Publications

interaction between bacteriophage dms3 and host crispr region inhibits group behaviors of pseudomonas aeruginosa.	bacteriophage infection has profound effects on bacterial biology. clustered regular interspaced short palindromic repeats (crisprs) and cas (crispr-associated) genes are found in most archaea and many bacteria and have been reported to play a role in resistance to bacteriophage infection. we observed that lysogenic infection of pseudomonas aeruginosa pa14 with bacteriophage dms3 inhibits biofilm formation and swarming motility, both important bacterial group behaviors. this inhibition requires ...	2009	18952788
non-identity-mediated crispr-bacteriophage interaction mediated via the csy and cas3 proteins.	studies of the escherichia, neisseria, thermotoga, and mycobacteria clustered regularly interspaced short palindromic repeat (crispr) subtypes have resulted in a model whereby crisprs function as a defense system against bacteriophage infection and conjugative plasmid transfer. in contrast, we previously showed that the yersinia-subtype crispr region of pseudomonas aeruginosa strain ucbpp-pa14 plays no detectable role in viral immunity but instead is required for bacteriophage dms3-dependent inh ...	2011	21398535