| presence of human papillomavirus 6/11 dna in condyloma acuminatum of the urinary bladder. | a japanese woman with condyloma acuminatum of the urinary bladder is presented. the condyloma acuminatum lesion was resected endoscopically and human papillomavirus 6/11 dna was detected. after treatment, there has been no recurrence of the disease. | 1992 | 1316664 |
| evaluation of sexually abused and nonabused young girls for intravaginal human papillomavirus infection. | the objective of this study was to compare the prevalence of intravaginal human papillomavirus-associated disease in two groups of girls to develop information regarding the means of transmission of anal-genital human papillomavirus disease. | 1992 | 1317670 |
| histological distribution of polymerase chain reaction--amplified human papillomavirus 6 and 11 dna in penile lesions. | the purpose of this study was to ascertain the histological pattern of distribution of human papillomavirus (hpv) 6 and 11 dna in penile lesions by in situ hybridization after amplification by the polymerase chain reaction (pcr). hpv dna was routinely detected by in situ hybridization with or without pcr amplification in granular layer cells that showed perinuclear halos and nuclear atypia. cells that lack these histological features rarely exhibited hpv dna with conventional in situ hybridizati ... | 1992 | 1317997 |
| human papillomavirus in sinonasal papillomas and squamous cell carcinoma. | the diagnostic and prognostic relevance of human papillomavirus (hpv) types 6, 11, 16, and 18 in squamous papilloma, inverted papilloma, and squamous carcinoma of the sinonasal epithelium was examined using the polymerase chain reaction (pcr) technique. four (15%) of 26 squamous papillomas, 7 (24%) of 29 inverted papillomas, and 1 (4%) of 24 squamous carcinomas were positive for hpv when examined using the pcr amplification technique. human papillomavirus 6 was present in 5 specimens (3 squamous ... | 1992 | 1325585 |
| molecular cloning and characterization of a new subtype of human papillomavirus 6 dna. | a new subtype of human papillomavirus (hpv) 6 was molecularly cloned from a laryngeal papilloma specimen. the dna of this isolate showed a strong hybridization signal with hpv 6b dna under stringent conditions. comparison of restriction enzyme fragment patterns of this hpv dna with hpv 6b dna revealed that this dna is not identical to hpv 6b dna. thus, it represents a new subtype of hpv 6 dna, which we have tentatively designated as hpv 6e dna. a map of the physical structure of hpv 6e was also ... | 1991 | 1650237 |
| human papillomavirus 6, 11, and 16 in laryngeal papillomas. | twenty-seven cases of benign laryngeal papillomas, both single and multiple variants, were analysed for human papillomavirus (hpv) by dna slot-blot hybridization chiefly to determine the pattern of infection in hong kong chinese. dna was extracted from paraffin blocks of formalin-fixed tissue and probed separately for hpv 6, 11, 16, and 18. sixteen cases (59 per cent) showed the presence of at least one of these four hpv genomes. thirteen cases (48 per cent) were positive for hpv 11 only. three ... | 1991 | 1662265 |
| human papillomavirus in prostatic cancer: no evidence found by in situ dna hybridization. | human papillomavirus has been associated with benign squamous tumors, intraepithelial neoplasia, and invasive squamous cancer. the role of human papillomavirus as the most likely precursor of cervical dysplasia is well studied. we know of no available information as to the possible role of human papillomavirus in prostatic hyperplasia and cancer. we studied formalin-fixed paraffin-embedded tissues of 20 cases of glandular hyperplasia and 20 cases of prostatic cancer by in situ dna hybridization ... | 1991 | 1703667 |
| buschke-löwenstein tumor: verrucous carcinoma of the anogenitalia. | buschke-löwenstein tumor is a rare type of anogenital squamous cell carcinoma with a distinctive clinical appearance. we present the case of a thirty-four-year-old man with this tumor, which was excised surgically. human papillomavirus was detected in formalin-fixed, paraffin-embedded sections with a human papillomavirus 6/11 probe, but not with a human papillomavirus 16 or a human papillomavirus 18 probe. | 1991 | 2070647 |
| human papillomavirus 6/11 and 16/18 in schneiderian inverted papillomas. in situ hybridization with human papillomavirus rna probes. | schneiderian inverted papillomas may be troublesome lesions for clinicians with propensity for recurrences. dysplasia is not uncommonly seen, and some of these lesions do progress to develop squamous carcinoma. the authors hybridized in situ seven inverted papillomas with rna probes to human papillomavirus (hpv) 6, 11, 16, and 18. four of these contained dysplasia, two were without dysplasia, and one contained invasive squamous cell carcinoma. five inverted papillomas showed evidence of hpv infe ... | 1989 | 2539243 |
