| [observations on the anti-aging, antihypertensive and antihyperlipemic effect of apocynum venetum leaf extract]. | the effect of apocynum venetum leaf extract on hypertension, hyperlipemia, sod content of erythrocyte, platelet aggregation rate, pulse wave transmission time (rp interval) and human diploid cell was studied to evaluate if it has some anti-aging effects. the mean bp in 60 cases of the treated group decreased from 171 +/- 19/98 +/- 11 mmhg to 154 +/- 22/91 +/- 10 mmhg and 148 +/- 17/89 +/- 10 mmhg after treatment for 4 and 8 weeks (p less than 0.01). the hdl-c in 40 cases of hyperlipemia increase ... | 1989 | 2776275 |
| [an experimental observation on the diuretic effect of an extract of luobuma (apocynum venetum) leaves]. | | 1988 | 3252992 |
| [double-blind clinical study on the effects of apocynum venetum l. extractum tablets on aging]. | | 1988 | 3416389 |
| hepatoprotective effect of apocynum venetum and its active constituents. | the leaves of apocynum venetum l. are used as a tea material in north china and japan. a water extract (500 mg/kg/day, one week administration) of the leaves of a. venetum showed protective effects against carbon tetrachloride (ccl4, 30 microliters/mouse) or d-galactosamine (d-galn, 700 mg/kg)/lipopolysaccharide (lps, 20 micrograms/kg)-induced liver injury in mice. tumor necrosis factor-alpha (tnf-alpha) secreted from lps-stimulated macrophages is the most crucial mediator in the d-galn/lps-indu ... | 2000 | 10763585 |
| effects of aqueous extracts of apocynum venetum leaves on spontaneously hypertensive, renal hypertensive and nacl-fed-hypertensive rats. | effects of aqueous extracts of apocynum venetum leaves (luobuma extracts) on the blood pressure were evaluated in hypertensive animal models, such as spontaneously hypertensive rats (shr), renal hypertensive rats and nacl-induced hypertensive rats. in shr, administration of luobuma (heat-processed and unprocessed leaves) extracts at a dose of 70 mg/rat per day significantly decreased the systolic blood pressure value, but their decreasing effects were weaker than that of captopril. the urine vol ... | 2000 | 10967454 |
| antidepressant effects of apocynum venetum leaves in a forced swimming test. | an extract of the leaves of apocynum venetum l. (apocynaceae) markedly shortened the immobility time of male rats in a forced swimming test (fst) in a dose range of 30-125 mg/kg, indicating a possible antidepressant activity. this effect was comparable to that of the tricyclic antidepressant imipramine (20 mg/kg). neither imipramine (20 mg/kg) nor the apocynum extract in various doses (30, 60, 125 mg/kg) produced any overt behavioural change or motor dysfunction in the open field test. this resu ... | 2001 | 11456130 |
| long-term effects of an apocynum venetum extract on brain monoamine levels and beta-ar density in rats. | the present study was designed to get further insight into the mode of antidepressant action of an extract prepared of the leaves of apocynum venetum l. (av). to evaluate biochemical changes, we used a high-performance liquid chromatography system to examine the effects of short-term (2 weeks) and long-term (8 weeks) administration of imipramine (15 mg/kg po) and an av-extract (15, 60 and 250 mg/kg) on regional levels of serotonin (5-ht), norepinephrine (ne), dopamine (da) and their metabolites ... | 2003 | 12895673 |
| apocynum venetum extract does not induce cyp3a and p-glycoprotein in rats. | we investigated the effect of apocynum venetum l. extract (av) on the activity of cytochrome p450 (cyp) 3a and p-glycoprotein (p-gp). the plasma concentration of nifedipine (nf), which is a substrate for cyp3a, did not change after oral administration with av (3.3 mg/kg). also, av (3.3 and 33 mg/kg) did not affect the intestinal absorption of nf. in the rats treated with multiple administrations (15 mg/kg/d) of st. john's wort extract (sjw) for 2 weeks, the plasma concentration of nf after oral ... | 2004 | 15467212 |
| [studies on antihypertensive effect of luobuma (apocynum venetum l.) leaf extract (3)]. | to clarify the mechanisms underlying the antihypertensive effect of luobuma (apocynum venetum l. (apocynaceae)) leaf extract (lle), we investigated the vasodilator effect of lle in the rat mesenteric vascular bed, which plays an important role in changes in peripheral resistance and thus the regulation of blood pressure. in the perfused mesenteric vascular bed with active tone and intact endothelium, perfusion of lle (0.1 ng to 100 mg/ml for 15 min) caused dose-dependent vasodilation, which was ... | 2004 | 15516813 |
