| a comparative study of the effects of venoms from five rear-fanged snake species on the growth of leishmania major: identification of a protein with inhibitory activity against the parasite. | leishmania parasites of several species cause cutaneous and visceral disease to millions of people worldwide, and treatment for this vector-borne protozoan parasite typically involves administration of highly toxic antimonial drugs. snake venoms are one of the most concentrated enzyme sources in nature, displaying a broad range of biological effects, and several drugs now used in humans were derived from venoms. in this study, we compared the effects of the venoms of the south american rear-fang ... | 2011 | 21601589 |
| in vitro neuromuscular activity of 'colubrid' venoms: clinical and evolutionary implications. | in this study, venoms from species in the colubrinae, homalopsinae, natricinae, pseudoxyrhophiinae and psammophiinae snake families were assayed for activity in the chick biventer cervicis skeletal nerve muscle preparation. boiga dendrophila, boiga cynodon, boiga dendrophila gemincincta, boiga drapiezii, boiga irregularis, boiga nigriceps and telescopus dhara venoms (10 microg/ml) displayed postsynaptic neuromuscular activity as evidenced by inhibition of indirect (0.1 hz, 0.2 ms, supramaximal v ... | 2004 | 15284016 |
| characterization of venom (duvernoy's secretion) from twelve species of colubrid snakes and partial sequence of four venom proteins. | r.e. hill and s.p. mackessy. characterization of venom (duvernoy's secretion) from twelve species of colubrid snakes and partial sequence of four venom proteins. toxicon xx, xx-yy, 2000. - venomous colubrids, which include more than 700 snake species worldwide, represent a vast potential source of novel biological compounds. the present study characterized venom (duvernoy's gland secretion) collected from twelve species of opisthoglyphous (rear-fanged) colubrid snakes, an extremely diverse assem ... | 2000 | 10858509 |
| venom proteomes of south and north american opisthoglyphous (colubridae and dipsadidae) snake species: a preliminary approach to understanding their biological roles. | opisthoglyphous snake venoms remain under-explored despite being promising sources for ecological, evolutionary and biomedical/biotechnological research. herein, we compared the protein composition and enzymatic properties of the venoms of philodryas baroni (pbv), philodryas olfersii olfersii (poov) and philodryas patagoniensis (ppv) from south america, and hypsiglena torquata texana (httv) and trimorphodon biscutatus lambda (tblv) from north america. all venoms degraded azocasein, and this meta ... | 2012 | 22974712 |
| phylogeography of the western lyresnake (trimorphodon biscutatus): testing aridland biogeographical hypotheses across the nearctic-neotropical transition. | the western lyresnake (trimorphodon biscutatus) is a widespread, polytypic taxon inhabiting arid regions from the warm deserts of the southwestern united states southward along the pacific versant of mexico to the tropical deciduous forests of mesoamerica. this broadly distributed species provides a unique opportunity to evaluate a priori biogeographical hypotheses spanning two major distinct biogeographical realms (the nearctic and neotropical) that are usually treated separately in phylogeogra ... | 2006 | 17107472 |
| biochemical characterization of phospholipase a2 (trimorphin) from the venom of the sonoran lyre snake trimorphodon biscutatus lambda (family colubridae). | phospholipases a(2) (pla(2)), common venom components and bioregulatory enzymes, have been isolated and sequenced from many snake venoms, but never from the venom (duvernoy's gland secretion) of colubrid snakes. we report for the first time the purification, biochemical characterization and partial sequence of a pla(2) (trimorphin) from the venom of a colubrid snake, trimorphodon biscutatus lambda (sonoran lyre snake). specific phospholipase activity of the purified pla(2) was confirmed by enzym ... | 2004 | 15225559 |