| influenza a virus reassortants with surface glycoprotein genes of the avian parent viruses: effects of ha and na gene combinations on virus aggregation. | a series of 33 human-avian and human-mammalian influenza virus reassortant clones possessing either ha or both ha and na genes of the avian or mammalian virus was obtained by crosses of a/ussr/90/77 (h1n1) human virus with 5 avian and 1 mammalian influenza virus strains. all of the reassortants possessing na genes of the h1n1 human parent virus and ha gene of an avian or mammalian parent virus had high values of infectivity/ha activity ratio. since this feature could result from a limited virion ... | 1993 | 8257298 |
| surveillance of avian influenza viruses in northern pintails (anas acuta) in tohoku district, japan. | among winter migratory waterfowl, northern pintails (anas acuta), in one of the largest flocks in tohoku district, northeast japan, were surveyed for influenza a viruses at five wintering sites in three prefectures, viz., aomori, akita, and miyagi. a total of 38 influenza a viruses were isolated from 2066 fecal samples collected during november 2006 through march 2007. the overall isolation rate was 1.84%. eleven different subtypes were isolated, including nine h5n2, seven h6n8, seven h10n1, fou ... | 2008 | 18459295 |
| mono- and quadri-subtype virus-like particles (vlps) containing h10 subtype elicit protective immunity to h10 influenza in a ferret challenge model. | avian-origin influenza represents a global public health concern. in 2013, the h10n8 virus caused documented human infections for the first time. currently, there is no approved vaccine against h10 influenza. recombinant virus-like particles (vlps) represent a promising vaccine approach. in this study, we evaluated h10 vlps containing hemagglutinin from h10n8 virus as an experimental vaccine in a ferret challenge model. in addition, we evaluated quadri-subtype vlps co-localizing h5, h7, h9 and h ... | 2016 | 27663671 |
| lethal nephrotropism of an h10n1 avian influenza virus stands out as an atypical pathotype. | a nephrotropic h10n1 avian influenza virus (aiv) with an intravenous pathogenicity index (ivpi) of 1.9 and a haemagglutinin monobasic amino acid cleavage site motif, was genetically and phenotypically characterized. specific pathogen free chickens of 3 or 6 weeks of age were challenged with a 10(6)eid50/0.1ml dose by either oro-nasal or intravenous route, to study the distribution, tissue tropism and virulence of the virus. direct transmission was tested by introducing sentinel birds on day 4 po ... | 2014 | 25190277 |
| genome sequence of a novel h10n9 avian influenza virus isolated from chickens in a live poultry market in eastern china. | an h10n9 avian influenza virus (aiv) strain, a/chicken/jiangsu/rd5/2013, was isolated in china. the hemagglutinin (ha) and neuraminidase (na) genes in this strain originated from h10n1 and h7n9 aivs, respectively, and the other genes derived from h7n3 aivs. sequence analysis implies that the h10n9 aiv may be an na gene donor for the human h7n9 influenza viruses. | 2013 | 23814107 |