Publications

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evolution of rattlesnakes (viperidae; crotalus) in the warm deserts of western north america shaped by neogene vicariance and quaternary climate change.during pleistocene, the laurentide ice sheet rearranged and diversified biotic distributions in eastern north america, yet had minimal physical impact in western north america where lineage diversification is instead hypothesized to result from climatic changes. if pleistocene climatic fluctuations impacted desert species, the latter would reflect patterns of restricted gene flow concomitant with indications of demographic bottlenecks. accordingly, molecular evidence for refugia should be presen ...200616968275
in vitro cytotoxicity of l-amino acid oxidase from the venom of crotalus mitchellii pyrrhus.l-amino acid oxidase isolated from crotalus mitchellii pyrrhus (cmp-laao) exhibited cytotoxicity against lncap prostate adenocarcinoma cells. the viability of lncap cells decreased in a concentration- and time-dependent manner upon administration of cmp-laao. cmp-laao induced apoptosis as evidenced by annexinv/pi staining using flow cytometry. an increase in caspase-9 and caspase-3 activity were also observed. the damaging effect of laao appears to be due to its enzymatic activity, that produces ...201728943466
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