| a novel in vitro endothelium-dependent vascular relaxant effect of apocynum venetum leaf extract. | 1. in the present study, a novel in vitro vascular relaxant effect of apocynum venetum leaf extract (avle; also called 'luobuma'), obtained from a traditional chinese medicinal herb with known antihypertensive effects, is reported in isometric contraction studies of rat aorta and superior mesenteric artery. at low concentrations (0.3-10 microg/ml), avle had no effect on the resting tension of either blood vessel and caused relaxation in agonist-precontracted vessels with functionally intact endo ... | 2005 | 16173937 |
| approach to novel functional foods for stress control 5. antioxidant activity profiles of antidepressant herbs and their active components. | oxidative stress is frequently mentioned in relation to the neurodegenerative diseases. this study examined the effect of three herb extracts, hypericum perforatum, ginkgo biloba l. and apocynum venetum l., and their components on lipid hydroperoxide-induced oxidative stress in pc-12 cells. among them, the extract of apocynum venetum and its components showed the remarkable inhibitory effect, indicating that this herb extract serves as a protective agent against lipid peroxidation-related oxidat ... | 2005 | 16366510 |
| anti-anxiety effects of apocynum venetum l. in the elevated plus maze test. | the purpose of this study was to characterize the putative anxiolytic-like activity of an ethanolic extract prepared from the leaves of apocynum venetum (av) using the elevated plus maze (epm) in mice. male c75bl/6 mice were either treated orally with the av extract or the positive controls diazepam and buspirone, respectively, 1h before behavioral evaluation in the epm. a single treatment of av extract markedly increased the percentage time spent on and the number of entries into the open arms ... | 2007 | 17101250 |
| cardiotonic effect of apocynum venetum l. extracts on isolated guinea pig atrium. | the effects on guinea-pig heart muscle of extracts of apocynum venetum l. leaf, root, stem, old stem and venetron--a polyphenol-rich extract of leaves--were studied by recording the mechanical activity and heart rate of isolated right atria. cymarin--a cardiac glycoside--was also determined in a. venetum extracts by lc-ms/ms analysis. all extracts examined here showed a weak cardiotonic effect, i.e., induced a contractile response of the isolated atria and increased the pulse at a concentration ... | 2009 | 19002560 |
| agrobacterium rhizogenes-mediated transformation and regeneration of the apocynum venetum. | a system for the agrobacterium rhizogenes-mediated transformation and plant regeneration of a. venetum has been developed. the highest transformation frequency was 100%, achieved by using strain lba9402 with root explants. the highest density of hairy roots reached 22 when root explants transformed by r1000 cultured in the dark. adventitious shoots were obtained from profusely branched, fast-growing (type pbf) hairy roots, and the adventitious shoot induction frequency was 20%. regenerated shoot ... | 2008 | 19149183 |
| kaempferol from the leaves of apocynum venetum possesses anxiolytic activities in the elevated plus maze test in mice. | the present work evaluated the anxiolytic activity of an aqueous extract of apocynum venetum l. (apocynaceae) and bioguided its fractionation using the elevated plus maze (epm) in mice as a model of anxiety. a single treatment of av extract markedly increased the percentage time spent on the open arms of the epm in two distinct concentration ranges of 22.5-30 and 100-125 mg/kg p.o., respectively, indicating a putative anxiolytic-like activity. fractions showing anxiolytic effects in concentratio ... | 2009 | 19303276 |
| apocynum venetum leaf extract protects rat cortical neurons from injury induced by oxygen and glucose deprivation in vitro. | this study aimed to investigate the protective effect of apocynum venetum leaf extract (avle) on an in vitro model of ischemia-reperfusion induced by oxygen and glucose deprivation (ogd) and further explored the possible mechanisms underlying protection. cell injury was assessed by morphological examination using phase-contrast microscopy and quantified by measuring the amount of lactate dehydrogenase (ldh) leakage; cell viability was measured by xtt reduction. neuronal apoptosis was determined ... | 2010 | 20921977 |
| protective effects of flavonoid extract from apocynum venetum leaves against corticosterone-induced neurotoxicity in pc12 cells. | depression is a major psychiatric disorder affecting nearly 21% of the world population and imposes a substantial health burden on society. although significant progress has been made in depression research, the common molecular mechanism of antidepressants is still far from clearly understood. the neuroprotective effect of antidepressants has been proposed as a possible mechanism. although apocynum venetum (av) l. (apocynaceae) was previously shown to produce an antidepressant-like effect in th ... | 2010 | 21170580 |
