| [cytogenetic studies of brown field-mouse]. | the karyotype of brown field-mouse (microtus mandarinus) is reported in this paper. the formula of karyotypes is:2n = 50 = 2 (m,t)+2sm+44t+xx(m,sm)xy(sm,st). the first pair of the autosomes and the x-chromosomes show polymorphism. only one x-chromosome can be found in the seven out of the fifteen female specimens studied. the formula of its karyotypes is 2n = 49 = 2(m,st)+2sm+44t+x o. the x-chromosomes of these seven specimens are metacentric, and are different from the x (that is sm) of normal ... | 1993 | 8329214 |
| [prevalence of capillaria hepatica among house rat in seoul] | during may-july, 1978 a survey on the prevalence of c. hepatica among house rat(rattus norvegicus erxl.) and wild mice (mus musailus molossinus and microtus mandarinus) in two districts in seoul was carried out. approximately 38% of 1,000 house rats examined were infected. rat population as an established group in ahyundong, neighbouring the city, revealed 39.2% of infection among 660 house rats, and that as newly formed group in shinrimdong, a developing residential quarter on the southern outs ... | 1979 | 12902748 |
| [detection of y chromosome in human and microtus mandarinus with fish]. | the purpose of the investigation was to detect the y chromosome of human and microtus mandarinus with the satellite dna probe in human's yq by fluorescence in situ hybridization(fish). we hybridizied the probe with the metaphase chromosome and interphase nucleus specimens of humanbeing and microtus mandarinus respectively. the results showed that there was hybridization signal on metaphase chromosome and interphase nucleus of human, but no signal on metaphase chromosome and interphase nucleus of ... | 2003 | 15639920 |
| sex determination of microtus mandarinus mandarinus is independent of sry gene. | pcr was performed with primers corresponding to the sry hmg-box of the mouse and eight microtus species. primers for the sall4 gene and the zfy/zfx gene were used as positive controls. none of these sets of primers can amplify any homologous segment of the sry gene in the genomic dna of microtus mandarinus mandarinus, but both can amplify the sry hmg-box in the male mouse, sall4 bands, and zfy/zfx bands in both male and female m. m. mandarinus and mouse. southern blotting was also used. we used ... | 2008 | 18188648 |
| exclusion of r-spondin1 as the sex determination gene of microtus mandarinus mandarinus. | | 2009 | 19358265 |
| response to chronic intermittent hypoxia in blood system of mandarin vole (lasiopodomys mandarinus). | mandarin voles (lasiopodomys mandarinus) spend almost all their lives underground and must have evolved remarkable physiological adaptations to subterranean hypoxic stress. to understand the response to hypoxia in blood system of this rodent in a region with lower altitude, we tested and compared the responding characteristics between mandarin vole and kunming mouse (mus musculus) under chronic normobaric hypoxic treatment (10.0% o(2), 4 w). the results showed that: 1) as for responses to chroni ... | 2010 | 20371298 |
| [comparison of hemogram changes under chronic intermittent hypoxia in lasiopodomys mandarinus and kunming mus musculus]. | mandarin vole (lasiopodomys mandarinus) spends almost all of its life underground and must have evolved remarkable adaptations to cope with the subterranean hypoxic stress. the aim of present study is to explore the adaptation mechanism through the comparison of hemogram changes under chronic intermittent hypoxia in mandarin vole and kunming (km) mouse (mus musculus). mandarin vole and km mouse were treated with chronic intermittent hypoxia (10.0% oxygen), which was maintained by an oxygen cabin ... | 2010 | 20401448 |
| exclusion of sall 4 as the sex-determining gene in the mandarin vole microtus mandarinus mandarinus. | in previous studies, we have shown that the sry hmg-box is absent in microtus mandarinus mandarinus (m. m. mandarinus), suggesting that sex determination of m. m. mandarinus is independent of the sry gene. we amplified a 312 bp fragment within exon 2 of the sall4 gene in the mouse and m. m. mandarinus using polymerase chain reaction (pcr) and detected sall4 using fluorescence in situ hybridization (fish) technique. the probes for the sall4 gene were labeled with digoxigenin using pcr and hybridi ... | 2011 | 21756254 |
| rapid karyotype evolution in lasiopodomys involved at least two autosome - sex chromosome translocations. | the generic status of lasiopodomys and its division into subgenera lasiopodomys (l. mandarinus, l. brandtii) and stenocranius (l. gregalis, l. raddei) are not generally accepted because of contradictions between the morphological and molecular data. to obtain cytogenetic evidence for the lasiopodomys genus and its subgenera and to test the autosome to sex chromosome translocation hypothesis of sex chromosome complex origin in l. mandarinus proposed previously, we hybridized chromosome painting p ... | 2016 | 27936177 |
| [care of young, aggressiveness, and secretion of testosterone in male rodents: a correlation analysis ]. | to test the current hypotheses on the relationship between the mating system, reproductive strategy, aggression, and secretion of testosterone, a comparative study of interactions in pair encounters, the level of parental care, and the gonadal testosterone level in males was performed in six rodent species (clethrionomys rutilus, meriones meridianus, microtus arvalis, lagurus lagurus, lasiopodomys mandarinus, and meriones unguiculatus) with different types of spatial-and-ethological population s ... | 2016 | 25510112 |
| evolution of the clock and bmal1 genes in a subterranean rodent species (lasiopodomys mandarinus). | lasiopodomys mandarinus, a subterranean rodent, spends its entire life underground. to test whether the clock and bmal1 genes of l. mandarinus have undergone adaptive evolution to underground darkness, we cloned and analyzed their complete cdna sequences, using lasiopodomys brandtii as a control. the phylogenetic trees of the clock and bmal1 genes were similar to the trees of the conserved cyt b gene，further, l. mandarinus clustered with l. brandtii and microtus ochrogaster in the phylogenetic t ... | 2017 | 29141193 |
| different behavioral, neural and neuropeptide responses of fathers to their own and to alien pups in mandarin voles. | mothers often prefer to care for their own offspring rather than those of other females. however, whether fathers respond differently to their own pups and to alien ones remains unclear. in this study, we found that male mandarin voles (microtus mandarinus) directed more sniffing toward their own pups than toward alien pups. the numbers of fos-immunoreactive neurons in the medial preoptic nucleus, bed nucleus of the stria terminalis, nucleus accumbens, anterior cingulate cortex were significantl ... | 2017 | 29209769 |