| anal cancer. microscopic condyloma and tissue demonstration of human papillomavirus capsid antigen and viral dna. | sixteen cases of squamous cell carcinoma of the anus, including 4 incidentally discovered in situ lesions, and 3 anal condylomas, were examined for the presence of human papillomavirus (hpv). all in situ tumors and 6 of the invasive tumors were associated with histologic changes typical of condyloma, despite the absence of clinical anogenital warts. immunohistochemical studies for viral capsid antigen gave positive reactions in two anal warts and in the condylomatous area associated with one inv ... | 1989 | 2552954 |
| duplication of enhancer sequences in human papillomavirus 6 from condylomas of the mamilla. | human papillomavirus (hpv) 6 usually induces tumors of the genital, oral, or laryngeal mucosa. an hpv 6-related dna of 8.2 kb was detected in an extrachromosomal state in atypically located condylomas of the mamilla and was molecularly cloned. the identity of the cloned hpv dna and the viral dna in the biopsy was confirmed by comparative pstl cleavage analysis, which showed typical hpv 6 dna fragment patterns except for 0.2-kb larger b fragments. sequencing revealed an exact 236-bp duplication e ... | 1989 | 2554574 |
| multifocal squamous neoplasia of the female genital tract: significance of human papillomavirus infection of the vagina after hysterectomy. | six hundred sixteen women with a history of hysterectomy were examined for the presence of human papillomavirus deoxyribonucleic acid (dna) in vaginal smears using filter in situ hybridization. one hundred twenty patients had had hysterectomy for cervical intraepithelial neoplasia and invasive neoplasia, 54 for noncervical anogenital cancer, and 442 for benign uterine disorders. human papillomavirus dna was detected in 18% of all vaginal smears. a history of cervical neoplasia was associated wit ... | 1987 | 2819794 |
| human papillomavirus deoxyribonucleic acid in lesions of the female genital tract: evidence for type 6/11 in squamous carcinoma of the vulva. | tissue specimens from 51 patients with genital condyloma acuminata or invasive cervical or vulvar carcinomas were analyzed for the presence of human papillomavirus deoxyribonucleic acid (dna) using the dot blot technique. of ten condylomas, 80% contained dna related to human papillomavirus 6 or 11. sixty percent had evidence of dna related to human papillomavirus 16, and 30% contained dna related to human papillomavirus 18. of 24 squamous cervical carcinomas, 58% had human papillomavirus type 16 ... | 1987 | 2819798 |
| detection of human papillomavirus-6 in primary carcinoma of the urethra in men. | the authors report a case of primary urethral carcinoma which seems to be linked to human papillomavirus (hpv) infection. southern blot hybridization of phosphorus 32 (32p)-labeled dna extracted from the cancer tissue gave a positive reaction with hpv-6. specimens of the tumor material subjected to in situ hybridization with 3h-labeled hpv-6 dna showed numerous tumor cell clusters with clearly labeled nuclei. using immunoperoxidase staining the authors found papillomavirus structural antigen wit ... | 1987 | 2820563 |
| colposcopic correlates of cervical papillomavirus infection. | we compared the colposcopic and histologic features of 39 papillomavirus-related cervical lesions with their associated human papillomavirus type. two thirds of the lesions contained human papillomavirus type 16-related deoxyribonucleic acid, and 69% of them were classified as cervical intraepithelial neoplasia i or ii, in contrast to 92% of lesions containing human papillomavirus 6/11 deoxyribonucleic acid. on histologic examination, low-grade cervical intraepithelial neoplastic lesions tended ... | 1987 | 2823611 |
| human papillomaviruses in buschke-löwenstein tumors: physical state of the dna and identification of a tandem duplication in the noncoding region of a human papillomavirus 6 subtype. | six buschke-löwenstein tumors, i.e., highly differentiated squamous cell tumors of the genital region, were shown to contain human papillomavirus 6 (hpv 6) or hpv 11 genomes. the viral dna was found in an episomal state, including a very small fraction of circular oligomers. hpv 6a and hpv 6d genomes were cloned from two of the tumors. comparison with hpv 6b, cloned from a benign genital wart (e. -m. de villiers, l. gissmann, and h. zur hausen, j. virol. 40:932-935, 1981) by restriction mapping ... | 1986 | 3009899 |
| human papillomaviruses in women with a history of abnormal papanicolaou smears and in their male partners. | human papillomavirus infection of the genital tract was identified by the filter in situ hybridization test. exfoliated cervical cells were tested separately for the prevalence of human papillomavirus 6/11 and 16/18. human papillomavirus deoxyribonucleic acid (dna) was identified in 70 and 92% of specimens of u.s. and west german women, respectively, who showed concurrent cytologic and colposcopic abnormalities, and in 50 and 54% of women, respectively, who showed neither cytologic nor colposcop ... | 1987 | 3029642 |
| simultaneously occurring condylomata acuminata, carcinoma in situ and verrucous carcinoma of the vulva and carcinoma in situ of the cervix in a young woman. a case report. | a case of simultaneously occurring condylomata acuminata, carcinoma in situ and verrucous carcinoma of the vulva and carcinoma in situ of the cervix was seen in a 26-year-old woman. in situ dna hybridization on sections of the condyloma acuminata and verrucous carcinoma yielded dna sequences for human papillomavirus 6. | 1988 | 3404512 |
