| hypoglycemic effects of coccinia indica: inhibition of key gluconeogenic enzyme, glucose-6-phosphatase. | coccinia indica (family: cucurbitaceae, locally known as telakucha) leaves were extracted with 95% ethanol. following evaporation of the solvents, the residue was suspended in distilled water. when this suspension was fed orally to male normal-fed and 48-hr starved rats, the blood glucose was lowered 21% (p less than 0.01) in normal-fed and 24% (p less than 0.001) in 48-hr starved animals respectively. starvation had induced a 3-fold increase in the activity of glucose-6-phosphatase and this act ... | 1992 | 1334043 |
| blood sugar lowering potentiality of selected cucurbitaceae plants of indian origin. | using five experimental models, the blood sugar lowering efficacy of eight plants of cucurbitaceae family has been assessed. the ethanolic extract of cucumis sativus linn, cucumis melo utilissimum roxb, cucumis melo linn, benincasa hispida thunb cogn and tricosanthes anguina nees, when administered in 250 mg/kg dose, orally to rats failed to lower blood sugar or to depress the peak value, after glucose load. however, ethanolic extract of momordica charantia linn plant and coccinia indica whit an ... | 1989 | 2620957 |
| a study on the anti-diabetic activity of coccinia indica in dogs. | | 1985 | 3997215 |
| coccinia indica linn. as potential hypoglycaemic agent. | | 1972 | 4658184 |
| hypoglycaemic effect of coccinia indica: mechanism of action. | the hypoglycaemic effect of orally administered extracts of leaves and roots of coccinia indica has been reported earlier. the oral administration of the pectin isolated from the fruit of the above plant at a dose of 200 mg/100 g bw/day showed a significant hypoglycaemic action in normal rats. pectins isolated from many other plants have also been reported to have hypoglycaemic actions. the pectin administration resulted in a significant reduction in blood glucose and an increase in the liver gl ... | 1993 | 8372150 |
| hypoglycaemic activity of coccinia indica and momordica charantia in diabetic rats: depression of the hepatic gluconeogenic enzymes glucose-6-phosphatase and fructose-1,6-bisphosphatase and elevation of both liver and red-cell shunt enzyme glucose-6-phosphate dehydrogenase. | coccinia indica leaves were extracted with 60% ethanol, solvents were evaporated and the residue was suspended in water. this suspension was administered orally at a dose of 200 mg/kg body wt. after 18 h of fasting to normal fed and streptozotocin-induced male diabetic rats (180-250 g). after 90 min the rats were killed, and blood-glucose, hepatic glucose-6-phosphatase, fructose-1,6-bisphosphatase and glucose-6-phosphate dehydrogenase (g6pdh) and red-cell g6pdh were assayed. blood sugar was depr ... | 1993 | 8389127 |
| plant foods in the management of diabetes mellitus: vegetables as potential hypoglycaemic agents. | vegetables are among the numerous plant adjuncts tried for the treatment of diabetes mellitus. a few vegetables that are commonly consumed in india have been claimed to possess antidiabetic potency. in recent years, there has been a renewed interest to screen such plant food materials, for a possible beneficial use. considerable amount of work has been carried out in this regard with bitter gourd (momordica charantia) and ivy gourd (coccinia indica) both in experimental animals and human diabeti ... | 1997 | 9188186 |
| influence of coccinia indica on certain enzymes in glycolytic and lipolytic pathway in human diabetes. | dried extract of c indica in doses of 500 mgm/kg body weight were administered orally to 30 diabetic patients for six weeks. blood samples were collected 15 minutes after administration of 10 iu heparin for estimation of lpl, before and after treatment with c. indica non heparinised samples were utilized for estimation for g-6-p (ase), ldh and blood sugar. severity of disease were assessed by the findings of blood sugar level. mild diabetes had no effect on lpl, ldh and g-6-p (ase). but, reduced ... | 1998 | 9770877 |
| medicinal plants of india with anti-diabetic potential. | since ancient times, plants have been an exemplary source of medicine. ayurveda and other indian literature mention the use of plants in treatment of various human ailments. india has about 45000 plant species and among them, several thousands have been claimed to possess medicinal properties. research conducted in last few decades on plants mentioned in ancient literature or used traditionally for diabetes have shown anti-diabetic property. the present paper reviews 45 such plants and their pro ... | 2002 | 12020931 |
| comparative evaluation of hypoglycaemic activity of some indian medicinal plants in alloxan diabetic rats. | in our experiments 30 hypoglycaemic medicinal plants (known and less known) have been selected for thorough studies from indigenous folk medicines, ayurvedic, unani and siddha systems of medicines. in all the experiments with different herbal samples (vacuum dried 95% ethanolic extracts), definite blood glucose lowering effect within 2 weeks have been confirmed in alloxan diabetic albino rats. blood glucose values are brought down close to normal fasting level using herbal samples at a dose of 2 ... | 2003 | 12499084 |