| postnatal separation prevents the development of prenatal stress-induced anxiety in association with changes in oestrogen receptor and oxytocin immunoreactivity in female mandarin vole (microtus mandarinus) offspring. | oestrogen has both anxiogenic and anxiolytic effects because of variation in opposing action on alpha (erα) and beta (erβ) estrogen receptors in the medial preoptic area (mpoa), bed nucleus of the stria terminalis (bnst) and medial amygdala (mea). oxytocin (ot) reverses some of the anxiogenic effects of oestrogen in the hypothalamic paraventricular nucleus (pvn) and supraoptic nucleus (son). because anxiety disorders are twice as common in women as in men, and oestrogen and ot are more important ... | 2018 | 29205599 |
| effects of chronic social defeat on social behaviors in adult female mandarin voles (microtus mandarinus): involvement of the oxytocin system in the nucleus accumbens. | chronic social defeat affects many aspects of behavior. most previous studies have focused on effects on males and defeat during adolescence. the extents to which chronic social defeat can impact female social behavior in adulthood and the neural mechanisms of such effects are poorly understood. using highly social and aggressive female mandarin voles (microtus mandarinus), the present study found that chronic social defeat reduced social preference in adult females, and that the defeated voles ... | 2017 | 29126982 |
| chronic central oxytocin infusion impairs sociability in mandarin voles. | oxytocin (ot) has been reported to increase social contact, however some studies have related ot to reduced social contact, particularly with unfamiliar individuals. the underlying mechanisms of ot on social contact remain unclear. in this study, male mandarin vole (microtus mandarinus), a socially monogamous rodent, was used as an animal model in which osmotic minipumps were used to intracerebroventricularly administer two dosages of ot or saline for 12 consecutive days. we examined the effect ... | 2017 | 28918226 |
| involvement of gabaa receptors in the regulation of social preference and emotional behaviors by oxytocin in the central amygdala of female mandarin voles. | the central nucleus of the amygdala (cea) is the main output of the amygdala and plays an important role in behavioral and neuroendocrine responses to stress. receptors for the neuropeptide oxytocin (ot) and gabaa are found in high concentration in the cea. the mechanisms underlying regulation of cea ot in emotional and social behavior remain unclear. in this study we evaluated the effects of intra-cea ot administration of different doses (0.1, 1 and 10ng/side), ot receptor antagonist (otr-a) (1 ... | 2017 | 28764883 |
| effects of paternal deprivation on cocaine-induced behavioral response and hypothalamic oxytocin immunoreactivity and serum oxytocin level in female mandarin voles. | early paternal behavior plays a critical role in behavioral development in monogamous species. the vast majority of laboratory studies investigating the influence of parental behavior on cocaine vulnerability focus on the effects of early maternal separation. however, comparable studies on whether early paternal deprivation influences cocaine-induced behavioral response are substantially lacking. mandarin vole (microtus mandarinus) is a monogamous rodent with high levels of paternal care. after ... | 2017 | 28756211 |
| oxytocin receptor antagonist treatments alter levels of attachment to mothers and central dopamine activity in pre-weaning mandarin vole pups. | oxytocin (ot) is known to be important in mother-infant bonding. although the relationship between ot and filial attachment behavior has been studied in a few mammalian species, the effects on infant social behavior have received little attention in monogamous species. the present study examined the effects of ot receptor antagonist (ota) treatment on attachment behavior and central dopamine (da) activity in male and female pre-weaning mandarin voles (microtus mandarinus). our data showed that o ... | 2017 | 28710956 |
| place preferences associated with pups or cocaine change the expression of d2r, v1ar and otr in the nacc and mea and the levels of plasma avp, ot, t and e2 in mandarin vole fathers. | drug abuse often has negative impacts on parenting behavior. the dopamine (da), arginine vasopressin (avp) and oxytocin (ot) systems are involved in paternal behavior and drug-induced behaviors. mandarin voles (microtus mandarinus) are socially monogamous rodents with high levels of paternal behavior. the aims of this study were to examine the protein expression levels of the da 2-type receptor (d2r), avp receptor 1a(v1ar) and ot receptor (otr) in the nucleus accumbens (nacc) and medial amygdala ... | 2017 | 28371737 |
| emotional attachment of pre-weaning pups to mothers and fathers in mandarin voles. | studies into the effects of maternal and paternal deprivation on the brain and behavior are traditionally done on animals from postnatal day 0 to 14 when parents display high levels of licking and grooming. deprivation experiments that reveal attachment conducted during this period are confounded because physiological and emotional deprivation occur simultaneously. whether rodent pups of greater physiological independence from postnatal 14 to 21days show emotional attachment towards mothers and ... | 2017 | 28013063 |
| effects of nucleus accumbens oxytocin and its antagonist on social approach behavior. | severe impairment of social interaction is a core symptom of numerous psychiatric disorders. oxytocin (ot) has been shown to be involved in various aspects of social behavior related to reproduction, but little is known about its effects on nonreproductive social interaction between adults or the neuroanatomical location where ot exerts its action. here, we examined the nucleus accumbens, a region of the brain containing high levels of the oxytocin receptor (otr) and comprising an important node ... | 2016 | 26960161 |
| sequence and phylogenetic analysis of the complete mitochondrial genome of lasiopodomys mandarinus mandarinus (arvicolinae, rodentia). | mandarin vole (lasiopodomys mandarinus) is a subterranean rodent that is often used as a model for studying subterranean hypoxic stress in mammals. however the taxonomy of this species is still in dispute. mitochondrial dna (mtdna) has long been used for phylogenetic reconstruction and, in this study, the complete mitochondrial genome of l. mandarinus mandarinus was sequenced. our results showed that the mitochondrial genome of l. m. mandarinus is a circular molecule of 16,367bp, which contains ... | 2016 | 27562081 |
