several purposes. they possess several biological activities such as anti-inflammatory, antifungal, antiviral and tissue regenerative, among others. although the antibacterial activity of propolis has already been demonstrated, very few studies have been done on bacteria of clinical relevance in dentistry. also, the antimicrobial activity of arnica has not been extensively investigated. therefore the aim here was to e ... | 2000 | 10716618 |
| final report on the safety assessment of arnica montana extract and arnica montana. | arnica montana extract is an extract of dried flowerheads of the plant, arnica montana. arnica montana is a generic term used to describe a plant material derived from the dried flowers, roots, or rhizomes of a. montana. common names for a. montana include leopard's bane, mountain tobacco, mountain snuff, and wolf's bane. two techniques for preparing arnica montana extract are hydroalcoholic maceration and gentle disintegration in soybean oil. propylene glycol and butylene glycol extractions wer ... | 2001 | 11558636 |
| studies on the anti-inflammatory activity of phytopharmaceuticals prepared from arnica flowers. | phytopharmaceuticals prepared from flowerheads of arnica montana of spanish origin and of the new type "arbo", which can be easily and economically cultivated, were studied for their capability to impair activation of the transcription factors nf-kappa b and nf-at. both proteins are responsible for the transcription of genes encoding various inflammatory mediators. additionally, their influence on the release of the cytokines il-1 and tnf-alpha were examined. the inhibitory activities correlate ... | 2002 | 12058311 |
| antibacterial activity of medicinal plant extracts against periodontopathic bacteria. | this study was performed to evaluate the antibacterial activity of althaea officinalis l. roots, arnica montana l. flowers, calendula officinalis l. flowers, hamamelis virginiana l. leaves, illicium verum hook. fruits and melissa officinalis l. leaves, against anaerobic and facultative aerobic periodontal bacteria: porphyromonas gingivalis, prevotella spp., fusobacterium nucleatum, capnocytophaga gingivalis, veilonella parvula, eikenella corrodens, peptostreptococcus micros and actinomyces odont ... | 2003 | 12820224 |
| nonlinear effects of glutamate and kcl on glutamate toxicity in cultured rat cerebellar neurons. | nonlinear responses to toxin exposure have been observed in multiple cell types and organisms across a wide array of phyla. high dose toxin exposures inhibit or kill biological systems, while low dose exposures can stimulate survival mechanisms. we examined the effects of low (10(-3), 10(-5), 10(-7), and 10(-9) m) and ultra-low (10(-25) and 10(-61) m) kcl and glutamate pretreatment (72 h) against glutamate toxicity in rat cerebellar neurons. ultra-low dilutions (10(-31), 10(-61), and 10(-401)) o ... | 2003 | 12856478 |
| dual inhibition of 5-lipoxygenase/cyclooxygenase by a reconstituted homeopathic remedy; possible explanation for clinical efficacy and favourable gastrointestinal tolerability. | in order to elucidate potential anti-inflammatory activities of zeel comp. n and its constituents, the inhibition of the synthesis of leukotriene b4 (ltb4) and prostaglandin (pge2) by 5-lipoxygenase (5-lox) and cyclo-oxygenase 1 and 2 (cox 1 and 2) respectively were examined in vitro. | 2004 | 15060721 |
| in vitro behaviour of sesquiterpene lactones and sesquiterpene lactone-containing plant preparations in human blood, plasma and human serum albumin solutions. | the interactions of the three sesquiterpene lactones (sls) dihydrohelenalin acetate, dihydrohelenalin methacrylate and helenalin isobutyrate from arnica montana and of parthenolide from tanacetum parthenium as well as of three ethanolic arnica preparations with human blood proteins using different matrices, human serum albumin (hsa), plasma and whole blood, were investigated. the extent of protein binding in human plasma or to human albumin differed significantly between individual sls (dihydroh ... | 2004 | 15114499 |
| anti-inflammatory activity of arnica montana 6ch: preclinical study in animals. | the anti-inflammatory effect of arnica montana 6ch was evaluated using acute and chronic inflammation models. in the acute, model, carrageenin-induced rat paw oedema, the group treated with arnica montana 6ch showed 30% inhibition compared to control (p < 0.05). treatment with arnica 6ch, 30 min prior to carrageenin, did not produce any inhibition of the inflammatory process. in the chronic model, nystatin-induced oedema, the group treated 3 days previously with arnica montana 6ch had reduced in ... | 2004 | 15139092 |
| skin penetration studies of arnica preparations and of their sesquiterpene lactones. | alcoholic preparations of arnica montana are widely used for the topical treatment of various inflammatory diseases. sesquiterpene lactones (sls) are mainly responsible for their anti-inflammatory activity. here we have studied the penetration kinetics of arnica tinctures prepared from dried arnica flowers originating from different chemotypes as well as of their respective dominating sls, helenalin isobutyrate and 11alpha,13-dihydrohelenalin acetate. some alcoholic preparations of fresh arnica ... | 2004 | 15490315 |
| new sesquiterpene lactones from arnica tincture prepared from fresh flowerheads of arnica montana. | investigation of an ethanolic extract prepared from fresh arnica montana flowers afforded three new 1,5- trans-guaianolides, of which 11alpha,13-dihydro-2-o-tigloylflorilenalin and the respective 2-o-isovaleryl derivative are reported for the first time. additionally, three new and one known 2beta-ethoxy-2,3-dihydrohelenalin esters were isolated. gc/ms studies of the extract after a two year storage at 4 degrees c demonstrated that the latter were artefacts that had been formed by addition of et ... | 2005 | 16320207 |