| modulatory effect of coccinia indica on aortic collagen in streptozotocin-induced diabetic rats. | 1. the effects of coccinia indica, an indigenous plant used in ayurvedic medicine in india, on aortic collagen content and its characteristics were assessed in streptozotocin (stz) diabetic rats. 2. rats were made diabetic with a single intraperitoneal injection of stz (45 mg/kg). blood glucose, hydroxyproline, collagen, extent of glycation, collagen-linked fluorescence, soluble pattern of pepsin-soluble collagen, shrinkage temperature, alpha/beta ratio of type i collagen and type i/type iii col ... | 2003 | 12603344 |
| effect of coccinia indica leaves on antioxidant status in streptozotocin-induced diabetic rats. | the antioxidant effect of an ethanolic extract of coccinia indica leaves, an indigenous plant used in ayurvedic medicine in india, was studied in streptozotocin-diabetic rats. oral administration of coccinia indica leaf extract (clet) (200 mg/kg body weight) for 45 days resulted in a significant reduction in thiobarbituric acid reactive substances and hydroperoxides. the extract also causes a significant increase in reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase and ... | 2003 | 12648810 |
| systematic review of herbs and dietary supplements for glycemic control in diabetes. | to conduct a systematic review of the published literature on the efficacy and safety of herbal therapies and vitamin/mineral supplements for glucose control in patients with diabetes. | 2003 | 12663610 |
| ivy gourd (coccinia grandis voigt, coccinia cordifolia, coccinia indica) in human nutrition and traditional applications. | | 2003 | 12747088 |
| effect of coccinia indica leaf extract on plasma antioxidants in streptozotocin- induced experimental diabetes in rats. | the present study was carried out to investigate the antioxidant effect of an ethanolic extract of coccinia indica leaves, an indigenous plant used in ayurvedic medicine in india, in streptozotocin-diabetic rats. oral administration of coccinia indica leaf extract (clet) (200 mg/kg body weight) for 45 days resulted in a significant reduction in plasma thiobarbituric acid reactive substances, hydroperoxides, vitamin e and ceruloplasmin. the extract also caused a significant increase in plasma vit ... | 2003 | 12820225 |
| protective effect of coccinia indica on changes in the fatty acid composition in streptozotocin induced diabetic rats. | the present study was undertaken to investigate the effect of coccinia indica, an indigenous plant used in ayurvedic medicine in india, on blood glucose, plasma insulin, cholesterol, triglycerides, free fatty acids and phospholipids and fatty acid composition of total lipids in liver, kidney and brain of normal and streptozotocin (stz) diabetic rats. oral administration of the ethanolic extract of coccinia indica leaves (200 mg/kg body weight, clet) for 45 days to diabetic rats decreased the con ... | 2003 | 12857005 |
| experimental studies on pituitary diabetes. iv. effect of gymnema sylvestre and coccinia indica against the hyperglycaemic response of somatotropin and corticotropin hormones. | | 1964 | 14122605 |
| xanthine oxidase inhibitory activity of some indian medical plants. | xanthine oxidase inhibitory activity was assayed from six species belonging to different families traditionally used for the treatment of gout and related symptoms by indigenous people of india. the aqueous, methanol-water mixture and methanolic extract of these plants were used for the experiment. of the 18 extracts assayed, 14 extracts demonstrated xanthine oxidase inhibitory activity at 100 microg/ml, among which 10 extracts showed an inhibition greater than 50% and ic(50) values below 100 mi ... | 2007 | 17014977 |
| protection of testicular dysfunctions by mtec, a formulated herbal drug, in streptozotocin induced diabetic rat. | single injection of streptozotocin (stz) resulted diabetes mellitus which was reflected here by the levels of fasting blood glucose and serum insulin. moreover, this experimental diabetes also resulted testicular dysfunctions evaluated by count, viability and motility of sperm as well as by the activities of key enzymes for androgen synthesis. diabetes induced testicular oxidative stress has been indicated here by the monitoring of testicular peroxidase and catalase activities as well as by quan ... | 2007 | 17202665 |
| epr as an analytical tool in assessing the mineral nutrients and irradiated food products-vegetables. | epr spectral investigations of some commonly available vegetables in south india, which are of global importance like daucus carota (carrot), cyamopsis tetragonoloba (cluster beans), coccinia indica (little gourd) and beta vulgaris (beet root) have been carried out. in all the vegetable samples a free radical corresponding to cellulose radical is observed. almost all the samples under investigation exhibit mn ions in different oxidation states. the temperature variation epr studies are done and ... | 2008 | 18372211 |