| condylomata acuminata arising in a neovagina. | a case is reported in which condylomata acuminata arose in a mcindoe neovagina. histopathologic and virologic evidence are provided to support the characterization of these lesions as benign warty processes secondary to human papillomavirus-6. factors influencing viral site specificity are discussed. | 1987 | 3808542 |
| acanthosis nigricans maligna. clinical and virological investigations. | 2 cases of acanthosis nigricans associated with an adenocarcinoma (signet ring cell carcinoma) of the stomach and a metastasizing small-cell carcinoma of unknown origin are reported. in both cases the skin lesions preceded the diagnosis of the carcinoma by months and acanthosis nigricans maligna was suspected by onset and localization of the dermatosis. there was no evidence of a papillomavirus etiology of the warty skin lesions. virus particles could not be demonstrated either in ultrathin sect ... | 1984 | 6086413 |
| identification of human papillomavirus in cervical swabs by deoxyribonucleic acid in situ hybridization. | a series of 47 lesions diagnosed cytologically as cervical intraepithelial neoplasia (cin) iii in 22 cases, cin i/ii in 13 cases, and 12 cases showing abnormal smears consistent with human papillomavirus infection were analyzed. thirty-six cases with negative cytology were used as the control group. sixty-eight percent of cin iii were positive for a mixture of human papillomavirus 16 and human papillomavirus 18, 18% reacted with human papillomavirus 6 or 11, and 14% were negative. of the group w ... | 1984 | 6095155 |
| human papillomavirus types important in progression of inverted papilloma. | recent evidence suggests that human papillomavirus may play a role in the pathogenesis of inverted papilloma, a benign but locally aggressive neoplasm with a high recurrence rate and an association with squamous cell carcinoma. histologic features of inverted papilloma have not been useful in discriminating lesions at high risk for malignant transformation. we studied archival pathology specimens from 39 patients with inverted papilloma treated at the university of michigan between 1980 and 1994 ... | 1995 | 7478645 |
| [a buschke and lowenstein tumor in a female patient]. | although it presents clinically as a malignant formation, the buschke-lowenstein tumour is known to be a histologically benign tumour caused by a papillomavirus infection from an condyloma acuminatum. the buschke-lowenstein tumour is generally observed in male subjects, usually on the penis, and rarely occurs in women. a female case is reported. in the literature, human papillomavirus 6 is the most common type although types 11, 16 and 18 are also reported. surgery is the only treatment for this ... | 1995 | 7499735 |
| in vitro pharmacokinetics of phosphorothioate antisense oligonucleotides. | isis 2105 (afovirsen), a 20-mer phosphorothioate oligonucleotide that inhibits the production of a gene product essential to the growth of human papillomavirus, is in phase ii clinical trials for the treatment of genital warts induced by human papillomavirus-6 and human papillomavirus-11. the uptake, subcellular distribution and metabolism of isis 2105 and three other similar length phosphorothioates have been studied in a variety of cell lines. our experiments indicated that isis 2105 and other ... | 1995 | 7562586 |
| invasive squamous-cell carcinoma in giant anorectal condyloma (buschke-löwenstein tumor). | giant condyloma acuminata, first described by buschke and löwenstein in 1925 as a penile lesion, is extremely rare in the anorectal region. the cauliflower-like tumor behaves clinically in a malignant fashion, although it shows no histomorphological criteria of malignancy. up to the time of writing only 33 cases of anorectal origin, 42% with malignant transformation, have been published. the authors report 2 more cases of squamous-cell carcinoma in giant anorectal condylomata acuminata. buschke- ... | 1995 | 7760649 |
| a new method for direct analysis of polymerase chain reaction-amplified human papillomavirus using dna enzyme immunoassay. | we describe use of a polymerase chain reaction in conjunction with a dna enzyme immunoassay for the simultaneous detection of multiple types of human papillomavirus in a single microtiter plate. the method is specific, sensitive, rapid, and capable of detecting human papillomavirus-6, -11, -16, -18, and -33 in cervical biopsy specimens. | 1994 | 7894049 |
| [human papillomavirus 6/11 in conjunctival papilloma]. | human papilloma virus is highly prevalent, but rarely localized in the conjunctiva. | 1996 | 8761758 |
| human papillomavirus-associated oral epithelial dysplasia (koilocytic dysplasia): an entity of unknown biologic potential. | intraepithelial neoplasia of the female genital tract has long been associated with human papillomavirus infection. to date, there have been no previously published studies of oral dysplasia that have identified light microscopic features predictive of the presence of human papillomavirus. we identified a variant of oral epithelial dysplasia, koilocytic dysplasia, that exhibited light microscopic features suggestive of hpv infection. to determine if these microscopic features were specifically c ... | 1996 | 8843454 |