| perinatal stress effects on later anxiety and hormone secretion in male mandarin voles. | the estradiol (e2), estrogen receptor-α (erα), testosterone (t), and androgen receptor (ar) can contribute to anxiety, but whether they are associated with the reversion of prenatal adverse outcomes remains unclear. here, we tested the interactive effects of prenatal maternal restraint stress and early postnatal short-term maternal separation on adult male mandarin vole (microtus mandarinus) behavior and changes in e2, t, and their receptors. the results showed that ps adult males (ps/nh) exhibi ... | 2015 | 26501180 |
| complete mitochondrial genome of lasiopodomys mandarinus mandarinus (arvicolinae, rodentia). | mandarin voles (lasiopodomys mandarinus) is a subterranean rodent species that are often used as a model for studying subterranean hypoxic stress in mammals. its subspecies l. m. mandarinus span in cropland in most area of north china and is regarded as an agricultural pest. in this paper, the complete mitochondrial genome of l. m. mandarinus has been determined. our results showed that the mitochondrial genome of l. m. mandarinus is a circular molecule of 16,367 bp, which contents 13 protein-co ... | 2016 | 26258511 |
| early bi-parental separation or neonatal paternal deprivation in mandarin voles reduces adult offspring paternal behavior and alters serum corticosterone levels and neurochemistry. | although the effect of early social environments on maternal care in adulthood has been examined in detail, few studies have addressed the long-term effect on paternal care and its underlying neuroendocrine mechanisms. here, using monogamous mandarin voles (microtus mandarinus) that show high levels of paternal care, the effects of early bi-parental separation (ebps) or neonatal paternal deprivation (npd) on adult paternal behavior, serum corticosterone levels, and receptor mrna expression in th ... | 2015 | 26012712 |
| natural variation in paternal behavior is associated with central estrogen receptor alpha and oxytocin levels. | in monogamous mammals paternal care plays an important role in the neural and behavioral development of offspring. however, the neuroendocrine mechanisms underlying paternal behavior remain poorly understood. here, we investigate the association between natural variation in paternal responsiveness and central levels of oxytocin (ot) and estrogen receptor alpha (erα). we used the frequency of licking and grooming behavior to distinguish low paternal responsiveness and high paternal responsiveness ... | 2015 | 25652439 |
| behavioral responses to pups in males with different reproductive experiences are associated with changes in central ot, th and otr, d1r, d2r mrna expression in mandarin voles. | male rodents behave differently toward pups because of different sexual and/or paternal experiences; however, the mechanisms underlying these responses are not well understood. using socially monogamous mandarin voles (microtus mandarinus) we investigated the behavioral responses of males with different reproductive experiences (virgin males, paired males and new fathers) to new born pups. central levels of neuropeptide oxytocin (ot), tyrosine hydroxylase (th), as well as oxytocin receptor (otr) ... | 2015 | 25496756 |
| postpartum repeated separation from pups affects the behavior and neuroendocrine parameters of mandarin vole fathers. | repeated separation from pups results in anxiety and depression-like behaviors in mothers. this level of attachment has also been established between fathers and pups in monogamous rodents. we hypothesized that brief and lengthy separation from their pups would affect emotion, social behavior and neuroendocrine parameters in socially monogamous male mandarin voles (microtus mandarinus). the results indicate that brief pup separation (bps) of 15 min/day significantly reduced the percentage of tim ... | 2015 | 25446219 |
| levels of central oxytocin and glucocorticoid receptor and serum adrenocorticotropic hormone and corticosterone in mandarin voles with different levels of sociability. | sociability is the prerequisite to social living. oxytocin and the hypothalamo-pituitary-adrenocortical axis mediate various social behaviors across different social contexts in different rodents. we hypothesized that they also mediate levels of non-reproductive social behavior. here we explored naturally occurring variation in sociability through a social preference test and compared central oxytocin, glucocorticoid receptors, serum adrenocorticotropic hormone and corticosterone in mandarin vol ... | 2014 | 25141210 |
| early paternal deprivation alters levels of hippocampal brain-derived neurotrophic factor and glucocorticoid receptor and serum corticosterone and adrenocorticotropin in a sex-specific way in socially monogamous mandarin voles. | in monogamous mammals, fathers play an important role in the development of the brain and typical behavior in offspring, but the exact nature of this process is not well understood. in particular, little research has addressed whether the presence or absence of paternal care alters levels of hippocampal glucocorticoid receptor (gr) and brain-derived neurotrophic factor (bdnf), and basal levels of serum corticosterone (cort) and adrenocorticotropin (acth). here, we explored this concept using soc ... | 2014 | 25116057 |
| complete mitochondrial genome of the mandarin vole lasiopodomys mandarinus (rodentia: cricetidae). | the complete sequence of the mitochondrial genome of the mandarin vole (lasiopodomys mandarinus) was completed and annotated in this study. the circular genome is 16,375 bp in length and contains the typical 37 genes that are arranged in the same order as that of the putative ancestor of vertebrate, 13 protein-coding genes, 22 trna genes, 2 rrna genes and 2 non-coding regions. this study will provide genetic resource to clarify the taxonomic position of genus lasiopodomys. | 2016 | 24845440 |
| the relationship of prenatal ethanol exposure and anxiety-related behaviors and central androgen receptor and vasopressin expression in adult male mandarin voles. | prenatal exposure to ethanol has been shown to increase the risk of anxiety in offspring. here, we tested the effect of prenatal ethanol exposure on adult male mandarin voles (microtus mandarinus). we examined anxiety-like behavior in the open field and elevated plus-maze tests in males exposed to ethanol prenatally. one control group was not exposed to ethanol or saline, while another control group was exposed to saline. at the age of 90days, males were tested and levels of serum testosterone, ... | 2014 | 24583039 |