| efficacy of dietary supplementation with botanicals on carbohydrate metabolism in humans. | botanical products are widely used in nutritional supplementation for promotion of health or prevention of diseases. with the high prevalence of obesity and type 2 diabetes, abnormalities in carbohydrate metabolism are common in the general population and obtaining glycemic control is important in reducing the complications of diabetes. if shown to be effective, botanical products have a unique position in potentially aiding the general public in regard to obesity and diabetes. they can be obtai ... | 2008 | 18537692 |
| correction of protein metabolic disorders by composite extract of musa paradisiaca and coccinia indica in streptozotocin-induced diabetic albino rat: an approach through the pancreas. | the study focused on the ability of the extracts of musa paradisiaca and coccinia indica on protein metabolic disorders in streptozotocin (stz)-induced diabetes. | 2009 | 19169172 |
| response of melittia oedipus (lepidoptera: sesiidae) to visual cues is increased by the presence of food source. | visual and olfactory cues were shown to mediate short-distance orientation to different colors in the presence and in the absence of food in melittia oedipus oberthür (lepidoptera: sesiidae), a biological control agent of coccinia grandis (l.) voigt (violales: cucurbitaceae). yellow was the color most preferred by m. oedipus, and adults landed significantly more on yellow paper moistened with honey-water. the next preferred colors were gray and white with the identical food source. colors such a ... | 2009 | 19253627 |
| anti-inflammatory, analgesic and antipyretic activity of aqueous extract of fresh leaves of coccinia indica. | this study was aimed to evaluate both post- and pre-treatment anti-inflammatory activities of the aqueous extract of fresh leaves of coccinia indica in rats using the carrageenan-induced paw oedema method at various dose levels. analgesic and antipyretic properties were evaluated using tail flick model and yeast-induced hyperpyrexia, respectively. ceiling effect of the extract was observed at 50 mg/kg in pre-treatment carrageenan test. in post-treatment studies, a dose-dependent anti-inflammator ... | 2009 | 19626277 |
| antihyperglycemic effects of separate and composite extract of root of musa paradisiaca and leaf of coccinia indica in streptozotocin-induced diabetic male albino rat. | we evaluated the antihyperglycaemic properties of aqueous-methanolic (40:60) extract of root of musa paradisiaca and leaf of coccinia indica in separate as well as in composite manner by conducting experiment on streptozotocin-induced diabetic rats. we measured food and water intake ability, the fasting blood glucose level, glucose tolerance, activities of important carbohydrate metabolic enzymes like glucose-6-phosphatase, glucose-6-phosphate dehydrogenase, hexokinase in liver along with quanti ... | 2007 | 20161901 |
| potent α-amylase inhibitory activity of indian ayurvedic medicinal plants. | indian medicinal plants used in the ayurvedic traditional system to treat diabetes are a valuable source of novel anti-diabetic agents. pancreatic α-amylase inhibitors offer an effective strategy to lower the levels of post-prandial hyperglycemia via control of starch breakdown. in this study, seventeen indian medicinal plants with known hypoglycemic properties were subjected to sequential solvent extraction and tested for α-amylase inhibition, in order to assess and evaluate their inhibitory po ... | 2011 | 21251279 |
| antimicrobial activity of protease inhibitor from leaves of coccinia grandis (l.) voigt. | antimicrobial activity of protease inhibitor isolated from coccinia grandis (l.) voigt. has been reported. a 14.3 kda protease inhibitor (pi) was isolated and purified to homogeneity by ammonium sulfate precipitation (20-85% saturation), sephadex g-75, deae sepharose column and trypsin-sepharose affinity chromatography from the leaves of c. grandis. the purity was checked by reverse phase high performance liquid chromatography. pi exhibited marked growth inhibitory effects on colon cell lines in ... | 2011 | 21615062 |
| a creeper, coccinia indica, has anti-hyperglycaemic and anti-ureogenic effects in diabetic rats. | to explore how ethanolic extract of coccinia indica affects normal and diabetic rats. | 2012 | 23866400 |
| characterization of a new cucurbit-infecting ipomovirus from sudan. | two members of the genus ipomovirus (family potyviridae) are known to infect cucurbits: cucumber vein yellowing virus (cvyv), which is emerging throughout the mediterranean basin, and squash vein yellowing virus (sqvyv), which has been described in america and the caribbean basin, and more recently in israel. in this work, an ipomovirus different from cvyv and sqvyv, tentatively named coccinia mottle virus (cocmov), was detected in a sample of the cucurbit coccinia grandis collected in central s ... | 2016 | 27430562 |
