| sesquiterpene lactone 12,8-eudesmanolides from the fungus xylaria ianthinovelutina. | the investigation of xylaria ianthinovelutina (mont.) led to the isolation of four new 12,8-eudesmanolides (1-4). their structures were determined by spectroscopy and the relative stereochemistry was assigned based on noesy and cd spectral data. compounds 1-4 exhibited biological activity against plasmodium falciparum k-1 strain, nci-h187, kb, mcf-7 with ic(50) values varying in the range 0.78-19.15 microg/ml. | 2009 | 19452435 |