| human papillomavirus and schistosomiasis associated bladder cancer. | to determine the human papillomavirus dna status of schistosomal associated squamous cell carcinoma of the urinary bladder in south africa. | 1997 | 9292149 |
| incidence of human papillomavirus 6, 11, 16, 18 and 33 in normal oral mucosa of a greek population. | the polymerase chain reaction (pcr) was applied for the detection of human papillomavirus (hpv) infection in samples obtained from the clinically normal mucosa of the oral cavity of 169 asymptomatic subjects in northern greece. of the subjects, 9.5% were found to be infected with hpv. typing of hpv by southern blot hybridization revealed that 2.4%, 0%, 0%, 4.1%, 0.6% of the subjects were infected with hpv 16, 18, 33, 6 and 11, respectively. | 1997 | 9298359 |
| expression of human papillomavirus 6 in inverted papilloma arising in a renal transplant recipient. | a 36-year-old renal transplant recipient taking cyclosporin a presented with bilateral nasal polypoid lesions involving the nasal septum and lateral nasal walls. pathologic findings from surgical excision demonstrated inverted papilloma (ip) with focal atypia and mild dysplasia. dna extracted from the tissue was tested with the polymerase chain reaction (pcr) using human papillomavirus (hpv) e6 and l1 consensus primers. this revealed amplification of the expected size fragment consistent with th ... | 1998 | 9432079 |
| disseminated mucosal papilloma/condyloma secondary to human papillomavirus. | this report details the histopathologic findings in a woman who acquired the human papillomavirus 6/11 in her late teens and developed papilloma/condyloma of the nasopharynx, oropharynx, anogenital region, urethra, and urinary bladder. general evaluations of immune function reveal no defect, and there was no evidence of hiv infection. the morphologic expression of hpv 6/11 infection appears to be completely dependent on the mucosal epithelium affected. the complete spectrum of benign and premali ... | 1998 | 9777992 |
| phase iia safety and immunogenicity of a therapeutic vaccine, ta-gw, in persons with genital warts. | a fusion protein vaccine consisting of human papillomavirus 6 l2e7 with alhydrogel was developed for the treatment of genital warts. twenty-seven subjects with genital warts received 3 immunizations over 4 weeks in an open-label study. the vaccine was well-tolerated, and all subjects made serum igg antibodies, predominantly igg1, against l2e7. nineteen of 25 tested persons made antigen-specific t cell proliferative responses to l2e7, and peripheral blood mononuclear cells when cultured with l2e7 ... | 1999 | 9952367 |
| dna vaccination of mice with plasmid expressing human papillomavirus 6 major capsid protein l1 elicits type-specific antibodies neutralizing pseudovirions constructed in vitro. | human papillomavirus 6 (hpv 6) causes benign condylomata. as a model for hpv vaccine development, we tested a hpv 6 dna vaccine candidate, constructed by subcloning the major capsid protein (l1) gene into an expression plasmid having the cytomegalovirus promoter, for its immunogenicity in balb/c mice. three intracutaneous inoculations of the plasmid with a gene gun at 2-week intervals elicited anti-l1 serum antibodies. the antibodies were found to recognize highly type-specific, conformation-dep ... | 2000 | 10596021 |
| solitary squamous cell papilloma of the lung in a 40-year-old woman with recurrent laryngeal papillomatosis. | a rare case of recurrent respiratory papillomatosis (rrp) is reported with a review of the literature. a 40-year-old japanese woman had suffered from rrp since 1 year of age. she developed a pulmonary squamous papilloma with a thin-walled cavity, which was suspected as being lung carcinoma. the trachea and bronchi around the tumor were intact, and no malignant transformation was present. two types of human papillomavirus, 6 and 16, were detected, both in the laryngeal and pulmonary papillomas by ... | 2000 | 10849335 |
| human papillomavirus-11-associated recurrent respiratory papillomatosis is more aggressive than human papillomavirus-6-associated disease. | the aim of this study was to determine whether viral type (hpv-6 vs. hpv-11) could predict the clinical course of recurrent respiratory papillomatosis in children. viral typing, using the polymerase chain reaction, was performed on laryngeal biopsies of 61 patients treated at children's hospital of michigan. hpv-6 was detected in 29 of the patients' biopsies and hpv-11 in 32 biopsies. hpv-11 was more common among the african-american patients than among caucasians (p = 0.001). patients with hpv- ... | 2001 | 11200493 |
| investigation of human papillomavirus in transitional cell carcinomas of the urinary bladder in south africa. | to investigate the prevalence of human papillomavirus in transitional cell carcinoma of the urinary bladder in south africa. | 2001 | 11280602 |
