| evaluation of human papillomavirus type 5 on frozen sections of multiple lesions from transplant recipients with in situ hybridization and non-isotopic probes. | transplant recipients are at high risk to develop multiple cutaneous lesions after grafting. the frequency of the potentially oncogenic human papillomavirus (hpv) type 5 dna was evaluated in cutaneous lesions taken from sun-exposed areas in transplant recipients (92 lesions and 5 samples from normal skin) and compared with a nontransplanted population (22 lesions and 7 samples from normal skin) using in situ hybridization and biotinylated probes to hpv types 1, 2, 5, 16 and 18. hpv type 5 dna wa ... | 1992 | 1323355 |
| dermatopathologic findings in patients infected with hiv. | several inflammatory, infectious, and neoplastic conditions in hiv-infected patients are distinctive or require a biopsy for diagnosis. some differ subtly from similar conditions seen in noninfected patients. the exanthem of acute hiv infection cannot be diagnosed specifically on biopsy as its histologic appearance is similar to that of other viral exanthemata. a condition that closely resembles seborrheic dermatitis occurs in hiv-infected patients. plasma cells, necrotic keratinocytes, and leuk ... | 1992 | 1730173 |
| natural cell-mediated cytotoxicity against various target cells in patients with epidermodysplasia verruciformis. | natural cell-mediated cytotoxicity of peripheral blood mononuclear cells was studied in eight patients with epidermodysplasia verruciformis induced by human papillomaviruses specific for epidermodysplasia verruciformis and in five patients with epidermodysplasia verruciformis-induced exclusively by human papillomavirus type 3. nine patients with various cutaneous warts and 25 age- and sex-matched healthy persons were control subjects. natural cell-mediated cytotoxicity against both k-562 erythro ... | 1990 | 2155952 |
| widespread flat warts associated with human papillomavirus type 5: a cutaneous manifestation of human immunodeficiency virus infection. | numerous flat and tinea versicolor-like warts developed on the face, trunk, and upper extremities of a 10-year-old boy with human immunodeficiency virus infection. nucleic acid analysis of involved skin revealed human papillomavirus type 5, which has sometimes been associated with epidermodysplasia verruciformis. this human papillomavirus type has also been described in patients with common variable immunodeficiency and dyskeratosis congenita and in renal allograft recipients. human immunodefici ... | 1990 | 2172338 |
| epidermodysplasia verruciformis. skin carcinoma containing human papillomavirus type 5 dna sequences and primary hepatocellular carcinoma associated with chronic hepatitis b virus infection in a patient. | in a case of epidermodysplasia verruciformis with impaired cell-mediated immunity and multiple skin cancers human papillomavirus type 5 (hpv5) dna sequences were demonstrated in a cutaneous squamous cell carcinoma. hpv5 and hpv8 were detected in the benign disseminated skin lesions together with three newly characterized hpvs: hpv17, hpv19 and hpv24. a chronic infection with hepatitis b virus resulting in macronodular cirrhosis associated with a primary hepatocellular carcinoma was also acquired ... | 1986 | 2426900 |
| human papillomavirus (hpv) type 50, a type associated with epidermodysplasia verruciformis (ev) and only weakly related to other ev-specific hpvs. | the cloning and partial characterization of the genome of human papillomavirus type 50 is presented. alignment of the genomic map with that of human papillomavirus type 5, with which it is only weakly related, was permitted by partial dna sequence analysis. | 1989 | 2552168 |
| human papillomavirus type 5 and skin cancer in renal allograft recipients. | | 1987 | 2885608 |
| molecular cloning and nucleotide sequence analysis of several naturally occurring hpv-5 deletion mutant genomes. | three deletion mutants of naturally occurring human papillomavirus type 5 (hpv-5) were molecularly cloned into phage vectors. the nature of these deletions was characterized initially by restriction endonuclease mapping and electron microscopic heteroduplex analysis and ultimately by nucleotide sequence analysis. the sizes of the deletions are 353, 1329, 1571, and 2267 bp and map to the late gene region of the hpv-5 genome. the 80 nucleotides immediately adjacent to the deletions exhibit no sign ... | 1987 | 3033891 |