| neuroendocrine responses to social isolation and paternal deprivation at different postnatal ages in mandarin voles. | neonatal isolation and paternal deprivation have long lasting effects on the behavior and neuroendocrine system at adulthood. whether these effects at adulthood are induced by neonatal changes in relevant neuroendocrine parameters lead by these early-life social experiences is not well understood. whether monogamous rodents exhibit a stress hypo-responsive period (shrp) also remains unclear. using the monogamous mandarin vole, we found that 30 min of isolation did not affect levels of corticoste ... | 2014 | 24464494 |
| sociality and oxytocin and vasopressin in the brain of male and female dominant and subordinate mandarin voles. | the dominant-subordinate hierarchy in animals often needs to be established via agonistic encounters and consequently affects reproduction and survival. differences in brain neuropeptides and sociality among dominant and subordinate males and females remain poorly understood. here we explore neuropeptide levels and sociality during agonistic encounter tests in mandarin voles. we found that dominant mandarin voles engaged in higher levels of approaching, investigating, self-grooming and exploring ... | 2014 | 24292210 |
| neonatal paternal deprivation impairs social recognition and alters levels of oxytocin and estrogen receptor α mrna expression in the mea and nacc, and serum oxytocin in mandarin voles. | paternal care is necessary for the healthy development of social behavior in monogamous rodents and social recognition underpins social behavior in these animals. the effects of paternal care on the development of social recognition and underlying neuroendocrine mechanisms, especially the involvement of oxytocin and estrogen pathways, remain poorly understood. we investigated the effects of paternal deprivation (pd: father was removed from neonatal pups and mother alone raised the offspring) on ... | 2014 | 24291055 |
| cocaine withdrawal influences paternal behavior and associated central expression of vasopressin, oxytocin and tyrosine hydroxylase in mandarin voles. | although the disruptive effects of cocaine on the maternal care are well known, little is known about paternal care in the context of cocaine abuse. vasopressin (avp), oxytocin (ot) and dopamine (da) have been found to regulate paternal behavior and are also involved in cocaine abuse. mandarin voles (microtus mandarinus) are socially monogamous and display high levels of paternal care. here, we investigated whether paternal behavior and associated central levels of avp, ot and da were altered fo ... | 2014 | 24238615 |
| study of fos, androgen receptor and testosterone expression in the sub-regions of medial amygdala, bed nucleus of stria terminalis and medial preoptic area in male mandarin voles in response to chemosensory stimulation. | in many rodent species, including mandarin voles (microtus mandarinus), the behavioral response to odors is regulated by a network of steroid-sensitive ventral forebrain nuclei including the medial amygdala (me), bed nucleus of the striaterminalis (bnst), and medial preoptic area (mpoa). although it is well-known that me, bnst, and mpoa are closely interconnected, function independently in regulating odor-guided social behaviors, little is known about how order information is processed in the su ... | 2014 | 24129216 |
| early social deprivation impairs pair bonding and alters serum corticosterone and the nacc dopamine system in mandarin voles. | early life stress has a long-term negative impact on emotion, learning, memory and adult sexual behavior, and these deficits most likely impair pair bonding. here, we investigated whether early social deprivation (ed) affects the formation of pair bonds in socially monogamous mandarin voles (microtus mandarinus). in a partner preference test (ppt), ed-reared adult females and males did not show a preference for their partner, spent more time exploring the cage of an unfamiliar animal and directe ... | 2013 | 24103891 |
| relationship between sexual satiety and motivation, brain androgen receptors and testosterone in male mandarin voles. | androgen receptors participate in the neuroendocrine regulation of male sexual behavior, primarily in brain areas located in the limbic system. males of many species present a long-term inhibition of sexual behavior after several ejaculations, known as sexual satiety. it has been shown in rats that androgen receptor expression is reduced 24h after a single ejaculation, or mating to satiety, in the medial preoptic area, nucleus accumbens and ventromedial hypothalamus. the aim of this study was to ... | 2013 | 23707935 |
| post-weaning living with parents during juvenile period alters locomotor activity, social and parental behaviors in mandarin voles. | neonatal parental care plays an important role in the development of offspring behavior, but little is known about the effect of post-weaning contact between offspring and parents on locomotory, social and parental behavior. here, we explore this concept using socially monogamous mandarin voles (microtus mandarinus). voles were assigned to live with parents and siblings from the same litter until 45d (natural dispersal time in the field) or to live with siblings from the same litter after weanin ... | 2013 | 23707890 |
| neonatal tactile stimulation alleviates the negative effects of neonatal isolation on novel object recognition, sociability and neuroendocrine levels in male adult mandarin voles (microtus mandarinus). | neonatal isolation results in long-lasting negative alterations to the brain and behavior. some of these changes include effects on non-spatial learning and memory, sociability and neuroendocrine levels. theoretically, neonatal tactile stimulation should reverse the impacts of neonatal isolation; however, this remains unknown for changes relating to learning, memory, sociability and hormones in social animals. using socially monogamous mandarin voles (microtus mandarinus), the long-lasting effec ... | 2013 | 23438372 |