| endophytic fungus nigrospora oryzae from a medicinal plant coccinia grandis, a high yielding new source of phenazine-1-carboxamide. | nigrospora oryzae was isolated as an endophytic fungus from the leaves of coccinia grandis, a popular medicinal plant used to control diabetes. fermentation of the fungus in potato dextrose broth and chromatographic purification of the ethyl acetate extracts of the broth and mycelium yielded two phenazine secondary metabolites, which were identified as phenazine-1-carboxylic acid (1) and phenazine-1-carboxamide (2) by comparing their spectral data with those reported in the literature. compound ... | 2015 | 26669097 |
| coccinia grandis (l.) voigt leaf extract exhibits antileishmanial effect through pro-inflammatory response: an in vitro study. | the conventional drugs used for the treatment of human visceral leishmaniasis have concerns about the toxicity and most importantly parasite resistance. to overcome these troubles, more efforts are made for the development of innovative therapeutic agents having effective antileishmanial activity and simultaneously stimulate adaptive immune system of host cells. hence, search for new leishmanicidal from the natural origin like plants has shown its effectiveness for the treatment of this tropical ... | 2017 | 27796492 |
| antiproteolytic and leishmanicidal activity of coccinia grandis (l.) voigt leaf extract against leishmania donovani promastigotes. | in visceral leishmaniasis (vl), development of alternative safe therapeutic strategy is gaining paramount wherein natural components of plant origin have prominence. we explored coccinia grandis (l.) voigt, a medicinal plant known in traditional folk medicine, for its antileishmanial efficacy. sds-page analysis of the c. grandis leaf extract (cg-ex) showed few protein bands about 14-66 kda among which three (64.8, 55.8 and 15.3 kda) were identified as serine protease inhibitors by reverse zymogr ... | 2015 | 26669017 |
| molecular characterization of a distinct bipartite begomovirus species infecting ivy gourd (coccinia grandis l.) in tamil nadu, india. | a distinct bipartite begomovirus was found to be associated with the mosaic disease on ivy gourd (coccinia grandis l.) in tamil nadu, india. the complete dna a and dna b components were cloned by rolling circle amplification. genome organization of this virus is found to be typical of old world bipartite begomovirus. the association of betasatellite component with this virus is absent. the closest nucleotide identity of 73.4 % was seen with the loofa yellow mosaic virus (lymv-[vn]-af509739) sugg ... | 2016 | 26739457 |
| anti-mycobacterial screening of five indian medicinal plants and partial purification of active extracts of cassia sophera and urtica dioica. | to find out the anti-mycobacterial potential of cassia sophera (c. sophera), urtica dioica (u. dioica), momordica dioica, tribulus terrestris and coccinia indica plants against multi-drug resistant (mdr) strain of mycobacterium tuberculosis (m. tuberculosis). | 2013 | 23608375 |
| ethnopharmacological survey on medicinal plants used in herbal drinks among the traditional communities of pakistan. | there is very limited information regarding medicinal plants used by traditional healers in pakistan, for treating wide-ranging diseases. current study provides significant ethnopharmacological information, both qualitative and quantitative on medical plants in pakistan and the pharmacological importance of herbal drinks, especially in the discovery of new drugs. | 2016 | 26947900 |
| larvicidal efficacy of five cucurbitaceous plant leaf extracts against mosquito species. | larvicidal activity of crude hexane, ethyl acetate, petroleum ether, acetone, and methanol extracts of the leaf of five species of cucurbitaceous plants, citrullus colocynthis, coccinia indica, cucumis sativus, momordica charantia, and trichosanthes anguina, were tested against the early fourth instar larvae of aedes aegypti l. and culex quinquefasciatus (say) (diptera: culicidae). the larval mortality was observed after 24 h of exposure. all extracts showed moderate larvicidal effects; however, ... | 2008 | 18340464 |
| an appraisal of eighteen commonly consumed edible plants as functional food based on their antioxidant and starch hydrolase inhibitory activities. | eighteen edible plants were assessed for their antioxidant potential based on oxygen radical absorbance capacity (orac), 2,2-diphenyl-1-picrylhydrazyl (dpph) radical scavenging activity, total phenolics, vitamin c content and various lipophilic antioxidants. the inhibitory activities of the plant extracts against the enzymatic activities of α-amylase and α-glucosidase were also evaluated. | 2015 | 25491037 |
| effect of leaf essential oil of coccinia indica on egg hatchability and different larval instars of malarial mosquito anopheles stephensi. | to assess the larvicidal and egg hatching inhibition property of the leaf essential oil of coccinia indica (c. indica) against anopheles stephensi (an. stephensi). | 2011 | 22118029 |