| [protective effect of extract of apocynum venetum on kidneys of streptozotocin-induced diabetic rats]. | the aim of this study is to investigate the effects and mechanism of extract of apocynum venetum (av) on kidneys of streptozotocin-induced diabetic rats. diabetes mellitus (dm) was induced in rats by intraperitoneal injection of streptozotocin (stz). the indexes of the blood glucose, renal function and oxidative stress were observed. the dm rats were administrated with the av for 8 weeks, the above-mentioned indexes were detected. the blood glucose level, bun, 24 h urine protein excretion, urine ... | 2010 | 21351445 |
| apocynum venetum leaf aqueous extract inhibits voltage-gated sodium channels of mouse neuroblastoma n2a cells. | apocynum venetum linn. (apocynaceae family), also called luobuma, is a shrub which grows widely in the xinjiang autonomous region of china. its leaves are used in herbal tea for the treatment of hypertension, anxiety and depression. animal studies have also shown that apocynum venetum leaf extract (avle) also exerts anti-depressant and anti-anxiety activities. the effects of avle on neuronal tissues in vitro are not fully understood. | 2011 | 21530630 |
| flavonoids from the halophyte apocynum venetum and their antifouling activities against marine biofilm-derived bacteria. | eleven flavonoids were isolated from the leaves of the halophyte apocynum venetum. among them, the isolation of plumbocatechin a (1), 8-o-methylretusin (2) and kaempferol 3-o-(6″-o-acetyl)-β-d-galactopyranoside (7) was reported for the first time from this plant. their structures were identified by using spectral methods, including 2d nmr experiments, and confirmed by comparing with the literature data. in addition, the antifouling activities of these compounds against the marine fouling bacteri ... | 2014 | 24588258 |
| overexpression of an apocynum venetum dead-box helicase gene (avdh1) in cotton confers salinity tolerance and increases yield in a saline field. | soil salinity is a major environmental stress limiting plant growth and productivity. we have reported previously the isolation of an apocynum venetum dead-box helicase 1 (avdh1) that is expressed in response to salt exposure. here, we report that the overexpression of avdh1 driven by a constitutive cauliflower mosaic virus-35s promoter in cotton plants confers salinity tolerance. southern and northern blotting analyses showed that the avdh1 gene was integrated into the cotton genome and express ... | 2015 | 26779246 |
| plant-based medicines for anxiety disorders, part 1: a review of preclinical studies. | research in the area of herbal psychopharmacology has revealed a variety of promising medicines that may provide benefit in the treatment of general anxiety and specific anxiety disorders. however, a comprehensive review of plant-based anxiolytics has been absent to date. this article (part 1) reviews herbal medicines for which only preclinical investigations for anxiolytic activity have been performed. in part 2, we review herbal medicines for which there have been clinical investigations for a ... | 2013 | 23436255 |
| development of an igy antibody-based immunoassay for the screening of the cyp2e1 inhibitor/enhancer from herbal medicines. | cytochrome p450 (cyp) 2e1 is an important enzyme involved in the metabolism of many endogenous and exogenous compounds. it is essential to evaluate the expression of cyp2e1 in the studies of drug-drug interactions and the screening of drugs, natural products, and foodstuffs. the present work is a feasibility study on the development of immunoassays using a specific and sensitive chicken-sourced anti-cyp2e1 igy antibody. cloning, expression, and purification of a recombinant cyp2e1 (mice origin) ... | 2016 | 28066249 |
| retraction of: molecular cloning and characterization of a salinity stress-induced gene encoding dead-box helicase from the halophyte apocynum venetum. | | 2016 | 27811006 |
| corrigendum: overexpression of an apocynum venetum dead-box helicase gene (avdh1) in cotton confers salinity tolerance and increases yield in a saline field. | [this corrects the article on p. 1227 in vol. 6, pmid: 26779246.]. | 2016 | 27468296 |
| response of soil fungi community structure to salt vegetation succession in the yellow river delta. | high-throughput sequencing technology was used to reveal the composition and distribution of fungal community structure in the yellow river delta under bare land and four kinds of halophyte vegetation (saline seepweed, angiospermae, imperata and apocynum venetum [a. venetum]). the results showed that the soil quality continuously improved with the succession of salt vegetation types. the soil fungi richness of mild-salt communities (imperata and a. venetum) was relatively higher, with shannon in ... | 2016 | 27449214 |