| thymol derivatives from hairy roots of arnica montana. | five known thymol derivatives were isolated from roots of arnica montana transformed with agrobacterium rhizogenes lba 9402. the compounds were characterized by spectral methods. the pattern of thymol derivatives in light-grown hairy roots was slightly different from that in dark-grown ones. this is the first report on the presence of thymol derivatives in hairy roots of the plant. | 2006 | 16586074 |
| skin penetration behaviour of sesquiterpene lactones from different arnica preparations using a validated gc-msd method. | preparations of arnica montana l. are widely used for the topical treatment of inflammatory diseases. the anti-inflammatory activity is mainly attributed to their sesquiterpene lactones (sls) from the helenalin and 11alpha,13-dihydrohelenalin type. to study the penetration kinetics of sls in arnica preparations, a stripping method with adhesive tape and pig skin as a model was used. for the determination of sls in the stripped layers of the stratum corneum (sc), a gas chromatography/mass spectro ... | 2007 | 16930911 |
| permeation of bioactive constituents from arnica montana preparations through human skin in-vitro. | this study investigated and characterised transdermal permeation of bioactive agents from a topically applied arnica montana tincture. permeation experiments conducted over 48 h used polydimethylsiloxane (silastic) and human epidermal membranes mounted in franz-type diffusion cells with a methanol-water (50:50 v/v) receptor fluid. a commercially available tincture of a. montana l. derived from dried spanish flower heads was a donor solution. further donor solutions prepared from this stock tinct ... | 2006 | 16945174 |
| rat models of acute inflammation: a randomized controlled study on the effects of homeopathic remedies. | one of the cardinal principles of homeopathy is the "law of similarities", according to which patients can be treated by administering substances which, when tested in healthy subjects, cause symptoms that are similar to those presented by the patients themselves. over the last few years, there has been an increase in the number of pre-clinical (in vitro and animal) studies aimed at evaluating the pharmacological activity or efficacy of some homeopathic remedies under potentially reproducible co ... | 2007 | 17233886 |
| effect of vehicles on topical application of aloe vera and arnica montana components. | in this study two types of gels and microemulsions are investigated for their ability to dissolve, release, and induce the permeation of helenalin, a flavonoid responsible for the anti-inflammatory activity of arnica montana extract, and aloin, an anthrone-c-glucosyls with antibacterial activity present in aloe vera extract. the release of these agents from each vehicle was followed by hplc, and transcutaneous permeation was examined using a modified franz cell and a porcine skin membrane. the s ... | 2007 | 17994359 |
| reduced nitrogen has a greater effect than oxidised nitrogen on dry heathland vegetation. | we investigated the effects of different ratios of reduced (nh4+) versus oxidised (no3(-)) nitrogen in deposition on heathland and species-rich grassland vegetation at high nitrogen deposition levels in large mesocosms filled with nutrient-poor soils to which different nh4+/no3(-) ratios were applied. the response of the forbs, antennaria dioica, arnica montana, gentiana pneumonanthe, thymus serpyllum, the grasses danthonia decumbens, deschampsia flexuosa, nardus stricta and the shrub calluna vu ... | 2008 | 18206283 |
| anti-inflammatory and immune-regulatory mechanisms prevent contact hypersensitivity to arnica montana l. | sesquiterpene lactones (sl), secondary plant metabolites from flowerheads of arnica, exert anti-inflammatory effects mainly by preventing nuclear factor (nf)-kappab activation because of alkylation of the p65 subunit. despite its known immunosuppressive action, arnica has been classified as a plant with strong potency to induce allergic contact dermatitis. here we examined the dual role of sl as anti-inflammatory compounds and contact allergens in vitro and in vivo. we tested the anti-inflammato ... | 2008 | 18341569 |
| effects of phonophoresis with arnica montana onto acute inflammatory process in rat skeletal muscles: an experimental study. | this study aimed at verifying the effects of phonophoresis associated with arnica montana on the acute phase of an inflammatory muscle lesion. forty wistar male rats (300+/-50 g), of which the tibialis anterior muscle was surgically lesioned, were divided into four groups (n=10 each): control group received no treatment; the ultrasound group (us) was treated in pulsed mode with 1-mhz frequency, 0.5 w/cm(2) intensity (spatial and temporal average - sata), duty cycle of 1:2 (2 ms on, 4 ms off, 50% ... | 2009 | 19152953 |
| helenalin suppresses essential immune functions of activated cd4+ t cells by multiple mechanisms. | helenalin is a naturally occuring sesquiterpene lactone extracted from arnica montana and arnica chamissonis ssp. foliosa. helenalin and its derivatives are known for anti-cancer and anti-inflammatory effects via inhibiting nf-kappab and telomerase activity and impairing protein and dna synthesis, suggesting that helenalin is a potential candidate for the treatment of deregulated and unwanted t cell-mediated immune responses. here we show that helenalin induces apoptosis in activated cd4+ t cell ... | 2009 | 19656571 |