| traditional medicinal plants used for the treatment of diabetes in rural and urban areas of dhaka, bangladesh--an ethnobotanical survey. | the usage of medicinal plants is traditionally rooted in bangladesh and still an essential part of public healthcare. recently, a dramatically increasing prevalence brought diabetes mellitus and its therapy to the focus of public health interests in bangladesh. we conducted an ethnobotanical survey to identify the traditional medicinal plants being used to treat diabetes in bangladesh and to critically assess their anti-diabetic potentials with focus on evidence-based criteria. | 2013 | 23800215 |
| the geometric approach to explore the bactrocera tau complex (diptera: tephritidae) in thailand. | specimens of the genus bactrocera were collected from several host plants in northern and western thailand. they were morphologically recognized as bactrocera tau and were subdivided into eleven samples according to host plant, geographic origin and time of collection. twelve landmarks of the right wing were described in a total of 264 males and 276 females. an exploratory analysis using kernel density estimates was performed on the multivariate morphometric space. non-parametric classification ... | 2010 | 20817492 |
| use of household ingredients as complementary medicines for perceived hypoglycemic benefit among sri lankan diabetic patients; a cross-sectional survey. | biologic based therapies are frequently used as complementary medicines in diabetes. the aim of this study was to identify the commonly used herbal remedies and their preparations in sri lankan patients with type 2 diabetes. | 2017 | 26401401 |
| medicinal plants used for treatment of diabetes by the marakh sect of the garo tribe living in mymensingh district, bangladesh. | diabetes mellitus is an endocrinological disorder arising from insulin deficiency or due to ineffectiveness of the insulin produced by the body. this results in high blood glucose and with time, to neurological, cardiovascular, retinal and renal complications. it is a debilitating disease and affects the population of every country of the world. around 200 million people of the world suffer from this disease and this figure is projected to rise to 300 million in the coming years. the disease can ... | 2012 | 23983370 |
| suppression of vegf-induced angiogenesis and tumor growth by eugenia jambolana, musa paradisiaca, and coccinia indica extracts. | abnormal angiogenesis and evasion of apoptosis are hallmarks of cancer. accordingly, anti-angiogenic and pro-apoptotic therapies are effective strategies for cancer treatment. medicinal plants, namely, eugenia jambolana lam. (myrtaceae), musa paradisiaca l. (musaceae), and coccinia indica wight & arn. (cucurbitaceae), have not been greatly investigated for their anticancer potential. | 2017 | 28367666 |
| cytogenetic comparison of heteromorphic and homomorphic sex chromosomes in coccinia (cucurbitaceae) points to sex chromosome turnover. | our understanding of the evolution of plant sex chromosomes is increasing rapidly due to high-throughput sequencing data and phylogenetic and molecular-cytogenetic approaches that make it possible to infer the evolutionary direction and steps leading from homomorphic to heteromorphic sex chromosomes. here, we focus on four species of coccinia, a genus of 25 dioecious species, including coccinia grandis, the species with the largest known plant y chromosome. based on a phylogeny for the genus, we ... | 2017 | 28343268 |
| antioxidant, antiglycation and insulinotrophic properties of coccinia grandis (l.) in vitro: possible role in prevention of diabetic complications. | in an attempt to develop complementary and alternative medicine (cam) for the treatment of diabetes and related complications, the antidiabetic potential of the mature unripe fruits of coccinia grandis (cgf) was evaluated. oxidative stress and glycation plays an important role in manifesting of diabetes and vascular complications. agents with antioxidant and antiglycation properties may retard these pathological alterations. in this study, the edible plant coccinia grandis was assessed for in vi ... | 2017 | 28053889 |
| analysis of transposable elements and organellar dna in male and female genomes of a species with a huge y chromosome reveals distinct y centromeres. | few angiosperms have distinct y chromosomes. among those that do are silene latifolia (caryophyllaceae), rumex acetosa (polygonaceae) and coccinia grandis (cucurbitaceae), the latter having a male/female difference of 10% of the total genome (female individuals have a 0.85 pg genome, male individuals 0.94 pg), due to a y chromosome that arose about 3 million years ago. we compared the sequence composition of male and female c. grandis plants and determined the chromosomal distribution of repetit ... | 2016 | 27354172 |
