| [inhibition of protein kinase c by stilbenoids]. | the effect of 15 stilbenoids on protein kinase c (pkc) was studied in order to search for naturally occurring pkc inhibitors. all these compounds were isolated from chinese medicines. three oligomeric stilbenes from caragana sinica, alpha-viniferin, kobophenol a and miyabenol c, were shown to intensely inhibit the activity of partially purified rat brain pkc with ic50 values of 62.5, 52.0, and 27.5 mumol.l-1, respectively. kinetic analyses revealed that that inhibition was noncompetitive. the ot ... | 1994 | 7863783 |
| metabolites and the pharmacokinetics of kobophenol a from caragana sinica in rats. | this research aims to study the metabolism and pharmacokinetics of phytoestrogen kobophenol a (1), the main active compound of caragana sinica (buc'hoz) rehd. (fabaceae), in rats. metabolites of 1 in rats' feces were isolated and purified by multi-chromatograph techniques; three new metabolites of 1, named koboquinone a (m1), koboquinone b (m2) and koboquinone c (m3), were isolated, purified from rats' feces after they being orally administered with 1. structure identification of the metabolites ... | 2005 | 16099120 |
| anti-herpetic activity of various medicinal plant extracts. | in order to find antiviral compounds againstherpes simplex virus type i (hsv-1) and ii (hsv-2) from natural products, a convenient virus-induced cytopathic effect (cpe) inhibition assay was introduced. more than 300 fractions were prepared by solvent fractionation from sixty collected plants or purchased herbal medicines, and their anti-herpetic activities were evaluated. among them, several medicinal plants showed potent anti-herpetic activity. selective indexes (si) of the etoac extract of car ... | 1997 | 18975213 |
| stilbene derivatives as human 5-ht(6) receptor antagonists from the root of caragana sinica. | the 5-ht₆ receptor (5-ht₆r) is a member of the class of recently discovered 5-hydroxytryptamine (5-ht) receptors. due to the lack of selective 5-ht₆r ligands, the cellular signaling mechanisms of the 5-ht₆r are poorly understood. we previously developed a cell-based high-throughput screening (hts) method for the 5-ht₆r and screened synthetic chemical compounds. in the present study, we expanded our screening into natural products to find novel 5-ht₆r ligands. we found that the ethyl acetate frac ... | 2010 | 21139245 |
| caragasinin c: a new oligostilbene from the roots of caragana sinica. | a new oligostilbene, caragasinin c (1), and seven known compounds, betulinic acid (2), 4-hydroxybenzaldehyde (3), (‒)-medicarpin (4), wistin (5), (2e,4s)-4-hydroxy-2-nonenoic acid (6), pallidol (7), and (+)-α-viniferin (8), were isolated from the roots of caragana sinica. the structure of caragasinin c was established on the basis of spectroscopic techniques, including hresims, 1d and 2d-nmr. | 2017 | 28347167 |
| extract of caragana sinica as a potential therapeutic option for increasing alpha-secretase gene expression. | alzheimer's disease represents one of the main neurological disorders in the aging population. treatment options so far are only of symptomatic nature and efforts in developing disease modifying drugs by targeting amyloid beta peptide-generating enzymes remain fruitless in the majority of human studies. during the last years, an alternative approach emerged to target the physiological alpha-secretase adam10, which is not only able to prevent formation of toxic amyloid beta peptides but also prov ... | 2015 | 26407945 |
| kobophenol a inhibits sodium nitroprusside-induced cardiac h9c2 cell death through suppressing activation of jnk and preserving mitochondrial anti-apoptotic bcl-2 and mcl-1. | sodium nitroprusside (snp) releases nitric oxide (no), a powerful vasodilator, and thus widely used in intensive care unit for treating hypertension emergency. however, cardiac toxicity after snp administration is a clinical problem. for finding a natural compound that suppressing snp-induced cardiac toxicity, we tested the protective potential of kobophenol a (kob a), purified from the root of caragana sinica, against the toxic effects of snp. the severe cardiac h9c2 cell death was induced by s ... | 2014 | 24759620 |
| antioxidative oligostilbenes from caragana sinica. | two new oligostilbenes, caragasinins a (5) and b (10), and eight known compounds, kobophenol a (1), (+)-α-viniferin (2), (+)-ampelopsin f (3), pallidol (4), (+)-isoampelopsin f (6), miyabenol c (7), carasinaurone (8) and caraphenol b (9) were isolated from the ethylacetate-soluble extract of the roots of caragana sinica. the structures of the isolates were determined on the basis of extensive spectroscopic analysis including 1d, 2d nmr and hresi-ms. these compounds were assessed for antioxidant ... | 2012 | 22209460 |
| structural characterization of lignins isolated from caragana sinica using ft-ir and nmr spectroscopy. | in order to efficiently explore and use woody biomass, six lignin fractions were isolated from dewaxed caragana sinica via successive extraction with organic solvents and alkaline solutions. the lignin structures were characterized by fourier transform infrared spectroscopy (ft-ir) and 1d and 2d nuclear magnetic resonance (nmr). ft-ir spectra revealed that the "core" of the lignin structure did not significantly change during the treatment under the conditions given. the results of 1h and 13c nm ... | 2011 | 22097829 |