| inflammatory process modulation by homeopathic arnica montana 6ch: the role of individual variation. | the effects of arnica montana 6ch on the individual modulation of acute inflammation kinetics in rats were evaluated. adult male wistar rats were inoculated with 1% carrageenan into the footpad and treated with arnica montana 6ch, dexamethasone (4.0?mg/kg; positive control) or 5% hydroalcoholic solution (negative control), per os, each 15 minutes, between 30 and 180 minutes after the irritant inoculation. histopathological and immunohistochemistry procedures were done in order to get a panel of ... | 2011 | 21318109 |
| endophytic streptomyces in the traditional medicinal plant arnica montana l.: secondary metabolites and biological activity. | arnica montana l. is a medical plant of the asteraceae family and grows preferably on nutrient poor soils in mountainous environments. such surroundings are known to make plants dependent on symbiosis with other organisms. up to now only arbuscular mycorrhizal fungi were found to act as endophytic symbiosis partners for a. montana. here we identified five streptomyces strains, microorganisms also known to occur as endophytes in plants and to produce a huge variety of active secondary metabolites ... | 2015 | 26036671 |
| dermatitis from arnica montana. | | 2003 | 145351 |
| identification of hsp70-inducing activity in arnica montana extract and purification and characterization of hsp70-inducers. | the expression of heat shock proteins (hsps), particularly hsp70, is receiving considerable attention in the field of cosmetics, particularly given our recent report that ultraviolet-induced melanin production, skin damage and wrinkle formation were all suppressed in transgenic mice expressing hsp70. | 2015 | 25724362 |
| plants with topical uses in the ripollès district (pyrenees, catalonia, iberian peninsula): ethnobotanical survey and pharmacological validation in the literature. | the skin is the main structure that protects the human body from environmental factors and has, in addition, a relevant relationship to people׳s appearance and beauty. official medicine and cosmetics have shown interest on elaborating products to protect the dermal system, yet the role of folk medicine is highly unknown in this field. taking this into account, we performed an ethnobotanical study in a catalan district of the eastern pyrenees (northeast iberian peninsula), with the purpose of ass ... | 2015 | 25666424 |
| fourteen polymorphic microsatellite markers for the threatened arnica montana (asteraceae). | | 2015 | 25606354 |
| in vitro antimicrobial activity of romanian medicinal plants hydroalcoholic extracts on planktonic and adhered cells. | the aim of this study was to assess the antibacterial and antifungal potential of some romanian medicinal plants, arnica--arnica montana, wormwood--artemisia absinthium and nettle--urtica dioica. in order to perform this antimicrobial screening, we obtained the vegetal extracts and we tested them on a series of gram-positive and gram-negative bacteria, and also against two fungal strains. the vegetal extracts showed antimicrobial activity preferentially directed against the planktonic fungal and ... | 2011 | 21717806 |
| the effect of polyphenolic-polysaccharide conjugates from selected medicinal plants of asteraceae family on the peroxynitrite-induced changes in blood platelet proteins. | lots of plants belonging to asteraceae family are very popular in folk medicine in poland. these plants are also known as being rich in acidic polysaccharides, due to the presence of hexuronic acids or its derivatives. our preliminary experiments have shown that the extract from conyza canadensis l. possesses various biological activity, including antiplatelet, antiocoagulant and antioxidant properties. the aim of our study was to assess if macromolecular glycoconjugates from selected herbal pla ... | 2010 | 20869393 |
| a sensitive sensor cell line for the detection of oxidative stress responses in cultured human keratinocytes. | in the progress of allergic and irritant contact dermatitis, chemicals that cause the generation of reactive oxygen species trigger a heat shock response in keratinocytes. in this study, an optical sensor cell line based on cultured human keratinocytes (hacat cells) expressing green fluorescent protein (gfp) under the control of the stress-inducible hsp70b' promoter were constructed. exposure of hacat sensor cells to 25 µm cadmium, a model substance for oxidative stress induction, provoked a 1.7 ... | 2014 | 24967604 |
| ethnobotanical and phytomedical knowledge in the north-western ligurian alps. | the ethnobotany of european alpine regions is much diversified and scarcely investigated. these regions retain a well-developed heritage culture and botanical traditional knowledge, favored by the isolated montane location. we carried out a study of therapeutic and traditional uses of native plants of a poorly explored area of the western italian alps in the ligurian region (nw italy). the area has been the object of human activities since prehistoric ages, and an obliged crossroad for people mo ... | 2014 | 24910407 |
| characterization and pharmacodynamic properties of arnica montana complex. | a dark brown polymeric complex was isolated from flowering parts of medicinal plant arnica montana l. by hot alkaline extraction followed by neutralization and multi-step extractions with organic solvents. it was recovered in 5.7% yield, on gpc showed two peaks of molecular mass of 9 and 3.5kda. the compositional analyses of arnica complex revealed the presence of carbohydrates (26%), uronic acids (12%), phenolics (1.25mm or 213mg of gae/1g), and low protein content (∼1%). the carbohydrate moiet ... | 2014 | 24875316 |