| subclinical human papillomavirus infection of the cervix. | a prospective study to investigate a group of iraqi woman with proved genital vulval warts, to seek evidence of human papillomavirus infection in apparently normal looking cervixes and to investigate the natural history of infection. | 2001 | 11573115 |
| prevalence and determinants of human papillomavirus genital infection in men. | four-hundred-forty-five husbands of women with invasive cervical carcinoma, 165 of women with in situ cervical cancer, and 717 of control women (age range 19-82 years) were interviewed and a sample of exfoliated cells from the penis obtained in seven case-control studies conducted by the international agency for research on cancer. the characteristics of human papillomavirus-positive and human papillomavirus-negative husbands were compared using odds ratios and 95% confidence intervals. thirteen ... | 2002 | 11875730 |
| risk factors of invasive cervical cancer in mali. | cervical cancer is the most common cancer in women in mali and the second commonest cause of cancer mortality. | 2002 | 11914322 |
| carcinoma cuniculatum of the jaw: a rare variant of oral carcinoma. | carcinoma cuniculatum is a rare variant of carcinoma usually involving the foot. only 13 cases have been described in the oral cavity, none of which was in the english-language literature. we describe a 56-year-old man who presented with a soft exophytic mass in the maxillary gingiva, alveolar bone destruction, and loosening of the teeth. histopathologic study revealed thin papillary projections covered by a thick keratin layer in the superficial areas and multiple, branching keratin-filled cryp ... | 2002 | 12424455 |
| [presence of human papillomavirus in malignant oral lesions]. | the purpose of this study was to investigate the prevalence of human papillomavirus 6/11 and 16/18 in patients, with oral lesions clinically diagnosed as leucoplakia, attending the school of dentistry, university of são paulo state/unesp, brazil. after paraffin embedded process, in the sections staining with h&e, 30 biopsies were screened and separated on 3 groups: 10 oral lesions without dysplasia, 10 with dysplasia, and 10 with invasive squamous cell carcinoma. the lesions with dysplasia were ... | 2002 | 12621661 |
| morphologic and biologic studies on ten cases of verrucous carcinoma of the vulva supporting the theory of a discrete clinico-pathologic entity. | ten cases of verrucous carcinoma (vc) of the vulva diagnosed from january 1989 to december 1996 were studied. patient age ranged from 50 to 83 years. the following examinations were performed on buffered formalin-fixed material: 1). in situ dna hybridization, probes hpv 6/11, 16/18, 31/35/51; and 2). a series of immunohistochemical stainings to demonstrate wild and mutant types of the p53 protein, cytokeratin expression and pattern distribution (ae1 and ae3), and proliferating pattern (mib 1). i ... | 2003 | 12801263 |
| requirement of stat3 activation for differentiation of mucosal stratified squamous epithelium. | stat3, a member of the signal transducers and activators of transcription (stat) family, has been shown to play a key role in promoting proliferation, differentiation, or cell cycle progression, depending on cell type. a number of signaling pathways are altered in laryngeal papillomas, benign tumors induced by human papillomavirus 6/11. papillomas overexpress the epidermal growth factor receptor and display enhanced map kinase and pi-3-kinase activity. they also show reduced activation of akt an ... | 2003 | 12865943 |
| human papillomavirus 6/11, 16 and 18 in oral carcinomas and benign oral lesions. | we have examined 118 oral squamous cell carcinomas, 72 oral leukoplakias, 12 cases of cheilitis and 65 of oral lichen planus for the presence of human papillomavirus (hpv) 6/11, 16 and 18 dna by pcr/southern blot hybridization. hpv dna were found in 51/118 carcinomas (43.2%), in 16/72 (22.2%) leukoplakias, 3/12 (25.0%) cheilitic lesions and 10/65 (15.4%) lichen planus cases. these differences were even stronger when analyzing separately for the high-risk types hpv 16 and 18 as compared to low-ri ... | 2003 | 12920590 |
| postoperative follow-up of anal condylomata acuminata in hiv-positive patients. | the purpose of this study was to analyze the postoperative follow-up of hiv-positive patients with anal condylomata acuminata, associating recurrence to the aids status. | 2003 | 14530675 |
| [gene optimization is necessary to express hpv type 6 l1 protein in the methylotrophic yeast pichia pastoris]. | human papillomavirus 6 (hpv 6) causes genital warts, a common sexually transmitted disease. l1-capsids protein is a highly promising vaccine candidate that has entered phase ii clinical trial. but the existing methodologies for producing l1-capsids in insect cells is expensive for use in developing countries. as methylotrophic yeast,the pichia pastoris expression system offers economy,and high expression levels. over-expression of hpv6-l1 protein in p. pastoris was the purpose of this study. | 2003 | 15340539 |