| ethnobotany, phytochemistry and pharmacology of the genus caragana used in traditional chinese medicine. | the genus caragana is a member of the family fabaceae, subfamily faboideae and is native to arid and semi-arid areas of the temperate zones of asia and eastern europe. many species are cultured for dune-fixation, livestock forage and biological resources for fuel energy and fiber production. more than 10 species in this genus have a long history of use in traditional chinese, mongolian and tibetan medicines and are believed to "nourish yin, invigorate the spleen, temper the blood and promote blo ... | 2009 | 19422901 |
| determination of hypaphorine and oligomeric stilbenes in the root of caragana sinica by capillary electrophoresis with electrochemical detection. | capillary electrophoresis with electrochemical detection (ce-ed) was employed for the determination of hypaphorine (an alkaloid) and four oligomeric stilbenes (including pallidol, kobophenol a, miyabenol c and (+)-alpha-viniferin) in radix seu cortex caraganae sinicae, the root of caragana sinica (buc'hoz) rehd. the effects of several important factors were investigated to find optimum conditions. the working electrode was a 300 mum diameter carbon disc electrode positioned opposite the outlet o ... | 2001 | 18968328 |
| [studies on chemical constituents from roots of caragana sinica]. | to study the chemical constituents in roots of caragana sinica. | 2008 | 18536372 |
| biological screening of 100 plant extracts for cosmetic use (i): inhibitory activities of tyrosinase and dopa auto-oxidation. | the aim of this study was to evaluate several plant extracts with a view to developing melanogenesis inhibitors. in this study, 100 plant extracts were screened to elucidate their whitening effects using in vitro inhibition of tyrosinase and dopa auto-oxidation activity. several plant extracts such as chaenomeles speciosa, dryopteris crassirhizoma, gastrodia ellata, glycyrrhiza glabra, morus alba, myristica fragrans, rheum palmatum and sophora japonica showed inhibition of mushroom tyrosinase ac ... | 1997 | 18505483 |
| simultaneous determination of the contents of three stilbene oligomers in caragana sinica collected in different seasons using an improved hplc method. | the objectives of this research were to determine simultaneously the contents of two stilbene tetramers, carasinol b (1) and kobophenol a (2), and one stilbene trimer, (+)-alpha-viniferin (3), in the roots, tubers, and leaves of caragana sinica in various seasons. a hplc method has been developed for efficiently quantifying the three analytes in the plant. using this method, different samples of caragana sinica were evaluated. the results showed that the contents of 1, 2, and 3 in the roots were ... | 2006 | 16595888 |
| two new oligostilbenes from caragana sinica. | a new resveratrol dimer, carasiphenol a (1), and a new resveratrol trimer, carasiphenol b (2), have been isolated from the aerial parts of caragana sinica. their structures have been elucidated from spectroscopic evidence, especially hmbc and noe experiments. the relative configuration of the known dimer pallidol (6) was confirmed by x-ray diffraction. | 2004 | 15621582 |
| identification and determination of oligomeric stilbenes in the roots of caragana species by capillary electrophoresis. | a method based on capillary electrophoresis with electrochemical detection (ce-ed) was employed for the determination of one alkaloid (hypaphorine) and the four oligomeric stilbenes, pallidol, kobophenol a, miyabenol c and (+)-alpha-viniferin in the roots of caragana species. the five analytes could be well separated within 12 min in a 40 cm length capillary at a separation voltage of 12 kv in a 100 mmol/l borate buffer (ph 10.0). the response was linear over about 3 orders of magnitude for all ... | 2001 | 11582547 |
| naturally occurring protein kinase c inhibitors; ii. isolation of oligomeric stilbenes from caragana sinica. | the oligomeric stilbenes (+)-alpha-viniferin (1), miyabenol c (2), and kobophenol a (3) have been isolated from caragana sinica (buchoz) rehd (leguminosae). (+)-alpha-viniferin (1) and miyabenol c (2) exhibited protein kinase c inhibitory activity at low micromolar concentrations. (+)-alpha-viniferin inhibited keratinocyte proliferation (0.4 microm) and free radical release in whole blood (47 microm), in vitro, and may be useful in treating hyperproliferative or inflammatory skin diseases. | 1995 | 7700990 |
| acid-catalyzed epimerization of kobophenol a to carasinol b. | the conversion from kobophenol a into carasinol b, two main chemical constituents of caragana sinica, was confirmed by in vitro acid-catalyzed epimerization. the result provides important information about the biotransformation of kobophenol a in plants and its metabolism in rats. | 2008 | 18463595 |