| paternal deprivation alters play-fighting, serum corticosterone and the expression of hypothalamic vasopressin and oxytocin in juvenile male mandarin voles. | although early paternal deprivation significantly affects offspring behavioral and neuroendocrine development, the link between paternal deprivation and social play behavior remains unclear. mandarin voles (microtus mandarinus) are socially monogamous and display bi-paternal care. the present study examined the development of social play in juvenile male mandarin voles and the paternal influence on play-fighting, vasopressin- and oxytocin-immunoreactive neurons and serum corticosterone and testo ... | 2012 | 22926316 |
| cocaine-induced rewarding properties, behavioural sensitization and alteration in social behaviours in group-housed and postpuberty isolated female mandarin voles. | although it is widely accepted that postweaning housing conditions may affect the behaviour of animals and their responses to drugs, it remains unclear whether analogous effects exist for postpubertal housing conditions. the present study examines the effects of postpubertal housing conditions on cocaine-induced rewarding properties, behavioural sensitization and social behaviour in socially monogamous female mandarin voles (microtus mandarinus). we found that both group-housed and postpuberty i ... | 2012 | 22914076 |
| reinforcing properties of pups versus cocaine for fathers and associated central expression of fos and tyrosine hydroxylase in mandarin voles (microtus mandarinus). | the reciprocal interaction of pups and cocaine on reward effects in rodent mothers is known. however,it remains unclear whether such effects are apparent in father-offspring bonding. the mandarin vole (microtus mandarinus) is a monogamous rodent with a high level of paternal care. we investigated the reinforcing properties of pups on vole fathers using a conditioned place preference paradigm across the postpartum period and looked for interactions and differences between the reinforcing effects ... | 2012 | 22454845 |
| the effects of neonatal paternal deprivation on pair bonding, nacc dopamine receptor mrna expression and serum corticosterone in mandarin voles. | high levels of paternal care are important for the development of social behavior in monogamous rodents. however, the effects of paternal care on the formation of pair bonding and underlying neuroendocrine mechanisms, especially the involvements of dopamine system and corticosterone, are not well understood. we investigated effects of paternal deprivation on pair bonding in mandarin voles (microtus mandarinus), a socially monogamous rodent. paternal deprivation was found to inhibit the formation ... | 2012 | 22421629 |
| effects of castration on aggression and levels of serum sex hormones and their central receptors in mandarin voles (microtus mandarinus). | aggression in socially monogamous mandarin vole (microtus mandarinus) was observed after castration. levels of serum sex hormones and their central receptors were also measured using enzyme-linked immunosorbent assay and immunohistochemistry methods. the data indicate that adult males showed higher levels of aggression after castration. however, castration significantly reduced levels of serum testosterone, and the number of androgen receptor immunoreactive neurons in the anterior hypothalamus, ... | 2012 | 22311556 |
| the effects of repeated early deprivation on ultrasonic vocalizations and ontogenetic development in mandarin vole pups. | early deprivation is popularly used in rodent models as an early life social stress to investigate and determine the factors that affect the development of the brain and behavior. ultrasonic calls made by pups play an important role in parental-pup interactions during the neonatal period. however, whether repeated early deprivation affects the properties of ultrasonic vocalizations (usvs) produced by mandarin vole (microtus mandarinus) pups, and whether ontogenetic development is subsequently af ... | 2011 | 21925576 |
| neonatal paternal deprivation or early deprivation reduces adult parental behavior and central estrogen receptor α expression in mandarin voles (microtus mandarinus). | previous studies on parental behavior have primarily focused on maternal behavior, with little research directed at observing paternal behavior. the effects of neonatal paternal deprivation and early deprivation on adult parental behavior and estrogen receptor α (erα) especially remain unclear. this study examined whether paternal deprivation or early deprivation has long-term effects on the parental behavior and central erα expression of adult mandarin vole offspring. the parental behaviors of ... | 2011 | 21684307 |
| comparison of sociability, parental care and central estrogen receptor α expression between two populations of mandarin voles (microtus mandarinus). | the socially monogamous mandarin vole (microtus mandarinus) shows significant behavioral plasticity. we examined whether levels of sociability, parental care and central expression of estrogen receptor alpha differed between two populations with different ecologies. our results show that males from the chengcun population display significantly more amicable and less aggressive behaviors towards novel same-sex individuals compared to males from the second population of xinzheng. chengcun voles di ... | 2011 | 21104088 |
| sexual or paternal experiences alter alloparental behavior and the central expression of eralpha and ot in male mandarin voles (microtus mandarinus). | various hypotheses have been proposed to explain factors influencing male alloparental behavior in cooperatively breeding species. mandarin voles (microtus mandarinus) are ideal animal models to investigate these factors because they are highly social rodents and display biparental care and spontaneous parental care when exposed to foster pups. here we test the idea that the sexual and paternal experience of males influences alloparental behavior toward novel pups, and that these experiences alt ... | 2010 | 20678985 |
| two new karyotypes and bandings in microtus mandarinus faeceus (rodentia). | here we report our study on two new karyotypes and c-bandings of m. m. faeceus. our study shows that there are polymorphisms in the x chromosome of m. m. faeceus (rodentia), which exibitsubtelocentric x(st), metacentric x(m) and submetacentric x(sm) patterns, respectively. one new karyotype formula is: 2n = 49 = 4sm + 42t + 1m + xx (sm,sm), and the sex chromosomes are: x(m) x(sm); the other new karyotype formula is: 2n = 50 = 4sm + 43t + 1m + xx (sm,sm), and the sex chromosomes are: x(sm)x(sm). ... | 2010 | 20626766 |
| paternal care, aggressiveness, and testosterone secretion in male mandarin voles (lasiopodomys mandarinus). | | 2017 | 19760872 |