| protective effects of hyperoside against h2o2-induced apoptosis in human umbilical vein endothelial cells. | the vascular endothelium is important in the physiological homeostasis of blood vessels. increasing evidence demonstrates that oxidative stress‑induced endothelial damage is involved in the pathogenesis of several cardiovascular diseases, including atherosclerosis. hyperoside, one of major active components from apocynum venetum l. (luo‑bu‑ma), which is a traditional chinese herbal medicine commonly used for the prevention of cardiovascular diseases, exhibits diverse bioactivities, including ant ... | 2016 | 27176644 |
| extraction, preconcentration and isolation of flavonoids from apocynum venetum l. leaves using ionic liquid-based ultrasonic-assisted extraction coupled with an aqueous biphasic system. | ionic liquids (ils) are considered as green solvents, and widely applied for the extraction of various compounds. | 2016 | 26959002 |
| itraq-based quantitative proteomic analysis of the anti-apoptotic effect of hyperin, which is mediated by mcl-1 and bid, in h2o2-injured ea.hy926 cells. | endothelial injury has been implicated in the pathogenesis of many cardiovascular diseases, including thrombotic disorders. hyperin (quercetin-3-o-galactoside), a flavonoid compound and major bioactive component of the medicinal herb apocynum venetum l., is commonly used to prevent endothelium dysfunction. however, its mode of action remains unclear. to the best of our knowledge, we have for the first time investigated the protective effect hyperin exerts against h2o2-induced injury in human end ... | 2016 | 26935776 |
| discrimination between leave of apocynum venetum and its adulterant, a. pictum based on antioxidant assay and chemical profiles combined with multivariate statistical analysis. | an integrated approach including chemical and biological assessments was developed to investigate the differences between apocynum venetum l. (av) and its adulterant, apocynum pictum schrenk (ap). ten flavonoids were tentatively identified by ultra-visible and mass spectra data. the chemical component, hyperoside, was identified as a critical parameter for discrimination of two species from the results of principal component analysis (pca) and quantitative analysis. the anti-oxidative power of t ... | 2015 | 26783710 |
| protective effect of hyperoside against acetaminophen (apap) induced liver injury through enhancement of apap clearance. | acetaminphen (apap) overdose leads to severe hepatotoxicity. apocynum venetum l. (a. venetum) possess potent hepatoprotective effect. hyperoside is one of the major compounds exist in apocynum venetum l. and might be a potential agent to protect against apap-induce liver injury. in this study, we investigated the effect of hyperoside on apap hepatotoxicity in mice. mice were treated intragastrically with hyperoside (10, 50 or 100 mg/kg) for 3 days before apap (300 mg/kg) injection. apap alone ca ... | 2016 | 26772156 |
| endothelium-dependent relaxation effect of apocynum venetum leaf extract via src/pi3k/akt signalling pathway. | botanical herbs are consumed globally not only as an essential diet but also as medicines or as functional/recreational food supplements. the extract of the apocynum venetum leaves (avle), also known as luobuma, exerts its antihypertensive effect via dilating the blood vessels in an endothelium- and concentration-dependent manner with optimal effect seen at as low as 10 µg/ml. a commercial luoboma "antihypertensive tea" is available commercially in the western province of china. the present stud ... | 2015 | 26133970 |
| the improvement of sleep by oral intake of gaba and apocynum venetum leaf extract. | the effects of two food materials, γ-aminobutyric acid (gaba) produced by natural fermentation and apocynum venetum leaf extract (avle), on the improvement of sleep were investigated in humans. the electroencephalogram (eeg) test revealed that oral administration of gaba (100 mg) and avle (50 mg) had beneficial effects on sleep. gaba shortened sleep latency by 5.3 min and avle increased non-rapid eye movement (rem) sleep time by 7.6%. simultaneous intake of gaba and avle shortened sleep latency ... | 2015 | 26052150 |
| microemulsion liquid chromatographic method for simultaneous separation and determination of six flavonoids of apocynum venetum leaf extract. | a simple, cost-effective, and efficient method was developed for the rapid simultaneous separation and determination of six flavonoids (rutin, hyperoside, quercetin-3-o-sophoroside, isoquercitrin, astragalin and quercetin) of apocynum venetum leaf extract by reversed phase high performance liquid chromatography using a microemulsion system mixture as the mobile phase. separations were performed on the zorbax extend-c18 column with uv detection at 360nm. the flow rate was 0.8mlmin(-1). the optimi ... | 2015 | 26021846 |