| antifertility efficacy of coccinia indica in male mice and its possible mechanisms of action on spermatogenesis. | the purpose of the present study was to investigate the antifertility efficacy of coccinia indica and its possible mechanisms of action on testicular functions in parkes male mice. mice were orally administered 50% ethanolic leaf extract of coccinia indica (200 and 500mgkg(-1) body weight day(-1)) or distilled water (controls) for 35days. to assess reversibility, additional mice were treated with 500mgkg(-1) body weight of coccinia or distilled water for 35days and sacrificed 56days later. sever ... | 2017 | 27174748 |
| biomolecular characterization of putative antidiabetic herbal extracts. | induction of glut4 translocation in the absence of insulin is considered a key concept to decrease elevated blood glucose levels in diabetics. due to the lack of pharmaceuticals that specifically increase the uptake of glucose from the blood circuit, application of natural compounds might be an alternative strategy. however, the effects and mechanisms of action remain unknown for many of those substances. for this study we investigated extracts prepared from seven different plants, which have be ... | 2016 | 26820984 |
| analysis of glycation induced protein cross-linking inhibitory effects of some antidiabetic plants and spices. | protein cross-linking which occurs towards the latter part of protein glycation is implicated in the development of chronic diabetic complications. glycation induced protein cross-linking inhibitory effects of nine antidiabetic plants and three spices were evaluated in this study using a novel, simple, electrophoresis based method. | 2015 | 26055093 |
| screening of antidepressant activity and estimation of quercetin from coccinia indica using tlc densitometry. | coccinia indica naud (cucurbitaceae) has been traditionally used for the treatment of depression but these claims have not been validated. | 2015 | 25845639 |
| chromosomal localization of 45s rdna, sex-specific c values, and heterochromatin distribution in coccinia grandis (l.) voigt. | coccinia grandis is a widely distributed dioecious cucurbit in india, with heteromorphic sex chromosomes and x-y sex determination mode. the present study aids in the cytogenetic characterization of four native populations of this plant employing distribution patterns of 45s rdna on chromosomes and guanine-cytosine (gc)-rich heterochromatin in the genome coupled with flow cytometric determination of genome sizes. existence of four nucleolar chromosomes could be confirmed by the presence of four ... | 2016 | 25795278 |
| flower development, pollen fertility and sex expression analyses of three sexual phenotypes of coccinia grandis. | coccinia grandis is a dioecious species of cucurbitaceae having heteromorphic sex chromosomes. the chromosome constitution of male and female plants is 22 + xy and 22 + xx respectively. y chromosome of male sex is conspicuously large and plays a decisive role in determining maleness. sex modification has been studied in hypogynous silene latifolia (caryophyllaceae) but there is no such report in epigynous coccinia grandis. moreover, the role of organ identity genes during sex expression in cocci ... | 2014 | 25430000 |
| the use of complementary and alternative medicines (cams) in the treatment of diabetes mellitus: is continued use safe and effective? | diabetes mellitus is a major cause of morbidity and mortality worldwide, with a prevalence of 347 million in 2013. complementary and alternative medicines (cam) are a group of remedies that is fast gaining acceptance among individuals. cinnamon, bitter gourd (momordica charantia) and fenugreek (trigonella foenum-graecum) are 3 widely used cams used worldwide for the treatment of diabetes. data on safety and efficacy is limited, but the consumption is wide. crepe ginger (costus speciosus) and ivy ... | 2014 | 25331834 |
| nutraceutical properties of dietary plants extracts: prevention of diabetic nephropathy through inhibition of glycation and toxicity to erythrocytes and hek293 cells. | glycated albumin is reported to elicit pathobiologic effects in diabetic nephropathy and abrogating its biologic effects has novel therapeutic potential. | 2015 | 25243884 |
| ivy gourd (coccinia grandis l. voigt) root suppresses adipocyte differentiation in 3t3-l1 cells. | ivy gourd (coccinia grandis l. voigt) is a tropical plant widely distributed throughout asia, africa, and the pacific islands. the anti-obesity property of this plant has been claimed but still remains to be scientifically proven. we therefore investigated the effects of ivy gourd leaf, stem, and root on adipocyte differentiation by employing cell culture model. | 2014 | 24884680 |
| chemoprotective potential of coccinia indica against cyclophosphamide-induced toxicity. | although cyclophosphamide (cp), an alkylating agent, is used in the treatment of cancer owing to its broad-spectrum efficacy, its metabolites exhibit severe undesired toxicities in normal cells. the present study was aimed to investigate the chemoprotective potential of coccinia indica against cp-induced oxidative stress, genotoxicity, and hepatotoxicity. | 2017 | 24130387 |