| effects of neonatal paternal deprivation or early deprivation on anxiety and social behaviors of the adults in mandarin voles. | this study examined whether neonatal paternal deprivation (pd: father was removed and pups were raised just by mother) or early deprivation (ed: pups were raised by both parents except separated from not only the dam but also the peers for three hours a day from pnd 0 to 13) has long-term effects on anxiety and social behaviors of adult mandarin voles. newborn mandarin voles of f2 generation were randomly assigned to one of three groups: bi-parental care (pc: pups were raised by both parents), p ... | 2009 | 19635534 |
| [recent advances on sex determining mechanisms of microtus mandarinus]. | most mammalian sex determination belongs to male heterogametic type of genetic sex determination. sex determination of most mammals depends on the y chromosome. sry gene is the testis-determining factor on y chromosome of most mammals, which is thought to be the most important gene in sex determination by far. recent studies on microtus mandarinus mandarinus demonstrated that the subspecies has y chromosome, but there is no sry gene on y chromosome. sex determination of microtus mandarinus manda ... | 2009 | 19586857 |
| neonatal manipulation of oxytocin influences the partner preference in mandarin voles (microtus mandarinus). | neonatal manipulation of oxytocin (ot) has long-term effects on behavior and physiology. the objective of this research was to determine if neonatal exposure to ot can affect partner preferences and to characterize the mechanisms underlying social behavior such as neural activities of relevant brain regions in socially monogamous mandarin voles (microtus mandarinus). after receiving a subcutaneous injection of isotonic saline (sal) or ot within 24h of birth, mandarin vole at 60 days of age was p ... | 2008 | 18675458 |
| effects of neonatal oxytocin treatment on aggression and neural activities in mandarin voles. | neonatal manipulation of oxytocin (ot) has long-term effects on behavior and physiology. here we test the hypothesis that neonatal ot treatment can affect the subsequent expression of intrasexual aggression partly by reprogramming the neural activities of relevant brain regions. to test this hypothesis, mandarin voles (lasiopodomys mandarinus) received ot or isotonic saline treatment within 24 h of birth. at about 75 days of age, aggressive behaviors and fos expression in different brain regions ... | 2008 | 18508098 |
| daily activity of the mandarin vole (lasiopodomys mandarinus) under laboratory conditions. | | 2016 | 21249551 |
| [feeding rate of sibling vole microtus rossiaemeridionalis and mandarin vole lasiopodomys mandarinus]. | consumption of food of different nutritive value by sibling vole microtus rossiaemeridionalis and mandarin vole lasiopodomys mandarinus as a function of housing conditions--in cages or enclosures--was comparatively studied. experimental groups included 8-14 adult non-reproducing animals of both sexes kept one per cage or enclosure. the rate of food consumption and digestibility were studied by standard methods and the obtained data were statistically analyzed using statistica 6.0. significant di ... | 2016 | 17853693 |
| numerical and structural variations of the x chromosomes and no. 2 autosomes in mandarin vole, microtus mandarinus (rodentia). | here we describe our studies on microtus mandarinus faeceus of jiangyan in jiangsu province of china. by karyotype and g-banding analysis we have found variation in chromosome number and polymorphisms of the x chromosome and the second pair of autosomes of the subspecies. chromosome number of the subspecies is 2n=47-50. the subspecies has three kinds of chromosomal sex: xx, xo and xy, among which one of the x chromosomes is subtelocentric (x(st)) and the other is metacentric (x(m)). after compar ... | 2006 | 17362346 |
| the origin of the genetical diversity of microtus mandarinus chromosomes. | here we describe our comparative studies on two types of x chromosomes, namely x(m) and x(sm,) of the mandarin vole (microtus mandarinus). by chromosome g- and c-banding analysis, we have found that two different types of x chromosomes exist in mandarin voles. the two types of x chromosomes present two different g- and c-banding patterns: the x(m) chromosome is a longer metacentric x chromosome which is c-band negative; and the x(sm) is a shorter submetacentric x chromosome which has one c-band ... | 2003 | 15061809 |
| chromosomal polymorphism of mandarin vole, microtus mandarinus (rodentia). | the mitotic and meiotic chromosomes of mandarin vole, microtus mandarinus milne-edwards, from shandong province of china were analyzed by conventional, g- and c-banding and silver-staining techniques. we detected chromosomal polymorphism in the vole, exhibiting diploid chromosome numbers 2n = 48-50 and variable morphology of the 1st pair, one medium sized telocentric pair and the x chromosomes. four types of karyotypes were revealed in the population. according to banding analysis, there were pe ... | 2003 | 12830984 |
| [studies on the robertsonian translocation of microtus mandarinus]. | the type of chromosome no. 1 and chromosome number from 53 individuals of microtus mandarinus have been studied and compared in three sex types: xy, xx, xo. we found that the first pair of autosomes are very unstable, and there are three types: (1) m, m (with a double metacentric chromosome), (2) m, t, t, (with single metacentric chromosome). (3) t, t, t, t (without metacentric chromosome). the chromosome number of the same sex individuals changes regularly with the type change of chromosome no. ... | 2000 | 12549076 |
| involvement of oxytocin and gaba in consolation behavior elicited by socially defeated individuals in mandarin voles. | consolation, which entails comforting contact directed toward a distressed party, is a common empathetic response in humans and other species with advanced cognition. here, using the social defeat paradigm, we provide empirical evidence that highly social and monogamous mandarin voles (microtus mandarinus) increased grooming toward a socially defeated partner but not toward a partner who underwent only separation. this selective behavioral response existed in both males and females. accompanied ... | 2019 | 30605804 |
| differential responses of lasiopodomys mandarinus and lasiopodomys brandtii to chronic hypoxia: a cross-species brain transcriptome analysis. | subterranean rodents have evolved many features to adapt to their hypoxic environment. the brain is an organ that is particularly vulnerable to damage caused by exposure to hypoxic conditions. to investigate the mechanisms of adaption to a hypoxic underground environment, we carried out a cross-species brain transcriptome analysis by rna sequencing and identified genes that are differentially expressed between the subterranean vole lasiopodomys mandarinus and the closely related above-ground spe ... | 2018 | 30537924 |