| apocynum venetum attenuates acetaminophen-induced liver injury in mice. | apocynum venetum l. (a. venetum) has long been used in oriental folk medicine for the treatment of some liver diseases; however, the underlying mechanisms remain to be fully elucidated. acetaminophen (apap) is a widely used analgesic drug that can cause acute liver injury in overdose situations. in this study, we investigated the potential protective effect of a. venetum leaf extract (ale) against apap-induced hepatotoxicity. mice were intragastrically administered with ale once daily for 3 cons ... | 2015 | 25967663 |
| anti-platelet aggregation activities of different fractions in leaves of apocynum venetum l. | ethnopharmacological relevance apocynum venetum: is widely used in uygur and traditional chinese medicine. modern pharmaceutical studies have shown that leaves of a. venetum have effects of liver protection, antidepressant and regulation of blood pressure. however, it is unclear that which components have pharmacological activities. | 2015 | 25835371 |
| application of mixed cloud point extraction for the analysis of six flavonoids in apocynum venetum leaf samples by high performance liquid chromatography. | a simple, inexpensive and efficient method based on the mixed cloud point extraction (mcpe) combined with high performance liquid chromatography was developed for the simultaneous separation and determination of six flavonoids (rutin, hyperoside, quercetin-3-o-sophoroside, isoquercitrin, astragalin and quercetin) in apocynum venetum leaf samples. the non-ionic surfactant genapol x-080 and cetyl-trimethyl ammonium bromide (ctab) was chosen as the mixed extracting solvent. parameters that affect t ... | 2015 | 25625477 |
| apocynum venetum leaf attenuates myocardial ischemia/reperfusion injury by inhibiting oxidative stress. | apocynum venetum, a chinese medicinal herb, is reported to be neuroprotective. however, whether apocynum venetum leaf extract (avle) protects against ischemic myocardium remains elusive. our present study was aimed to observe the effects of avle preconditioning on myocardial ischemia/reperfusion (mi/r) injury and to investigate the possible mechanisms. rats were treated with avle (500 mg/kg/d, o.g.) or distilled water once daily for one week. afterward, all the animals were subjected to 30 min o ... | 2015 | 25579758 |
| screening and analysis of metabolites in rat urine after oral administration of apocynum venetum l. extracts using hplc-tof-ms. | hplc with diode array detection and esi-tof-ms was used for the study of the constituents in apocynum venetum l. extracts and the metabolites in rat urine after oral administration of a. venetum l. extracts. a formula database of the known constituents in a. venetum l. was established, and 21 constituents were rapidly identified by accurately matching their molecular masses with the formulae of the compounds in the database. furthermore, 34 metabolites were detected and elucidated in the rat uri ... | 2014 | 24376178 |
| simultaneous qualitative and quantitative analysis of phenolic acids and flavonoids for the quality control of apocynum venetum l. leaves by hplc-dad-esi-it-tof-ms and hplc-dad. | a reliable method based on high performance liquid chromatography-diode array detector-electrospray ionization-ion trap-time of flight-mass spectrometry (hplc-dad-esi-it-tof-ms) was developed for the identification of phenolic acids and flavonoids in apocynum venetum l. leaves and its adulterant, pocynum hendersonii (hook. f.) woodson leaves. a total of 21 compounds were identified or tentatively identified, including 4 phenolic acids and 17 flavonoids. 3-o-caffeoylquinic acid (3-cqa) and caffei ... | 2013 | 23973760 |
| antidepressant-like effect of flavonoids extracted from apocynum venetum leaves on brain monoamine levels and dopaminergic system. | apocynum venetum l. (apocynaceae), a traditional medicinal plant, has been used for the improvement of emotions in asian countries. | 2013 | 23453939 |
| application of microdialysis for elucidating the existing form of hyperoside in rat brain: comparison between intragastric and intraperitoneal administration. | hypericum perforatum (st. john's wort) is an important anti-depressant herb used in clinic and commonly prescribed for mild depression. hyperoside is one of the major components of h. perforatum and is also detected in many plant species such as abelmoschus manihot, black currant, rosa agrestis, apocynum venetum and nelumbo nucifera. | 2012 | 23063958 |
| apocynum venetum leaf extract, an antihypertensive herb, inhibits rat aortic contraction induced by angiotensin ii: a nitric oxide and superoxide connection. | the leaves extract of apocynum venetum (avle), also known as "luobuma", have long been used in traditional chinese medicine to treat hypertension and depression in parts of china and it has been shown to possess anti-oxidant and anti-lipid peroxidation effects. avle (10 μg/ml) has been reported to have a long-lasting endothelium-dependent relaxant effect and this effect has been proposed to be due to its nitric oxide(no)-releasing and superoxide anion(soa)-scavenging properties. | 2012 | 22835814 |