| high frequency of human papillomavirus 6/11, 16, and 18 infections in precancerous lesions and squamous cell carcinoma of the conjunctiva in subtropical tanzania. | dysplastic lesions and epithelial neoplasms of the conjunctiva account for approximately 2% of all malignant tumors in subtropical tanzania. we examined the pathophysiologic role of human papillomavirus (hpv) in the development of conjunctival carcinoma in subtropical tanzania, which has a high hpv prevalence. tissue samples from 14 patients were obtained from the cancer registry archives at the medical center of the university in dar es salaam, tanzania. a highly sensitive nonradioactive in sit ... | 2004 | 15539387 |
| simultaneous human papillomavirus 6 (hpv 6) -positive condyloma acuminatum, hpv 31-positive bowen's disease, and non hpv-associated extramammary paget's disease coexisting within an area presenting clinically as condyloma acuminatum. | an 83-year-old japanese man presented with multiple verrucous papules clustering on a plaque located on the frontal aspect of the scrotum. histologically, there were three distinct epithelial changes compatible with condyloma acuminatum, bowen's disease, and extramammary paget's disease (empd). by in situ hybridization, the zone of condyloma acuminatum was positive for hpv 6 and well demarcated from hpv 31-positive bowen's disease. empd was negative for targeted hpv 6/11/16/18/31/33 probes. immu ... | 2005 | 16148417 |
| sexually transmitted disease/hiv risk behaviour among women who have sex with women. | to analyse the epidemiological aspects of sexually transmitted diseases (std) among women who have sex with women (wsw) in são paulo, brazil. | 2005 | 16249657 |
| biopsy vs. superficial scraping: detection of human papillomavirus 6, 11, 16, and 18 in potentially malignant and malignant oral lesions. | several epidemiologic studies have shown a broad variation in the prevalence of human papillomavirus (hpv) in oral precancerous tissues and oral carcinomas. | 2006 | 16762014 |
| longitudinal measures of human papillomavirus 6 and 11 viral loads and antibody response in children with recurrent respiratory papillomatosis. | to measure human papillomavirus (hpv) 6 and 11 viral load and antibody response in longitudinal specimens obtained from children with recurrent respiratory papillomatosis and to examine the association of type-specific viral load with clinical severity of disease. | 2006 | 16847177 |
| incidence and duration of cervical human papillomavirus 6, 11, 16, and 18 infections in young women: an evaluation from multiple analytic perspectives. | to estimate the incidence and duration of cervical human papillomavirus (hpv)-6, hpv-11, hpv-16, and hpv-18 infections in a population of young american women. | 2007 | 17416761 |
| behavior in early adolescence and risk of human papillomavirus infection as a young adult: results from a population-based study. | the goal of this study was to determine the utility of a risk factor-based approach to human papillomavirus catch-up vaccination. | 2008 | 18595979 |
| human papillomavirus 6 seropositivity is associated with risk of head and neck squamous cell carcinoma, independent of tobacco and alcohol use. | the risk of head and neck squamous cell carcinoma (hnscc) associated with common human papillomavirus types has not been well defined. | 2009 | 19087986 |
| pregnancy and infant outcomes in the clinical trials of a human papillomavirus type 6/11/16/18 vaccine: a combined analysis of five randomized controlled trials. | to present a combined analysis of the pregnancy outcomes for women aged up to 45 years enrolled in five phase iii clinical studies of the prophylactic quadrivalent human papillomavirus 6/11/16/18 vaccine. | 2009 | 19935017 |
| recurrent respiratory papillomatosis: a complex defect in immune responsiveness to human papillomavirus-6 and -11. | recurrent respiratory papillomatosis (rrp) is a rare disease of the larynx caused by infection with human papillomaviruses (hpv) -6 or -11, associated with significant morbidity and on occasion mortality. here we summarize our current understanding of the permissive adaptive and innate responses made by patients with rrp that support chronic hpv infection and prevent immune clearance of these viruses. furthermore, we provide new evidence of t(h)2-like polarization in papillomas and blood of pati ... | 2010 | 20553528 |
| seroprevalence of human papillomavirus 6, 11, 16, and 18 in young primiparous women in sao paulo, brazil. | data on epidemiology of hpv infection are needed for the development of human papillomavirus (hpv) vaccine recommendations, especially in countries where hpv vaccination is not yet included in public vaccination programs. the aim of this study was to determine the prevalence of serum antibodies to hpv types 6, 11, 16, and 18 and associated factors among young women after birth of the first child. | 2010 | 21051985 |
| prevention of cervical, vaginal, and vulval cancers: role of the quadrivalent human papillomavirus (6, 11, 16, 18) recombinant vaccine. | the relationship between the human papillomavirus (hpv) and malignancies of the uterine cervix, vagina, and vulva has been established. the development of a quadrivalent hpv recombinant prophylactic vaccine represents the first time in history that primary prevention of these cancers is offered to girls and women. the prevalence of oncogenic hpv subtypes in cervical cancers has been the most studied, but prevalence has also been established for vaginal and vulvar cancers. clinical trials demonst ... | 2010 | 21072282 |