| light-resetting impact on behavior and the central circadian clock in two vole species (genus: lasiopodomys). | the behavioral circadian rhythms of subterranean rodents show intra- and interspecies diversity in terms of adaptation to dark underground environments, but the endogenous molecular mechanism of rhythm regulation in the suprachiasmatic nuclei (scn) is stable to many species. in this study, we sought to determine the rhythms of behavior and central molecular regulatory mechanisms in the scn of the subterranean mandarin voles (lasiopodomys mandarinus) compared with a related aboveground species, b ... | 2020 | 32687979 |
| neonatal exposure to chlordecone alters female social behaviors and central estrogen alpha receptor expression in socially monogamous mandarin voles. | chlordecone (cd) is one of the common persistent organic pollutants in nature and has a profound impact on the environment and on public health. accumulating evidence has demonstrated that neonatal exposure of cd influences adult physiology and behavior due to its estrogenic properties. using socially monogamous mandarin voles as an experimental animal model, the present study aimed to evaluate the impact of neonatal exposure to cd on female social behaviors and central estrogen receptor alpha ( ... | 2020 | 32670549 |
| evolution of hemoglobin genes in a subterranean rodent species (lasiopodomys mandarinus). | the mandarin vole (lasiopodomys mandarinus), a typical subterranean rodent, has undergone hematological adaptations to tolerate the hypoxic/hypercapnic underground environment. hemoglobin (hb) genes encode respiratory proteins functioning principally in oxygen binding and transport to various tissues and organs. to investigate the evolution of α- and β-hemoglobin (hb) in subterranean rodent species, we sequenced hb genes of the mandarin vole and the related aboveground brandt's vole (l. brandtii ... | 2020 | 32443792 |
| expression patterns of clock genes in the hypothalamus and eye of two lasiopodomys species. | to investigate the relationship between light sensing systems in the eye and circadian oscillators in the hypothalamus of subterranean rodents, we studied subterranean mandarin voles (lasiopodomys mandarinus) that spend their entire lives under dark conditions with degenerated eyes, and compared oscillatory expression patterns of clock genes in the hypothalamus and eye between mandarin voles and their aboveground relatives, brandt's voles (l. brandtii). individuals of both vole species were kept ... | 2020 | 32308052 |
| transcriptome analysis of the response provided by lasiopodomys mandarinus to severe hypoxia includes enhancing dna repair and damage prevention. | severe hypoxia induces a series of stress responses in mammals; however, subterranean rodents have evolved several adaptation mechanisms of energy metabolisms and o2 utilization for hypoxia. mammalian brains show extreme aerobic metabolism. following hypoxia exposure, mammals usually experience irreversible brain damage and can even develop serious diseases, such as hypoxic ischemic encephalopathy and brain edema. to investigate mechanisms underlying the responses of subterranean rodents to seve ... | 2020 | 32256671 |
| complex structure of lasiopodomys mandarinus vinogradovi sex chromosomes, sex determination, and intraspecific autosomal polymorphism. | the mandarin vole, lasiopodomys mandarinus, is one of the most intriguing species among mammals with non-xx/xy sex chromosome system. it combines polymorphism in diploid chromosome numbers, variation in the morphology of autosomes, heteromorphism of x chromosomes, and several sex chromosome systems the origin of which remains unexplained. here we elucidate the sex determination system in lasiopodomys mandarinus vinogradovi using extensive karyotyping, crossbreeding experiments, molecular cytogen ... | 2020 | 32235544 |
| the involvement of oxytocin in the effects of chronic social defeat stress on emotional behaviours in adult female mandarin voles. | chronic social defeat stress (csds) can induce anxiety and depression in male rodents, but the prevalence of anxiety and depression is much higher in females, and effects of csds on adult females and its underlying mechanism remain unclear. oxytocin is a stress-buffering hormone in the brain that modulates the physiological effects of stress. strikingly, research regarding the effect of oxytocin on emotional changes caused by csds is still lacking in females. thus, we focused on the involvement ... | 2020 | 32011013 |
| estradiol treatment during perinatal development alters adult partner preference, mating behavior and estrogen receptors α and β in the female mandarin vole (microtus mandarinus). | during development, many aspects of behavior, including partner preferences and sexual conduct, are "organized" by estradiol. this study aimed at analyze these processes in the mandarin vole (microtus mandarinus), a novel experimental mammal with strong monogamous pair bonds. female pups were treated daily with an oil vehicle (fc) or β-estradiol (e2, ft) from prenatal day 14 to postnatal day 10. male pups were treated daily with the oil vehicle only (mc). partner preferences, sexual conduct and ... | 2019 | 31966342 |
| reduced consolation behaviors in physically stressed mandarin voles: involvement of oxytocin, dopamine d2 and serotonin 1a receptors within the anterior cingulate cortex. | consolation is a type of empathy-like behavior that has recently been observed in some socially living rodents. despite the growing body of literature suggesting that stress affects empathy, the relationship between stress and consolation remains understudied at the preclinical level. here, we examined the effects of chronic emotional stress (es) or physical stress (ps) exposure on consolation and emotional behaviors by using the socially monogamous mandarin vole (microtus mandarinus) in both ma ... | 2019 | 31760433 |
| the serotonin system in the hippocampus ca3 involves in effects of csds on social recognition in adult female mandarin voles (microtus mandarinus). | chronic social defeat stress (csds) exacerbated the development of stress-related psychiatric disorders, and the social recognition dysfunction is the core feature of many psychiatric disorders. however, the effects of csds on female social recognition and the underlying neural mechanisms remain unclear. using highly aggressive adult female mandarin voles (microtus mandarinus) as animal model, the aim of this work is to investigate the effects of csds on social recognition in adult female rodent ... | 2019 | 31330217 |