| dental practice scenario in a government homeopathic hospital in west bengal, india. | this pilot investigation initiated a research-targeted systematic dental homeopathy data collection in the dental outpatient section in a government homeopathic hospital in west bengal, india. one conventionally trained dentist and 3 homeopathic doctors collected data from 949 appointments of 411 patients over 3 months. a specifically designed excel spreadsheet enabled recording of consecutive dental appointments that was subjected to data synthesis and analysis in the end. a total of 87.3% cond ... | 2014 | 24742607 |
| arbuscular mycorrhiza of arnica montana under field conditions--conventional and molecular studies. | two distinct populations of arnica montana, an endangered medicinal plant, were studied under field conditions. the material was investigated using microscopic and molecular methods. the analyzed plants were always found to be mycorrhizal. nineteen arbuscular mycorrhizal fungal dna sequences were obtained from the roots. they were related to glomus group a, but most did not match any known species. some showed a degree of similarity to fungi colonizing liverworts. conventional analysis of spores ... | 2010 | 20195874 |
| perioperative arnica montana for reduction of ecchymosis in rhinoplasty surgery. | studies of homeopathic therapies to decrease postrhinoplasty ecchymosis have previously used subjective measurements, limiting their clinical significance. recently, arnica montana was shown to decrease postoperative ecchymosis after rhytidectomy, using an objective measuring tool. we believe that oral a. montana, given perioperatively, can be objectively shown to reduce extent and intensity of postoperative ecchymosis in rhinoplasty surgery. | 2016 | 25954844 |
| inhibitory effects of β-cyclodextrin-helenalin complexes on h-tert gene expression in the t47d breast cancer cell line - results of real time quantitative pcr. | nowadays, the encapsulation of cytotoxic chemotherapeutic agents is attracting interest as a method for drug delivery. we hypothesized that the efficiency of helenalin might be maximized by encapsulation in β-cyclodextrin nanoparticles. helenalin, with a hydrophobic structure obtained from flowers of arnica chamissonis and arnica montana, has anti-cancer and anti-inflammatory activity but low water solubility and bioavailability. β-cyclodextrin (β-cd) is a cyclic oligosaccharide comprising seven ... | 2013 | 24377631 |
| cumulative therapeutic effects of phytochemicals in arnica montana flower extract alleviated collagen-induced arthritis: inhibition of both pro-inflammatory mediators and oxidative stress. | the plant arnica montana is used in folk medicine to alleviate pain, inflammation and swelling of muscles and joints associated with rheumatoid arthritis and other inflammatory conditions. the present study aimed to investigate the therapeutic effects and mechanism of action of a. montana flower methanol extract (amme) against both inflammation and oxidative stress in a collagen-induced arthritis (cia) rat model. | 2016 | 25966322 |
| physiotherapy and a homeopathic complex for chronic low-back pain due to osteoarthritis: a randomized, controlled pilot study. | osteoarthritis (oa) is a common cause of chronic low-back pain (clbp) and can be managed with drug therapy and physiotherapy. homeopathic remedies may assist managing oa; however, research that supports their effectiveness is limited. | 2016 | 26773321 |
| assessing the effectiveness of arnica montana and rhododendron tomentosum (ledum palustre) in the reduction of ecchymosis and edema after oculofacial surgery: preliminary results. | the purpose of this study was to provide preliminary data on the potential effectiveness of the combination of topical arnica montana and rhododendron tomentosum (ledum palustre) in reducing postoperative ecchymosis and edema in a select population of healthy volunteers after oculofacial surgery. | 2017 | 26863038 |
| chemometrics-based approach in analysis of arnicae flos. | arnica montana flowers have a long history as herbal medicines for external use on injuries and rheumatic complaints. | 2015 | 27013791 |
| arnica montana effects on gene expression in a human macrophage cell line. evaluation by quantitative real-time pcr. | arnica montana is a popular traditional remedy widely used in complementary medicine, also for its wound healing properties. despite its acknowledged action in clinical settings at various doses, the molecular aspects relating to how a. montana promotes wound healing remain to be elucidated. to fill this gap, we evaluated the whole plant extract, in a wide range of dilutions, in thp-1 human cells, differentiated into mature macrophages and into an alternative il-4-activated phenotype involved in ... | 2016 | 27211321 |
| quality control of saffron (crocus sativus l.): development of scar markers for the detection of plant adulterants used as bulking agents. | a method based on sequence-characterized amplified regions (scars) was developed from random amplified polymorphic dna markers (rapds) specific for arnica montana l., bixa orellana l., calendula officinalis l., carthamus tinctorius l., crocus vernus l. (hill), curcuma longa l., and hemerocallis sp. to detect these common bulking agents in commercial saffron (crocus sativus). the method enabled the unequivocal detection of low amounts (up to 1%) of each adulterant, allowing the preemptive rejecti ... | 2012 | 22989071 |