| ils-based microwave-assisted extraction coupled with aqueous two-phase for the extraction of useful compounds from chinese medicine. | ionic liquids-based microwave-assisted extraction (ils-mae) of medicinal or useful compounds from plants was investigated as an alternative to conventional organic solvent extractions. the extraction and the preconcentration of aqueous two-phase (atp) systems have been integrated. various operating parameters were systematically considered by single-factor and l(9) (3(4)) orthogonal array experiments. 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim][bf(4)]) has been selected to extract apoc ... | 2012 | 22785248 |
| [preparation and in vitro release characteristics of pulsed-release tablets of apocynum venetum]. | using apocynum venetum as a model drug to prepare pulsed-release tablets based on diffusion, swelling, osmotic pressure mechanism and to evaluate the release characteristics. | 2011 | 22779170 |
| apocynum venetum leaf extract attenuates disruption of the blood-brain barrier and upregulation of matrix metalloproteinase-9/-2 in a rat model of cerebral ischemia-reperfusion injury. | we investigated the neuroprotective effects of apocynum venetum leaf extract (avle) on a rat model of cerebral ischemia-reperfusion injury and explored the underlying mechanisms. rats were randomly divided into five groups: sham, ischemia-reperfusion, avle125, avle250, and avle500. cerebral ischemia was induced by 1.5 h of occlusion of the middle cerebral artery. cerebral infarct area was measured by tetrazolium staining at 24 and 72 h after reperfusion, and neurological function was evaluated a ... | 2012 | 22592643 |
| botany, traditional uses, phytochemistry and pharmacology of apocynum venetum l. (luobuma): a review. | apocynum venetum l. (apocynaceae, luobuma ) has a long history as a chinese traditional medicine with uses to calm the liver, soothe the nerves, dissipate heat, and promote diuresis. recently, luobuma tea has been commercialized as a sedative and anti-aging supplement that has become increasingly popular in north american and east asian health food markets. | 2012 | 22421379 |
| [location and relative quantity of flavonoids in the leaf of apocynum venetum]. | in this study, laser scanning confocal microscopy (lscm) was used to determine the location and relative quantity of flavonoids in the leaves of apocynum venetum l. from the top, middle and basal parts of the branch. the leaves of the plants of one, two and three years old, separately, were collected in july. anova and lsd test were employed in the statistical analysis. the results indicated that flavonoids located mainly in xylem conduit of vein, collenchyma, epidermic cells and cuticle. the da ... | 2011 | 22007528 |
| highly selective and sensitive determination of free and total amino acids in apocynum venetum l. (luobuma tea) by a developed hplc-fld method coupled with pre-column fluorescent labelling. | amino acids (aa) are important chemical constituents of tea leaves remarkably influencing the quality of tea. in this study, free aa and total aa in apocynum venetum l. (luobuma tea) were estimated by hplc equipped with fluorescent detector using 2-[2-(7h-dibenzo[a,g]carbazol-7-yl)-ethoxy] ethyl chloroformate (dbceec) as a fluorescent labelling reagent. different parameters for derivatization and separation were optimized. aa were rapidly derivatized within 3 min at room temperature with dbceec. ... | 2012 | 21875374 |
| antidepressant-like effect of hyperoside isolated from apocynum venetum leaves: possible cellular mechanisms. | in the present work, we studied the possible cellular mechanisms of hyperoside isolated from apocynum venetum leaves in corticosterone-induced neurotoxicity, using pc12 cells as a suitable in vitro model of depression. cell viability was quantitated by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (mtt) assay. the release amount of lactic dehydrogenase (ldh) and intracellular ca(2+) concentration were measured using kit and transcript abundances of brain-derived neurotrophic fac ... | 2012 | 21802268 |
| [simultaneous determination of six flavonoids in apocynum venetum by hplc]. | to develop a high-performance liquid chromatography (hplc) method for the simultaneous determination of rutin, hyperoside, isoquercetin, astragulin, quercetin, and kaempferol in apocynum venetum and its extracts. | 2011 | 21657078 |