| nucleotide sequence and genome organization of human papillomavirus type 5. | human papillomavirus (hpv) type 5 is associated with benign and malignant lesions of the disease epidermodysplasia verruciformis (ev). because of the strong correlation between the presence of hpv-5 and malignant progression in these patients, we have elucidated the nucleotide sequence of the hpv-5 genome. the size of the hpv-5 genome is 7746 nucleotides and its organization is similar to that of other papillomaviruses. the hpv-5 genome exhibits extensive sequence homology with another ev-associ ... | 1987 | 3033892 |
| failure of etretinate in epidermodysplasia verruciformis. | in a patient suffering from benign lesions of epidermodysplasia verruciformis due to human papillomavirus type 5 little clinical improvement could be observed after 6 months of oral etretinate. the drug was given 75 mg/day for 1 month before dosage was reduced to 50 mg/day. control biopsy after 3 months of treatment still revealed large quantities of virions and typical cytopathic effects in light and electron microscopic examination. | 1986 | 3792602 |
| papillomaviruses and skin cancer in africa. | although it was suggested long ago that certain epithelial cancers preceded by papillomas might be caused by viruses, the first proof that papillomaviruses were associated with cancer dates from the work on rabbits in 1934 by shope and rose. in the 1970s, the introduction of the blot hybridization technique enabled orth and his co-workers at the institut pasteur, paris, to demonstrate the presence in man of the dna of human papillomavirus type 5 (hpv-5) in cancers following lutz-lewandovsky epid ... | 1984 | 6100284 |
| detection of human papillomavirus type 5 dna in skin cancers of an immunosuppressed renal allograft recipient. | a renal allograft recipient with an epidermodysplasia-verruciformis-like syndrome was found to have human papillomavirus type 5 (hpv-5) in his benign warty lesions and hpv-5 dna in two of his skin cancers. this finding points to a role for hpv-5 in skin oncogenesis in renal allograft recipients. | 1983 | 6135911 |
| oral retinoid treatment of human papillomavirus type 5-induced epidermodysplasia verruciformis. | | 1980 | 6245361 |
| a potentially oncogenic human papillomavirus (hpv-5) found in two renal allograft recipients. | we have observed 2 immunosuppressed renal allograft recipients with skin lesions induced by human papillomavirus type 5 (hpv-5). one recipient had multiple pityriasis versicolor-like (pv-like) skin lesions on his arms and trunk, and multiple bowenoid in-situ skin cancers. the other had 2 warty lesions on the back of her fingers. structural antigens of human papillomavirus type 5 (hpv-5) were identified in benign lesions from both patients by immunofluorescence. the histologic and ultrastructural ... | 1980 | 6253573 |
| genetic heterogeneity of oncogenic human papillomavirus type 5 (hpv5) and phylogeny of hpv5 variants associated with epidermodysplasia verruciformis. | variants of oncogenic human papillomavirus type 5 (hpv5), specifically associated with epidermodysplasia verruciformis, were recognized on the basis of the genetic heterogeneity of the e6 open reading frame (orf). to further evaluate the genetic heterogeneity of hpv5, we sequenced the long control region (lcr), the e7 orf, and the terminal parts of the e2 orf of five previously characterized hpv5 variants and compared the data with the published hpv5a1 and hpv5b sequences. alignment of the varia ... | 1993 | 8263176 |
| biological and biochemical activity of e7 genes of the cutaneous human papillomavirus type 5 and 8. | in contrast to the observed activity of the e7 genes of the genital high-risk human papillomavirus (hpv)16 and hpv18, e7s of the cutaneous high-risk hpv5 and hpv8 show no in vitro transforming activity in established rodent cells. we recently reported that the hpv8 e7 driven by the sv40 enhancer/promoter oncogenically transforms primary rat embryo fibroblast (ref) cells collaboratively with the ejras oncogene (jpn. j. cancer res., 82, 1340-1343, 1991). to study the functional differences between ... | 1993 | 8395681 |