| evaluation of antioxidant and cytoprotective activities of arnica montana l. and artemisia absinthium l. ethanolic extracts. | arnica montana l. and artemisia absinthium l. (asteraceae) are medicinal plants native to temperate regions of europe, including romania, traditionally used for treatment of skin wounds, bruises and contusions. in the present study, a. montana and a. absinthium ethanolic extracts were evaluated for their chemical composition, antioxidant activity and protective effect against h2o2-induced oxidative stress in a mouse fibroblast-like nctc cell line. | 2012 | 22958433 |
| árnica: a multivariate analysis of the botany and ethnopharmacology of a medicinal plant complex in the iberian peninsula and the balearic islands. | medicinal plant complexes of different species sharing vernacular names, morphological and aromatic characteristics and uses are common in traditional medicine of different cultures. a quantitative methodology as a tool for ethnopharmacological studies is presented for systematically analyzing morphological and therapeutic features shared by several species integrating such complexes. | 2012 | 22947388 |
| efficacy of a non-hormonal treatment, brn-01, on menopausal hot flashes: a multicenter, randomized, double-blind, placebo-controlled trial. | homeopathic medicines have a place among the non-hormonal therapies for the treatment of hot flashes during the menopause. | 2012 | 22852580 |
| developmental and environmental effects on sesquiterpene lactones in cultivated arnica montana l. | the amount of sesquiterpene lactones and the lactone profile of arnica montana l. in flowering and seed formation stages in vitro and in vivo propagated from seeds of german, ukrainian, and austrian origin and grown in two experimental fields were studied. it was found that in vitro propagated 2-year plants in full flowering stage accumulated higher amount of lactones in comparison to in vivo propagated 3-year plants and to the seed formation stage, respectively. helenalins predominated in in vi ... | 2016 | 27368426 |
| genetic structure of colline and montane populations of an endangered plant species. | due to land-use intensification, lowland and colline populations of many plants of nutrient-poor grasslands have been strongly fragmented in the last decades, with potentially negative consequences for their genetic diversity and persistence. populations in mountains might represent a genetic reservoir for grassland plants, because they have been less affected by land-use changes. we studied the genetic structure and diversity of colline and montane vosges populations of the threatened perennial ... | 2016 | 27519913 |
| commentary: arnica montana effects on gene expression in a human macrophage cell line: evaluation by quantitative real-time pcr. | | 2016 | 27660630 |
| identification and characterization of two new derivatives of chlorogenic acids in arnica (arnica montana l.) flowers by high-performance liquid chromatography/tandem mass spectrometry. | arnica montana is a medicinally important plant due to its broad health effects, and it is used in ayurvedic, homeopathic, unani, and folk medicines. we have used lc-ms(n) (n = 2-5) to detect and characterize in arnica flowers 11 quantitatively minor fumaric and methoxyoxalic acid-containing chlorogenic acids, nine of them not previously reported in nature. these comprise 1,5-dicaffeoyl-3-methoxyoxaloylquinic acid, 1,3-dicaffeoyl-4-methoxyoxaloylquinic acid, 3,5-dicaffeoyl-4-methoxyoxaloylquinic ... | 2011 | 21413809 |
| quantitative analysis of sesquiterpene lactones in extract of arnica montana l. by 1h nmr spectroscopy. | (1)h nmr spectroscopy was used as a method for quantitative analysis of sesquiterpene lactones present in a crude lactone fraction isolated from arnica montana. eight main components - tigloyl-, methacryloyl-, isobutyryl- and 2-methylbutyryl-esters of helenalin (h) and 11α,13-dihydrohelenalin (dh) were identified in the studied sample. the method allows the determination of the total amount of sesquiterpene lactones and the quantity of both type helenalin and 11α,13-dihydrohelenalin esters separ ... | 2011 | 20837387 |
| response to commentary: arnica montana effects on gene expression in a human macrophage cell line. evaluation by quantitative real-time pcr. | | 2016 | 27667990 |
| arnica montana stimulates extracellular matrix gene expression in a macrophage cell line differentiated to wound-healing phenotype. | arnica montana (arnica m.) is used for its purported anti-inflammatory and tissue healing actions after trauma, bruises, or tissue injuries, but its cellular and molecular mechanisms are largely unknown. this work tested arnica m. effects on gene expression using an in vitro model of macrophages polarized towards a "wound-healing" phenotype. the monocyte-macrophage human thp-1 cell line was cultured and differentiated with phorbol-myristate acetate and interleukin-4, then exposed for 24h to arni ... | 2016 | 27832158 |
| re: "assessing the effectiveness of arnica montana and rhododendron tomentosum (ledum palustre) in the reduction of ecchymosis and edema after oculofacial surgery: preliminary results". | | 2017 | 28060247 |
| variation of sesquiterpene lactone contents in different arnica montana populations: influence of ecological parameters. | in ten grassland or heathland sites along a geographic (north to south) and climatic gradient in germany, flowerheads of arnica montana were collected, and the total content of sesquiterpene lactones (sls) as well as the content of the detected single compounds were determined. the ratios of helenalin (h)- and corresponding 11 alpha,13-dihydrohelenalin(dh)-type compounds were calculated. all habitats were characterised concerning the climatic and soil conditions, and the values obtained were cor ... | 2010 | 20101561 |
| reply re: "assessing the efficacy of arnica montana and rhododendron tomentosum (ledum palustre) in the reduction of ecchymosis and edema after oculofacial surgery: preliminary results". | | 2017 | 28060248 |