| renoprotective effect of coccinia indica fruits and leaves in experimentally induced diabetic rats. | diabetic nephropathy is one of the secondary complications of diabetes mellitus that is marked by changes in extracellular matrix components leading to end-stage renal failure. diet plays an important role in managing diabetes. in the present study, the effect of coccinia indica consumption on diabetes-mediated kidney damage was determined. both control and diabetic rats were fed with ain-76 diet supplemented with c. indica fruits and leaves individually at 10% and 5%, respectively, for a period ... | 2013 | 24044493 |
| study of antihyperglycaemic activity of medicinal plant extracts in alloxan induced diabetic rats. | diabetes mellitus, for a long time, has been treated with plant derived medicines in sri lanka. | 2013 | 24991066 |
| molecular cytogenetics (fish, gish) of coccinia grandis : a ca. 3 myr-old species of cucurbitaceae with the largest y/autosome divergence in flowering plants. | the independent evolution of heteromorphic sex chromosomes in 19 species from 4 families of flowering plants permits studying x/y divergence after the initial recombination suppression. here, we document autosome/y divergence in the tropical cucurbitaceae coccinia grandis, which is ca. 3 myr old. karyotyping and c-value measurements show that the c. grandis y chromosome has twice the size of any of the other chromosomes, with a male/female c-value difference of 0.094 pg or 10% of the total genom ... | 2013 | 23207224 |
| ameliorative potential of coccinia grandis extract on serum and liver marker enzymes and lipid profile in streptozotocin induced diabetic rats. | diabetes mellitus is the most severe metabolic pandemic of the 21(st) century, affecting essential biochemical activities in almost every cell in the body. indian literatures have already mentioned herbal remediation for a number of human ailments. the present study was undertaken to evaluate the potential of coccinia grandis extract on serum and liver marker enzymes (alp, ast, alt and ldh) and lipid profile (total cholesterol, phospholipids, triglycerides and free fatty acids in serum and liver ... | 2011 | 22736887 |
| phytosynthesis of silver nanoparticles using coccinia grandis leaf extract and its application in the photocatalytic degradation. | silver nanoparticles were successfully synthesized from aqueous agno(3) through a simple green route using the leaf extract of coccinia grandis as a reducing as well as capping agent. the results obtained from uv-vis spectrum, x-ray diffraction (xrd), scanning electron microscopy (sem), energy dispersive spectroscopy (eds) and fourier-transform infra red spectroscopy (ftir) and high-resolution transmission electron microscopy (hrtem) revealed that the biosynthesis of silver nanoparticles were in ... | 2012 | 22348986 |
| ovicidal and repellent properties of coccinia indica wight and arn. (family:cucurbitaceae) against three important vector mosquitoes. | to determine the larvicidal and repellent activities of coccinia (c) indica wight and arnold (family:cucurbitaceae) extract against culex (cx.) quinquefasciatus, aedes (ae.) aegypti and anopheles (an.) stephensi. | 2011 | 22013723 |
| blood sugar lowering effect of coccinia grandis (l.) j. voigt: path for a new drug for diabetes mellitus. | role of herbs in the management and control of diabetes has emerged fast over the years. we assessed the efficacy of coccinia grandis (locally known as ken, kovakka) leaves as a hypoglycemic agent. | 2011 | 21822423 |
| antihyperglycemic and hypolipidemic effects of melothria maderaspatana and coccinia indica in streptozotocin induced diabetes in rats. | antihyperglycemic and hypolipidemic effects of ethanol extract of aerial parts of melothria maderaspatana and coccinia indica were evaluated in stz induced diabetes in sprague-dawley rats. the rats were concurrently treated with 100 or 200 mg/kg b.w. p.o. for 14 days. the changes in fasting blood glucose level and body weight were measured in 5 days interval. after 14 days experimental period, rats were sacrificed by cervical decapitation, blood and liver samples were collected. biochemical esti ... | 2010 | 23964177 |
| effect of supplementation of coccinia cordifolia extract on newly detected diabetic patients. | coccinia indica (synonym coccinia cordifolia), an herb growing abundantly in india, has been used in traditional treatment of diabetes. however, carefully controlled studies of its efficacy are lacking. this study aimed to evaluate the effectiveness of coccinia cordifolia on blood glucose levels of incident type 2 diabetic patients requiring only dietary or lifestyle modifications. | 2008 | 18000183 |
| hypoglycemic and hypolipidemic effect of coccinia indica wight & arn in alloxan induced diabetic rats. | diabetes mellitus is characterized by elevated plasma glucose concentrations resulting from insufficient insulin. the present study was aimed to investigate the hypolipidemic effect of coccinia indica aqueous leaf extract in alloxan induced diabetic rats. the results of this study revealed that a continuous administration of coccinia indica extract for 21 days prevents the elevation of the level of serum lipids secondary to the diabetes state. | 2007 | 22557267 |