| differentiation-dependent transcription of the epidermodysplasia verruciformis-associated human papillomavirus type 5 in benign lesions. | human papillomavirus type 5 (hpv 5) induces cutaneous lesions and persists in skin carcinomas of patients with epidermodysplasia verruciformis (ev). we investigated the expression pattern of hpv 5 in biopsies from benign skin lesions of ev patients by cdna analysis and in situ hybridization. nine different cdnas could be generated from total rna of one of these lesions by reverse transcription and pcr amplification with hpv 5-specific primers. we could identify two major splice donors: one was f ... | 1995 | 8525623 |
| variability and phylogeny of the l1 capsid protein gene of human papillomavirus type 5: contribution of clusters of nonsynonymous mutations and of a 30-nucleotide duplication. | we analyzed the variability and established the phylogeny of the l1 capsid protein gene of 33 isolates of human papillomavirus type 5 (hpv5) obtained from epidermodysplasia verruciformis patients from different continents. by comparing the sequences of a 419-bp fragment with those published for two japanese isolates, we found 12.9% variable nucleotide positions, defining 25 variants with mutation rates ranging from 0.2 to 8.8%. such a high intratypic diversity is unusual among hpvs. nine of the ... | 1996 | 8661427 |
| psoriasis: a possible reservoir for human papillomavirus type 5, the virus associated with skin carcinomas of epidermodysplasia verruciformis. | recent polymerase chain reaction data have shown that most human papillomavirus (hpv) genotypes associated with epidermodysplasia verruciformis (ev) are widespread; however, hpv5 associated with ev skin carcinomas has only rarely been detected in non-ev patients. to identify the reservoir of this virus, we examined 335 sera from different groups of patients for the presence of hpv5 antibodies by an enzyme-linked immunosorbent assay test based on hpv5 virus-like particles. the prevalence of antib ... | 1998 | 9540967 |
| is human papillomavirus type 5 the putative autoantigen involved in psoriasis? | | 1998 | 9740257 |
| puva therapy and human papillomavirus type 5 detection in psoriasis. | | 1998 | 9804361 |
| a susceptibility locus for epidermodysplasia verruciformis, an abnormal predisposition to infection with the oncogenic human papillomavirus type 5, maps to chromosome 17qter in a region containing a psoriasis locus. | epidermodysplasia verruciformis (ev) is a rare genodermatosis characterized by an abnormal susceptibility to infection with a specific group of related human papillomavirus (hpv) genotypes, including the oncogenic hpv5 associated with the skin carcinomas developing in about half of ev patients. ev is usually considered as an autosomal recessive condition. taking ev as a model to identify a locus underlying the susceptibility to hpv infections, we performed a genome-wide search for linkage with 2 ... | 1999 | 10084299 |
| high prevalence of a variety of epidermodysplasia verruciformis-associated human papillomaviruses in psoriatic skin of patients treated or not treated with puva. | epidermodysplasia verruciformis-associated human papillomaviruses and in particular human papillomavirus type 5 were recently shown to be highly prevalent in psoriatic skin. we have analyzed lesional skin from 54 psoriasis patients for infections with genital-specific and epidermodysplasia verruciformis-specific human papillomaviruses to define the spectrum of involved human papillomavirus types and to test if it is influenced by psoralen ultraviolet a therapy. using polymerase chain reaction an ... | 1999 | 10417630 |
| human papillomavirus type 5 is commonly present in immunosuppressed and immunocompetent individuals. | dna of a wide spectrum of epidermodysplasia verruciformis-associated human papillomavirus (hpv) types (ev-hpv) has been detected in skin lesions and plucked hairs from both immunosuppressed and a considerable proportion of non-immunosuppressed persons. recently, the skin of psoriatic patients was claimed to be an important reservoir for a particular ev-hpv type, hpv 5, which is considered as a high-risk hpv type for skin carcinomas. in the present study, we analysed plucked hairs from immunosupp ... | 1999 | 10468795 |
| antibodies to human papillomavirus type 5 are generated in epidermal repair processes. | we reported previously that patients with psoriasis harbored at a very high frequency dna sequences of the oncogenic human papillomavirus type 5 (hpv5) associated with epidermodysplasia verruciformis. moreover anti-hpv5 antibodies were detected in 25% of the cases. our aim was to find out whether keratinocyte hyperproliferation and/or autoimmunity could be responsible for hpv5 expression in psoriasis. we found that epidermal repair in patients with extensive second degree burns (n = 19) is frequ ... | 2000 | 10692096 |