| feasibility, acceptability, and tolerability of rgn107 in the palliative wound care management of chronic wound symptoms. | to assess the feasibility, acceptability and tolerability of rgn107 use, a natural powder blend of arnica montana, calendula officinalis, mentha arvensis and santalum album, among hospice patients and their wound caregivers in the palliative wound care management of chronic wound symptoms at end-of-life. | 2017 | 28105900 |
| remedies containing asteraceae extracts: a prospective observational study of prescribing patterns and adverse drug reactions in german primary care. | the use of complementary therapies by patients has increased over the past 20 years, both in terms of self-medication and physician prescriptions. among herbal medicines, those containing extracts of asteraceae (compositae), such as echinacea spp., arnica montana, matricaria recutita and calendula officinalis, are especially popular in the primary-care setting. however, there remains a gap between the growing acceptance of these remedies and the lack of data on their safety. | 2009 | 19591533 |
| is there a role for homeopathy in breast cancer surgery? a first randomized clinical trial on treatment with arnica montana to reduce post-operative seroma and bleeding in patients undergoing total mastectomy. | this study aimed to evaluate the benefits of arnica montana on post-operative blood loss and seroma production in women undergoing unilateral total mastectomy by administering arnica montana 1000 korsakovian dilution (1000 k). | 2017 | 28163953 |
| phytomedicine in joint disorders. | chronic joint inflammatory disorders such as osteoarthritis and rheumatoid arthritis have in common an upsurge of inflammation, and oxidative stress, resulting in progressive histological alterations and disabling symptoms. currently used conventional medication (ranging from pain-killers to biological agents) is potent, but frequently associated with serious, even life-threatening side effects. used for millennia in traditional herbalism, medicinal plants are a promising alternative, with lower ... | 2017 | 28275210 |
| identification of hydroxycinnamoylquinic acids of arnica flowers and burdock roots using a standardized lc-dad-esi/ms profiling method. | a screening method using lc-dad-esi/ms was developed for the identification of common hydroxycinnamoylquinic acids based on direct comparison with standards. a complete standard set for mono-, di-, and tricaffeoylquinic isomers was assembled from commercially available standards, positively identified compounds in common plants (artichokes, asparagus, coffee bean, honeysuckle flowers, sweet potato, and vernonia amygdalina leaves) and chemically modified standards. four c18 reversed phase columns ... | 2008 | 18837557 |
| contact allergy to compositae plants in patients with atopic dermatitis. | to investigate the frequency of compositae sensitivity is one of the most important goals of current dermatology and allergology. we have patch tested 30 adult patients suffering from "extrinsic" atopic dermatitis with sesquiterpene lactone mix and compositae mix including compositae mix individual ingredients, extracts of arnica (arnica montana), chamomile (chamomilla recutita), tansy (tanacetum vulgare), fever few (tanacetum parthenium) and yarrow (achillea millefolium) as well as with specifi ... | 2009 | 15503788 |
| quantitative analysis of flavonoids and phenolic acids in arnica montana l. by micellar electrokinetic capillary chromatography. | arnica montana preparations have been used in europe for centuries to treat skin disorders. among the biologically active ingredients in the flower heads of the plant are sequiterpenes, flavonoids and phenolic acids. for the simultaneous determination of compounds belonging to the latter two groups a micellar electrokinetic capillary chromatography (mekc) method was developed and validated. by using an electrolyte solution containing 50 mm borax, 25 mm sodium dodecyl sulfate and 30% of acetonitr ... | 2008 | 18420051 |
| determination of the hydroxycinnamate profile of 12 members of the asteraceae family. | the hydroxycinnamates of the leaves of 12 plants of the astreraceae family, achillea millefolium, arnica montana, artemesia dracunculus, cichorium intybus, cnicus benedictus, cynara scolymus, echinops humilis, inula helenium, lactuca sativa, petasites hybridus, solidago virgaurea, and tanacetum parthenium were investigated qualitatively by lc-ms(n). thirty-nine chlorogenic acids were detected and all characterized to regioisomeric level on the basis of their fragmentation pattern in the tandem m ... | 2011 | 21453943 |
| effect of homeopathy on analgesic intake following knee ligament reconstruction: a phase iii monocentre randomized placebo controlled study. | the efficacy of homeopathy is still under debate and a recent meta-analysis recommended further randomized double-blind clinical trials to identify any clinical situation in which homeopathy might be effective. | 2008 | 18251757 |
| efficacy of arnica montana d4 for healing of wounds after hallux valgus surgery compared to diclofenac. | this study was undertaken to answer the question: "is arnica d4 as efficacious as diclofenac in relation to symptoms and wound healing after foot surgery?" | 2013 | 18199022 |
| cosmetics and herbal remedies with compositae plant extracts - are they tolerated by compositae-allergic patients? | compositae-sensitive patients are routinely warned against topical use of compositae-containing cosmetics and herbal remedies. however, the risk of elicitation of dermatitis in presensitized persons is unknown. | 2008 | 18154553 |