| incidence and predictors of human papillomavirus-6, -11, -16, and -18 infection in young norwegian women. | : natural history data on human papillomavirus (hpv) incidence and its risk factors have not been reported on from young women in norway. we report on incidence and predictors of hpv-6, 11, 16, and 18; 6 or 11; 16 or 18; or all 4. | 2011 | 21301390 |
| [detection and typing of human papillomavirus by a gexp based multiplex pcr assay]. | to establish a new and rapid gexp based multiplex pcr assay for the detection and typing of human papillomavirus 6, 11, 31, 33 and 52. | 2011 | 21789861 |
| the efficacy and safety of the quadrivalent human papillomavirus 6/11/16/18 vaccine gardasil. | human papillomavirus (hpv) infection causes cervical cancer, a significant portion of anal, genital, and oropharyngeal cancers, genital warts, and recurrent respiratory papillomatosis. in june 2006, a quadrivalent hpv-6/11/16/18 vaccine (gardasil/silgard) was licensed in the united states, and subsequently in the european union (september 2006). it has since been approved in 121 countries, with >74 million doses distributed globally as of march 2011. as the incidence of hpv infection peaks 5-10 ... | 2011 | 22018560 |
| clinical trial experience with prophylactic human papillomavirus 6/11/16/18 vaccine in young black women. | human papillomavirus (hpv) is the causative agent of cervical cancer. black women are disproportionally diagnosed and have higher mortality from cervical cancer in the united states. here we describe the prophylactic efficacy and safety of a quadrivalent hpv-6/11/16/18 vaccine in black women. | 2012 | 23299013 |
| no evidence for cross-protection of the hpv-16/18 vaccine against hpv-6/11 positivity in female sti clinic visitors. | data from a vaccine trial and from post-vaccine surveillance in the united kingdom have suggested that the bivalent hpv-16/18 vaccine offers cross-protection against hpv-6/11 and protection against anogenital warts (agw). we studied the effect of the bivalent vaccine on genital hpv-6/11 positivity and agw in the netherlands. | 2017 | 28126492 |
| cost-effectiveness analysis of as04-adjuvanted human papillomavirus 16/18 vaccine compared with human papillomavirus 6/11/16/18 vaccine in the philippines, with the new 2-dose schedule. | cervical cancer (cc) is the second leading cause of cancer death among filipino women. human papillomavirus (hpv) vaccination protects against cc. two vaccines (as04-hpv-16/18 and 4vhpv) are approved in the philippines; they were originally developed for a 3-dose (3d) administration and have recently been approved in a 2-dose schedule (2d). this study aims to evaluate the cost-effectiveness of hpv vaccination of 13-year-old filipino girls, in addition to current screening, in the new 2d schedule ... | 2017 | 28075249 |
| papillomavirus and cancers: should we extend vaccination to boys in france? | in 2006, the hpv (human papillomavirus) 6/11/16/18 quadrivalent vaccine was approved by the european medicines agency and obtained its marketing authorization in both girls and boys. currently, the french guidelines recommend and refund vaccination of girls aged 11 to 14 with a catch-up program for females from 15 to 19 years old. | 2016 | 27679660 |
| quantitative and epitope-specific antigenicity analysis of the human papillomavirus 6 capsid protein in aqueous solution or when adsorbed on particulate adjuvants. | human papillomavirus (hpv) 6 is a human pathogen which causes genital warts. recombinant virus-like particle (vlp) based antigens are the active components in prophylactic vaccines to elicit functional antibodies. the binding and functional characteristics of a panel of 15 murine monoclonal antibodies (mabs) against hpv6 was quantitatively assessed. elite conformational indicators, recognizing the conformational epitopes, are also elite viral neutralizers as demonstrated with their viral neutral ... | 2016 | 27426626 |
| multiple human papillomavirus infection is associated with high-risk infection in male genital warts in ulsan, korea. | further understanding of male human papillomavirus (hpv) infection is necessary to prevent infection in men, as well as transmission to women. in our current study, we investigated patterns of hpv infection and genotype distributions in male genital warts using the anyplex ii hpv28 detection kit. we reviewed the medical records of 80 male patients who presented to 5 neighborhood clinics in ulsan, korea, for the treatment of genital warts between april 2014 and january 2015. all patients underwen ... | 2016 | 26955236 |
| [human papilloma virus genotyping in women with abnormal cytology]. | to assess presence of hpv infection and identification of the most common hpv types in patients with abnormal cytology based on the bethesda system (atypical squamous cells). | 2015 | 26376534 |
| [safety of human papillomavirus 6, 11, 16 and 18 (recombinant): systematic review and meta-analysis]. | to identify and quantify the adverse effects associated with the recombinant human papillomavirus (types 6, 11, 16 and 18) vaccine in adolescents. | 2015 | 26376359 |