| comparison of the phenolic content and antioxidant activities of apocynum venetum l. (luo-bu-ma) and two of its alternative species. | the leaves of apocynum venetum l. (av), a native chinese plant, have been used as folk medicine in china and japan. this study evaluated the content of the active antioxidant component and antioxidant activities of av, and its two alternative species, poacynum pictum (schrenk) baill. (pp) and poacynum hendersonii (hook.f.) woodson (ph). the total phenolic and total flavonoid contents were determined. in addition, the quantitative analysis of two major flavonoid compounds (hyperoside and isoquerc ... | 2010 | 21151449 |
| comprehensive separation and identification of chemical constituents from apocynum venetum leaves by high-performance counter-current chromatography and high performance liquid chromatography coupled with mass spectrometry. | high-performance counter-current chromatography (hpccc) and high performance liquid chromatography coupled with mass spectrometry (hplc-ms) was efficiently utilized for the separation and identification of the chemical components with a wide range of polarity from the mixed extract of chinese medicinal herb apocynum venetum. for hpccc separation, four sets of solvent systems, n-hexane-ethyl acetate-acetonitrile-water (1.5:3.5:2:4.5, v:v:v:v), ethyl acetate-methanol-water (5:2:5, v:v:v) and n-but ... | 2010 | 20965796 |
| solvent gradient elution for comprehensive separation of constituents with wide range of polarity in apocynum venetum leaves by high-speed counter-current chromatography. | a novel gradient elution was efficiently utilized for the separation of the chemical components with a wide range of polarity from the mixed extract of the chinese medicinal herb apocynum venetum or mixed standards by high-speed counter-current chromatography. three sets of solvent systems, n-hexane-ethyl acetate-methanol-water (1.5:3.5:2:4.5 v/v/v/v), ethyl acetate-methanol-water (5:2:5 v/v/v) and n-butanol-methanol-water (5:1:5 v/v/v) were used for the one-step elution. the separation was init ... | 2010 | 20730835 |
| [impact of high salt stress on apocynum venetum growth and ionic homeostasis]. | a pot experiment was conducted in a net room to study the growth responses and related mechanisms of apocynum venetum treated with different concentrations (100-400 mmol x l(-1)) of nacl for 30 days. the biomass accumulation, growth rate, root vigor, salt ion content and mineral ion uptake and distribution were measured. compared with the control, treatment 100 mmol x l(-1) nacl had lesser effects on the plant dry mass, but decreased the plant fresh mass and growth rate significantly. with incre ... | 2010 | 20462001 |
| development of randomly amplified polymorphic dna-sequence characterized amplified region marker for identification of apocynum venetum linn. from a. pictum schrenk. | apocynum venetum linn. is an important chinese crude drug, and its sibling species a. pictum schrenk is a confusable herb which is similar to it. the purpose of this study is to develop dna molecular markers to distinguish a. venetum from a. pictum through the combinative technologies of bulked segregate analysis (bsa) and randomly amplified polymorphic dna (rapd). two putative markers b08-407 and b03-1368 specific for a. venetum were identified and sequenced. based on the sequence information, ... | 2010 | 20190420 |
| [textual research of medicinal and edible plants in shanhaijing]. | to investigate the purification process of total flavones and total tannins from apocynum venetum leaves with macroreticular resin. | 2008 | 18720878 |
| [separation and purification process of total flavones and total tannins from apocynum venetum leaves with macroreticular resin]. | to investigate the purification process of total flavones and total tannins from apocynum venetum leaves with macroreticular resin. | 2008 | 18720863 |
| constituents from leaves of apocynum venetum l. | an analysis using hplc-ms revealed that an extract from dried leaves of apocynum venetum l. contained more than 15 kinds of phenolic constituents. two malonated flavonol glycosides were further isolated, and their structures were determined to be quercetin 3-o-(6''-o-malonyl)-beta-d-glucoside (1) and quercetin 3-o-(6''-o-malonyl)-beta-d-galactoside (2) by nmr spectroscopic analysis. this is the first report describing the isolation of these malonated flavonol glycosides from a. venetum l. both g ... | 2008 | 18404316 |
| molecular cloning and characterization of a salinity stress-induced gene encoding dead-box helicase from the halophyte apocynum venetum. | the genes encoding dead-box helicases play a key role in various abiotic stresses, including temperature, light, oxygen, and salt stress. a salt-responsive gene, designated avdh1, was isolated from the halophyte dogbane (apocynum venetum) by using suppression subtractive hybridization and race (rapid amplification of cdna ends) pcr. the deduced amino acid sequence has nine conserved helicase motifs of the dead-box protein family. the avdh1 gene is present as a single copy in the dogbane genome. ... | 2008 | 18272921 |