| retrospective analysis of 736 implants inserted without antibiotic therapy. | the routine use of antibiotics in oral implant treatment seems to be widespread. the principle of antibiotic prophylaxis before oral surgical procedures in patients at risk for endocarditis or in those who are severely immunocompromised is well established. antibiotic therapy in conjunction with implant surgery in fit patients and its correlation with failure and success rates remains poorly documented, however. the debate regarding overprescription of antibiotics raises the need for a critical ... | 2007 | 17954332 |
| quantification of sesquiterpene lactones in asteraceae plant extracts: evaluation of their allergenic potential. | sesquiterpene lactones (sls), mainly those with an activated exocyclic methylene group, are important allergens in asteraceae (compositae) plants. as a screening tool, the compositae mix, consisting of five asteraceae plant extracts with allergenic potential (feverfew, tansy, arnica, yarrow, and german chamomile) is part of several national patch test baseline series. however, the sl content of the compositae mix may vary due to the source material. therefore, a simple spectrophotometric method ... | 2017 | 24106675 |
| potential of the homeopathic remedy, arnica montana 30c, to reduce dna damage in escherichia coli exposed to ultraviolet irradiation through up-regulation of nucleotide excision repair genes. | to examine to what degree an ultra-highly diluted homeopathic remedy, arnica montana 30c (am-30c), used in the treatment of shock and injury, can modulate the expression of nucleotide excision repair genes in escherichia coli exposed to ultraviolet (uv) irradiation. | 2012 | 22409925 |
| homeopathic arnica montana for post-tonsillectomy analgesia: a randomised placebo control trial. | to evaluate the efficacy of homeopathic arnica in reducing the morbidity following tonsillectomy. | 2007 | 17227743 |
| homeopathic arnica therapy in patients receiving knee surgery: results of three randomised double-blind trials. | we investigated the effectiveness of homeopathic arnica montana on postoperative swelling and pain after arthroscopy (art), artificial knee joint implantation (akj), and cruciate ligament reconstruction (clr). | 2006 | 17105693 |
| core-hom: a powerful and exhaustive database of clinical trials in homeopathy. | the core-hom database was created to answer the need for a reliable and publicly available source of information in the field of clinical research in homeopathy. as of may 2014 it held 1048 entries of clinical trials, observational studies and surveys in the field of homeopathy, including second publications and re-analyses. 352 of the trials referenced in the database were published in peer reviewed journals, 198 of which were randomised controlled trials. the most often used remedies were arni ... | 2014 | 25439037 |
| effectiveness and safety of arnica montana in post-surgical setting, pain and inflammation. | arnica montana has been widely used as a homeopathic remedy for the treatment of several inflammatory conditions in pain management and postoperative settings. this review gives an overview of the therapeutic use of arnica montana in the above-mentioned fields also focusing on its mechanisms of action learned from animal models and in vitro studies. arnica montana is more effective than placebo when used for the treatment of several conditions including post-traumatic and postoperative pain, ede ... | 2016 | 25171757 |
| practice patterns in the perioperative treatment of patients undergoing septorhinoplasty: a survey of facial plastic surgeons. | importance the common practices used in the perioperative care of patients undergoing septorhinoplasty are diverse and controversial. a consensus statement on the preferred clinical pathway in the perioperative treatment of patients undergoing septorhinoplasty has yet to be approached formally. objectives to investigate the perioperative treatment of patients undergoing septorhinoplasty and to identify common practice patterns based on the preferences of leading facial plastic surgeons. design, ... | 2015 | 24311187 |
| altitudinal variation of secondary metabolite profiles in flowering heads of arnica montana cv. arbo. | the altitudinal variation on the contents of secondary metabolites in flowering heads of arnica montana was assessed. plants of a. montana cultivar arbo were grown in nine experimental plots at altitudes between 590 and 2230m at mount patscherkofel near innsbruck/austria. the total contents of sesquiterpene lactones and flavonoids were not positively correlated with the altitude of the growing site. however, the proportion of flavonoids with vicinal free hydroxy groups in ring b to flavonoids la ... | 2006 | 16405933 |
| propagation and introduction of arnica montana l. into cultivation: a step to reduce the pressure on endangered and high-valued medicinal plant species. | arnica montana (l.) is an endangered and endemic medicinal plant species in europe. the pressure on natural sources of this plant is alleviated by a suitable use of arnica resources in the european region and introduction into cultivation. the objective of this study was to describe the impact of different ways of plant propagation and introduction on the growth and reproduction mode of this species. during the six consecutive years of the field experiment, the vegetative and reproductive traits ... | 2013 | 24282381 |
| effect of the oral administration homeopathic arnica montana on mitochondrial oxidative stress. | to analyze the effect of homeopathic arnica on mitochondrial oxidative stress induced by ca(2+) plus inorganic phosphate and/or fe(2+)-citrate-mediated lipid peroxidation through changes in oxygen consumption rates. | 2013 | 23290879 |
