| first evidence of batrachochytrium dendrobatidis in china: discovery of chytridiomycosis in introduced american bullfrogs and native amphibians in the yunnan province, china. | although the chytrid fungus batrachochytrium dendrobatidis (bd), the etiological agent of amphibian chytridiomycosis, has been implicated in mass mortality and population declines on several continents around the world, there have been no reports on the presence of bd infections in amphibians in china. we employed quantitative pcr and histological techniques to investigate the presence of bd in introduced north american bullfrogs (rana catesbeiana) (referred to hereafter as bullfrog) and native ... | 2010 | 20372969 |
| oa-gl21, a novel bioactive peptide from odorrana andersonii, accelerated the healing of skin wounds. | nowadays, the number of chronic trauma cases caused by a variety of factors such as the world's population-ageing and chronic diseases is increasing steadily, and thus effective treatment for chronic wounds has become a severe clinical challenge, which also burdens the patient both physically and financially. therefore, it is urgent to develop new drugs to accelerate the healing of wounds. bioactive peptides, which are relatively low cost, easy to produce, store and transport, have become an exc ... | 2018 | 29752337 |
| identification and characterization of a novel gene-encoded antioxidant peptide from odorous frog skin. | amphibian skin plays an essential role in protecting organisms from harmful external factors such as uv radiation. how amphibians protect themselves from reactive oxygen species following long-term sun exposure is an important and interesting question. amphibian skins possess a novel antioxidant system composed of various antioxidant peptides (aops), which maintain redox homeostasis. however, only a few aops have been identified so far. | 2019 | 30430935 |
| accelerated wound healing induced by a novel amphibian peptide (oa-ff10). | despite the continued development of modern medicine, chronic wounds are still a critical issue in clinical treatment, placing a great physiological, psychological, and financial burden on patients. researchers have investigated many methods to solve this problem, with bioactive peptides gaining increasing attention due to their considerable advantages and diverse functions, as well as low cost, simple storage, and easy transportation. | 2019 | 30678611 |
| a short peptide potentially promotes the healing of skin wound. | skin wound, a common form of skin damage in daily life, remains a serious challenge in clinical treatment. bioactive peptides with high efficiency have been considered as potential therapeutic candidates for wound healing. in this report, a novel short linear peptide, with mature peptide sequence of 'gllsginaewpc' and no obvious similarity with other known bioactive peptides, was identified by genomic method from the skin of odorous frog, odorrana andersonii our results suggested that oa-gl12 (o ... | 2019 | 30842341 |
| potential skin protective effects after uvb irradiation afforded by an antioxidant peptide from odorrana andersonii. | with increasing demand, the development of new natural antioxidants has become a primary direction of scientific research. we previously identified a short gene-encoded peptide (oa-vi12) from odorrana andersonii frog skin secretions that exerted direct scavenging capacity against free radicals, suggesting a possible function in protecting skin against photodamage caused by their high-altitude habitat. in the current research, we examined the effects of oa-vi12 on both uvb-irradiation and hydroge ... | 2019 | 31610428 |
| cathelicidin-oa1, a novel antioxidant peptide identified from an amphibian, accelerates skin wound healing. | cathelicidins play pivotal roles in host defense. the discovery of novel cathelicidins is important research; however, despite the identification of many cathelicidins in vertebrates, few have been reported in amphibians. here we identified a novel cathelicidin (named cathelicidin-oa1) from the skin of an amphibian species, odorrana andersonii. produced by posttranslational processing of a 198-residue prepropeptide, cathelicidin-oa1 presented an amino acid sequence of 'igrdptwshlaasclkcifddlpkth ... | 2018 | 29343843 |
| characterization of an insulinotropic peptide from skin secretions of odorrana andersonii. | insulinotropic peptide agents are regarded as potential candidates for anti-diabetic treatment. in the present study, a novel insulinotropic peptide, termed oa-a1, was purified from frog skin secretions of odorrana andersonii. mature oa-a1 was determined to be a 1965.049 da peptide with an amino acid sequence of lvgkllkgavgdvcgllpic, in which an intramolecular disulfide bridge was formed by two cysteine residues. at the cellular level, oa-a1 exhibited potent proliferation promoting effects on mo ... | 2017 | 28608418 |
| rich diversity and potency of skin antioxidant peptides revealed a novel molecular basis for high-altitude adaptation of amphibians. | elucidating the mechanisms of high-altitude adaptation is an important research area in modern biology. to date, however, knowledge has been limited to the genetic mechanisms of adaptation to the lower oxygen and temperature levels prevalent at high altitudes, with adaptation to uv radiation largely neglected. furthermore, few proteomic or peptidomic analyses of these factors have been performed. in this study, the molecular adaptation of high-altitude odorrana andersonii and cavernicolous o. wu ... | 2016 | 26813022 |