| mutation and abnormal expression of the p53 gene in the viral skin carcinogenesis of epidermodysplasia verruciformis. | patients suffering from epidermodysplasia verruciformis are prone to nonmelanoma skin cancers, due to an inherited abnormal susceptibility to the oncogenic human papillomavirus type 5. genotoxic sunlight ultraviolet b radiations are likely to be a cofactor. lesions of two human-papillomavirus-type-5-infected epidermodysplasia verruciformis patients collected during an 8 y period were retrospectively studied for p53 mutations in exons 5 through 8 by a polymerase chain reaction single-strand confo ... | 2001 | 11676835 |
| human papillomavirus type 5 in primary keratinocytes from psoriatic skin. | the role of human papillomaviruses (hpvs) in the pathogenesis of psoriasis is uncertain, and it has been postulated that the virus can act as a putative superantigen or it is activated from a latent status by inflammatory cytokines. to determine the involvement of hpv in the pathogenesis of psoriasis, primary cultures of keratinocytes from psoriatic lesions were analysed for the viral presence and for the production of inflammatory cytokines. biopsies were taken from psoriatic lesions of 11 pati ... | 2005 | 16232304 |
| human papillomavirus type 5 e6 oncoprotein represses the transforming growth factor beta signaling pathway by binding to smad3. | mechanisms of cellular transformation associated with human papillomavirus type 5 (hpv5), which is responsible for skin carcinomas in epidermodysplasia verruciformis (ev) patients, are poorly understood. using a yeast two-hybrid screening and molecular and cellular biology experiments, we found that hpv5 oncoprotein e6 interacts with smad3, a key component in the transforming growth factor beta1 (tgf-beta1) signaling pathway. hpv5 e6 inhibits smad3 transactivation by destabilizing the smad3/smad ... | 2006 | 17020941 |
| human papillomavirus type 5 infection in a patient with hailey-hailey disease successfully treated with imiquimod. | | 2007 | 17300256 |
| transcriptional activation of the human papillomavirus type 5 and 16 long control region in cells from cutaneous and mucosal origin. | human papillomavirus type-16 (hpv-16) infects mucosal epithelium and is the most common type found in cervical cancer. hpv-5 infects cornified epithelium and is the most common type found on normal skin and belongs to the types frequently associated with skin cancers of epidermodysplasia verruciformis patients. one factor by which this anatomical tropism could be determined is the regulation of hpv gene expression in the host cell. the hpv long control region (lcr) contains cis-responsive elemen ... | 2007 | 17352804 |
| genital warts in burmeister's porpoises: characterization of phocoena spinipinnis papillomavirus type 1 (pspv-1) and evidence for a second, distantly related pspv. | we identified sequences from two distantly related papillomaviruses in genital warts from two burmeister's porpoises, including a pv antigen-positive specimen, and characterized phocoena spinipinnis papillomavirus type 1 (pspv-1). the pspv-1 genome comprises 7879 nt and presents unusual features. it lacks an e7, an e8 and a bona fide e5 open reading frame (orf) and has a large e6 orf. pspv-1 l1 orf showed the highest percentage of nucleotide identity (54-55 %) with human papillomavirus type 5, b ... | 2007 | 17554024 |
| interaction between human papillomavirus type 5 e2 and polo-like kinase 1. | the e2 protein of the papillomavirus plays an essential role in the viral life cycle. through a yeast two-hybrid screening, human polo-like kinase 1 was found to interact with human papillomavirus type 5 e2. further characterization identified that the domains responsible for the interaction are the transactivation domain of hpv-5 e2 and the sequence between the kinase and the polo box domains of plk1. in vivo, plk1 and hpv-5 e2 are colocalized at the nuclear speckles. in the skin epithelium not ... | 2009 | 19152411 |
| two sisters reveal autosomal recessive inheritance of epidermodysplasia verruciformis: a case report. | epidermodysplasia verruciformis is a rare genodermatosis characterized by a unique susceptibility to cutaneous human papillomaviruses infection. most patients show autosomal recessive patterns of inheritance. | 2014 | 25048734 |