| in silico and in vivo evaluation of bacteriophage phief24c, a candidate for treatment of enterococcus faecalis infections. | along with the increasing threat of nosocomial infections by vancomycin-resistant enterococcus faecalis, bacteriophage (phage) therapy has been expected as an alternative therapy against infectious disease. although genome information and proof of applicability are prerequisites for a modern therapeutic phage, e. faecalis phage has not been analyzed in terms of these aspects. previously, we reported a novel virulent phage, phief24c, and its biology indicated its therapeutic potential against e. ... | 2008 | 18456848 |
| the terminally redundant, nonpermuted genome of listeria bacteriophage a511: a model for the spo1-like myoviruses of gram-positive bacteria. | only little information on a particular class of myoviruses, the spo1-like bacteriophages infecting low-g+c-content, gram-positive host bacteria (firmicutes), is available. we present the genome analysis and molecular characterization of the large, virulent, broad-host-range listeria phage a511. a511 contains a unit (informational) genome of 134,494 bp, encompassing 190 putative open reading frames (orfs) and 16 trna genes, organized in a modular fashion common among the caudovirales. electron m ... | 2008 | 18567664 |