| [chemical constituents of flavonoids from apocynum venetum]. | to study the chemical constituents of flavonoids from apocynum venetum l. | 2007 | 18236750 |
| [studies on chemical constituents from flowers of apocynum venetum]. | to study the chemical constituents of the flowers of apocynum venetum. | 2005 | 16323543 |
| inhibitory effects of luobuma tea and its components against glucose-mediated protein damage. | luobuma tea, prepared from the leaves of apocynum venetum l., is a popular beverage in china. in this study, the activity of luobuma leaf extract and its components against the formation of advanced glycation endproducts (ages), which are largely involved in the pathogenesis of diabetic vascular complications, was examined using the in vitro glycation reaction. strong inhibitory activity against the formation of ages was shown by luobuma aqueous extract. following further fractionation of this e ... | 2004 | 15110107 |
| determination of hydroxyl radical by capillary electrophoresis and studies on hydroxyl radical scavenging activities of chinese herbs. | high-performance capillary electrophoresis (ce) with electrochemical detection (ed) was employed to determine hydroxyl radicals in the fenton reaction. hydroxyl radicals can react with salicylic acid to produce 2,3-dihydroxy benzoic acid and 2,5-dihydroxy benzoic acid, which can be analyzed by ce-ed. based on this principle, hydroxyl radicals were determined indirectly. in a 20 mmol/l phosphate running buffer (ph 7.4), 2,3-dihydroxy benzoic acid and 2,5-dihydroxy benzoic acid would elute simulta ... | 2003 | 12802570 |
| seasonal, spatial, and interspecific variation in quercetin in apocynum venetum and poacynum hendersonii, chinese traditional herbal teas. | quercetin is of particular importance as it has been found to have functions of suppressing tumors, reducing blood pressure, and scavenging free radicals. it is one of the major flavonoids in apocynum venetum and poacynum hendersonii, whose leaves have long been used as traditional herbal teas in china and japan. both species are also cultivated as fiber plants because of their outstanding quality of phloem fiber in stems. to obtain high output of both quercetin and fiber, it is necessary to opt ... | 2003 | 12670186 |
| medicinal foodstuffs. xxiv. chemical constituents of the processed leaves of apocynum venetum l.: absolute stereostructures of apocynosides i and ii. | two new ionone glucosides, named apocynosides i and ii, were isolated from the roasted leaves of apocynum venetum l. together with nine known compounds. the absolute stereostructures of apocynosides i and ii were determined by chemical and physicochemical evidence, which included the application of a modified mosher's method and the circular dichroism helicity rule. | 2001 | 11456089 |
| inhibitory effects of an aqueous extract of apocynum venetum leaves and its constituents on cu(2+)-induced oxidative modification of low density lipoprotein. | an aqueous extract of apocynum venetum leaves and its constituents inhibited thiobarbituric acid reactive substances (tbars) and conjugated-diene formation in the cu(2+)-induced oxidation of low density lipoprotein (ldl) in vitro. the tbars formation was most strongly inhibited by chlorogenic acid with an ic(50) value of 1.9 microm, but other constituents were in a range of 2.3-23.3 microm. on the other hand, the lag time in the conjugated-diene formation was dose-dependently prolonged by additi ... | 2000 | 11054838 |
| [sedative chemical constituents of leaves of apocynum venetum linn]. | eight constituents were isolated from the ether solvent fraction of leaves of apocynum venetum and identified as triacontanol, beta-sitosterol, quercetin, hyperin, long-chain fatty acids (c28-c34), lupeol, scopoletin and isofraxidin. isofraxidin and hyperin were effective sedative components. | 1991 | 1820793 |
| [anti-damage effect of apocynum venetum l. leaf extract on chromosomes]. | | 1988 | 3197222 |
| progress in the study on the medical effects of apocynum venetum (a. lancifolium). | | 1988 | 3292845 |
| [pulse polarographic determination of hyperoside from apocynum venetum l]. | | 1986 | 3776546 |
| [relation between the growth period and quercetin content of apocynum venetum]. | | 1986 | 2943451 |
| [constituents of the lipophilic fraction of the apocynum venetum leaf]. | | 1985 | 2934156 |
| [quantitative determination of quercetin in the leaves of luo-bu-ma (apocynum venetum)]. | | 1982 | 6215154 |
| [studies on the constituents of apocynaceae plants. isolation of flavonol glycosides and other components from the leaves of apocynum venetum l. var. basikurumon hara. (1) (author's transl)]. | | 1978 | 745047 |
| the phenolic compounds of underground parts of apocynum venetum. | | 1971 | 5119017 |