| preweaning paternal deprivation impacts parental responses to pups and alters the serum oxytocin and corticosterone levels and oxytocin receptor, vasopressin 1a receptor, oestrogen receptor, dopamine type i receptor, dopamine type ii receptor levels in relevant brain regions in adult mandarin voles. | although maternal separation and neonatal paternal deprivation (pd) have been found to exert a profound and persistent effects on the physiological and behavioural development of offspring, whether preweaning pd (ppd; from pnd 10 to 21) affects maternal and parental responses to pups and the underlying neuroendocrine mechanism are under-investigated. using monogamous mandarin voles (microtus mandarinus), the present study found that ppd increased the latency to approach a pup-containing ball, de ... | 2020 | 31256151 |
| increased anxiety and decreased sociability induced by paternal deprivation involve the pvn-prl otergic pathway. | early adverse experiences often have devastating consequences. however, whether preweaning paternal deprivation (pd) affects emotional and social behaviors and their underlying neural mechanisms remain unexplored. using monogamous mandarin voles, we found that pd increased anxiety-like behavior and attenuated social preference in adulthood. pd also decreased the number of oxytocin (ot)-positive neurons projecting from the paraventricular nucleus (pvn) and reduced the levels of the medial prefron ... | 2019 | 31084703 |
| role of oxytocin in the medial preoptic area (mpoa) in the modulation of paternal behavior in mandarin voles. | parental care plays an important role in individual survival and development in mammals. many studies have focused on the mechanisms underlying maternal behavior. however, the underlying neural mechanisms of paternal behavior are less understood. using monogamous mandarin voles (microtus mandarinus), the present study found that fathers initiated more paternal behavior and the virgin male showed more infanticide. moreover fathers had shorter latency to approach a pup at the postnatal day (pnd) 1 ... | 2019 | 30836063 |
| alteration in oxytocin levels induced by early social environment affects maternal behavior and estrogen receptor alpha in mandarin voles (microtus mandarinus). | many studies have shown that the early social environment exerts long-term effects on the brain and also the parental behavior of adults. oxytocin (oxt) is one of the most important neurotransmitters that regulate social behavior; howerve, whether the early social environment affects parental behavior via oxt remains unclear. using socially monogamous adult mandarin voles (microtus mandarinus), the present study found that 1) both paternal deprivation and early social deprivation significantly d ... | 2019 | 30802533 |
| serotonin signaling trough prelimbic 5-ht1a receptors modulates csds-induced behavioral changes in adult female voles. | most previous studies have focused on the effects of social defeat in male juvenile individuals. whether chronic social defeat stress in adulthood affects female emotion and the underlying mechanisms remains unclear. | 2019 | 30445535 |
| pre-weaning paternal deprivation impairs social recognition and alters hippocampal neurogenesis and spine density in adult mandarin voles. | disruption of the early social environment, such as maternal separation or early deprivation, can impair cognitive function, alter offspring neurogenesis and restrict dendritic architecture in the hippocampus. however, whether paternal deprivation during the pre-weaning period affects adult neurogenesis, synaptogenesis and social recognition remains unclear in monogamous species. in the present study, mandarin vole (microtus mandarinus) pups were deprived of fathers during postnatal day 14-21. t ... | 2018 | 30243848 |
| effects of reproductive experience on paternal behavior, levels of testosterone, prolactin in serum and dendritic spines in medial prefrontal cortex of mandarin voles. | maternal behaviors and brains change dramatically with pregnancy, parturition and other mothering experiences. however, whether paternal behavior, brain plasticity and levels of relevant hormones also change along with fathering experience and pups' age remains unclear. using socially monogamous mandarin voles (microtus mandarinus), we found that experienced fathers exhibited more active paternal behaviors, such as licking, retrievals and nest building, but less paternal care, such as huddling, ... | 2018 | 30019853 |
| evolution of circadian genes per and cry in subterranean rodents. | there is considerable interest in examining how circadian rhythms function and evolve in subterranean rodents that spend its entire life in underground, darkness environments. here, we investigated the evolution of per and cry genes that are important for mammalian biological clocks in the subterranean rodents. we performed phylogenetic analyses using newly sequenced per and cry from the subterranean rodent lasiopodomys mandarinus, the related aboveground rodent lasiopodomys brandtii, sequences ... | 2018 | 29959015 |
| the effects of fathering experience on paternal behaviors and levels of central expression of oxytocin and dopamine-2 type receptors in mandarin voles. | mothers' brains change dramatically in response to the release of hormones related to pregnancy and labor; however, fathers' brains are also sensitive to the experience of paternal care. thus, fathers with differing fathering experience may exhibit different behavioral responses towards pups. using socially monogamous mandarin voles (microtus mandarinus), effects of fathering experience on levels of paternal behavior as well as oxytocin (ot) and dopamine-2 type (d2) receptors in the nucleus accu ... | 2018 | 29730036 |
| parent-offspring cohabitation after weaning inhibits partner preference and alters central oxytocin and dopamine systems in adult mandarin vole. | in some mammals, offspring may live with their parents for a very long time after weaning, but little is known about the effect of post-weaning parent-offspring cohabitation on the behavioral and neurobiological development of offspring. here, we explored the effect of this experience on partner preference in adult mandarin vole (microtus mandarinus). levels of central oxytocin (ot), tyrosine hydroxylase (th), as well as ot receptor (otr), dopamine d1-type and d2-type receptors (d1r and d2r) mrn ... | 2018 | 29671049 |