| a new cytotoxic guaianolide from chrysanthemum boreale. | a new cytotoxic guaianolide was isolated from chrysanthemum boreale makino. the structure of guaianolide was elucidated as 8-acetoxy-4,10-dihydroxy-2,11(13)-guaiadiene-12,6-olide (1). compound 1 exhibited cytotoxic activity (ic(50)< or =4 microg/ml) against all five human cancer cell lines tested. | 2009 | 18983901 |
| inhibitory effects of chrysanthemum boreale essential oil on biofilm formation and virulence factor expression of streptococcus mutans. | the aim of the study was to evaluate the antibacterial activity of essential oil extracted from chrysanthemum boreale (c. boreale) on streptococcus mutans (s. mutans). to investigate anticariogenic properties, and bacterial growth, acid production, biofilm formation, bacterial adherence of s. mutans were evaluated. then gene expression of several virulence factors was also evaluated. c. boreale essential oil exhibited significant inhibition of bacterial growth, adherence capacity, and acid produ ... | 2015 | 25763094 |
| chrysanthemum boreale flower floral water inhibits platelet-derived growth factor-stimulated migration and proliferation in vascular smooth muscle cells. | chrysanthemum boreale makino (compositae) (cbm) is a traditional medicine that has been used for the prevention or treatment of various disorders; it has various properties including antioxidation, anti-inflammation, and antitumor. | 2015 | 25330930 |
| chrysanthemum boreale makino essential oil induces keratinocyte proliferation and skin regeneration. | we investigated the effect of essential oil from the flower of chrysanthemum boreale makino (cbmeo) on growth of human keratinocytes (hacats) and explored a possible mechanism for this response. cbmeo was extracted using the steam distillation method. cbmeo contained a total of 33 compounds. cbmeo stimulated hacat proliferation (ec50, 0.028 μg/ml) and also induced phosphorylation of akt and erk1/2 in hacats (ec50, 0.007 and 0.005 μg/ml, for phosphorylated akt and erk1/2, respectively). moreover, ... | 2015 | 25167931 |
| suppression of inflammatory responses by handelin, a guaianolide dimer from chrysanthemum boreale, via downregulation of nf-κb signaling and pro-inflammatory cytokine production. | the anti-inflammatory activity of handelin (1), a guaianolide dimer from chrysanthemum boreale flowers, was evaluated in vivo, and the effects on mediators nitric oxide (no), prostaglandin e2 (pge2), tumor necrosis factor-α (tnf-α), and interleukin-1β (il-1β) and the nuclear factor-κb (nf-κb) and erk/jnk signaling pathways were investigated in vitro. compound 1 inhibited lipopolysaccharide (lps)-induced production of no and pge2 in cultured mouse macrophage raw 264.7 cells. the suppression of no ... | 2014 | 24689881 |
| identification and quantification of the sedative and anticonvulsant flavone glycoside from chrysanthemum boreale. | the flowers or leaves of chrysanthemum boreale (compositae) have been traditionally used as herb tea to reduce anxiety, insomnia, and stress. sedative and anticonvulsant activities were evaluated in mice using pentobarbital-induced sleeping assay and pentylenetetrazole (ptz)-induced convulsion assay. the flower extract exhibited more potent activities than the extracts of the leaves and stems, and chromatographic isolation yielded the five compounds acacetin, linarin, acacetin 7-o-β-d-glucopyran ... | 2013 | 23325489 |
| synthesis of stereoisomers of artemisia and chrysanthemum bis(acetylenic) enol ether spiroacetals. | an 11-step synthesis is described of two diastereomeric candidates for a bis(acetylenic) enol ether spiroacetal isolated from chrysanthemum boreale. key steps in the synthetic route include spiroacetal lactone alkylidenation and subseqent modified cadiot-chodkiewicz cross-coupling to install the bis(acetylenic) enol ether functionality. from nmr comparisons, neither of the candidates, whose structures were confirmed by single-crystal x-ray diffraction, correspond to the natural product, and a pr ... | 2012 | 23113738 |
| effect of chrysanthemi borealis flos on atopic dermatitis induced by 1-chloro 2,4-dinitrobenzene in nc/nga mouse. | the flower of chrysanthemum boreale has traditionally been used for treatment of various inflammatory disease including atopic dermatitis (ad). however, its action on ad is unclear. therefore, we investigated the effect of cb on ad using nc/nga mice as an ad model. the effect of cb on 1-chloro-2,4-dinitrobenzene (dncb) induced nc/nga mice was evaluated by examining skin symptom severity, itching behavior, ear thickness, levels of serum immunoglobulin e (ige), tumor necrosis factor-α (tnf-α), and ... | 2012 | 22564174 |
| involvement of heme oxygenase-1 in the anti-inflammatory activity of chrysanthemum boreale makino extracts on the expression of inducible nitric oxide synthase in raw264.7 macrophages. | this study is to elucidate the involvement of anti-inflammatory heme oxygenase-1 (ho-1) in the inhibitory activity of a chrysanthemum boreale makino (cb) extract on nitric oxide (no) production and inducible nitric oxide synthase (inos) expression in lipopolysaccharide (lps)-stimulated raw264.7 macrophages. | 2010 | 20656003 |
| new guaianolides from leaves and stems of chrysanthemum boreale. | the 8-acetoxy-2-methoxy-10-hydroxy-3,11(13)-guaiaden-12,6-olide 1 and 8,10-diacetoxy-2-methoxy-3,11(13)-guaiadiene-12,6-olide 2 were isolated from chrysanthemum boreale makino. compound 1 inhibited the etoposide-induced apoptosis in u 937 cells with an ic50 value 8.6 microg/ml. | 2003 | 14598224 |
| antibacterial activity and chemical composition of essential oil of chrysanthemum boreale. | the essential oil of chrysanthemum boreale makino was analyzed by means of gc and gc-ms. eighty-seven constituents were identified, representing 94.13 % of the total oil and the major components were camphor, alpha-thujone, cis-chrysanthenol, 1,8-cineole, alpha-pinene, and beta-caryophyllene. furthermore, the essential oil exhibited antibacterial activity (mic, more than 800 microg/ml versus 0.125 microg/ml for ampicillin) after it was tested against 6 gram(+) bacteria and 8 gram(-) bacteria. | 2003 | 12677536 |
| a new guaianolide as apoptosis inhibitor from chrysanthemum boreale. | the 8-o-acetyl-3,10-dihydroxy-4(15),11(13)-guaiadien-12,6-olide, named borenolide, was isolated from chrysanthemum boreale m. borenolide inhibits the etoposide-induced apoptosis in u937 cell with an ic(50) value of 6.2 microg/ml. structural assignment was based on nmr-spectroscopic methods and x-ray crystallographic analysis. | 2001 | 11509991 |
| structural analogues of cumambrin b from the flower of chrysanthemum boreale. | the structural analogues of cumambrin b (1, 2, 3, 4) were isolated from the flower of chrysanthemum boreale makino. the structures of compounds were determined by two-dimensional 1h-1h cosy and 13c-1h cosy spectra with the aid of homonuclear and heteronuclear double resonance experiment. the stereochemistry of compounds has been verified from single crystal x-ray diffraction of cumambrin a (2). the antimicrobial activities of these guaianolides have been studied. | 1998 | 9875500 |