| analysis of the entire genomes of fifteen torque teno midi virus variants classifiable into a third group of genus anellovirus. | recently, we identified a novel human virus with a circular dna genome of 3.2 kb, tentatively designated as torque teno midi virus (ttmdv), with a genomic organization resembling those of torque teno virus (ttv) of 3.8-3.9 kb and torque teno mini virus (ttmv) of 2.8-2.9 kb. to investigate the extent of genomic variability of ttmdv genomes, the full-length sequence was determined for 15 ttmdv isolates obtained from viremic individuals in japan. the 15 ttmdv isolates comprised 3175-3230 bases and ... | 2007 | 17712598 |
| development of pcr assays with nested primers specific for differential detection of three human anelloviruses and early acquisition of dual or triple infection during infancy. | we recently identified a novel human virus classifiable into a third group in the genus anellovirus, tentatively designated torque teno midi virus (ttmdv), with a circular dna genome of 3.2 kb and genomic organization resembling those of torque teno virus (ttv) (3.8 to 3.9 kb) and torque teno mini virus (ttmv) (2.8 to 2.9 kb). ttmdv was characterized by extreme genetic diversity similar to the ttv and ttmv genomes. taking advantage of universal and virus species-specific primers derived from a h ... | 2008 | 18094127 |
| analysis of the entire genomes of torque teno midi virus variants in chimpanzees: infrequent cross-species infection between humans and chimpanzees. | humans are frequently infected with three anelloviruses which have circular dna genomes of 3.6-3.9 kb [torque teno virus (ttv)], 2.8-2.9 kb [torque teno mini virus (ttmv)] and 3.2 kb [a recently discovered anellovirus named torque teno midi virus (ttmdv)]. unexpectedly, human ttmdv dna was not detectable in any of 74 chimpanzees tested, although all but one tested positive for both human ttv and ttmv dna. using universal primers for anelloviruses, novel variants of ttmdv that are phylogeneticall ... | 2009 | 19141443 |
| history of discoveries and pathogenicity of tt viruses. | since 1997, groups of novel nonenveloped dna viruses with a circular, single-stranded (negative sense) dna genome of 3.6-3.9 kb, 3.2 kb, or 2.8-2.9 kb in size have been discovered and designated torque teno virus (ttv), torque teno midi virus (ttmdv), and torque teno mini virus (ttmv), respectively, in the floating genus anellovirus. these three anelloviruses frequently and ubiquitously infect humans, and the infections are characterized by lifelong viremia and great genetic variability. althoug ... | 2009 | 19230554 |
| transfusion transmission of highly prevalent commensal human viruses. | anellovirus species torque teno virus (ttv), torque teno mini virus (ttmv), and torque teno midi virus (ttmdv) and flavivirus gbv-c are highly prevalent and genetically diverse chronic human viral infections that have not yet been associated with disease. | 2010 | 20497515 |
| detection and follow-up of torque teno midi virus ("small anelloviruses") in nasopharyngeal aspirates and three other human body fluids in children. | torque teno midi virus/small anellovirus (ttmdv/sav) is a member of the family anelloviridae. it has a single-stranded, circular, negative-sense dna genome. its pathogenic role in human disease remains to be confirmed. in this study, viral shedding, molecular epidemiology and genetic diversity of ttmdv/sav were studied in human body fluids. nasopharyngeal aspirates collected from children with acute respiratory disease were tested by pcr/nested pcr for ttmdv/sav in two seasons (2005/2006, 2006/2 ... | 2011 | 21594596 |
| sequence analysis of a torque teno canis virus isolated in china. | in the present study, a total of 158 fecal samples were collected from diarrheal dogs younger than 1 year old in pet clinic in china. 20 specimens (20/158, 13%) were positive for torque teno canis virus dna using detection pcr. one representative positive isolate designated ldl was randomly selected, cloned and sequenced. the complete genome of the ldl chinese strain was 2799 nucleotides in length and contains three open reading frames (orfs), which encode 576 (orf1), 101 (orf2), and 243 (orf3) ... | 2011 | 21645561 |
| detection of torque teno midi virus/small anellovirus (ttmdv/sav) in chronic cervicitis and cervical tumors in isfahan, iran. | torque teno midi virus and small anellovirus (ttmdv/sav) are members of the genus gammatorquevirus within the family anelloviridae. cervical cancer is the second most prevalent cancer after breast cancer. the aim of this study was to determine the frequency of infection by these viruses in cervicitis and cervical tumors of women from isfahan, iran. formalin-fixed, paraffin-embedded tissue samples from cervical cancers (n = 42) and cervicitis cases (n = 79) were subjected to nested pcr to identif ... | 2011 | 22086157 |