| phase iii, randomized controlled trial in girls 9-15 years old to evaluate lot consistency of a novel nine-valent human papillomavirus l1 virus-like particle vaccine. | a 9-valent human papillomavirus (6/11/16/18/31/33/45/52/58) vlp (9vhpv) vaccine has recently been proven highly efficacious in preventing disease associated with vaccine hpv types in a pivotal phase iii study. the demonstration of lot-to-lot consistency to confirm the reliability of the manufacturing process is a regulatory requirement for vaccine licensure in the united states. a randomized trial was conducted to demonstrate that three lots of 9vhpv vaccine elicit equivalent antibody response f ... | 2015 | 26086587 |
| evaluation of the long-term anti-human papillomavirus 6 (hpv6), 11, 16, and 18 immune responses generated by the quadrivalent hpv vaccine. | this quadrivalent human papillomavirus (qhpv) (hpv6, -11, -16, and -18) vaccine long-term follow-up (ltfu) study is an ongoing extension of a pivotal clinical study (future ii) taking place in the nordic region. the ltfu study was designed to evaluate the effectiveness, immunogenicity, and safety of the qhpv vaccine (gardasil) for at least 10 years following completion of the base study. the current report presents immunogenicity data from testing samples of the year 5 ltfu visit (approximately ... | 2015 | 26084514 |
| electrocautery resection, shaving with a scalpel, and podophyllin: a combination therapy for giant condyloma acuminatum. | giant condyloma acuminatum (also known as buschke-löwenstein tumor) is a rare disease, for which the treatment of choice is still controversial. in the case described in this report, we used a combination of electrocautery and a surgical scalpel to resect a huge genital wart, followed by long-term local treatment with podophyllin. this procedure was relatively fast, easy to perform, involved minimal bleeding, and did not result in any complications. moreover, combination therapy enabled us to av ... | 2015 | 25927062 |
| evaluation of vaccine seroresponse rates and adverse event rates through bayesian and frequentist methods. | in the evaluation of vaccine seroresponse rates and adverse reaction rates, extreme test results often occur, with substantial adverse event rates of 0% and/or seroresponse rates of 100%, which has produced several data challenges. few studies have used both the bayesian and frequentist methods on the same sets of data that contain extreme test cases to evaluate vaccine safety and immunogenicity. in this study, bayesian methods were introduced, and the comparison with frequentist methods was mad ... | 2015 | 25909683 |
| clinical course of recurrent respiratory papillomatosis: comparison between aggressiveness of human papillomavirus-6 and human papillomavirus-11. | recurrent respiratory papillomatosis (rrp) is mainly associated with human papillomavirus (hpv)6 or hpv11. the purpose of this study was to compare clinical outcome, aggressiveness, and treatment response between hpv6- and hpv11-associated rrp. | 2015 | 24955561 |
| global genomic diversity of human papillomavirus 6 based on 724 isolates and 190 complete genome sequences. | human papillomavirus type 6 (hpv6) is the major etiological agent of anogenital warts and laryngeal papillomas and has been included in both the quadrivalent and nonavalent prophylactic hpv vaccines. this study investigated the global genomic diversity of hpv6, using 724 isolates and 190 complete genomes from six continents, and the association of hpv6 genomic variants with geographical location, anatomical site of infection/disease, and gender. initially, a 2,800-bp e5a-e5b-l1-lcr fragment was ... | 2014 | 24741079 |
| immunogenicity and safety of the human papillomavirus 6, 11, 16, 18 vaccine in hiv-infected young women. | the objective of this study was to determine whether the 3-dose quadrivalent human papillomavirus (hpv) vaccine series (hpv-6, -11, -16, -18) is immunogenic and safe in young women infected with human immunodeficiency virus (hiv). | 2013 | 23667266 |
| deterministic modelling for transmission of human papillomavirus 6/11: impact of vaccination. | this paper is devoted to assess the impact of quadrivalent human papillomavirus (hpv) vaccine on the prevalence of non-oncogenic hpv 6/11 types in french males and females. for this purpose, a non-linear dynamic model of heterosexual transmission for hpv 6/11 types infection is developed, which accounts for immunity due to vaccination, in particular. the vaccinated reproduction number rv is derived using the approach described by diekmann et al. (2010) called the next generation operator approac ... | 2014 | 23475425 |
| a prophylactic quadrivalent vaccine for the prevention of infection and disease related to hpv-6, -11, -16 and -18. | human papillomavirus infection causes cervical cancer, a significant portion of anal, genital and oropharyngeal cancers, genital warts and recurrent respiratory papillomatosis. in june 2006, a quadrivalent human papillomavirus-6/11/16/18 vaccine (gardasil/silgard®; merck, nj, usa) was licensed in the usa; subsequent approval has been granted in the eu (september 2006). it has since been approved in 121 countries with over 74 million doses distributed globally as of march 2011. | 2012 | 22551023 |