| anti-proliferative and cytotoxic activity of pentadactylin isolated from leptodactylus labyrinthicus on melanoma cells. | nowadays, the emergence of resistance to the current available chemotherapeutic drugs by cancer cells makes the development of new agents imperative. the skin secretion of amphibians is a natural rich source of antimicrobial peptides (amp), and researchers have shown that some of these wide spectrum molecules are also toxic to cancer cells. the aim of this study was to verify a putative anticancer activity of the amp pentadactylin isolated for the first time from the skin secretion of the frog l ... | 2011 | 20012549 |
| synergic effects between ocellatin-f1 and bufotenine on the inhibition of bhk-21 cellular infection by the rabies virus. | rabies is an incurable neglected zoonosis with worldwide distribution characterized as a lethal progressive acute encephalitis caused by a lyssavirus. animal venoms and secretions have long been studied as new bioactive molecular sources, presenting a wide spectrum of biological effects, including new antiviral agents. bufotenine, for instance, is an alkaloid isolated from the skin secretion of the anuran rhinella jimi that inhibits cellular penetration by the rabies virus. antimicrobial peptide ... | 2015 | 26635873 |
| perspectives on invasive amphibians in brazil. | introduced species have the potential to become invasive and jeopardize entire ecosystems. the success of species establishing viable populations outside their original extent depends primarily on favorable climatic conditions in the invasive ranges. species distribution modeling (sdm) can thus be used to estimate potential habitat suitability for populations of invasive species. here we review the status of six amphibian species with invasive populations in brazil (four domestic species and two ... | 2017 | 28938024 |
| further notes on the natural history of the south american pepper frog, leptodactylus labyrinthicus (spix, 1824) (anura, leptodactylidae). | leptodactylus labyrinthicus tadpoles reach a large size in the nest through consumption of trophic eggs. we previously suggested that the trophic eggs are laid just after amplexus has finished, but our new data do not support this hypothesis. we also present further details on the natural history of the species with regard to breeding activity, spawning site, retreats and the ability of tadpoles in preying upon fully-growth heterospecific tadpoles. we also show that the tadpoles are mainly noctu ... | 2008 | 18660971 |
| the crude skin secretion of the pepper frog leptodactylus labyrinthicus is rich in metallo and serine peptidases. | peptidases are ubiquitous enzymes involved in diverse biological processes. fragments from bioactive peptides have been found in skin secretions from frogs, and their presence suggests processing by peptidases. thus, the aim of this work was to characterize the peptidase activity present in the skin secretion of leptodactylus labyrinthicus. zymography revealed the presence of three bands of gelatinase activity of approximately 60 kda, 66 kda, and 80 kda, which the first two were calcium-dependen ... | 2014 | 24906116 |
| ocellatin peptides from the skin secretion of the south american frog leptodactylus labyrinthicus (leptodactylidae): characterization, antimicrobial activities and membrane interactions. | the availability of antimicrobial peptides from several different natural sources has opened an avenue for the discovery of new biologically active molecules. to the best of our knowledge, only two peptides isolated from the frog leptodactylus labyrinthicus, namely pentadactylin and ocellatin-f1, have shown antimicrobial activities. therefore, in order to explore the antimicrobial potential of this species, we have investigated the biological activities and membrane interactions of three peptide ... | 2017 | 28115922 |
| nmr structures in different membrane environments of three ocellatin peptides isolated from leptodactylus labyrinthicus. | the peptides ocellatin-lb1, -lb2 and -f1 have previously been isolated from anurans of the leptodactylus genus and the sequences are identical from residue 1-22, which correspond to ocellatin-lb1 sequence (gvvdilkgaakdiaghlaskvm-nh2), whereas ocellatin-lb2 carries an extra n and ocellatin-f1 extra nkl residues at their c-termini. these peptides showed different spectra of activities and biophysical investigations indicated a direct correlation between membrane-disruptive properties and antimicro ... | 2018 | 29596881 |