| first occurrence of tetrodotoxin in a dendrobatid frog (colostethus inguinalis), with further reports for the bufonid genus atelopus. | the water-soluble toxin present in skin of colostethus inguinalis (dendrobatidae) was identified as tetrodotoxin by fluorometric hplc analysis. the amount of tetrodotoxin per frog skin was estimated by hplc, mouse toxicity, and inhibition of [3h]saxitoxin binding to brain membranes as 0.1 to 1.2 micrograms. small amounts of anhydrotetrodotoxin and 4-epietrodotoxin also were present. tetrodotoxin-like activity was not detected by inhibition of [3h]saxitoxin binding in other species of colostethus ... | 1994 | 8016850 |