| antidyslipidemic activity of polyprenol from coccinia grandis in high-fat diet-fed hamster model. | ethanol extract of coccinia grandis (l.) voigt showed significant triglyceride (tg) and cholesterol-lowering effects in dyslipidemic hamster model. ethanolic extract was fractionated into chloroform, n-butanol and water-soluble fractions and were evaluated. activity was proved to be concentrated in chloroform-soluble fraction. chloroform-soluble fraction containing active component was subjected to repeated column chromatography, furnished a polyprenol characterized as c(60)-polyprenol (1) isola ... | 2007 | 17689941 |
| in vitro antioxidant activities of the fractions of coccinia grandis l. leaf extract. | the present study was aimed at investigating the antioxidant activities of the various fractions of the hydromethanolic extract of the leaves of coccinia grandis l. voigt. (cucurbitaceae). the antioxidant activities of the fractions have been evaluated by using nine in vitro assays and were compared to standard antioxidants such as ascorbic acid, alpha-tocopherol, curcumin and butylated hydroxyl toluene (bht). all the fractions showed effective h-donor activity, reducing power, free radical scav ... | 2007 | 20162057 |
| releases of psyttalia fletcheri (hymenoptera: braconidae) and sterile flies to suppress melon fly (diptera: tephritidae) in hawaii. | ivy gourd, coccinia grandis (l.) voigt, patches throughout kailua-kona, hawaii island, hi, were identified as persistent sources of melon fly, bactrocera cucurbitae (coquillett). these patches had a low incidence of psyttalia fletcheri (silvestri), its major braconid parasitoid natural enemy in hawaii, and were used to evaluate augmentative releases of p. fletcheri against melon fly. in field cage studies of releases, numbers of melon flies emerging from ivy gourd fruit placed inside treatment c ... | 2004 | 15568340 |
| effect ofcoccinia indica (l.) andabroma augusta (l.) on glycemia, lipid profile and on indicators of end-organ damage in streptozotocin induced diabetic rats. | inayurvedic system of medicine in india, not only extracts of one plant or the other but also a combination of plant extracts are used for the treatment of diabetes mellitus. the present paper reports the combined effect ofabroma augusta andcoccinia indica known to be useful for the treatment of diabetes in ayurveda on the fasting blood sugar, glucose tolerance and lipid profile of streptozotocin (stz) induced albino rats. 300mg of water extract of the mixture of dried powdered roots ofa. august ... | 2003 | 23105393 |
| antihepatotoxic acticity of coccinia indica. | aqueous, light petroleum, chloroform, alcohol, benzene and acetone extracts of the leaves of coccinia indica. (family: cucurbitaceae) were screened for antihepatotoxic activity. the extracts were given after the liver was damaged with ccl4 liver function was assessed based on liver to body weight ratio pentobarbitone sleep time, serum levels of transaminase (sgpt, sgot), alkaline phosphatase (salp and bilirubin. alcohol and light petroleum was found to have good anti-hepatotoxic activity. | 2001 | 22557027 |
| trace element analysis of some copper containing herbs. | siddha system specifies medicinal plants containing various metal constituents for curing ailments. the plants reported as copper containing were subjected to atomic absorption spectrophotometic analysis. among these mangifera indica and coccinia indica were found to contain comparatively higher content of copper while manganese was move in coccinia indica aloe perfoliata, cassia auriculata and nelumbium nicifera. | 1997 | 22556811 |
| studies on a chitooligosaccharide-specific lectin from coccinia indica. thermodynamics and kinetics of umbelliferyl glycoside binding. | coccinia indica agglutinin (cia) is a chitooligosaccharide-specific lectin with two binding sites/homodimer of m(r) 32,000. quenching studies implied tryptophan involvement in binding activity, which was confirmed by chemical modification experiments (a. r. sanadi and a. surolia, submitted for publication). binding of 4-methylumbelliferyl chitooligosaccharides has been carried out to study their binding by cia. reversal experiments confirm the validity of the data previously obtained (a. r. sana ... | 1994 | 8106485 |
| treatment of diabetes mellitus with coccinia indica. | | 1980 | 6996780 |
| coccinia indica in the treatment of patients with diabetes mellitus. | coccinia indica is a creeper which grows wildly in bangladesh and in many parts of the indian sub-continent. the plant has been used since ancient times as an antidiabetic drug by physicians who practice the indian system of medicine known as ayurvedha. we have conducted a double blind control trial with preparation from the leaves of the plant on uncontrolled, maturity onset diabetics. the trial lasted for six weeks for an individual patient. out of the 16 patients who received the experimental ... | 1979 | 399436 |
| sex mechanism in coccinia indica wight and arn. | | 1952 | 12993156 |