| traditional knowledge on medicinal and food plants used in val san giacomo (sondrio, italy)--an alpine ethnobotanical study. | this work increases the ethnobotanical data from northern italy and, in particular, the lombardy region, till now poorly documented, safeguarding the local folk knowledge, and provides information on new or scarcely reported properties of medicinal plants, whose traditional use needs to be validated experimentally. | 2013 | 23220197 |
| sesquiterpene lactones in arnica montana: a rapid analytical method and the effects of flower maturity and simulated mechanical harvesting on quality and yield. | a rapid extraction, clean-up and rplc procedure suitable for routine quantitative analyses of sesquiterpene lactones (sls) in arnica montana is described. seven sls were isolated of which tigloyl and methacryloyl esters of helenalin made up over 50 % of the total. this method was applied to analyses of replicated samples of different flower parts, different stages of flower maturity, and herb from different harvest methods. the mean total sl levels were higher in the disk flowers (0.872 % w/w) t ... | 2004 | 14994196 |
| arnica montana and homeopathic dosing guidelines. | | 2003 | 12900640 |
| a systematic review and meta-analysis on the use of hypericum perforatum (st. john's wort) for pain conditions in dental practice. | hypericum perforatum (st. john's wort) has been used for a variety of medicinal indications. most recent research has focussed on its use in herbal form for depression, but its claimed analgesic and anti-inflammatory properties in homeopathic form have also led to a number of studies in patients with acute pain conditions. this systematic review overviews the literature on the use of st. john's wort for pain conditions in homeopathic dental practice. | 2012 | 23089215 |
| effects of microcurrent application alone or in combination with topical hypericum perforatum l. and arnica montana l. on surgically induced wound healing in wistar rats. | this study evaluated the wound healing activity of microcurrent application alone or in combination with topical hypericum perforatum l. and arnica montana l. on skin surgical incision surgically induced on the back of wistar rats. | 2012 | 22818231 |
| contact sensitization from compositae-containing herbal remedies and cosmetics. | the compositae (asteraceae) family of plants is currently an important cause of allergic plant contact dermatitis in europe. the family comprises some of the oldest and most valued medicinal plants, and the increasing popularity of herbal medicine and cosmetics may theoretically result in a growing number of compositae sensitizations from these sources. according to the literature at least 15 species, including among others arnica (arnica montana), german and roman chamomile (chamomilla recutita ... | 2002 | 12492516 |
| a homeopathic remedy from arnica, marigold, st. john's wort and comfrey accelerates in vitro wound scratch closure of nih 3t3 fibroblasts. | drugs of plant origin such as arnica montana, calendula officinalis or hypericum perforatum have been frequently used to promote wound healing. while their effect on wound healing using preparations at pharmacological concentrations was supported by several in vitro and clinical studies, investigations of herbal homeopathic remedies on wound healing process are rare. the objective of this study was to investigate the effect of a commercial low potency homeopathic remedy similasan® arnica plus sp ... | 2012 | 22809174 |
| a homeopathic arnica patch for the relief of cellulitis-derived pain and numbness in the hand. | arnica montana, belonging to the compositae family, is a plant with a longstanding tradition of relieving pain and/or inflammation in muscles and joints and may thus represent an alternative to nonsteroidal antiinflammatory drugs, which are often ineffective or lead to a number of adverse effects. a homeopathic arnica patch (3x dilution according to the homeopathic pharmacopoeia of the united states) was developed to alleviate pain symptoms in the back and neck muscles and joints. | 2012 | 24278813 |
| potential for danger with arnica montana. | | 2001 | 11293536 |
| efficacy of homeopathic arnica: a systematic review of placebo-controlled clinical trials. | the efficacy of homeopathic remedies has remained controversial. the homeopathic remedy most frequently studied in placebo-controlled clinical trials is arnica montana. | 1998 | 9820349 |
| [selenium as a modifier of antioxidant protection and lipid peroxidation in microclones of arnica montana l. as affected by c-range ultraviolet rays]. | selenium was studied for its effect on the node components of antioxidant protection of plants irradiated by uv of c-range. it is shown that selenium modifies the uv action of c-range and decreases the oxidation of sh-groups, increases activity of superoxide dismutase and glutathione peroxidase and decreases the accumulation of the end product of peroxidation: malondialdehyde. | 2015 | 9606837 |
| the effect of topical arnica on muscle pain. | the herb arnica montana, in topical formulations, has been reputed to decrease bruising and muscle pain. this claim has been inadequately and incompletely addressed. | 2010 | 20807867 |
| evaluation of homeopathic arnica montana for ecchymosis after upper blepharoplasty: a placebo-controlled, randomized, double-blind study. | ecchymosis is commonly encountered after upper eyelid blepharoplasty. the use of homeopathic preparations of arnica montana, a flowering herb, has been advocated by physicians, patients, and manufacturers for reduction of postsurgical ecchymosis. the authors evaluate its efficacy after upper eyelid blepharoplasty. | 2010 | 20683279 |